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Aliases for PECAM1 Gene

Aliases for PECAM1 Gene

  • Platelet/Endothelial Cell Adhesion Molecule 1 2 3
  • CD31 Antigen 2 3 4
  • EndoCAM 3 4
  • PECAM-1 3 4
  • GPIIA 3 4
  • PECA1 3 4
  • Platelet/Endothelial Cell Adhesion Molecule 2
  • Platelet Endothelial Cell Adhesion Molecule 3
  • CD31/EndoCAM 3
  • CD31 3

External Ids for PECAM1 Gene

Previous GeneCards Identifiers for PECAM1 Gene

  • GC17U990071
  • GC17M064827
  • GC17M062740
  • GC17M062873
  • GC17M059754
  • GC17M062399

Summaries for PECAM1 Gene

Entrez Gene Summary for PECAM1 Gene

  • The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

GeneCards Summary for PECAM1 Gene

PECAM1 (Platelet/Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include angiosarcoma and erythema elevatum diutinum. Among its related pathways are Angiogenesis (CST) and Integrin Pathway.

UniProtKB/Swiss-Prot for PECAM1 Gene

  • Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Gene Wiki entry for PECAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PECAM1 Gene

Genomics for PECAM1 Gene

Regulatory Elements for PECAM1 Gene

Genomic Location for PECAM1 Gene

Start:
64,319,415 bp from pter
End:
64,413,779 bp from pter
Size:
94,365 bases
Orientation:
Minus strand

Genomic View for PECAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PECAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PECAM1 Gene

Proteins for PECAM1 Gene

  • Protein details for PECAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16284-PECA1_HUMAN
    Recommended name:
    Platelet endothelial cell adhesion molecule
    Protein Accession:
    P16284
    Secondary Accessions:
    • A8K3S7
    • D3DU31
    • Q6LDA9
    • Q8TBH1
    • Q96RF5
    • Q96RF6
    • Q9NP65
    • Q9NPB7
    • Q9NPG9
    • Q9NQS9
    • Q9NQT0
    • Q9NQT1
    • Q9NQT2

    Protein attributes for PECAM1 Gene

    Size:
    738 amino acids
    Molecular mass:
    82536 Da
    Quaternary structure:
    • Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

    Three dimensional structures from OCA and Proteopedia for PECAM1 Gene

    Alternative splice isoforms for PECAM1 Gene

neXtProt entry for PECAM1 Gene

Proteomics data for PECAM1 Gene at MOPED

Post-translational modifications for PECAM1 Gene

  • Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells.
  • Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.
  • Ubiquitination at Lys446 and Lys543
  • Glycosylation at Asn52, Asn84, Asn151, Asn301, Asn320, Asn344, Asn356, Asn453, and Asn551
  • Modification sites at PhosphoSitePlus

Other Protein References for PECAM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PECAM1 Gene

Domains for PECAM1 Gene

Gene Families for PECAM1 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for PECAM1 Gene

Suggested Antigen Peptide Sequences for PECAM1 Gene

Graphical View of Domain Structure for InterPro Entry

P16284

UniProtKB/Swiss-Prot:

PECA1_HUMAN :
  • P16284
Domain:
  • The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PECAM1: view

Function for PECAM1 Gene

Molecular function for PECAM1 Gene

GENATLAS Biochemistry: platelet endothelial cell adhesion molecule 1,immunoglobulin superfamily,expressed on circulating platelets,monocytes,neutrophils,subsets of T cells,also a major constituent of the endothelial intercellular cell junction
UniProtKB/Swiss-Prot Function: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Gene Ontology (GO) - Molecular Function for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10704309
genes like me logo Genes that share ontologies with PECAM1: view
genes like me logo Genes that share phenotypes with PECAM1: view

Animal Models for PECAM1 Gene

MGI Knock Outs for PECAM1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PECAM1 Gene

Localization for PECAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PECAM1 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Gene Ontology (GO) - Cellular Components for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane --
GO:0009986 cell surface --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PECAM1: view

No data available for Subcellular locations from COMPARTMENTS for PECAM1 Gene

Pathways for PECAM1 Gene

genes like me logo Genes that share pathways with PECAM1: view

Pathways by source for PECAM1 Gene

Gene Ontology (GO) - Biological Process for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002687 positive regulation of leukocyte migration --
GO:0006909 phagocytosis IDA 12110892
GO:0006928 movement of cell or subcellular component --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with PECAM1: view

Compounds for PECAM1 Gene

(60) Novoseek inferred chemical compound relationships for PECAM1 Gene

Compound -log(P) Hits PubMed IDs
vegf 70.3 62
matrigel 58.4 5
tyrosine 48.9 95
laccer 35.2 10
slex 31.2 1
genes like me logo Genes that share compounds with PECAM1: view

