Aliases for PGC Gene
External Ids for PGC Gene
Previous GeneCards Identifiers for PGC Gene
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
GeneCards Summary for PGC Gene
PGC (Progastricsin (Pepsinogen C)) is a Protein Coding gene. Diseases associated with PGC include gastritis and atrophic gastritis. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.
UniProtKB/Swiss-Prot for PGC Gene
Hydrolyzes a variety of proteins