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Aliases for CDK14 Gene

Aliases for CDK14 Gene

  • Cyclin-Dependent Kinase 14 2 3
  • PFTK1 3 4 6
  • Serine/Threonine-Protein Kinase PFTAIRE-1 3 4
  • Cell Division Protein Kinase 14 3 4
  • PFTAIRE Protein Kinase 1 2 3
  • EC 2.7.11.22 4 64
  • PFTAIRE1 3 6
  • KIAA0834 4 6
  • HPFTAIRE1 4
  • EC 2.7.11 64

External Ids for CDK14 Gene

Previous Symbols for CDK14 Gene

  • PFTK1

Summaries for CDK14 Gene

Entrez Gene Summary for CDK14 Gene

  • PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CDK14 Gene

CDK14 (Cyclin-Dependent Kinase 14) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and cyclin binding. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK14 Gene

  • Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Gene Wiki entry for CDK14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK14 Gene

Genomics for CDK14 Gene

Genomic Location for CDK14 Gene

Start:
90,466,424 bp from pter
End:
91,210,590 bp from pter
Size:
744,167 bases
Orientation:
Plus strand

Genomic View for CDK14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK14 Gene

No data available for Regulatory Elements for CDK14 Gene

Proteins for CDK14 Gene

  • Protein details for CDK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94921-CDK14_HUMAN
    Recommended name:
    Cyclin-dependent kinase 14
    Protein Accession:
    O94921
    Secondary Accessions:
    • A4D1E6
    • A6NK51
    • A8WFP6
    • B4DHG5
    • B4DNM2
    • Q75N06
    • Q75N22
    • Q8N764
    • Q9H3D7
    • Q9UDR0

    Protein attributes for CDK14 Gene

    Size:
    469 amino acids
    Molecular mass:
    53057 Da
    Quaternary structure:
    • Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.
    SequenceCaution:
    • Sequence=BAA74857.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK14 Gene

Proteomics data for CDK14 Gene at MOPED

Post-translational modifications for CDK14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for CDK14 Gene

Gene Families for CDK14 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

UniProtKB/Swiss-Prot:

CDK14_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • O94921
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • O94921
genes like me logo Genes that share domains with CDK14: view

Function for CDK14 Gene

Molecular function for CDK14 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Enzyme Numbers (IUBMB) for CDK14 Gene

Gene Ontology (GO) - Molecular Function for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IMP 19524571
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16775625
genes like me logo Genes that share ontologies with CDK14: view
genes like me logo Genes that share phenotypes with CDK14: view

miRNA for CDK14 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK14 Gene

Localization for CDK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK14 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK14 Gene COMPARTMENTS Subcellular localization image for CDK14 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 19524571
genes like me logo Genes that share ontologies with CDK14: view

Pathways for CDK14 Gene

genes like me logo Genes that share pathways with CDK14: view

Pathways by source for CDK14 Gene

1 KEGG pathway for CDK14 Gene

Gene Ontology (GO) - Biological Process for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 20059949
GO:0006468 protein phosphorylation IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IMP 19524571
genes like me logo Genes that share ontologies with CDK14: view

Transcripts for CDK14 Gene

Unigene Clusters for CDK14 Gene

Cyclin-dependent kinase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK14 Gene

No ASD Table

Relevant External Links for CDK14 Gene

GeneLoc Exon Structure for
CDK14
ECgene alternative splicing isoforms for
CDK14

Expression for CDK14 Gene

mRNA expression in normal human tissues for CDK14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK14 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK14 Gene

SOURCE GeneReport for Unigene cluster for CDK14 Gene Hs.258576

mRNA Expression by UniProt/SwissProt for CDK14 Gene

O94921-CDK14_HUMAN
Tissue specificity: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
genes like me logo Genes that share expressions with CDK14: view

