Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP5I Gene

Aliases for ATP5I Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit E 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit E 2 3
  • ATPase Subunit E 3 4
  • ATP5K 3 4
  • ATP Synthase E Chain, Mitochondrial 3
  • F1F0-ATP Synthase, Murine E Subunit 3

External Ids for ATP5I Gene

Previous GeneCards Identifiers for ATP5I Gene

  • GC04M000672
  • GC04M000656
  • GC04M000642

Summaries for ATP5I Gene

Entrez Gene Summary for ATP5I Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5I Gene

ATP5I (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit E) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5I Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5I Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5I Gene

Genomics for ATP5I Gene

Regulatory Elements for ATP5I Gene


Promoters for ATP5I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP5I on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP5I Gene

Chromosome:
4
Start:
672,436 bp from pter
End:
674,338 bp from pter
Size:
1,903 bases
Orientation:
Minus strand

Genomic View for ATP5I Gene

Genes around ATP5I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5I Gene

Proteins for ATP5I Gene

  • Protein details for ATP5I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56385-ATP5I_HUMAN
    Recommended name:
    ATP synthase subunit e, mitochondrial
    Protein Accession:
    P56385
    Secondary Accessions:
    • Q0D2L9

    Protein attributes for ATP5I Gene

    Size:
    69 amino acids
    Molecular mass:
    7933 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5I Gene

Proteomics data for ATP5I Gene at MOPED

Post-translational modifications for ATP5I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5I Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5I Gene

Domains & Families for ATP5I Gene

Protein Domains for ATP5I Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56385

UniProtKB/Swiss-Prot:

ATP5I_HUMAN :
  • Belongs to the ATPase e subunit family.
Family:
  • Belongs to the ATPase e subunit family.
genes like me logo Genes that share domains with ATP5I: view

Function for ATP5I Gene

Molecular function for ATP5I Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,inner mitochondrial matrix (F0 segment),subunit e,complex V of oxidative phosphorylation (OXPHOS),mediating proton transport
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
genes like me logo Genes that share phenotypes with ATP5I: view

Animal Model Products

CRISPR Products

miRNA for ATP5I Gene

miRTarBase miRNAs that target ATP5I

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5I Gene

Localization for ATP5I Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5I Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5I Gene COMPARTMENTS Subcellular localization image for ATP5I gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
genes like me logo Genes that share ontologies with ATP5I: view

Pathways & Interactions for ATP5I Gene

genes like me logo Genes that share pathways with ATP5I: view

Gene Ontology (GO) - Biological Process for ATP5I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5I: view

No data available for SIGNOR curated interactions for ATP5I Gene

Drugs & Compounds for ATP5I Gene

(1) Drugs for ATP5I Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for ATP5I Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATP5I: view

Transcripts for ATP5I Gene

Unigene Clusters for ATP5I Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5I Gene

No ASD Table

Relevant External Links for ATP5I Gene

GeneLoc Exon Structure for
ATP5I
ECgene alternative splicing isoforms for
ATP5I

Expression for ATP5I Gene

mRNA expression in normal human tissues for ATP5I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP5I Gene

This gene is overexpressed in Nasal epithelium (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5I Gene



SOURCE GeneReport for Unigene cluster for ATP5I Gene Hs.85539

genes like me logo Genes that share expression patterns with ATP5I: view

Protein tissue co-expression partners for ATP5I Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5I Gene

Orthologs for ATP5I Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5I 35
  • 99.52 (n)
  • 100 (a)
ATP5I 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
OneToMany
ATP5I 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5I 36
  • 21 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5k 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5I 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBF 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5I 36
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atp5ia 36
  • 62 (a)
OneToMany
atp5ib 36
  • 65 (a)
OneToMany
Species with no ortholog for ATP5I:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5I Gene

ENSEMBL:
Gene Tree for ATP5I (if available)
TreeFam:
Gene Tree for ATP5I (if available)

Paralogs for ATP5I Gene

No data available for Paralogs for ATP5I Gene

Variants for ATP5I Gene

Sequence variations from dbSNP and Humsavar for ATP5I Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs28470912 -- 671,948(+) GCACT(C/T)AGGCC downstream-variant-500B
rs78677748 -- 671,990(+) TAGTC(C/T)CAAGT downstream-variant-500B
rs370739863 -- 672,112(+) TGCCT(-/A)CCCCT downstream-variant-500B
rs529195231 -- 672,095(+) GTAAG(G/T)GCGTC downstream-variant-500B
rs377270928 -- 672,053(+) GGGGC(A/G)AGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATP5I Gene

Variant ID Type Subtype PubMed ID
nsv878245 CNV Loss 21882294
nsv508986 CNV Insertion 20534489
nsv822425 CNV Loss 20364138
nsv878246 CNV Loss 21882294
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
dgv5387n71 CNV Loss 21882294
nsv829834 CNV Loss 17160897
nsv10413 CNV Gain 18304495

Variation tolerance for ATP5I Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP5I Gene

Disorders for ATP5I Gene

Relevant External Links for ATP5I

Genetic Association Database (GAD)
ATP5I
Human Genome Epidemiology (HuGE) Navigator
ATP5I
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5I

No disorders were found for ATP5I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5I Gene

Publications for ATP5I Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. (PMID: 8702853) Swartz D.A. … Kaput J. (J. Biol. Chem. 1996) 2 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3

Products for ATP5I Gene

Sources for ATP5I Gene

Content