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Aliases for PGR Gene

Aliases for PGR Gene

  • Progesterone Receptor 2 3 5
  • Nuclear Receptor Subfamily 3 Group C Member 3 3 4
  • NR3C3 3 4
  • PR 3 4

External Ids for PGR Gene

Previous GeneCards Identifiers for PGR Gene

  • GC11M103103
  • GC11M102266
  • GC11M100446
  • GC11M100414
  • GC11M096837
  • GC11M100904

Summaries for PGR Gene

Entrez Gene Summary for PGR Gene

  • This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

GeneCards Summary for PGR Gene

PGR (Progesterone Receptor) is a Protein Coding gene. Diseases associated with PGR include Progesterone Resistance and Myoma. Among its related pathways are Nuclear Receptor transcription pathway and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and receptor binding. An important paralog of this gene is NR3C2.

UniProtKB/Swiss-Prot for PGR Gene

  • The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.

  • Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.

  • Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Tocris Summary for PGR Gene

  • Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.

Gene Wiki entry for PGR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGR Gene

Genomics for PGR Gene

Regulatory Elements for PGR Gene

Enhancers for PGR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PGR on UCSC Golden Path with GeneCards custom track

Promoters for PGR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGR on UCSC Golden Path with GeneCards custom track

Genomic Location for PGR Gene

Chromosome:
11
Start:
101,029,624 bp from pter
End:
101,130,668 bp from pter
Size:
101,045 bases
Orientation:
Minus strand

Genomic View for PGR Gene

Genes around PGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGR Gene

Proteins for PGR Gene

  • Protein details for PGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06401-PRGR_HUMAN
    Recommended name:
    Progesterone receptor
    Protein Accession:
    P06401
    Secondary Accessions:
    • A7LQ08
    • A7X8B0
    • B4E3T0
    • Q8TDS3
    • Q9UPF7

    Protein attributes for PGR Gene

    Size:
    933 amino acids
    Molecular mass:
    98981 Da
    Quaternary structure:
    • Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.

    Three dimensional structures from OCA and Proteopedia for PGR Gene

    Alternative splice isoforms for PGR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGR Gene

Post-translational modifications for PGR Gene

  • Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.
  • Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
  • Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
  • Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PGR (Progesterone R B/NR3C3)
  • R&D Systems Antibodies for PGR (Progesterone R/NR3C3)
  • Cell Signaling Technology (CST) Antibodies for PGR (PR)

No data available for DME Specific Peptides for PGR Gene

Domains & Families for PGR Gene

Gene Families for PGR Gene

Suggested Antigen Peptide Sequences for PGR Gene

Graphical View of Domain Structure for InterPro Entry

P06401

UniProtKB/Swiss-Prot:

PRGR_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
genes like me logo Genes that share domains with PGR: view

Function for PGR Gene

Molecular function for PGR Gene

GENATLAS Biochemistry:
progesterone receptor with two distinct forms PR-A (94kDa),PR-B (114kDa) transcribed from distinct promoters of PRG,with PR-A acting as a transcriptional repressor and PR-B as an activator,steroid/thyroid hormone receptor superfamily,required for normal mammary development in the puberty
UniProtKB/Swiss-Prot Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
UniProtKB/Swiss-Prot Function:
Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
UniProtKB/Swiss-Prot Function:
Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Gene Ontology (GO) - Molecular Function for PGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17785366
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 17785366
GO:0003677 DNA binding TAS 3551956
GO:0003707 steroid hormone receptor activity IEA --
GO:0005496 steroid binding IEA --
genes like me logo Genes that share ontologies with PGR: view
genes like me logo Genes that share phenotypes with PGR: view

Human Phenotype Ontology for PGR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PGR Gene

MGI Knock Outs for PGR:

Animal Model Products

CRISPR Products

miRNA for PGR Gene

miRTarBase miRNAs that target PGR
Targeted motifs for PGR Gene
HOMER Transcription Factor Regulatory Elements motif PGR
  • Consensus sequence: AAGAACATWHTGTTC Submotif: canonical Cell Type: EndoStromal GEO ID: GSE69539

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PGR
  • R&D Systems cDNA Clones for PGR (Progesterone R B/NR3C3)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for PGR Gene

Localization for PGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGR Gene

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.
Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
Isoform 4: Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGR Gene COMPARTMENTS Subcellular localization image for PGR gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
cytoskeleton 2
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with PGR: view

Pathways & Interactions for PGR Gene

genes like me logo Genes that share pathways with PGR: view

SIGNOR curated interactions for PGR Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 1557371
GO:0007267 cell-cell signaling TAS 1557371
GO:0010629 negative regulation of gene expression IEP 21695196
GO:0043401 steroid hormone mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with PGR: view

Drugs & Compounds for PGR Gene

(113) Drugs for PGR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levonorgestrel Approved, Investigational Pharma Agonist, binder, Target Synthetic progesterone analog 288
Mifepristone Approved, Investigational Pharma Agonist, antagonist, Target Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 144
Progesterone Approved, Vet_approved Pharma Full agonist, Activator, inhibitor, Target, agonist Endogenous progesterone receptor agonist 515
Dydrogesterone Approved, Withdrawn Pharma Agonist, agonist, Target 20
Norethindrone Approved Pharma Agonist, agonist, Target 91

(41) Additional Compounds for PGR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for PGR Gene

Compound Action Cas Number
Levonorgestrel Synthetic progesterone analog 797-63-7
Mifepristone Progesterone and glucocorticoid receptor antagonist 84371-65-3
Progesterone Endogenous progesterone receptor agonist 57-83-0

