Aliases for UIMC1 Gene
External Ids for UIMC1 Gene
Previous GeneCards Identifiers for UIMC1 Gene
GeneCards Summary for UIMC1 Gene
UIMC1 (Ubiquitin Interaction Motif Containing 1) is a Protein Coding gene. Diseases associated with UIMC1 include familial breast cancer. Among its related pathways are Cell Cycle, Mitotic and DNA Damage. GO annotations related to this gene include histone binding and K63-linked polyubiquitin binding.
UniProtKB/Swiss-Prot for UIMC1 Gene
Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than Lys-63-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.