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Aliases for CDK14 Gene

Aliases for CDK14 Gene

  • Cyclin-Dependent Kinase 14 2 3 5
  • Serine/Threonine-Protein Kinase PFTAIRE-1 3 4
  • Cell Division Protein Kinase 14 3 4
  • PFTAIRE Protein Kinase 1 2 3
  • EC 2.7.11.22 4 63
  • PFTK1 3 4
  • HPFTAIRE1 4
  • EC 2.7.11 63
  • PFTAIRE1 3
  • KIAA0834 4

External Ids for CDK14 Gene

Previous HGNC Symbols for CDK14 Gene

  • PFTK1

Previous GeneCards Identifiers for CDK14 Gene

  • GC07P090095
  • GC07P084947
  • GC07P090468

Summaries for CDK14 Gene

Entrez Gene Summary for CDK14 Gene

  • PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CDK14 Gene

CDK14 (Cyclin-Dependent Kinase 14) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK16.

UniProtKB/Swiss-Prot for CDK14 Gene

  • Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Gene Wiki entry for CDK14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK14 Gene

Genomics for CDK14 Gene

Genomic Location for CDK14 Gene

Chromosome:
7
Start:
90,466,424 bp from pter
End:
91,210,590 bp from pter
Size:
744,167 bases
Orientation:
Plus strand

Genomic View for CDK14 Gene

Genes around CDK14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK14 Gene

No data available for Regulatory Elements for CDK14 Gene

Proteins for CDK14 Gene

  • Protein details for CDK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94921-CDK14_HUMAN
    Recommended name:
    Cyclin-dependent kinase 14
    Protein Accession:
    O94921
    Secondary Accessions:
    • A4D1E6
    • A6NK51
    • A8WFP6
    • B4DHG5
    • B4DNM2
    • Q75N06
    • Q75N22
    • Q8N764
    • Q9H3D7
    • Q9UDR0

    Protein attributes for CDK14 Gene

    Size:
    469 amino acids
    Molecular mass:
    53057 Da
    Quaternary structure:
    • Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.
    SequenceCaution:
    • Sequence=BAA74857.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK14 Gene

Proteomics data for CDK14 Gene at MOPED

Post-translational modifications for CDK14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDK14 Gene

Gene Families for CDK14 Gene

Suggested Antigen Peptide Sequences for CDK14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94921

UniProtKB/Swiss-Prot:

CDK14_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK14: view

Function for CDK14 Gene

Molecular function for CDK14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Enzyme Numbers (IUBMB) for CDK14 Gene

Gene Ontology (GO) - Molecular Function for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with CDK14: view
genes like me logo Genes that share phenotypes with CDK14: view

Animal Models for CDK14 Gene

MGI Knock Outs for CDK14:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK14 Gene

Localization for CDK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK14 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK14 Gene COMPARTMENTS Subcellular localization image for CDK14 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with CDK14: view

Pathways & Interactions for CDK14 Gene

genes like me logo Genes that share pathways with CDK14: view

Pathways by source for CDK14 Gene

1 GeneTex pathway for CDK14 Gene
1 KEGG pathway for CDK14 Gene

SIGNOR curated interactions for CDK14 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDK14: view

Drugs & Compounds for CDK14 Gene

(1) Drugs for CDK14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK14: view

Transcripts for CDK14 Gene

Unigene Clusters for CDK14 Gene

Cyclin-dependent kinase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK14 Gene

No ASD Table

Relevant External Links for CDK14 Gene

GeneLoc Exon Structure for
CDK14
ECgene alternative splicing isoforms for
CDK14

Expression for CDK14 Gene

mRNA expression in normal human tissues for CDK14 Gene

mRNA differential expression in normal tissues according to GTEx for CDK14 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for CDK14 Gene

This gene is overexpressed in Frontal cortex (44.6) and Retina (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK14 Gene



SOURCE GeneReport for Unigene cluster for CDK14 Gene Hs.258576

mRNA Expression by UniProt/SwissProt for CDK14 Gene

O94921-CDK14_HUMAN
Tissue specificity: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
genes like me logo Genes that share expression patterns with CDK14: view

