Aliases for PEX14 Gene
External Ids for PEX14 Gene
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for PEX14 Gene
PEX14 (Peroxisomal Biogenesis Factor 14) is a Protein Coding gene. Diseases associated with PEX14 include peroxisome biogenesis disorder 13a and peroxisome biogenesis disorder 1b. Among its related pathways are Peroxisome. GO annotations related to this gene include receptor binding and microtubule binding.
UniProtKB/Swiss-Prot for PEX14 Gene
Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.