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Aliases for PGC Gene

Aliases for PGC Gene

  • Progastricsin (Pepsinogen C) 2 3
  • Pepsinogen C 3 4
  • EC 3.4.23.3 4 63
  • Pepsinogen Group II 3
  • Preprogastricsin 3
  • Gastricsin 3
  • EC 3.4.23 63
  • Pepsin C 3
  • PEPC 3
  • PGII 3

External Ids for PGC Gene

Previous GeneCards Identifiers for PGC Gene

  • GC06M041706
  • GC06M041751
  • GC06M041813
  • GC06M041704
  • GC06M041423

Summaries for PGC Gene

Entrez Gene Summary for PGC Gene

  • This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

GeneCards Summary for PGC Gene

PGC (Progastricsin (Pepsinogen C)) is a Protein Coding gene. Diseases associated with PGC include gastritis and stomach cancer. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for PGC Gene

  • Hydrolyzes a variety of proteins

Gene Wiki entry for PGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGC Gene

Genomics for PGC Gene

Regulatory Elements for PGC Gene

Genomic Location for PGC Gene

Start:
41,736,711 bp from pter
End:
41,754,109 bp from pter
Size:
17,399 bases
Orientation:
Minus strand

Genomic View for PGC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGC Gene

Proteins for PGC Gene

  • Protein details for PGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20142-PEPC_HUMAN
    Recommended name:
    Gastricsin
    Protein Accession:
    P20142
    Secondary Accessions:
    • B4DVZ3
    • Q5T3D7
    • Q5T3D8

    Protein attributes for PGC Gene

    Size:
    388 amino acids
    Molecular mass:
    42426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PGC Gene

    Alternative splice isoforms for PGC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGC Gene

Proteomics data for PGC Gene at MOPED

Post-translational modifications for PGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGC Gene

Domains for PGC Gene

Suggested Antigen Peptide Sequences for PGC Gene

Graphical View of Domain Structure for InterPro Entry

P20142

UniProtKB/Swiss-Prot:

PEPC_HUMAN :
  • P20142
Family:
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGC: view

No data available for Gene Families for PGC Gene

Function for PGC Gene

Molecular function for PGC Gene

GENATLAS Biochemistry: progastricsin (pepsinogen C)
UniProtKB/Swiss-Prot CatalyticActivity: More restricted specificity than pepsin A, but shows preferential cleavage at Tyr- -Xaa bonds. High activity on hemoglobin
UniProtKB/Swiss-Prot Function: Hydrolyzes a variety of proteins

Enzyme Numbers (IUBMB) for PGC Gene

Gene Ontology (GO) - Molecular Function for PGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PGC: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGC

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PGC Gene

Localization for PGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGC Gene COMPARTMENTS Subcellular localization image for PGC gene
Compartment Confidence
extracellular 5
nucleus 4
lysosome 2
plasma membrane 2
chloroplast 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 3335549
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PGC: view

Pathways for PGC Gene

SuperPathways for PGC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
genes like me logo Genes that share ontologies with PGC: view

No data available for Pathways by source for PGC Gene

Compounds for PGC Gene

(1) Novoseek inferred chemical compound relationships for PGC Gene

Compound -log(P) Hits PubMed IDs
pepsinogen 85.6 7
genes like me logo Genes that share compounds with PGC: view

Transcripts for PGC Gene

Unigene Clusters for PGC Gene

Progastricsin (pepsinogen C):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -

Relevant External Links for PGC Gene

GeneLoc Exon Structure for
PGC
ECgene alternative splicing isoforms for
PGC

Expression for PGC Gene

mRNA expression in normal human tissues for PGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGC Gene

This gene is overexpressed in Stomach (51.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGC Gene

SOURCE GeneReport for Unigene cluster for PGC Gene Hs.1867

genes like me logo Genes that share expressions with PGC: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PGC Gene

