Aliases for CALML5 Gene
External Ids for CALML5 Gene
Previous GeneCards Identifiers for CALML5 Gene
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for CALML5 Gene
CALML5 (Calmodulin Like 5) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.
UniProtKB/Swiss-Prot for CALML5 Gene
Binds calcium. May be involved in terminal differentiation of keratinocytes.