Aliases for PFKFB1 Gene
External Ids for PFKFB1 Gene
Previous Symbols for PFKFB1 Gene
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for PFKFB1 Gene
PFKFB1 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and Metabolism. GO annotations related to this gene include identical protein binding and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB3.
UniProtKB/Swiss-Prot for PFKFB1 Gene
Synthesis and degradation of fructose 2,6-bisphosphate