Aliases for PFKFB1 Gene
External Ids for PFKFB1 Gene
Previous HGNC Symbols for PFKFB1 Gene
Previous GeneCards Identifiers for PFKFB1 Gene
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for PFKFB1 Gene
PFKFB1 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1) is a Protein Coding gene. Among its related pathways are Glucagon signaling pathway and Integration of energy metabolism. GO annotations related to this gene include identical protein binding and kinase binding. An important paralog of this gene is PFKFB4.
UniProtKB/Swiss-Prot for PFKFB1 Gene
Synthesis and degradation of fructose 2,6-bisphosphate.