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Aliases for ATP5I Gene

Aliases for ATP5I Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit E 2 3
  • ATP5K 3 4 6
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E 2 3
  • ATPase Subunit E 3 4
  • ATP Synthase Subunit E, Mitochondrial 3
  • ATP Synthase E Chain, Mitochondrial 3
  • F1F0-ATP Synthase, Murine E Subunit 3

External Ids for ATP5I Gene

Previous GeneCards Identifiers for ATP5I Gene

  • GC04M000672
  • GC04M000656
  • GC04M000642

Summaries for ATP5I Gene

Entrez Gene Summary for ATP5I Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5I Gene

ATP5I (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit E) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5I Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane

Gene Wiki entry for ATP5I Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5I Gene

Genomics for ATP5I Gene

Regulatory Elements for ATP5I Gene

Genomic Location for ATP5I Gene

Start:
672,436 bp from pter
End:
674,338 bp from pter
Size:
1,903 bases
Orientation:
Minus strand

Genomic View for ATP5I Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5I Gene

Proteins for ATP5I Gene

  • Protein details for ATP5I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56385-ATP5I_HUMAN
    Recommended name:
    ATP synthase subunit e, mitochondrial
    Protein Accession:
    P56385
    Secondary Accessions:
    • Q0D2L9

    Protein attributes for ATP5I Gene

    Size:
    69 amino acids
    Molecular mass:
    7933 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5I Gene

Proteomics data for ATP5I Gene at MOPED

Post-translational modifications for ATP5I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5I Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5I Gene

Domains for ATP5I Gene

Gene Families for ATP5I Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V
IUPHAR :

Protein Domains for ATP5I Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56385

UniProtKB/Swiss-Prot:

ATP5I_HUMAN :
  • P56385
Family:
  • Belongs to the ATPase e subunit family.
genes like me logo Genes that share domains with ATP5I: view

Function for ATP5I Gene

Molecular function for ATP5I Gene

GENATLAS Biochemistry: ATP synthase H+ transporting,inner mitochondrial matrix (F0 segment),subunit e,complex V of oxidative phosphorylation (OXPHOS),mediating proton transport
UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane

Gene Ontology (GO) - Molecular Function for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5I: view

Phenotypes for ATP5I Gene

GenomeRNAi human phenotypes for ATP5I:
genes like me logo Genes that share phenotypes with ATP5I: view

miRNA for ATP5I Gene

miRTarBase miRNAs that target ATP5I

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5I Gene

Localization for ATP5I Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5I Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5I Gene COMPARTMENTS Subcellular localization image for ATP5I gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
genes like me logo Genes that share ontologies with ATP5I: view

Pathways for ATP5I Gene

genes like me logo Genes that share pathways with ATP5I: view

Gene Ontology (GO) - Biological Process for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0015986 ATP synthesis coupled proton transport --
GO:0022904 respiratory electron transport chain TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5I: view

Compounds for ATP5I Gene

(4) HMDB Compounds for ATP5I Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ATP5I: view

Transcripts for ATP5I Gene

Unigene Clusters for ATP5I Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5I Gene

No ASD Table

Relevant External Links for ATP5I Gene

GeneLoc Exon Structure for
ATP5I
ECgene alternative splicing isoforms for
ATP5I

Expression for ATP5I Gene

mRNA expression in normal human tissues for ATP5I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5I Gene

SOURCE GeneReport for Unigene cluster for ATP5I Gene Hs.85539

genes like me logo Genes that share expressions with ATP5I: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5I Gene

Orthologs for ATP5I Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5I 35
  • 99.52 (n)
  • 100 (a)
ATP5I 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
OneToMany
ATP5I 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5k 16
Atp5k 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5I 36
  • 21 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5I 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBF 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5I 36
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atp5ia 36
  • 62 (a)
OneToMany
atp5ib 36
  • 65 (a)
OneToMany
Species with no ortholog for ATP5I:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5I Gene

ENSEMBL:
Gene Tree for ATP5I (if available)
TreeFam:
Gene Tree for ATP5I (if available)

Paralogs for ATP5I Gene

No data available for Paralogs for ATP5I Gene

Variants for ATP5I Gene

Sequence variations from dbSNP and Humsavar for ATP5I Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs28470912 -- 671,948(+) GCACT(C/T)AGGCC downstream-variant-500B
rs78677748 -- 671,990(+) TAGTC(C/T)CAAGT downstream-variant-500B
rs370739863 -- 672,112(+) TGCCT(-/A)CCCCT downstream-variant-500B
rs377270928 -- 672,053(+) GGGGC(A/G)AGGGG downstream-variant-500B
rs529195231 -- 672,095(+) GTAAG(G/T)GCGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATP5I Gene

Variant ID Type Subtype PubMed ID
nsv878245 CNV Loss 21882294
nsv508986 CNV Insertion 20534489
nsv822425 CNV Loss 20364138
nsv878246 CNV Loss 21882294
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
dgv5387n71 CNV Loss 21882294
nsv829834 CNV Loss 17160897
nsv10413 CNV Gain 18304495

Relevant External Links for ATP5I Gene

HapMap Linkage Disequilibrium report
ATP5I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5I Gene

Disorders for ATP5I Gene

Relevant External Links for ATP5I

Genetic Association Database (GAD)
ATP5I
Human Genome Epidemiology (HuGE) Navigator
ATP5I
genes like me logo Genes that share disorders with ATP5I: view

No data available for UniProtKB/Swiss-Prot for ATP5I Gene

Publications for ATP5I Gene

  1. The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. (PMID: 8702853) Swartz D.A. … Kaput J. (J. Biol. Chem. 1996) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PMID: 22623428) Byron A. … Humphries M.J. (Proteomics 2012) 3

Products for ATP5I Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP5I
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5I
    • Block miRNA regulation of ATP5I using miScript Target Protectors

    Sources for ATP5I Gene

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