Aliases for PADI3 Gene
External Ids for PADI3 Gene
Previous GeneCards Identifiers for PADI3 Gene
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PADI3 Gene
PADI3 (Peptidyl Arginine Deiminase, Type III) is a Protein Coding gene. Among its related pathways are Chromatin organization and protein citrullination. GO annotations related to this gene include calcium ion binding and protein-arginine deiminase activity. An important paralog of this gene is PADI1.
UniProtKB/Swiss-Prot for PADI3 Gene
Catalyzes the deimination of arginine residues of proteins