Aliases for CD244 Gene
External Ids for CD244 Gene
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
GeneCards Summary for CD244 Gene
CD244 (CD244 Molecule, Natural Killer Cell Receptor 2B4) is a Protein Coding gene. Diseases associated with CD244 include rheumatoid arthritis. Among its related pathways are Hemostasis and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include receptor activity.
UniProtKB/Swiss-Prot for CD244 Gene
Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.