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Aliases for PGF Gene

Aliases for PGF Gene

  • Placental Growth Factor 2 3 5
  • Placental Growth Factor, Vascular Endothelial Growth Factor-Related Protein 2 3
  • PGFL 3 4
  • PLGF 3 4
  • Placental Growth Factor-Like 2
  • Placenta Growth Factor 2
  • SHGC-10760 3
  • D12S1900 3
  • PlGF-2 3

External Ids for PGF Gene

Previous HGNC Symbols for PGF Gene

  • PGFL

Previous GeneCards Identifiers for PGF Gene

  • GC14M072935
  • GC14M069225
  • GC14M073398
  • GC14M074478
  • GC14M075408
  • GC14M055576

Summaries for PGF Gene

Entrez Gene Summary for PGF Gene

  • This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for PGF Gene

PGF (Placental Growth Factor) is a Protein Coding gene. Diseases associated with PGF include placental insufficiency and twin-to-twin transfusion syndrome. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is VEGFB.

UniProtKB/Swiss-Prot for PGF Gene

  • Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

Gene Wiki entry for PGF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGF Gene

Genomics for PGF Gene

Regulatory Elements for PGF Gene

Promoters for PGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGF on UCSC Golden Path with GeneCards custom track

Genomic Location for PGF Gene

Chromosome:
14
Start:
74,941,830 bp from pter
End:
74,955,784 bp from pter
Size:
13,955 bases
Orientation:
Minus strand

Genomic View for PGF Gene

Genes around PGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGF Gene

Proteins for PGF Gene

  • Protein details for PGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49763-PLGF_HUMAN
    Recommended name:
    Placenta growth factor
    Protein Accession:
    P49763
    Secondary Accessions:
    • Q07101
    • Q9BV78
    • Q9Y6S8

    Protein attributes for PGF Gene

    Size:
    221 amino acids
    Molecular mass:
    24789 Da
    Quaternary structure:
    • Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is found both as homodimer and as monomer.
    SequenceCaution:
    • Sequence=AAB25832.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PGF Gene

    Alternative splice isoforms for PGF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGF Gene

Proteomics data for PGF Gene at MOPED

Post-translational modifications for PGF Gene

Other Protein References for PGF Gene

Antibody Products

No data available for DME Specific Peptides for PGF Gene

Domains & Families for PGF Gene

Suggested Antigen Peptide Sequences for PGF Gene

Graphical View of Domain Structure for InterPro Entry

P49763

UniProtKB/Swiss-Prot:

PLGF_HUMAN :
  • Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
  • Belongs to the PDGF/VEGF growth factor family.
Domain:
  • Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with PGF: view

No data available for Gene Families for PGF Gene

Function for PGF Gene

Molecular function for PGF Gene

GENATLAS Biochemistry:
placenta growth factor,angiogenic,vascular endothelial growth factor related
UniProtKB/Swiss-Prot Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
genes like me logo Genes that share phenotypes with PGF: view

Animal Models for PGF Gene

MGI Knock Outs for PGF:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGF Gene

Localization for PGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGF Gene

Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGF Gene COMPARTMENTS Subcellular localization image for PGF gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
mitochondrion 2
plasma membrane 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PGF Gene

Pathways & Interactions for PGF Gene

genes like me logo Genes that share pathways with PGF: view

Gene Ontology (GO) - Biological Process for PGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0007165 signal transduction TAS 9467961
GO:0007267 cell-cell signaling TAS 9467961
GO:0008284 positive regulation of cell proliferation IMP 21215706
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with PGF: view

No data available for SIGNOR curated interactions for PGF Gene

Drugs & Compounds for PGF Gene

(11) Drugs for PGF Gene - From: Novoseek, DGIdb, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aflibercept Approved Pharma Target, binder Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Zaltrap Approved August 2012 Pharma 0
TB-403 Pharma 0

(13) Additional Compounds for PGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PGF: view

Transcripts for PGF Gene

Unigene Clusters for PGF Gene

Placental growth factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGF Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for PGF Gene

GeneLoc Exon Structure for
PGF
ECgene alternative splicing isoforms for
PGF

Expression for PGF Gene

mRNA expression in normal human tissues for PGF Gene

mRNA differential expression in normal tissues according to GTEx for PGF Gene

This gene is overexpressed in Artery - Tibial (x4.8) and Thyroid (x4.5).

