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Aliases for SERPINB5 Gene

Aliases for SERPINB5 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 5 2 3
  • Protease Inhibitor 5 (Maspin) 2 3
  • Peptidase Inhibitor 5 3 4
  • Maspin 3 4
  • PI-5 3 4
  • PI5 3 4
  • Serpin B5 3
  • PI5, 6

External Ids for SERPINB5 Gene

Previous Symbols for SERPINB5 Gene

  • PI5

Summaries for SERPINB5 Gene

GeneCards Summary for SERPINB5 Gene

SERPINB5 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include polymorphous low-grade adenocarcinoma and laryngeal carcinoma. Among its related pathways are MicroRNAs in cancer and Angiogenesis (CST). GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB5 Gene

  • Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity

Gene Wiki entry for SERPINB5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB5 Gene

Genomics for SERPINB5 Gene

Genomic Location for SERPINB5 Gene

Start:
63,476,761 bp from pter
End:
63,505,085 bp from pter
Size:
28,325 bases
Orientation:
Plus strand

Genomic View for SERPINB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB5 Gene

Regulatory Elements for SERPINB5 Gene

Proteins for SERPINB5 Gene

  • Protein details for SERPINB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36952-SPB5_HUMAN
    Recommended name:
    Serpin B5
    Protein Accession:
    P36952
    Secondary Accessions:
    • B2R6Y4
    • Q6N0B4
    • Q8WW89

    Protein attributes for SERPINB5 Gene

    Size:
    375 amino acids
    Molecular mass:
    42100 Da
    Quaternary structure:
    • Interacts with IRF6.

    Three dimensional structures from OCA and Proteopedia for SERPINB5 Gene

    Alternative splice isoforms for SERPINB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB5 Gene

Proteomics data for SERPINB5 Gene at MOPED

Post-translational modifications for SERPINB5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn99, Asn133, Asn188, and Asn361

Other Protein References for SERPINB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB5 Gene

Domains for SERPINB5 Gene

Gene Families for SERPINB5 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB5 Gene

UniProtKB/Swiss-Prot:

SPB5_HUMAN
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.:
    • P36952
genes like me logo Genes that share domains with SERPINB5: view

Function for SERPINB5 Gene

Molecular function for SERPINB5 Gene

UniProtKB/Swiss-Prot Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity

Gene Ontology (GO) - Molecular Function for SERPINB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0005515 protein binding IPI 16049006
genes like me logo Genes that share ontologies with SERPINB5: view
genes like me logo Genes that share phenotypes with SERPINB5: view

Animal Models for SERPINB5 Gene

MGI Knock Outs for SERPINB5:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERPINB5 Gene

Localization for SERPINB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB5 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB5 Gene COMPARTMENTS Subcellular localization image for SERPINB5 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SERPINB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERPINB5: view

Pathways for SERPINB5 Gene

genes like me logo Genes that share pathways with SERPINB5: view

Pathways by source for SERPINB5 Gene

2 Cell Signaling Technology pathways for SERPINB5 Gene
2 BioSystems pathways for SERPINB5 Gene
2 KEGG pathways for SERPINB5 Gene

Gene Ontology (GO) - Biological Process for SERPINB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002009 morphogenesis of an epithelium IEA --
GO:0006928 movement of cell or subcellular component TAS 8290962
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with SERPINB5: view

Compounds for SERPINB5 Gene

(1) Drugbank Compounds for SERPINB5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S,S-(2-Hydroxyethyl)Thiocysteine
target

(20) Novoseek inferred chemical compound relationships for SERPINB5 Gene

Compound -log(P) Hits PubMed IDs
serine 74.3 84
5-aza-2deoxycytidine 74 15
scca1 66.7 3
matrigel 40 3
depsipeptide 34.7 4
genes like me logo Genes that share compounds with SERPINB5: view

Transcripts for SERPINB5 Gene

Unigene Clusters for SERPINB5 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB5 Gene

No ASD Table

Relevant External Links for SERPINB5 Gene

GeneLoc Exon Structure for
SERPINB5
ECgene alternative splicing isoforms for
SERPINB5

Expression for SERPINB5 Gene

mRNA expression in normal human tissues for SERPINB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (13.8), Skin - Not Sun Exposed (Suprapubic) (13.7), Esophagus - Mucosa (10.4), Minor Salivary Gland (5.7), and Vagina (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB5 Gene

