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Aliases for GNG13 Gene

Aliases for GNG13 Gene

  • G Protein Subunit Gamma 13 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 13 2 3
  • G Gamma Subunit, Clone:H2-35 2 3
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-13 3
  • Guanine Nucleotide Binding Protein 13, Gamma 3
  • G(Gamma)13 3
  • H2-35 3

External Ids for GNG13 Gene

Previous GeneCards Identifiers for GNG13 Gene

  • GC16M000867
  • GC16M000788
  • GC16M000848
  • GC16M000770
  • GC16M000806
  • GC16M000825
  • GC16M000846
  • GC16M000869
  • GC16M000886

Summaries for GNG13 Gene

Entrez Gene Summary for GNG13 Gene

  • Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

GeneCards Summary for GNG13 Gene

GNG13 (G Protein Subunit Gamma 13) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include signal transducer activity and G-protein beta-subunit binding.

UniProtKB/Swiss-Prot for GNG13 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG13 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG13 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG13 Gene

Genomics for GNG13 Gene

Regulatory Elements for GNG13 Gene

Enhancers for GNG13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G000562 0.6 FANTOM5 35 +238.6 238595 0.2 ZNF600 ZBTB33 ZBTB26 GNG13 PRR35 RGS11 ARHGDIG RHBDL1 PIGQ NHLRC4
GH16G000795 0.8 ENCODE 0.7 +5.0 4978 0.2 SIX4 ESRRA NFIB SIN3A HIC1 CTBP1 GATA3 POLR2A SCRT2 RCOR1 GNG13 RPUSD1
GH16G000787 1.1 ENCODE 0.4 +12.1 12114 2.8 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 FOS SP3 CHTF18 MSLN MSLNL NARFL RPUSD1 GNG13
GH16G000797 0.6 ENCODE 0.7 +3.5 3518 0.1 KLF1 SCRT2 KLF9 ZNF524 IRF1 KLF8 RBFOX2 GNG13 RPUSD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNG13 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNG13 Gene

Chromosome:
16
Start:
798,041 bp from pter
End:
800,733 bp from pter
Size:
2,693 bases
Orientation:
Minus strand

Genomic View for GNG13 Gene

Genes around GNG13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG13 Gene

Proteins for GNG13 Gene

  • Protein details for GNG13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2W3-GBG13_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
    Protein Accession:
    Q9P2W3
    Secondary Accessions:
    • B2R5C8
    • Q52LX0
    • Q9UJJ3

    Protein attributes for GNG13 Gene

    Size:
    67 amino acids
    Molecular mass:
    7949 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG13 Gene

Post-translational modifications for GNG13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG13 Gene

Domains & Families for GNG13 Gene

Gene Families for GNG13 Gene

Protein Domains for GNG13 Gene

Suggested Antigen Peptide Sequences for GNG13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2W3

UniProtKB/Swiss-Prot:

GBG13_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG13: view

Function for GNG13 Gene

Molecular function for GNG13 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with GNG13: view
genes like me logo Genes that share phenotypes with GNG13: view

Animal Models for GNG13 Gene

MGI Knock Outs for GNG13:

Animal Model Products

CRISPR Products

miRNA for GNG13 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG13 Gene

Localization for GNG13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG13 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG13 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with GNG13: view

Pathways & Interactions for GNG13 Gene

SuperPathways for GNG13 Gene

genes like me logo Genes that share pathways with GNG13: view

Gene Ontology (GO) - Biological Process for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG13: view

No data available for SIGNOR curated interactions for GNG13 Gene

Drugs & Compounds for GNG13 Gene

(3) Drugs for GNG13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG13 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNG13 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNG13: view

Transcripts for GNG13 Gene

mRNA/cDNA for GNG13 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG13 Gene

Guanine nucleotide binding protein (G protein), gamma 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG13 Gene

No ASD Table

Relevant External Links for GNG13 Gene

GeneLoc Exon Structure for
GNG13
ECgene alternative splicing isoforms for
GNG13

Expression for GNG13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG13 Gene

This gene is overexpressed in Brain - Cerebellum (x22.5), Brain - Cerebellar Hemisphere (x9.9), Brain - Frontal Cortex (BA9) (x6.0), and Brain - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for GNG13 Gene

This gene is overexpressed in Retina (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG13 Gene



Protein tissue co-expression partners for GNG13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNG13 Gene:

GNG13

SOURCE GeneReport for Unigene cluster for GNG13 Gene:

Hs.247888

Evidence on tissue expression from TISSUES for GNG13 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GNG13: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG13 Gene

Orthologs for GNG13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG13 34 35
  • 99.5 (n)
oppossum
(Monodelphis domestica)
Mammalia GNG13 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG13 34 35
  • 91.54 (n)
rat
(Rattus norvegicus)
Mammalia Gng13 34
  • 91.54 (n)
cow
(Bos Taurus)
Mammalia GNG13 34 35
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia Gng13 34 16 35
  • 90.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GNG13 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNG13 34 35
  • 84.08 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng13 34
  • 81.09 (n)
Str.2935 34
African clawed frog
(Xenopus laevis)
Amphibia gng13-prov 34
zebrafish
(Danio rerio)
Actinopterygii gng13b 34 35
  • 77.61 (n)
gng13a 35
  • 55 (a)
OneToMany
Dr.14190 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3115 34
Species where no ortholog for GNG13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG13 Gene

ENSEMBL:
Gene Tree for GNG13 (if available)
TreeFam:
Gene Tree for GNG13 (if available)

Paralogs for GNG13 Gene

(1) SIMAP similar genes for GNG13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG13: view

No data available for Paralogs for GNG13 Gene

Variants for GNG13 Gene

Sequence variations from dbSNP and Humsavar for GNG13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000512492 -- 800,254(+) CCTTT(A/T)CTCGG intron-variant
rs1000968959 -- 798,515(+) TCTTA(A/C)AAGAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001968399 -- 800,128(+) TGGGG(G/T)GGGAG intron-variant
rs1002035161 -- 799,276(+) ACAGA(A/G)CGAGT intron-variant
rs1002647091 -- 800,683(+) ACAGC(A/G)GAGGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GNG13 Gene

Variant ID Type Subtype PubMed ID
dgv4827n54 CNV loss 21841781
dgv4828n54 CNV gain 21841781
esv2422427 CNV duplication 17116639
esv3570042 CNV gain 25503493
esv3637582 CNV gain 21293372
esv3637584 CNV loss 21293372
esv3637585 CNV gain 21293372
esv3637586 CNV loss 21293372
esv3637587 CNV gain 21293372
esv3637588 CNV loss 21293372
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv482184 CNV gain 20164927
nsv517488 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571042 CNV loss 21841781
nsv571043 CNV loss 21841781
nsv571045 CNV gain 21841781
nsv817712 CNV loss 17921354
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for GNG13 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG13 Gene

Disorders for GNG13 Gene

Relevant External Links for GNG13

Human Genome Epidemiology (HuGE) Navigator
GNG13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG13

No disorders were found for GNG13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG13 Gene

Publications for GNG13 Gene

  1. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. (PMID: 10570481) Huang L. … Margolskee R.F. (Nat. Neurosci. 1999) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64
  5. Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. (PMID: 20660057) Fushan A.A. … Drayna D. (Chem. Senses 2010) 3 64

Products for GNG13 Gene

Sources for GNG13 Gene

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