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Aliases for SERPINB8 Gene

Aliases for SERPINB8 Gene

  • Serpin Family B Member 8 2 3 5
  • Cytoplasmic Antiproteinase 2 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 8 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 2 3
  • Peptidase Inhibitor 8 3 4
  • CAP2 3 4
  • PI-8 3 4
  • PI8 3 4
  • Protease Inhibitor 8 (Ovalbumin Type) 3
  • Serpin B8 3
  • CAP-2 4
  • PSS5 3

External Ids for SERPINB8 Gene

Previous HGNC Symbols for SERPINB8 Gene

  • PI8

Previous GeneCards Identifiers for SERPINB8 Gene

  • GC18P061476
  • GC18P061610
  • GC18P061422
  • GC18P059786
  • GC18P059295
  • GC18P059788
  • GC18P061637
  • GC18P058338

Summaries for SERPINB8 Gene

Entrez Gene Summary for SERPINB8 Gene

  • The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

GeneCards Summary for SERPINB8 Gene

SERPINB8 (Serpin Family B Member 8) is a Protein Coding gene. Diseases associated with SERPINB8 include Exfoliative Ichthyosis and Embryoma. Among its related pathways are CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF) and Dissolution of Fibrin Clot. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB6.

Gene Wiki entry for SERPINB8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB8 Gene

Genomics for SERPINB8 Gene

Regulatory Elements for SERPINB8 Gene

Enhancers for SERPINB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F063935 1.1 Ensembl ENCODE 12 -33.4 -33352 1.7 ELF3 CTCF MAX RAD21 GLIS2 POLR2A SCRT2 EED ZNF143 SMC3 SERPINB10 SERPINB8 HMSD
GH18F063979 0.7 ENCODE 10.6 +9.7 9707 0.4 ELF3 CTCF ZNF654 TEAD1 TEAD4 ZFP37 TRIM22 RAD21 TEAD3 ZNF143 SERPINB8 SERPINB10 LOC105372165 RPL12P39
GH18F063859 0.6 FANTOM5 ENCODE 11.4 -109.5 -109500 1.4 SERPINB10 SERPINB2 SERPINB8 VPS4B SERPINB7
GH18F063968 1 ENCODE 6.8 +0.8 750 3.4 HDGF PKNOX1 ATF1 SIN3A DMAP1 ZNF48 ETS1 YY1 GLIS2 ELK1 SERPINB10 SERPINB8 LOC105372165 RPL12P39
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERPINB8 on UCSC Golden Path with GeneCards custom track

Promoters for SERPINB8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000527555 575 1801 HDGF PKNOX1 ATF1 SIN3A DMAP1 ETS1 YY1 GLIS2 ELK1 KLF7

Genomic Location for SERPINB8 Gene

63,969,925 bp from pter
64,019,779 bp from pter
49,855 bases
Plus strand

Genomic View for SERPINB8 Gene

Genes around SERPINB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB8 Gene

Proteins for SERPINB8 Gene

  • Protein details for SERPINB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B8
    Protein Accession:
    Secondary Accessions:
    • B4DTW2
    • Q7Z2V6
    • Q8N178

    Protein attributes for SERPINB8 Gene

    374 amino acids
    Molecular mass:
    42767 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB8 Gene


neXtProt entry for SERPINB8 Gene

Post-translational modifications for SERPINB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SERPINB8 (Serpin B8/Proteinase Inhibitor 8)

No data available for DME Specific Peptides for SERPINB8 Gene

Domains & Families for SERPINB8 Gene

Gene Families for SERPINB8 Gene

Protein Domains for SERPINB8 Gene


Suggested Antigen Peptide Sequences for SERPINB8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family. Ov-serpin subfamily.
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB8: view

Function for SERPINB8 Gene

Gene Ontology (GO) - Molecular Function for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IDA 8530382
GO:0005515 protein binding IPI 8530382
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB8: view
genes like me logo Genes that share phenotypes with SERPINB8: view

