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Aliases for STK26 Gene

Aliases for STK26 Gene

  • Serine/Threonine Protein Kinase 26 2 3
  • MASK 3 4 6
  • MST4 3 4 6
  • Serine/Threonine-Protein Kinase MASK 3 4
  • STE20-Like Kinase MST4 3 4
  • STE20-Like Kinase 4 2 3
  • EC 2.7.11.1 4 63
  • Mammalian Ste20-Like Protein Kinase 4 3
  • Mammalian STE20-Like Protein Kinase 4 4
  • Serine/Threonine Protein Kinase MST4 3
  • Serine/Threonine-Protein Kinase 26 3
  • Mst3 And SOK1-Related Kinase 3
  • MST3 And SOK1-Related Kinase 4
  • Mammalian Sterile 20-Like 4 3
  • EC 2.7.11 63
  • MST-4 4

External Ids for STK26 Gene

Summaries for STK26 Gene

Entrez Gene Summary for STK26 Gene

  • The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK26 Gene

STK26 (Serine/Threonine Protein Kinase 26) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot for STK26 Gene

  • Mediator of cell growth. Modulates apoptosis.

Gene Wiki entry for STK26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK26 Gene

Genomics for STK26 Gene

Genomic Location for STK26 Gene

Start:
132,023,217 bp from pter
End:
132,075,943 bp from pter
Size:
52,727 bases
Orientation:
Plus strand

Genomic View for STK26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK26 Gene

No data available for Regulatory Elements for STK26 Gene

Proteins for STK26 Gene

  • Protein details for STK26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P289-STK26_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 26
    Protein Accession:
    Q9P289
    Secondary Accessions:
    • B2RAU2
    • Q3ZB77
    • Q8NC04
    • Q9BXC3
    • Q9BXC4

    Protein attributes for STK26 Gene

    Size:
    416 amino acids
    Molecular mass:
    46529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for STK26 Gene

    Alternative splice isoforms for STK26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK26 Gene

Proteomics data for STK26 Gene at MOPED

Post-translational modifications for STK26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK26 Gene

Domains for STK26 Gene

Protein Domains for STK26 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P289

UniProtKB/Swiss-Prot:

STK26_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9P289
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q9P289
genes like me logo Genes that share domains with STK26: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for STK26 Gene

Function for STK26 Gene

Molecular function for STK26 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.
UniProtKB/Swiss-Prot Function: Mediator of cell growth. Modulates apoptosis.

Enzyme Numbers (IUBMB) for STK26 Gene

Gene Ontology (GO) - Molecular Function for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11641781
GO:0004672 protein kinase activity IMP 22797597
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17360971
genes like me logo Genes that share ontologies with STK26: view

Phenotypes for STK26 Gene

genes like me logo Genes that share phenotypes with STK26: view

miRNA for STK26 Gene

miRTarBase miRNAs that target STK26

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK26 Gene

Localization for STK26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK26 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Golgi apparatus.

Gene Ontology (GO) - Cellular Components for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with STK26: view

No data available for Subcellular locations from COMPARTMENTS for STK26 Gene

Pathways for STK26 Gene

genes like me logo Genes that share pathways with STK26: view

Pathways by source for STK26 Gene

1 Cell Signaling Technology pathway for STK26 Gene
1 BioSystems pathway for STK26 Gene

Gene Ontology (GO) - Biological Process for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IMP 22291017
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0012501 programmed cell death TAS --
GO:0030033 microvillus assembly IDA 22797597
genes like me logo Genes that share ontologies with STK26: view

Transcripts for STK26 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for STK26 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - -
SP11: - -
SP12: -

ExUns: 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STK26 Gene

GeneLoc Exon Structure for
STK26
ECgene alternative splicing isoforms for
STK26

Expression for STK26 Gene

mRNA expression in normal human tissues for STK26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STK26 Gene

genes like me logo Genes that share expressions with STK26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STK26 Gene

Orthologs for STK26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToOne
MST4 35
  • 99.76 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MST4 35
  • 93.43 (n)
  • 98.8 (a)
MST4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToOne
MST4 35
  • 95.59 (n)
  • 99.76 (a)
mouse
(Mus musculus)
Mammalia 2610018G03Rik 35
  • 91.11 (n)
  • 98.08 (a)
2610018G03Rik 16
2610018G03Rik 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mst4 35
  • 90.62 (n)
  • 98.8 (a)
chicken
(Gallus gallus)
Aves MST4 35
  • 83.05 (n)
  • 91.57 (a)
MST4 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mst4 35
  • 78.29 (n)
  • 87.89 (a)
Str.19684 35
zebrafish
(Danio rerio)
Actinopterygii mst4 35
  • 69.02 (n)
  • 78.05 (a)
mst4 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GckIII 35
  • 69.08 (n)
  • 82.97 (a)
GckIII 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-1 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 36
  • 30 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.10170 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 36
  • 64 (a)
OneToMany
Species with no ortholog for STK26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK26 Gene

ENSEMBL:
Gene Tree for STK26 (if available)
TreeFam:
Gene Tree for STK26 (if available)

Paralogs for STK26 Gene

Paralogs for STK26 Gene

Pseudogenes.org Pseudogenes for STK26 Gene

genes like me logo Genes that share paralogs with STK26: view

Variants for STK26 Gene

Sequence variations from dbSNP and Humsavar for STK26 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs995246 -- 132,074,568(+) TTTTT(A/T)AAAAA utr-variant-3-prime
rs1321123 -- 132,038,205(+) GAAAT(C/T)CTTTG intron-variant
rs1852999 -- 132,051,922(+) ACATG(A/C)ACTCA intron-variant
rs2748724 -- 132,026,679(+) GTTAA(A/C)TCTTT intron-variant
rs2748725 -- 132,044,690(+) ATATA(G/T)AGAGA intron-variant

Relevant External Links for STK26 Gene

HapMap Linkage Disequilibrium report
STK26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STK26 Gene

Disorders for STK26 Gene

No disorders were found for STK26 Gene.

No data available for UniProtKB/Swiss-Prot for STK26 Gene

Publications for STK26 Gene

  1. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. (PMID: 11741893) Dan I. … Pandey A. (J. Biol. Chem. 2002) 3 4 23
  2. Cloning and characterization of MST4, a novel Ste20-like kinase. (PMID: 11306563) Qian Z. … Rosner M.R. (J. Biol. Chem. 2001) 2 3 4
  3. Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. (PMID: 19370760) Voss K. … Felbor U. (Hum. Mutat. 2009) 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (PMID: 15037601) Preisinger C. … Barr F.A. (J. Cell Biol. 2004) 3 4

Products for STK26 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate STK26
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for STK26
    • Block miRNA regulation of STK26 using miScript Target Protectors
    • Addgene plasmids for STK26

    Sources for STK26 Gene

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