Orthologs for CDK14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK14 36
  • 99.46 (n)
  • 99.3 (a)
CDK14 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK14 36
  • 94.53 (n)
  • 98.29 (a)
dog
(Canis familiaris)
Mammalia CDK14 36
  • 96.5 (n)
  • 99.3 (a)
CDK14 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk14 36
  • 91.61 (n)
  • 98.51 (a)
Cdk14 16
Cdk14 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK14 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK14 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk14 36
  • 91.39 (n)
  • 97.79 (a)
chicken
(Gallus gallus)
Aves CDK14 36
  • 87.93 (n)
  • 96.09 (a)
CDK14 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK14 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk14 36
  • 82.66 (n)
  • 93.85 (a)
zebrafish
(Danio rerio)
Actinopterygii CDK14 37
  • 90 (a)
OneToOne
zgc:172096 36
  • 78.85 (n)
  • 95.35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005729 36
  • 59.55 (n)
  • 65.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eip63E 36
  • 60.8 (n)
  • 68.24 (a)
Eip63E 37
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC123.4 36
  • 56.31 (n)
  • 56.63 (a)
ZC123.4 37
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 37
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2431 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10643 37
  • 56 (a)
OneToMany
Species with no ortholog for CDK14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK14 Gene

ENSEMBL:
Gene Tree for CDK14 (if available)
TreeFam:
Gene Tree for CDK14 (if available)

Paralogs for CDK14 Gene

Paralogs for CDK14 Gene

genes like me logo Genes that share paralogs with CDK14: view

Variants for CDK14 Gene

Sequence variations from dbSNP and Humsavar for CDK14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15322 -- 91,210,490(-) TACAA(A/C)TGGTA utr-variant-3-prime
rs16704 -- 90,840,909(-) AGACA(-/CAATGT)CAATG intron-variant
rs17648 -- 91,210,402(+) AGAAA(C/T)GTGGT utr-variant-3-prime
rs42999 -- 91,122,820(+) TGAAG(C/T)AGAGA intron-variant
rs43000 -- 91,123,783(+) TAACC(C/G)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK14 Gene

Variant ID Type Subtype PubMed ID
esv996268 CNV Insertion 20482838
nsv888730 CNV Loss 21882294
esv2675428 CNV Deletion 23128226
esv26448 CNV Loss 19812545
esv2657077 CNV Deletion 23128226
esv24639 CNV Loss 19812545
nsv470379 CNV Loss 18288195
nsv824208 CNV Gain 20364138
nsv5832 CNV Insertion 18451855
esv2523347 CNV Deletion 19546169
esv2017217 CNV Deletion 18987734
esv2967 CNV Deletion 18987735
esv2734811 CNV Deletion 23290073
esv998831 CNV Deletion 20482838
esv1647013 CNV Deletion 17803354
nsv5833 CNV Insertion 18451855
nsv510098 CNV Loss 20534489
esv32913 CNV Loss 17666407
esv33717 CNV Gain 17666407
nsv528932 CNV Loss 19592680
nsv510099 CNV Loss 20534489
nsv517959 CNV Loss 19592680
nsv524316 CNV Loss 19592680

Relevant External Links for CDK14 Gene

HapMap Linkage Disequilibrium report
CDK14

Disorders for CDK14 Gene

Relevant External Links for CDK14

Genetic Association Database (GAD)
CDK14
Human Genome Epidemiology (HuGE) Navigator
CDK14
genes like me logo Genes that share disorders with CDK14: view

No data available for UniProtKB/Swiss-Prot for CDK14 Gene

Publications for CDK14 Gene

  1. Identification and cellular localization of human PFTAIRE1. (PMID: 11313143) Yang T. … Chen J.-Y. (Gene 2001) 2 3 4
  2. KIAA0202, a human septin family member, interacting with hPFTAIRE1. (PMID: 12098780) Yang T. … Chen J.Y. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 3 4
  3. A novel cdc2-related protein kinase expressed in the nervous system. (PMID: 9202329) Lazzaro M.A. … Julien J.P. (J. Neurochem. 1997) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. (PMID: 16461467) Tang X. … Czech M.P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 4 23

Products for CDK14 Gene

  • Addgene plasmids for CDK14

Sources for CDK14 Gene

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