Orthologs for PGC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGC 35
  • 99.57 (n)
  • 98.97 (a)
PGC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PGC 35
  • 86.56 (n)
  • 83.72 (a)
PGC 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGC 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgc 35
  • 78.87 (n)
  • 74.81 (a)
Pgc 16
Pgc 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PGC 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGC 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgc 35
  • 79.98 (n)
  • 74.48 (a)
chicken
(Gallus gallus)
Aves PGC 35
  • 71.25 (n)
  • 66.58 (a)
PGC 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGC 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pgc-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496913 35
  • 66.85 (n)
  • 67.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17283 37
  • 35 (a)
CG5860 37
  • 37 (a)
CG17134 37
  • 43 (a)
CG6508 37
  • 42 (a)
CG13095 37
  • 43 (a)
pcl 37
  • 41 (a)
CG10104 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea C11D2.2 37
  • 34 (a)
Y39B6A.21 37
  • 32 (a)
asp-5 37
  • 32 (a)
F28A12.4 37
  • 31 (a)
F59D6.2 37
  • 31 (a)
Y39B6A.24 37
  • 32 (a)
F21F8.4 37
  • 33 (a)
Y39B6A.22 37
  • 31 (a)
C15C8.3 37
  • 31 (a)
F59D6.3 37
  • 30 (a)
asp-2 37
  • 34 (a)
Y39B6A.23 37
  • 34 (a)
asp-6 37
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR144W 35
  • 50.75 (n)
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPS3 38
Species with no ortholog for PGC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PGC Gene

ENSEMBL:
Gene Tree for PGC (if available)
TreeFam:
Gene Tree for PGC (if available)

Paralogs for PGC Gene

Paralogs for PGC Gene

Selected SIMAP similar genes for PGC Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PGC Gene

genes like me logo Genes that share paralogs with PGC: view

Variants for PGC Gene

Sequence variations from dbSNP and Humsavar for PGC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1316979 -- 41,740,926(-) GGGAC(A/G)CATCC utr-variant-3-prime, intron-variant
rs2027524 -- 41,747,501(+) TGTGC(A/T)TCGTG upstream-variant-2KB
rs2027525 -- 41,747,573(+) TTTTT(A/G)GTTCA upstream-variant-2KB
rs2040017 -- 41,748,259(+) ACTCA(C/T)AGAGT upstream-variant-2KB
rs2395785 -- 41,738,453(+) tgaaa(C/T)cccgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGC Gene

Variant ID Type Subtype PubMed ID
esv2731977 CNV Deletion 23290073
esv2211967 CNV Deletion 18987734
esv2731978 CNV Deletion 23290073

Relevant External Links for PGC Gene

HapMap Linkage Disequilibrium report
PGC
Human Gene Mutation Database (HGMD)
PGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGC Gene

Disorders for PGC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PGC Gene including...

Search for PGC Gene in MalaCards »

(3) University of Copenhagen DISEASES for PGC Gene

(3) Novoseek inferred disease relationships for PGC Gene

Disease -log(P) Hits PubMed IDs
gastritis 45.5 1
metastasis 0 3
cancer 0 2

Relevant External Links for PGC

Genetic Association Database (GAD)
PGC
Human Genome Epidemiology (HuGE) Navigator
PGC
genes like me logo Genes that share disorders with PGC: view

No data available for UniProtKB/Swiss-Prot for PGC Gene

Publications for PGC Gene

  1. Crystal and molecular structures of human progastricsin at 1.62-A resolution. (PMID: 7714902) Moore S.A. … James M.N.G. (J. Mol. Biol. 1995) 3 4 23
  2. Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin. (PMID: 9406551) Khan A.R. … James M.N. (Nat. Struct. Biol. 1997) 3 4 23
  3. Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. (PMID: 9794784) Richter C. … Yada R.Y. (Biochem. J. 1998) 3 23
  4. Pepsinogen C: a type 2 cell-specific protease. (PMID: 14578117) Foster C. … Guttentag S. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004) 3 23
  5. Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. (PMID: 11915945) Kageyama T. (Cell. Mol. Life Sci. 2002) 3 23

Products for PGC Gene

Sources for PGC Gene

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