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Aliases for DNAJB11 Gene

Aliases for DNAJB11 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B11 2 3 5
  • Endoplasmic Reticulum DNA J Domain-Containing Protein 3 3 4
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 11 2 3
  • ER-Associated Hsp40 Co-Chaperone 3 4
  • PWP1-Interacting Protein 4 3 4
  • APOBEC1-Binding Protein 2 3 4
  • ER-Resident Protein ERdj3 3 4
  • ABBP-2 3 4
  • ERdj3 3 4
  • ERj3p 3 4
  • ERj3 3 4
  • EDJ 3 4
  • ER-Associated DNAJ Protein 3 3
  • DnaJ Protein Homolog 9 4
  • Human DnaJ Protein 9 4
  • ER-Associated DNAJ 4
  • DnaJ Protein 9 3
  • PRO1080 3
  • UNQ537 3
  • ABBP2 3
  • HDj-9 4
  • Dj-9 3
  • HDJ9 4
  • HEDJ 4
  • DJ9 3

External Ids for DNAJB11 Gene

Previous GeneCards Identifiers for DNAJB11 Gene

  • GC03P183060
  • GC03P187545
  • GC03P187687
  • GC03P187606
  • GC03P187609
  • GC03P187767
  • GC03P186285
  • GC03P183697

Summaries for DNAJB11 Gene

Entrez Gene Summary for DNAJB11 Gene

  • This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

GeneCards Summary for DNAJB11 Gene

DNAJB11 (DnaJ Heat Shock Protein Family (Hsp40) Member B11) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJA4.

UniProtKB/Swiss-Prot for DNAJB11 Gene

  • Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.

Gene Wiki entry for DNAJB11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB11 Gene

Genomics for DNAJB11 Gene

Regulatory Elements for DNAJB11 Gene

Enhancers for DNAJB11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJB11 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJB11 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJB11 Gene

Chromosome:
3
Start:
186,567,403 bp from pter
End:
186,597,203 bp from pter
Size:
29,801 bases
Orientation:
Plus strand

Genomic View for DNAJB11 Gene

Genes around DNAJB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB11 Gene

Proteins for DNAJB11 Gene

  • Protein details for DNAJB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS4-DJB11_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 11
    Protein Accession:
    Q9UBS4
    Secondary Accessions:
    • Q542Y5
    • Q542Y9
    • Q6IAQ8
    • Q96JC6

    Protein attributes for DNAJB11 Gene

    Size:
    358 amino acids
    Molecular mass:
    40514 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds to denatured substrates in an ATP-independent manner. Interacts via the J domain with HSPA5 in an ATP-dependent manner.

neXtProt entry for DNAJB11 Gene

Proteomics data for DNAJB11 Gene at MOPED

Post-translational modifications for DNAJB11 Gene

  • Contains high-mannose Endo H-sensitive carbohydrates.
  • Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known.
  • Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR; however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven.
  • Ubiquitination at Lys 28
  • Glycosylation at Asn 261
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJB11 Gene

No data available for DME Specific Peptides for DNAJB11 Gene

Domains & Families for DNAJB11 Gene

Gene Families for DNAJB11 Gene

Protein Domains for DNAJB11 Gene

Suggested Antigen Peptide Sequences for DNAJB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBS4

UniProtKB/Swiss-Prot:

DJB11_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB11: view

Function for DNAJB11 Gene

Molecular function for DNAJB11 Gene

UniProtKB/Swiss-Prot Function:
Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress-inducing agents such as thapsigargin and tunicamycin.
genes like me logo Genes that share phenotypes with DNAJB11: view

Animal Model Products

CRISPR Products

miRNA for DNAJB11 Gene

miRTarBase miRNAs that target DNAJB11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB11 Gene

Localization for DNAJB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB11 Gene

Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB11 Gene COMPARTMENTS Subcellular localization image for DNAJB11 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with DNAJB11: view

Pathways & Interactions for DNAJB11 Gene

genes like me logo Genes that share pathways with DNAJB11: view

Pathways by source for DNAJB11 Gene

Gene Ontology (GO) - Biological Process for DNAJB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with DNAJB11: view