Transcripts for PECAM1 Gene

Unigene Clusters for PECAM1 Gene

Platelet/endothelial cell adhesion molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PECAM1 Gene

No ASD Table

Relevant External Links for PECAM1 Gene

GeneLoc Exon Structure for
PECAM1
ECgene alternative splicing isoforms for
PECAM1

Expression for PECAM1 Gene

mRNA expression in normal human tissues for PECAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PECAM1 Gene

SOURCE GeneReport for Unigene cluster for PECAM1 Gene Hs.376675

mRNA Expression by UniProt/SwissProt for PECAM1 Gene

P16284-PECA1_HUMAN
Tissue specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).
genes like me logo Genes that share expressions with PECAM1: view

No data available for mRNA differential expression in normal tissues for PECAM1 Gene

Orthologs for PECAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PECAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PECAM1 35
  • 99.19 (n)
  • 99.32 (a)
cow
(Bos Taurus)
Mammalia PECAM1 35
  • 78.61 (n)
  • 70.69 (a)
dog
(Canis familiaris)
Mammalia PECAM1 35
  • 81.28 (n)
  • 72.46 (a)
mouse
(Mus musculus)
Mammalia Pecam1 35
  • 73.48 (n)
  • 64.32 (a)
Pecam1 16
rat
(Rattus norvegicus)
Mammalia Pecam1 35
  • 73.88 (n)
  • 66.11 (a)
chicken
(Gallus gallus)
Aves PECAM1 35
  • 51.12 (n)
  • 35.66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493686 35
  • 45.85 (n)
  • 33.89 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-237i9.8 35
  • 44.44 (n)
  • 30.45 (a)
Species with no ortholog for PECAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PECAM1 Gene

ENSEMBL:
Gene Tree for PECAM1 (if available)
TreeFam:
Gene Tree for PECAM1 (if available)

Paralogs for PECAM1 Gene

Pseudogenes.org Pseudogenes for PECAM1 Gene

genes like me logo Genes that share paralogs with PECAM1: view

No data available for Paralogs for PECAM1 Gene

Variants for PECAM1 Gene

Sequence variations from dbSNP and Humsavar for PECAM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2812 -- 64,323,758(-) CAGAT(A/G)ATCCC utr-variant-3-prime
rs6808 -- 64,323,215(-) GACAC(C/G)GTTCA utr-variant-3-prime
rs6809 -- 64,323,350(-) TTTGG(C/G)TAGTC utr-variant-3-prime
rs10785 -- 64,319,485(+) CTTGG(A/G)TCAGG utr-variant-3-prime
rs12953 -, - 64,356,203(-) GGCTA(A/G/T)CAAGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PECAM1 Gene

Variant ID Type Subtype PubMed ID
nsv524852 CNV Gain 19592680

Relevant External Links for PECAM1 Gene

HapMap Linkage Disequilibrium report
PECAM1
Human Gene Mutation Database (HGMD)
PECAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PECAM1 Gene

Disorders for PECAM1 Gene

(80) Novoseek inferred disease relationships for PECAM1 Gene

Disease -log(P) Hits PubMed IDs
angiosarcoma 52.6 1
neovascularization 52.4 5
melanoma experimental 47.9 1
tumors 44.7 92
inflammation 43.3 19

Relevant External Links for PECAM1

Genetic Association Database (GAD)
PECAM1
Human Genome Epidemiology (HuGE) Navigator
PECAM1
genes like me logo Genes that share disorders with PECAM1: view

No data available for UniProtKB/Swiss-Prot for PECAM1 Gene

Publications for PECAM1 Gene

  1. Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium. (PMID: 8226797) Tang D.G. … Honn K.V. (J. Biol. Chem. 1993) 3 4 23
  2. Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity. (PMID: 9298995) Famiglietti J. … Albelda S.M. (J. Cell Biol. 1997) 3 4 23
  3. The homozygous combination of Leu125Val and Ser563Asn polymorphisms in the PECAM1 (CD31) gene is associated with early severe coronary heart disease. (PMID: 10571959) Wenzel K. … Felix S.B. (Hum. Mutat. 1999) 3 23 48
  4. Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese. (PMID: 11795274) Sasaoka T. … Izumi T. (Ann. N. Y. Acad. Sci. 2001) 3 23 48
  5. Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation. (PMID: 12393699) Rocha V. … Gluckman E. (Blood 2002) 3 23 48

Products for PECAM1 Gene

Sources for PECAM1 Gene

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