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Aliases for PGC Gene

Aliases for PGC Gene

  • Progastricsin (Pepsinogen C) 2 3 5
  • Pepsinogen C 3 4
  • EC 3.4.23.3 4 63
  • Pepsinogen Group II 3
  • Preprogastricsin 3
  • EC 3.4.23 63
  • Pepsin C 3
  • PGII 3
  • PEPC 3

External Ids for PGC Gene

Previous GeneCards Identifiers for PGC Gene

  • GC06M041706
  • GC06M041751
  • GC06M041813
  • GC06M041704
  • GC06M041423

Summaries for PGC Gene

Entrez Gene Summary for PGC Gene

  • This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

GeneCards Summary for PGC Gene

PGC (Progastricsin (Pepsinogen C)) is a Protein Coding gene. Diseases associated with PGC include Gastritis and Atrophic Gastritis. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is REN.

UniProtKB/Swiss-Prot for PGC Gene

  • Hydrolyzes a variety of proteins.

Gene Wiki entry for PGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGC Gene

Genomics for PGC Gene

Regulatory Elements for PGC Gene

Enhancers for PGC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGC on UCSC Golden Path with GeneCards custom track

Genomic Location for PGC Gene

Chromosome:
6
Start:
41,736,711 bp from pter
End:
41,754,109 bp from pter
Size:
17,399 bases
Orientation:
Minus strand

Genomic View for PGC Gene

Genes around PGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGC Gene

Proteins for PGC Gene

  • Protein details for PGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20142-PEPC_HUMAN
    Recommended name:
    Gastricsin
    Protein Accession:
    P20142
    Secondary Accessions:
    • B4DVZ3
    • Q5T3D7
    • Q5T3D8

    Protein attributes for PGC Gene

    Size:
    388 amino acids
    Molecular mass:
    42426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PGC Gene

    Alternative splice isoforms for PGC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGC Gene

Proteomics data for PGC Gene at MOPED

Post-translational modifications for PGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGC Gene

Domains & Families for PGC Gene

Suggested Antigen Peptide Sequences for PGC Gene

Graphical View of Domain Structure for InterPro Entry

P20142

UniProtKB/Swiss-Prot:

PEPC_HUMAN :
  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
Domain:
  • Contains 1 peptidase A1 domain.
Family:
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGC: view

No data available for Gene Families for PGC Gene

Function for PGC Gene

Molecular function for PGC Gene

GENATLAS Biochemistry:
progastricsin (pepsinogen C)
UniProtKB/Swiss-Prot CatalyticActivity:
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr- -Xaa bonds. High activity on hemoglobin.
UniProtKB/Swiss-Prot Function:
Hydrolyzes a variety of proteins.

Enzyme Numbers (IUBMB) for PGC Gene

genes like me logo Genes that share phenotypes with PGC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PGC

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PGC Gene

Localization for PGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGC Gene COMPARTMENTS Subcellular localization image for PGC gene
Compartment Confidence
extracellular 5
nucleus 3
chloroplast 2
cytosol 2
lysosome 2
mitochondrion 2
plasma membrane 2
vacuole 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for PGC Gene

Pathways & Interactions for PGC Gene

SuperPathways for PGC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PGC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PGC Gene

Drugs & Compounds for PGC Gene

(1) Drugs for PGC Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ecabet Approved, Investigational Pharma 5

(1) Additional Compounds for PGC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PGC: view

Transcripts for PGC Gene

Unigene Clusters for PGC Gene

Progastricsin (pepsinogen C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -

Relevant External Links for PGC Gene

GeneLoc Exon Structure for
PGC
ECgene alternative splicing isoforms for
PGC

Expression for PGC Gene

mRNA expression in normal human tissues for PGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGC Gene

This gene is overexpressed in Stomach (x51.9).

