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Aliases for PHB Gene

Aliases for PHB Gene

  • Prohibitin 2 3
  • Epididymis Secretory Sperm Binding Protein Li 54e 3
  • Epididymis Luminal Protein 215 3
  • HEL-S-54e 3
  • HEL-215 3
  • PHB1 3

External Ids for PHB Gene

Summaries for PHB Gene

Entrez Gene Summary for PHB Gene

  • This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PHB Gene

PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include breast cancer and brca1 and brca2 hereditary breast and ovarian cancer. Among its related pathways are Cell Cycle / Checkpoint Control and Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding RNA polymerase II transcription factor activity.

UniProtKB/Swiss-Prot for PHB Gene

  • Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Gene Wiki entry for PHB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHB Gene

Genomics for PHB Gene

Genomic Location for PHB Gene

Start:
49,404,048 bp from pter
End:
49,414,905 bp from pter
Size:
10,858 bases
Orientation:
Minus strand

Genomic View for PHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB Gene

Regulatory Elements for PHB Gene

Proteins for PHB Gene

  • Protein details for PHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35232-PHB_HUMAN
    Recommended name:
    Prohibitin
    Protein Accession:
    P35232
    Secondary Accessions:
    • B4DY47
    • Q4VBQ0

    Protein attributes for PHB Gene

    Size:
    272 amino acids
    Molecular mass:
    29804 Da
    Quaternary structure:
    • Interacts with PHB2. Interacts with STOML2.

    Three dimensional structures from OCA and Proteopedia for PHB Gene

    Alternative splice isoforms for PHB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB Gene

Proteomics data for PHB Gene at MOPED

Post-translational modifications for PHB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys128

No data available for DME Specific Peptides for PHB Gene

Domains for PHB Gene

Protein Domains for PHB Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PHB_HUMAN
Family:
  • Belongs to the prohibitin family.:
    • P35232
genes like me logo Genes that share domains with PHB: view

No data available for Gene Families for PHB Gene

Function for PHB Gene

Molecular function for PHB Gene

GENATLAS Biochemistry: prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function
UniProtKB/Swiss-Prot Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
UniProtKB/Swiss-Prot Induction: Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.

Gene Ontology (GO) - Molecular Function for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0001850 complement component C3a binding IDA 17070910
GO:0001851 complement component C3b binding IDA 17070910
GO:0005515 protein binding IPI 11302691
GO:0019899 enzyme binding IPI 23921388
genes like me logo Genes that share ontologies with PHB: view
genes like me logo Genes that share phenotypes with PHB: view

Animal Models for PHB Gene

MGI Knock Outs for PHB:

miRNA for PHB Gene

miRTarBase miRNAs that target PHB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PHB Gene

Localization for PHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHB Gene COMPARTMENTS Subcellular localization image for PHB gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 4
cytoskeleton 2
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm IDA 12466959
GO:0005737 cytoplasm IDA 16964284
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS 14500729
genes like me logo Genes that share ontologies with PHB: view

Pathways for PHB Gene

genes like me logo Genes that share pathways with PHB: view

Pathways by source for PHB Gene

1 Cell Signaling Technology pathway for PHB Gene
1 BioSystems pathway for PHB Gene

Gene Ontology (GO) - Biological Process for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16964284
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006355 regulation of transcription, DNA-templated IDA 14500729
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007005 mitochondrion organization IMP 17008324
genes like me logo Genes that share ontologies with PHB: view

Compounds for PHB Gene

(20) Novoseek inferred chemical compound relationships for PHB Gene

Compound -log(P) Hits PubMed IDs
1alpha-hydroxyvitamin d5 80.5 2
leptomycin b 39.3 2
glyceraldehyde 3-phosphate 28.2 4
camptothecin 27.6 6
pyruvate 25.3 4
genes like me logo Genes that share compounds with PHB: view

Transcripts for PHB Gene

Unigene Clusters for PHB Gene

Prohibitin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PHB Gene

GeneLoc Exon Structure for
PHB
ECgene alternative splicing isoforms for
PHB

Expression for PHB Gene

mRNA expression in normal human tissues for PHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHB Gene

SOURCE GeneReport for Unigene cluster for PHB Gene Hs.514303

mRNA Expression by UniProt/SwissProt for PHB Gene

P35232-PHB_HUMAN
Tissue specificity: Widely expressed in different tissues
genes like me logo Genes that share expressions with PHB: view

