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Aliases for SERPINB8 Gene

Aliases for SERPINB8 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 2 3
  • Cytoplasmic Antiproteinase 2 2 3 4
  • PI8 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 8 2 3
  • Peptidase Inhibitor 8 3 4
  • CAP2 3 4
  • PI-8 3 4
  • Protease Inhibitor 8 (Ovalbumin Type) 3
  • Serpin B8 3
  • CAP2, 6
  • CAP-2 4

External Ids for SERPINB8 Gene

Previous Symbols for SERPINB8 Gene

  • PI8

Summaries for SERPINB8 Gene

Entrez Gene Summary for SERPINB8 Gene

  • The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

GeneCards Summary for SERPINB8 Gene

SERPINB8 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Hemostasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

Gene Wiki entry for SERPINB8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB8 Gene

Genomics for SERPINB8 Gene

Genomic Location for SERPINB8 Gene

Start:
63,969,925 bp from pter
End:
64,005,667 bp from pter
Size:
35,743 bases
Orientation:
Plus strand

Genomic View for SERPINB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB8 Gene

Regulatory Elements for SERPINB8 Gene

Proteins for SERPINB8 Gene

  • Protein details for SERPINB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50452-SPB8_HUMAN
    Recommended name:
    Serpin B8
    Protein Accession:
    P50452
    Secondary Accessions:
    • B4DTW2
    • Q7Z2V6
    • Q8N178

    Protein attributes for SERPINB8 Gene

    Size:
    374 amino acids
    Molecular mass:
    42767 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB8 Gene

Proteomics data for SERPINB8 Gene at MOPED

Post-translational modifications for SERPINB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB8 Gene

No data available for DME Specific Peptides for SERPINB8 Gene

Domains for SERPINB8 Gene

Gene Families for SERPINB8 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB8 Gene

Graphical View of Domain Structure for InterPro Entry

P50452

UniProtKB/Swiss-Prot:

SPB8_HUMAN
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.:
    • P50452
genes like me logo Genes that share domains with SERPINB8: view

Function for SERPINB8 Gene

Gene Ontology (GO) - Molecular Function for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IDA 8530382
GO:0005515 protein binding IPI 8530382
genes like me logo Genes that share ontologies with SERPINB8: view

Phenotypes for SERPINB8 Gene

GenomeRNAi human phenotypes for SERPINB8:
genes like me logo Genes that share phenotypes with SERPINB8: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB8 Gene

Localization for SERPINB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB8 Gene COMPARTMENTS Subcellular localization image for SERPINB8 gene
Compartment Confidence
cytosol 5
extracellular 2
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005829 cytosol IDA 8530382
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SERPINB8: view

Pathways for SERPINB8 Gene

genes like me logo Genes that share pathways with SERPINB8: view

Pathways by source for SERPINB8 Gene

Gene Ontology (GO) - Biological Process for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IDA 8530382
GO:0030162 regulation of proteolysis --
genes like me logo Genes that share ontologies with SERPINB8: view

Transcripts for SERPINB8 Gene

Unigene Clusters for SERPINB8 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB8 Gene

No ASD Table

Relevant External Links for SERPINB8 Gene

GeneLoc Exon Structure for
SERPINB8
ECgene alternative splicing isoforms for
SERPINB8

Expression for SERPINB8 Gene

mRNA expression in normal human tissues for SERPINB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB8 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB8 Gene

SOURCE GeneReport for Unigene cluster for SERPINB8 Gene Hs.368077

genes like me logo Genes that share expressions with SERPINB8: view

No data available for mRNA Expression by UniProt/SwissProt for SERPINB8 Gene

Orthologs for SERPINB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB8 35
  • 99.38 (n)
  • 99.2 (a)
SERPINB8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB8 35
  • 85.29 (n)
  • 82.89 (a)
SERPINB8 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB8 35
  • 84.58 (n)
  • 83.42 (a)
SERPINB8 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb8 35
  • 81.11 (n)
  • 78.34 (a)
Serpinb8 16
Serpinb8 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb8 35
  • 81.11 (n)
  • 77.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn5 37
  • 30 (a)
Spn3 37
  • 35 (a)
Spn2 37
  • 34 (a)
Spn43Aa 37
  • 33 (a)
CG9455 37
  • 34 (a)
CG9460 37
  • 31 (a)
CG6687 37
  • 31 (a)
Spn1 37
  • 34 (a)
CG6717 37
  • 29 (a)
Spn6 37
  • 33 (a)
CG7722 37
  • 28 (a)
Species with no ortholog for SERPINB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB8 Gene

ENSEMBL:
Gene Tree for SERPINB8 (if available)
TreeFam:
Gene Tree for SERPINB8 (if available)

Paralogs for SERPINB8 Gene

Pseudogenes.org Pseudogenes for SERPINB8 Gene

genes like me logo Genes that share paralogs with SERPINB8: view

Variants for SERPINB8 Gene

Sequence variations from dbSNP and Humsavar for SERPINB8 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs480378 -- 63,978,742(+) CATCT(G/T)TGATA intron-variant
rs514315 -- 63,989,551(+) ttctc(C/T)cttct downstream-variant-500B
rs519694 -- 63,971,719(+) TCTTT(C/G)TAAAG intron-variant
rs574764 -- 63,974,140(-) AATAA(G/T)AAGAA intron-variant
rs595535 -- 63,972,514(-) ctaga(A/G)cttaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB8 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV Gain 19812545
nsv909693 CNV Gain 21882294
nsv833673 CNV Gain 17160897

Relevant External Links for SERPINB8 Gene

HapMap Linkage Disequilibrium report
SERPINB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB8 Gene

Disorders for SERPINB8 Gene

Relevant External Links for SERPINB8

Genetic Association Database (GAD)
SERPINB8
Human Genome Epidemiology (HuGE) Navigator
SERPINB8
genes like me logo Genes that share disorders with SERPINB8: view

No data available for UniProtKB/Swiss-Prot for SERPINB8 Gene

Publications for SERPINB8 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher C.A. … Kisiel W. (J. Biol. Chem. 1995) 2 3 4 23
  2. Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. (PMID: 12417609) Strik M.C. … Kummer J.A. (J. Histochem. Cytochem. 2002) 3 23
  3. Inhibition of soluble recombinant furin by human proteinase inhibitor 8. (PMID: 9442015) Dahlen J.R. … Kisiel W. (J. Biol. Chem. 1998) 3 23
  4. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. (PMID: 9268635) Bartuski A.J. … Silverman G.A. (Genomics 1997) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for SERPINB8 Gene

Sources for SERPINB8 Gene

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