Protein tissue co-expression partners for CDK14 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CDK14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK14 35
  • 99.46 (n)
  • 99.3 (a)
CDK14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK14 35
  • 94.53 (n)
  • 98.29 (a)
dog
(Canis familiaris)
Mammalia CDK14 35
  • 96.5 (n)
  • 99.3 (a)
CDK14 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk14 16
Cdk14 36
  • 91 (a)
OneToOne
Cdk14 35
  • 91.61 (n)
  • 98.51 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK14 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK14 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk14 35
  • 91.39 (n)
  • 97.79 (a)
chicken
(Gallus gallus)
Aves CDK14 36
  • 90 (a)
OneToOne
CDK14 35
  • 87.93 (n)
  • 96.09 (a)
lizard
(Anolis carolinensis)
Reptilia CDK14 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk14 35
  • 82.66 (n)
  • 93.85 (a)
zebrafish
(Danio rerio)
Actinopterygii CDK14 36
  • 90 (a)
OneToOne
zgc:172096 35
  • 78.85 (n)
  • 95.35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005729 35
  • 59.55 (n)
  • 65.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eip63E 35
  • 60.8 (n)
  • 68.24 (a)
Eip63E 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC123.4 35
  • 56.31 (n)
  • 56.63 (a)
ZC123.4 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2431 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10643 36
  • 56 (a)
OneToMany
Species with no ortholog for CDK14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK14 Gene

ENSEMBL:
Gene Tree for CDK14 (if available)
TreeFam:
Gene Tree for CDK14 (if available)

Paralogs for CDK14 Gene

Paralogs for CDK14 Gene

genes like me logo Genes that share paralogs with CDK14: view

Variants for CDK14 Gene

Sequence variations from dbSNP and Humsavar for CDK14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_046765 An ovarian mucinous carcinoma
VAR_046766 -
rs43005 -- 91,133,863(+) TACTA(C/G)GCAAG intron-variant
rs43009 -- 91,142,217(+) ttttt(A/G)ttgtt intron-variant
rs43014 -- 91,145,727(+) GCAAC(A/T)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK14 Gene

Variant ID Type Subtype PubMed ID
esv996268 CNV Insertion 20482838
nsv888730 CNV Loss 21882294
esv2675428 CNV Deletion 23128226
esv26448 CNV Loss 19812545
esv2657077 CNV Deletion 23128226
esv24639 CNV Loss 19812545
nsv470379 CNV Loss 18288195
nsv824208 CNV Gain 20364138
nsv5832 CNV Insertion 18451855
esv2523347 CNV Deletion 19546169
esv2017217 CNV Deletion 18987734
esv2967 CNV Deletion 18987735
esv2734811 CNV Deletion 23290073
esv998831 CNV Deletion 20482838
esv1647013 CNV Deletion 17803354
nsv5833 CNV Insertion 18451855
nsv510098 CNV Loss 20534489
esv32913 CNV Loss 17666407
esv33717 CNV Gain 17666407
nsv528932 CNV Loss 19592680
nsv510099 CNV Loss 20534489
nsv517959 CNV Loss 19592680
nsv524316 CNV Loss 19592680

Variation tolerance for CDK14 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK14 Gene

HapMap Linkage Disequilibrium report
CDK14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK14 Gene

Disorders for CDK14 Gene

Relevant External Links for CDK14

Genetic Association Database (GAD)
CDK14
Human Genome Epidemiology (HuGE) Navigator
CDK14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK14

No disorders were found for CDK14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK14 Gene

Publications for CDK14 Gene

  1. Identification and cellular localization of human PFTAIRE1. (PMID: 11313143) Yang T. … Chen J.-Y. (Gene 2001) 2 3 4 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. A novel cdc2-related protein kinase expressed in the nervous system. (PMID: 9202329) Lazzaro M.A. … Julien J.P. (J. Neurochem. 1997) 2 3
  4. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. (PMID: 25472883) Dhamija N. … Mitra D. (FEBS J. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CDK14 Gene

Sources for CDK14 Gene

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