Orthologs for PHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB 36
  • 99.75 (n)
  • 100 (a)
PHB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHB 36
  • 93.01 (n)
  • 100 (a)
PHB 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 93 (a)
OneToMany
PHB 36
  • 93.5 (n)
  • 100 (a)
PHB 37
  • 96 (a)
OneToMany
PHB 37
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Phb 36
  • 91.18 (n)
  • 99.63 (a)
Phb 16
Phb 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHB 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHB 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phb 36
  • 91.54 (n)
  • 99.63 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 89 (a)
OneToMany
PHB 36
  • 82.84 (n)
  • 95.96 (a)
PHB 37
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 92 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64447 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75944 36
phb 36
  • 78.8 (n)
  • 91.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10205 36
zebrafish
(Danio rerio)
Actinopterygii phb 36
  • 77.9 (n)
  • 92.22 (a)
phb 37
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009323 36
  • 67.03 (n)
  • 76.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cc 36
  • 68.51 (n)
  • 75.28 (a)
l(2)37Cc 37
  • 73 (a)
OneToOne
l(2)37Cc 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea phb-1 36
  • 62.21 (n)
  • 66.17 (a)
phb-1 37
  • 64 (a)
OneToOne
Y37E3.9 38
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR313C 36
  • 60.8 (n)
  • 58.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB1 36
  • 56.82 (n)
  • 54.17 (a)
PHB1 37
  • 50 (a)
OneToOne
PHB1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16302g 36
  • 55.71 (n)
  • 56.34 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3157 36
soybean
(Glycine max)
eudicotyledons Gma.15151 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB3 36
  • 56.63 (n)
  • 55.76 (a)
rice
(Oryza sativa)
Liliopsida Os02g0580500 36
  • 57.95 (n)
  • 55.68 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.24798 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08946 36
  • 58.04 (n)
  • 58.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb1 36
  • 56.58 (n)
  • 54.79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4549 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6789 37
  • 71 (a)
OneToOne
Species with no ortholog for PHB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB Gene

ENSEMBL:
Gene Tree for PHB (if available)
TreeFam:
Gene Tree for PHB (if available)

Paralogs for PHB Gene

Selected SIMAP similar genes for PHB Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PHB: view

No data available for Paralogs for PHB Gene

Variants for PHB Gene

Sequence variations from dbSNP and Humsavar for PHB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6917 -- 49,404,181(-) AAAGA(C/T)GTGTC utr-variant-3-prime
rs882030 -- 49,408,536(+) CTTGC(C/T)CCCTA intron-variant
rs882031 -- 49,408,624(+) AGCTT(C/T)GGACT intron-variant
rs935129 -- 49,408,654(+) CCAGG(A/G)GTCAG intron-variant
rs1049515 -- 49,409,392(-) CATCG(A/G)AGAGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PHB Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV Gain+Loss 17160897

Relevant External Links for PHB Gene

HapMap Linkage Disequilibrium report
PHB
Human Gene Mutation Database (HGMD)
PHB

Disorders for PHB Gene

(1) OMIM Diseases for PHB Gene (176705)

(15) Novoseek inferred disease relationships for PHB Gene

Disease -log(P) Hits PubMed IDs
shock 45.7 16
breast cancer 36.3 21
tumors 34.4 35
retinoblastoma 26.4 4
gastric cancer 25.9 13

Relevant External Links for PHB

Genetic Association Database (GAD)
PHB
Human Genome Epidemiology (HuGE) Navigator
PHB
Tumor Gene Database (TGDB):
PHB
genes like me logo Genes that share disorders with PHB: view

No data available for UniProtKB/Swiss-Prot for PHB Gene

Publications for PHB Gene

  1. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T. … Nakamura Y. (Genomics 1993) 2 3 4 23
  2. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. (PMID: 10376528) Wang S. … Chellappan S. (Oncogene 1999) 2 3 23
  3. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PMID: 11302691) Coates P.J. … Wright E.G. (Exp. Cell Res. 2001) 3 4 23
  4. Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility. (PMID: 11377649) Jupe E.R. … Thompson L.F. (Lancet 2001) 3 23 49
  5. Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women. (PMID: 12354477) Spurdle A.B. … Chenevix-Trench G. (Lancet 2002) 3 23 49

Products for PHB Gene

Sources for PHB Gene

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