Protein differential expression in normal tissues from HIPED for PGF Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PGF Gene



SOURCE GeneReport for Unigene cluster for PGF Gene Hs.252820

mRNA Expression by UniProt/SwissProt for PGF Gene

P49763-PLGF_HUMAN
Tissue specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
genes like me logo Genes that share expression patterns with PGF: view

Protein tissue co-expression partners for PGF Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGF 35
  • 82.98 (n)
  • 76.6 (a)
PGF 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGF 35
  • 87.94 (n)
  • 85.11 (a)
PGF 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgf 35
  • 73.28 (n)
  • 68.38 (a)
Pgf 16
Pgf 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGF 35
  • 98.24 (n)
  • 98.24 (a)
PGF 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgf 35
  • 73.77 (n)
  • 66.18 (a)
oppossum
(Monodelphis domestica)
Mammalia PGF 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGF 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGF 35
  • 71.58 (n)
  • 58.91 (a)
PGF 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGF 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC557468 35
  • 63.91 (n)
  • 57.85 (a)
CABZ01077555.1 36
  • 45 (a)
OneToMany
PGF (1 of 2) 36
  • 45 (a)
OneToMany
Species with no ortholog for PGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGF Gene

ENSEMBL:
Gene Tree for PGF (if available)
TreeFam:
Gene Tree for PGF (if available)

Paralogs for PGF Gene

Paralogs for PGF Gene

(3) SIMAP similar genes for PGF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PGF: view

Variants for PGF Gene

Sequence variations from dbSNP and Humsavar for PGF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8185 -- 74,942,086(-) CGGCC(A/G)AGGTG utr-variant-3-prime
rs12411 -- 74,942,340(+) GCTTG(A/T)CTGTG utr-variant-3-prime
rs741095 -- 74,957,320(+) TGTGC(A/G)CGTGT upstream-variant-2KB
rs759059 -- 74,948,114(+) GCTTG(C/G)CCCAG intron-variant
rs1009910 -- 74,945,395(+) GATGA(A/G)AGCAT intron-variant

Variation tolerance for PGF Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGF Gene

HapMap Linkage Disequilibrium report
PGF
Human Gene Mutation Database (HGMD)
PGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGF Gene

Disorders for PGF Gene

MalaCards: The human disease database

(26) MalaCards diseases for PGF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
placental insufficiency
  • uteroplacental vascular insufficiency
twin-to-twin transfusion syndrome
  • twin twin transfusion syndrome
severe pre-eclampsia
  • antepartum severe pre-eclampsia
placenta disease
  • placenta disorder
pre-eclampsia
  • preeclampsia
- elite association - COSMIC cancer census association via MalaCards
Search PGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for PGF

Genetic Association Database (GAD)
PGF
Human Genome Epidemiology (HuGE) Navigator
PGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGF
genes like me logo Genes that share disorders with PGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGF Gene

Publications for PGF Gene

  1. Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. (PMID: 7681160) Maglione D. … Persico M.G. (Oncogene 1993) 2 3 4 67
  2. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. (PMID: 20040765) Brittain J.E. … Ataga K.I. (Blood 2010) 3 23
  3. Relationship between serum vasoactive factors and plaque morphology in patients with non-ST-segment elevated acute coronary syndrome. (PMID: 20137369) Lu Y.F. … Chen Y.D. (Chin. Med. J. 2010) 3 23
  4. Elevation of plasma placental growth factor in the patients with ischemic cardiomyopathy. (PMID: 18192038) Nakamura T. … Ishikawa S.E. (Int. J. Cardiol. 2009) 3 23
  5. Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells. (PMID: 19022893) Nishimoto F. … Kimura T. (Endocrinology 2009) 3 23

Products for PGF Gene

Sources for PGF Gene

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