Protein differential expression in normal tissues from HIPED for PGC Gene

This gene is overexpressed in Stomach (49.9) and Cardia (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGC Gene



SOURCE GeneReport for Unigene cluster for PGC Gene Hs.1867

genes like me logo Genes that share expression patterns with PGC: view

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PGC Gene

Orthologs for PGC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGC 35
  • 86.56 (n)
  • 83.72 (a)
PGC 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgc 35
  • 78.87 (n)
  • 74.81 (a)
Pgc 16
Pgc 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGC 35
  • 99.57 (n)
  • 98.97 (a)
PGC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgc 35
  • 79.98 (n)
  • 74.48 (a)
dog
(Canis familiaris)
Mammalia PGC 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PGC 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGC 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGC 35
  • 71.25 (n)
  • 66.58 (a)
PGC 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGC 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496913 35
  • 66.85 (n)
  • 67.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia pgc-A 35
fruit fly
(Drosophila melanogaster)
Insecta CG10104 37
  • 39 (a)
CG13095 37
  • 43 (a)
CG17134 37
  • 43 (a)
CG17283 37
  • 35 (a)
CG5860 37
  • 37 (a)
CG6508 37
  • 42 (a)
pcl 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea asp-2 37
  • 34 (a)
asp-5 37
  • 32 (a)
asp-6 37
  • 33 (a)
C11D2.2 37
  • 34 (a)
C15C8.3 37
  • 31 (a)
F21F8.4 37
  • 33 (a)
F28A12.4 37
  • 31 (a)
F59D6.2 37
  • 31 (a)
F59D6.3 37
  • 30 (a)
Y39B6A.21 37
  • 32 (a)
Y39B6A.22 37
  • 31 (a)
Y39B6A.23 37
  • 34 (a)
Y39B6A.24 37
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR144W 35
  • 50.75 (n)
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPS3 38
Species with no ortholog for PGC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PGC Gene

ENSEMBL:
Gene Tree for PGC (if available)
TreeFam:
Gene Tree for PGC (if available)

Paralogs for PGC Gene

Paralogs for PGC Gene

(7) SIMAP similar genes for PGC Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PGC Gene

genes like me logo Genes that share paralogs with PGC: view

Variants for PGC Gene

Sequence variations from dbSNP and Humsavar for PGC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1316979 -- 41,740,926(-) GGGAC(A/G)CATCC intron-variant, utr-variant-3-prime
rs4987196 -- 41,748,283(+) CACAA(A/C/G/T)CAGAA upstream-variant-2KB
rs5875770 -- 41,738,285(+) acaca(C/T)ataca intron-variant
rs6458237 -- 41,745,473(+) gacct(C/T)gtgac intron-variant
rs6909468 -- 41,745,016(+) GTGTG(C/T)GCGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGC Gene

Variant ID Type Subtype PubMed ID
esv2731977 CNV Deletion 23290073
esv2211967 CNV Deletion 18987734
esv2731978 CNV Deletion 23290073

Variation tolerance for PGC Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGC Gene

Human Gene Mutation Database (HGMD)
PGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGC Gene

Disorders for PGC Gene

MalaCards: The human disease database

(5) MalaCards diseases for PGC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastritis
  • acute gastric mucosal erosion
atrophic gastritis
  • gastric atrophy
lymphocele
  • lymph cyst
stomach disease
  • gastric disease
duodenal ulcer
  • curling ulcer
- elite association - COSMIC cancer census association via MalaCards
Search PGC in MalaCards View complete list of genes associated with diseases

Relevant External Links for PGC

Genetic Association Database (GAD)
PGC
Human Genome Epidemiology (HuGE) Navigator
PGC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGC
genes like me logo Genes that share disorders with PGC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGC Gene

Publications for PGC Gene

  1. Crystal and molecular structures of human progastricsin at 1.62-A resolution. (PMID: 7714902) Moore S.A. … James M.N.G. (J. Mol. Biol. 1995) 3 4 23 67
  2. Pepsinogen C: a type 2 cell-specific protease. (PMID: 14578117) Foster C. … Guttentag S. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004) 3 23
  3. Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. (PMID: 11915945) Kageyama T. (Cell. Mol. Life Sci. 2002) 3 23
  4. Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. (PMID: 9794784) Richter C. … Yada R.Y. (Biochem. J. 1998) 3 23
  5. Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin. (PMID: 9406551) Khan A.R. … James M.N. (Nat. Struct. Biol. 1997) 3 23

Products for PGC Gene

Sources for PGC Gene

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