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Aliases for STK26 Gene

Aliases for STK26 Gene

  • Serine/Threonine Protein Kinase 26 2 3 5
  • Serine/Threonine-Protein Kinase MASK 3 4
  • STE20-Like Kinase MST4 3 4
  • STE20-Like Kinase 4 2 3
  • EC 2.7.11.1 4 63
  • MASK 3 4
  • MST4 3 4
  • Mammalian Ste20-Like Protein Kinase 4 3
  • Mammalian STE20-Like Protein Kinase 4 4
  • Serine/Threonine Protein Kinase MST4 3
  • Mst3 And SOK1-Related Kinase 3
  • MST3 And SOK1-Related Kinase 4
  • Mammalian Sterile 20-Like 4 3
  • EC 2.7.11 63
  • MST-4 4

External Ids for STK26 Gene

Summaries for STK26 Gene

Entrez Gene Summary for STK26 Gene

  • The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK26 Gene

STK26 (Serine/Threonine Protein Kinase 26) is a Protein Coding gene. Among its related pathways are Apoptotic cleavage of cellular proteins and LKB1 signaling events. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot for STK26 Gene

  • Mediator of cell growth. Modulates apoptosis.

Gene Wiki entry for STK26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK26 Gene

Genomics for STK26 Gene

Regulatory Elements for STK26 Gene

Enhancers for STK26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK26 on UCSC Golden Path with GeneCards custom track

Promoters for STK26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK26 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK26 Gene

Chromosome:
X
Start:
132,023,217 bp from pter
End:
132,075,943 bp from pter
Size:
52,727 bases
Orientation:
Plus strand

Genomic View for STK26 Gene

Genes around STK26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK26 Gene

Proteins for STK26 Gene

  • Protein details for STK26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P289-STK26_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 26
    Protein Accession:
    Q9P289
    Secondary Accessions:
    • B2RAU2
    • Q3ZB77
    • Q8NC04
    • Q9BXC3
    • Q9BXC4

    Protein attributes for STK26 Gene

    Size:
    416 amino acids
    Molecular mass:
    46529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for STK26 Gene

    Alternative splice isoforms for STK26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK26 Gene

Proteomics data for STK26 Gene at MOPED

Post-translational modifications for STK26 Gene

  • Ubiquitination at Lys 233
  • Modification sites at PhosphoSitePlus

Other Protein References for STK26 Gene

Domains & Families for STK26 Gene

Protein Domains for STK26 Gene

Suggested Antigen Peptide Sequences for STK26 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P289

UniProtKB/Swiss-Prot:

STK26_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK26: view

No data available for Gene Families for STK26 Gene

Function for STK26 Gene

Molecular function for STK26 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.
UniProtKB/Swiss-Prot Function:
Mediator of cell growth. Modulates apoptosis.

Enzyme Numbers (IUBMB) for STK26 Gene

Gene Ontology (GO) - Molecular Function for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 11741893
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with STK26: view
genes like me logo Genes that share phenotypes with STK26: view

Animal Model Products

miRNA for STK26 Gene

miRTarBase miRNAs that target STK26

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK26 Gene

Localization for STK26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK26 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Golgi apparatus.

Gene Ontology (GO) - Cellular Components for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with STK26: view

No data available for Subcellular locations from COMPARTMENTS for STK26 Gene

Pathways & Interactions for STK26 Gene

genes like me logo Genes that share pathways with STK26: view

Pathways by source for STK26 Gene

1 Cell Signaling Technology pathway for STK26 Gene
1 BioSystems pathway for STK26 Gene

SIGNOR curated interactions for STK26 Gene

Activates:

Gene Ontology (GO) - Biological Process for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IMP 22291017
GO:0006915 apoptotic process TAS --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0030033 microvillus assembly IDA 22797597
GO:0031098 stress-activated protein kinase signaling cascade IBA --
genes like me logo Genes that share ontologies with STK26: view

Drugs & Compounds for STK26 Gene

(3) Drugs for STK26 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Experimental Pharma Target 0
Magnesium Nutra 0

(1) Additional Compounds for STK26 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK26: view

Transcripts for STK26 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for STK26 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - -
SP11: - -
SP12: -

ExUns: 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STK26 Gene

GeneLoc Exon Structure for
STK26
ECgene alternative splicing isoforms for
STK26

Expression for STK26 Gene

mRNA expression in normal human tissues for STK26 Gene

Protein differential expression in normal tissues from HIPED for STK26 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8) and Tlymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK26 Gene



genes like me logo Genes that share expression patterns with STK26: view

Protein tissue co-expression partners for STK26 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STK26 Gene

Orthologs for STK26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MST4 35
  • 93.43 (n)
  • 98.8 (a)
MST4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MST4 35
  • 95.59 (n)
  • 99.76 (a)
-- 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610018G03Rik 35
  • 91.11 (n)
  • 98.08 (a)
Stk26 16
2610018G03Rik 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MST4 35
  • 99.76 (n)
  • 100 (a)
-- 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mst4 35
  • 90.62 (n)
  • 98.8 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves MST4 35
  • 83.05 (n)
  • 91.57 (a)
MST4 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mst4 35
  • 78.29 (n)
  • 87.89 (a)
Str.19684 35
zebrafish
(Danio rerio)
Actinopterygii mst4 35
  • 69.02 (n)
  • 78.05 (a)
mst4 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GckIII 35
  • 69.08 (n)
  • 82.97 (a)
GckIII 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-1 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 36
  • 30 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.10170 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 36
  • 64 (a)
OneToMany
Species with no ortholog for STK26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK26 Gene

ENSEMBL:
Gene Tree for STK26 (if available)
TreeFam:
Gene Tree for STK26 (if available)

Paralogs for STK26 Gene

Paralogs for STK26 Gene

Pseudogenes.org Pseudogenes for STK26 Gene

genes like me logo Genes that share paralogs with STK26: view

Variants for STK26 Gene

Sequence variations from dbSNP and Humsavar for STK26 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs56035648 - 132,023,643(+) TGTCC(A/G)AGTGC reference, missense, utr-variant-5-prime
VAR_040845 A gastric adenocarcinoma sample
rs56044451 - 132,054,721(+) ATAAC(C/T)GTACC intron-variant, reference, missense, utr-variant-5-prime
rs747674285 -- 132,032,379(+) TATAT(A/G)TTCAC intron-variant
rs747701237 -- 132,054,378(+) GGATA(C/T)ATTTG intron-variant

Variation tolerance for STK26 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for STK26 Gene

Disorders for STK26 Gene

Relevant External Links for STK26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK26

No disorders were found for STK26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK26 Gene

Publications for STK26 Gene

  1. Cloning and characterization of MST4, a novel Ste20-like kinase. (PMID: 11306563) Qian Z. … Rosner M.R. (J. Biol. Chem. 2001) 2 3 4 67
  2. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. (PMID: 11741893) Dan I. … Pandey A. (J. Biol. Chem. 2002) 3 23
  3. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. (PMID: 25642822) Jiao S. … Zhou Z. (Nat. Immunol. 2015) 3
  4. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. (PMID: 25650755) Xiong W. … Wierman M.E. (Mol. Endocrinol. 2015) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3

Products for STK26 Gene

Sources for STK26 Gene

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