(30) ApexBio Compounds for PGR Gene

Compound Action Cas Number
Alprostadil 745-65-3
Altrenogest 850-52-2
Bazedoxifene HCl 198480-56-7
Bimatoprost 155206-00-1
Clomiphene citrate 50-41-9
Dienogest 65928-58-7
Drospirenone 67392-87-4
Dydrogesterone 152-62-5
Equol 531-95-3
Estradiol Cypionate 313-06-4
Estriol 50-27-1
Estrone Estrogenic hormone 53-16-7
Ethinyl Estradiol Oral contraceptive 57-63-6
Ethisterone Progestogen hormone 434-03-7
Ethynodiol diacetate 297-76-7
Gestodene 60282-87-3
Hexestrol 84-16-2
Levomefolic acid Active form of folic acid 31690-09-2
Levonorgestrel 797-63-7
Medroxyprogesterone 520-85-4
Medroxyprogesterone acetate Steroidal progestin 71-58-9
Megestrol Acetate Anti-estrogen agent 595-33-5
Mifepristone Progesterone receptor antagonist 84371-65-3
Ospemifene 128607-22-7
Progesterone 57-83-0
Raloxifene HCl Estrogen receptor (ER) 82640-04-8
Tamoxifen Citrate Antiestrogen drug 54965-24-1
Tanaproget Progesterone receptor agonist 304853-42-7
Toremifene Citrate 89778-27-8
Ulipristal acetate 126784-99-4
genes like me logo Genes that share compounds with PGR: view

Drug Products

Transcripts for PGR Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PGR
  • R&D Systems cDNA Clones for PGR (Progesterone R B/NR3C3)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7: -

Relevant External Links for PGR Gene

GeneLoc Exon Structure for
PGR
ECgene alternative splicing isoforms for
PGR

Expression for PGR Gene

mRNA expression in normal human tissues for PGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGR Gene

This gene is overexpressed in Uterus (x10.5), Cervix - Endocervix (x8.6), Cervix - Ectocervix (x7.6), and Fallopian Tube (x4.3).

Protein differential expression in normal tissues from HIPED for PGR Gene

This gene is overexpressed in Liver (28.6), Bone (17.5), and Spleen (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGR Gene



NURSA nuclear receptor signaling pathways regulating expression of PGR Gene:

PGR

SOURCE GeneReport for Unigene cluster for PGR Gene:

Hs.32405
genes like me logo Genes that share expression patterns with PGR: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PGR Gene

Orthologs for PGR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGR 34
  • 84.63 (n)
  • 81.23 (a)
PGR 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGR 34
  • 81.73 (n)
  • 76.27 (a)
PGR 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgr 34
  • 79.93 (n)
  • 80.65 (a)
Pgr 16
Pgr 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGR 34
  • 99.57 (n)
  • 98.93 (a)
PGR 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgr 34
  • 80.01 (n)
  • 81.02 (a)
oppossum
(Monodelphis domestica)
Mammalia PGR 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGR 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGR 34
  • 76.49 (n)
  • 77.44 (a)
PGR 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGR 35
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pgr-A 34
zebrafish
(Danio rerio)
Actinopterygii pgr 35
  • 48 (a)
OneToOne
Species where no ortholog for PGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGR Gene

ENSEMBL:
Gene Tree for PGR (if available)
TreeFam:
Gene Tree for PGR (if available)

Paralogs for PGR Gene

Paralogs for PGR Gene

(5) SIMAP similar genes for PGR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PGR: view

Variants for PGR Gene

Sequence variations from dbSNP and Humsavar for PGR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2020874 - 101,091,792(-) MCTTA(G/T)AAAGT intron-variant, nc-transcript-variant, reference, missense
rs2020880 - 101,041,997(-) TGTGT(C/T)GAGCT nc-transcript-variant, reference, missense, utr-variant-3-prime
VAR_016117 -
rs1042838 - 101,062,681(-) AGCCA(G/T)TGGGC intron-variant, nc-transcript-variant, reference, missense
VAR_019221 -

Structural Variations from Database of Genomic Variants (DGV) for PGR Gene

Variant ID Type Subtype PubMed ID
esv2762939 CNV loss 21179565
esv3307869 CNV mobile element insertion 20981092
nsv1159933 CNV duplication 26073780
nsv556130 CNV loss 21841781
nsv556131 CNV gain 21841781
nsv826058 CNV loss 20364138
nsv826059 CNV loss 20364138

Variation tolerance for PGR Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGR Gene

Human Gene Mutation Database (HGMD)
PGR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGR Gene

Disorders for PGR Gene

MalaCards: The human disease database

(158) MalaCards diseases for PGR Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
progesterone resistance
myoma
  • benign neoplasm of the muscle
female breast cancer
  • female breast carcinoma
endometrial adenocarcinoma
  • adenocarcinoma of endometrium
progesterone-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search PGR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PGR

Genetic Association Database (GAD)
PGR
Human Genome Epidemiology (HuGE) Navigator
PGR
Tumor Gene Database (TGDB):
PGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGR
genes like me logo Genes that share disorders with PGR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGR Gene

Publications for PGR Gene

  1. Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women. (PMID: 20148360) Lin J. … Cook N.R. (Cancer Causes Control 2010) 3 22 46 65
  2. The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor. (PMID: 18375150) Chen C. … Wildman D.E. (Mol. Phylogenet. Evol. 2008) 3 4 22 65
  3. Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. (PMID: 15937332) Zhang Z. … Winneker R.C. (J. Biol. Chem. 2005) 3 4 22 65
  4. Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review. (PMID: 14769635) Modugno F. (Am. J. Epidemiol. 2004) 3 22 46 65
  5. Atomic structure of progesterone complexed with its receptor. (PMID: 9620806) Williams S.P. … Sigler P.B. (Nature 1998) 3 4 22 65

Products for PGR Gene

  • Addgene plasmids for PGR

Sources for PGR Gene

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