SOURCE GeneReport for Unigene cluster for SERPINB5 Gene Hs.55279

mRNA Expression by UniProt/SwissProt for SERPINB5 Gene

P36952-SPB5_HUMAN
Tissue specificity: Normal mammary epithelial cells
genes like me logo Genes that share expressions with SERPINB5: view

Orthologs for SERPINB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB5 36
  • 99.47 (n)
  • 99.47 (a)
SERPINB5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB5 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB5 36
  • 90.22 (n)
  • 92.8 (a)
SERPINB5 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb5 36
  • 86.58 (n)
  • 89.07 (a)
Serpinb5 16
Serpinb5 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINB5 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB5 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb5 36
  • 85.96 (n)
  • 88 (a)
chicken
(Gallus gallus)
Aves SERPINB5 36
  • 69.42 (n)
  • 64.53 (a)
SERPINB5 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINB5 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpinb5 36
  • 61.87 (n)
  • 53.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta nec 37
  • 19 (a)
ManyToMany
Spn1 37
  • 29 (a)
ManyToMany
Spn2 37
  • 29 (a)
ManyToMany
Spn28Da 37
  • 25 (a)
ManyToMany
Spn28Db 37
  • 26 (a)
ManyToMany
Spn3 37
  • 29 (a)
ManyToMany
Spn4 37
  • 22 (a)
ManyToMany
Spn42Db 37
  • 23 (a)
ManyToMany
Spn42Dc 37
  • 25 (a)
ManyToMany
Spn42De 37
  • 24 (a)
ManyToMany
Spn43Aa 37
  • 25 (a)
ManyToMany
Spn43Ab 37
  • 26 (a)
ManyToMany
Spn47C 37
  • 24 (a)
ManyToMany
Spn6 37
  • 29 (a)
ManyToMany
Spn7 37
  • 28 (a)
ManyToMany
Spn43Ab 38
  • 27 (a)
CG6717 38
  • 29 (a)
Spn6 38
  • 30 (a)
CG7722 38
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for SERPINB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB5 Gene

ENSEMBL:
Gene Tree for SERPINB5 (if available)
TreeFam:
Gene Tree for SERPINB5 (if available)

Paralogs for SERPINB5 Gene

genes like me logo Genes that share paralogs with SERPINB5: view

Variants for SERPINB5 Gene

Sequence variations from dbSNP and Humsavar for SERPINB5 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs894 -- 63,504,364(+) AATCA(A/C)CACCT utr-variant-3-prime
rs1004 -- 63,504,357(+) accta(A/C/T)aaatc utr-variant-3-prime
rs15964 -- 63,505,015(+) AATAG(C/G)TTCTT utr-variant-3-prime
rs1396782 -- 63,496,692(+) TGAAG(C/T)TTGAA intron-variant
rs1455555 - 63,503,549(-) GTGGA(C/T)AACAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SERPINB5 Gene

Variant ID Type Subtype PubMed ID
nsv131597 CNV Loss 16902084
esv26779 CNV Loss 19812545

Relevant External Links for SERPINB5 Gene

HapMap Linkage Disequilibrium report
SERPINB5
Human Gene Mutation Database (HGMD)
SERPINB5

Disorders for SERPINB5 Gene

(62) Novoseek inferred disease relationships for SERPINB5 Gene

Disease -log(P) Hits PubMed IDs
metastasis 68.6 123
tumors 66.6 286
breast cancer 63.8 141
carcinoma 61.2 64
myoepithelioma 60.9 2

Relevant External Links for SERPINB5

Human Genome Epidemiology (HuGE) Navigator
SERPINB5
genes like me logo Genes that share disorders with SERPINB5: view

No data available for UniProtKB/Swiss-Prot for SERPINB5 Gene

Publications for SERPINB5 Gene

  1. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PMID: 8290962) Zou Z. … Sager R. (Science 1994) 2 3 4 23
  2. The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PMID: 15760906) Law R.H. … Whisstock J.C. (J. Biol. Chem. 2005) 3 4 23
  3. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PMID: 7797587) Pemberton P.A. … Barr P.J. (J. Biol. Chem. 1995) 3 4 23
  4. Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PMID: 16720730) Cella N. … Zhang M. (FASEB J. 2006) 2 3 23
  5. Epigenetic regulation of maspin expression in the human placenta. (PMID: 16936308) Dokras A. … Madan A. (Mol. Hum. Reprod. 2006) 3 23

Products for SERPINB5 Gene

Sources for SERPINB5 Gene

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