Animal Model Products

miRNA for SERPINB8 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINB8 Gene

Localization for SERPINB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB8 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB8 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 8530382
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SERPINB8: view

Pathways & Interactions for SERPINB8 Gene

genes like me logo Genes that share pathways with SERPINB8: view

Pathways by source for SERPINB8 Gene

2 Reactome pathways for SERPINB8 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINB8 Gene

Gene Ontology (GO) - Biological Process for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IDA 8530382
GO:0090136 epithelial cell-cell adhesion IMP 27476651
genes like me logo Genes that share ontologies with SERPINB8: view

No data available for SIGNOR curated interactions for SERPINB8 Gene

Transcripts for SERPINB8 Gene

Unigene Clusters for SERPINB8 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB8 Gene

No ASD Table

Relevant External Links for SERPINB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB8 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for SERPINB8 Gene

This gene is overexpressed in Monocytes (18.1), Peripheral blood mononuclear cells (15.9), and Platelet (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERPINB8 Gene

Protein tissue co-expression partners for SERPINB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB8 Gene:


SOURCE GeneReport for Unigene cluster for SERPINB8 Gene:

genes like me logo Genes that share expression patterns with SERPINB8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SERPINB8 Gene

Orthologs for SERPINB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINB8 34 35
  • 99.38 (n)
(Bos Taurus)
Mammalia SERPINB8 34 35
  • 85.29 (n)
(Canis familiaris)
Mammalia SERPINB8 34 35
  • 84.58 (n)
(Mus musculus)
Mammalia Serpinb8 34 16 35
  • 81.11 (n)
(Rattus norvegicus)
Mammalia Serpinb8 34
  • 81.11 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn3 36
  • 35 (a)
CG9455 36
  • 34 (a)
Spn1 36
  • 34 (a)
Spn2 36
  • 34 (a)
Spn43Aa 36
  • 33 (a)
Spn6 36
  • 33 (a)
CG6687 36
  • 31 (a)
CG9460 36
  • 31 (a)
Spn5 36
  • 30 (a)
CG6717 36
  • 29 (a)
CG7722 36
  • 28 (a)
Species where no ortholog for SERPINB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB8 Gene

Gene Tree for SERPINB8 (if available)
Gene Tree for SERPINB8 (if available)

Paralogs for SERPINB8 Gene

Variants for SERPINB8 Gene

Sequence variations from dbSNP and Humsavar for SERPINB8 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs144666367 Pathogenic 63,987,003(+) TCCTT(C/T)GAAGA intron-variant, downstream-variant-500B, reference, utr-variant-3-prime, stop-gained
rs374612640 Pathogenic 63,978,310(+) TCTGA(C/T)GGATG intron-variant, reference, missense
rs10048273 -- 64,009,814(+) GTTAA(A/C)TGTTG intron-variant
rs10048342 -- 64,007,791(+) tgtcc(C/T)tgtga intron-variant
rs10048400 -- 64,007,816(+) accag(A/G)cccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB8 Gene

Variant ID Type Subtype PubMed ID
nsv833673 CNV gain 17160897
nsv1067311 CNV loss 25217958
nsv1066552 CNV gain 25217958
esv3642785 CNV gain 21293372
esv21739 CNV gain 19812545

Variation tolerance for SERPINB8 Gene

Residual Variation Intolerance Score: 65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.37; 81.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB8 Gene

Disorders for SERPINB8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SERPINB8 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
  • blastoma
chromosome 18q deletion syndrome
  • 18q- syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINB8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SERPINB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB8 Gene

Publications for SERPINB8 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher C.A. … Kisiel W. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. (PMID: 20953187) Sun L.D. … Zhang X.J. (Nat. Genet. 2010) 3 46 64
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64

Products for SERPINB8 Gene

Sources for SERPINB8 Gene

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