No data available for SIGNOR curated interactions for DNAJB11 Gene

Drugs & Compounds for DNAJB11 Gene

No Compound Related Data Available

Transcripts for DNAJB11 Gene

Unigene Clusters for DNAJB11 Gene

DnaJ (Hsp40) homolog, subfamily B, member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB11 Gene

No ASD Table

Relevant External Links for DNAJB11 Gene

GeneLoc Exon Structure for
DNAJB11
ECgene alternative splicing isoforms for
DNAJB11

Expression for DNAJB11 Gene

mRNA expression in normal human tissues for DNAJB11 Gene

Protein differential expression in normal tissues from HIPED for DNAJB11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB11 Gene



SOURCE GeneReport for Unigene cluster for DNAJB11 Gene Hs.317192

mRNA Expression by UniProt/SwissProt for DNAJB11 Gene

Q9UBS4-DJB11_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with DNAJB11: view

Protein tissue co-expression partners for DNAJB11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJB11 Gene

Orthologs for DNAJB11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJB11 35
  • 93.3 (n)
  • 98.32 (a)
DNAJB11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB11 35
  • 91.9 (n)
  • 96.37 (a)
DNAJB11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb11 35
  • 90.78 (n)
  • 98.32 (a)
Dnajb11 16
Dnajb11 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJB11 35
  • 99.81 (n)
  • 99.72 (a)
DNAJB11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb11 35
  • 90.32 (n)
  • 98.32 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJB11 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB11 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB11 35
  • 78.96 (n)
  • 91.9 (a)
DNAJB11 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB11 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb11 35
  • 76.34 (n)
  • 87.61 (a)
MGC75796 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5180 35
zebrafish
(Danio rerio)
Actinopterygii dnajb11 35
  • 71.67 (n)
  • 84.42 (a)
dnajb11 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4164 37
  • 63 (a)
CG4164 35
  • 59.98 (n)
  • 64.24 (a)
CG4164 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008327 35
  • 61.59 (n)
  • 64.66 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-20 35
  • 59.07 (n)
  • 58.88 (a)
dnj-20 36
  • 57 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATERDJ3B 35
  • 54.41 (n)
  • 49.54 (a)
rice
(Oryza sativa)
Liliopsida Os05g0156500 35
  • 54.17 (n)
  • 51.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4254 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9772 36
  • 52 (a)
OneToOne
Species with no ortholog for DNAJB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB11 Gene

ENSEMBL:
Gene Tree for DNAJB11 (if available)
TreeFam:
Gene Tree for DNAJB11 (if available)

Paralogs for DNAJB11 Gene

Paralogs for DNAJB11 Gene

(7) SIMAP similar genes for DNAJB11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DNAJB11: view

Variants for DNAJB11 Gene

Sequence variations from dbSNP and Humsavar for DNAJB11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs8147 - 186,583,914(+) TGACA(A/G)TCTCA reference, missense
rs1052842 -- 186,585,706(+) GAAAC(A/C)CAATA utr-variant-3-prime
rs2280388 -- 186,576,159(-) TGATA(C/T)GGTTG intron-variant
rs2280389 -- 186,576,101(-) GTGAA(A/G)ATAGA intron-variant
rs2280390 -- 186,576,031(-) TCATC(A/C)AAAGT intron-variant

Variation tolerance for DNAJB11 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.43; 85.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DNAJB11 Gene

Disorders for DNAJB11 Gene

Relevant External Links for DNAJB11

Genetic Association Database (GAD)
DNAJB11
Human Genome Epidemiology (HuGE) Navigator
DNAJB11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB11

No disorders were found for DNAJB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB11 Gene

Publications for DNAJB11 Gene

  1. HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. (PMID: 10827079) Yu M. … Haslam D.B. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. (PMID: 15544163) Nakanishi K. … Sato N. (Cell Stress Chaperones 2004) 3 23
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  4. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. (PMID: 25361606) Genereux J.C. … Wiseman R.L. (EMBO J. 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for DNAJB11 Gene

Sources for DNAJB11 Gene

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