Aliases for NLK Gene
Aliases for NLK Gene
External Ids for NLK Gene
- HGNC: 29858
- Entrez Gene: 51701
- Ensembl: ENSG00000087095
- OMIM: 609476
- UniProtKB: Q9UBE8
Previous GeneCards Identifiers for NLK Gene
- GC17P026225
- GC17P028269
- GC17P026515
- GC17P026514
- GC17P023393
- GC17P026369
- GC17P022577
Summaries for NLK Gene
GeneCards Summary for NLK Gene
NLK (Nemo Like Kinase) is a Protein Coding gene. Among its related pathways are ERK Signaling and Signaling by Wnt. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.
UniProtKB/Swiss-Prot for NLK Gene
-
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613).
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLK Gene
Genomics for NLK Gene
Regulatory Elements for NLK Gene
Enhancers for NLK Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around NLK on UCSC Golden Path with GeneCards custom track
Promoters for NLK Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around NLK on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NLK gene promoter:
Regulatory Element Products
Genomic Location for NLK Gene
- Chromosome:
- 17
- Start:
- 28,041,737 bp from pter
- End:
- 28,205,140 bp from pter
- Size:
- 163,404 bases
- Orientation:
- Plus strand
Genomic View for NLK Gene
Genes around NLK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by Ensembl
- 17q11.2 by Entrez Gene
- 17q11.2 by HGNC
NLK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NLK Gene
Proteins for NLK Gene
-
Protein details for NLK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBE8-NLK_HUMAN
- Recommended name:
- Serine/threonine-protein kinase NLK
- Protein Accession:
- Q9UBE8
- B2RCX1
- Q2PNI9
- Q6P2A3
Protein attributes for NLK Gene
- Size:
- 527 amino acids
- Molecular mass:
- 58283 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer. Homodimerization is required for intermolecular autophosphorylation, kinase activation and nuclear localization (By similarity). May interact with components of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes (By similarity). Interacts with LEF1, MEF2A, MYBL1 and MYBL2 (By similarity). Interacts with the upstream activating kinases HIPK2 and MAP3K7/TAK1. Interaction with MAP3K7/TAK1 seems to be indirect, and may be mediated by other proteins such as STAT3, TAB1 and TAB2. Interacts with and phosphorylates a number of transcription factors including FOXO1, FOXO3, FOXO4, MYB, NOTCH1 and TCF7L2/TCF4. Interacts with DAPK3/ZIPK, and this interaction may disrupt interaction with transcription factors such as TCF7L2/TCF4. Forms a transcriptional repressor complex with CHD7, PPARG and SETDB1. Interacts with RNF138/NARF. Interacts with ATF5; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (PubMed:25512613).
- SequenceCaution:
-
- Sequence=AAD56013.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF04857.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABC40748.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37718.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for NLK Gene
Selected DME Specific Peptides for NLK Gene
Post-translational modifications for NLK Gene
- Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NLK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NLK
- Novus Biologicals Antibodies for NLK
- Invitrogen Antibodies for NLK
- antibodies-online Antibodies for NLK: See all 106
- GeneTex NLK antibody for NLK
-
Santa Cruz Biotechnology (SCBT) Antibodies for NLK
Protein Products
- EMD Millipore Purified and/or Recombinant NLK Protein
-
OriGene Purified Proteins for NLK
- Search Origene for MassSpec and Protein Over-expression Lysates for NLK
- Origene Custom Protein Services for NLK
- Sino Biological Cell Lysates for NLK
- Sino Biological Recombinant Proteins for NLK
- antibodies-online Proteins for NLK: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NLK
Assay Products
- antibodies-online Kits for NLK: See all 5
Domains & Families for NLK Gene
Gene Families for NLK Gene
- IUPHAR :
Protein Domains for NLK Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NLK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBE8UniProtKB/Swiss-Prot:
NLK_HUMAN :- Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation.
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for NLK Gene
Molecular function for NLK Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by dimerization and subsequent intermolecular autophosphorylation on Thr-298 (By similarity). Activated by the non-canonical Wnt signaling pathway, in which WNT5A treatment leads to activation of MAP3K7/TAK1 and HIPK2, which subsequently phosphorylates and activates this protein. Other cytokines such as IL6 may also activate this regulatory circuit.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613).
Enzyme Numbers (IUBMB) for NLK Gene
- EC 2.7.11.24 63 4
- EC 2.7.11 63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IEA,ISS | -- |
| GO:0008134 | transcription factor binding | IPI | 16714285 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 16714285 |
Phenotypes for NLK Gene
- MGI mutant phenotypes for NLK:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NLK:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability after Maraba virus infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased Hepatitis C virus replication
- Decreased viability of wild-type and TP53 knockout cells
- Increased cell viability after pRB stimulation
- Decreased cell proliferation
- Decreased melanin production
- Apoptosis resistance
- Condensed cis-Golgi
Animal Models for NLK Gene
- MGI Knock Outs for NLK:
-
- Nlk tm1Tbo
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for NLK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
- Search ViGene Biosciences for NLK
CRISPR Products
-
OriGene CRISPR knockouts for NLK
-
Santa Cruz Biotechnology (SCBT) CRISPR for NLK
- GenScript: Design CRISPR guide RNA sequences for NLK
miRNA for NLK Gene
- miRTarBase miRNAs that target NLK
-
- hsa-mir-181c-5p (MIRT000233)
- hsa-mir-181b-5p (MIRT000238)
- hsa-mir-181a-5p (MIRT000243)
- hsa-mir-215-5p (MIRT024563)
- hsa-mir-192-5p (MIRT026531)
- hsa-mir-92b-3p (MIRT035518)
- hsa-mir-23a-3p (MIRT050387)
- hsa-mir-199b-5p (MIRT054629)
- hsa-mir-101-3p (MIRT438193)
- hsa-mir-3682-5p (MIRT472135)
- hsa-mir-513a-5p (MIRT472136)
- hsa-mir-545-3p (MIRT472137)
- hsa-mir-3120-3p (MIRT472138)
- hsa-mir-5692a (MIRT472139)
- hsa-mir-27a-3p (MIRT472140)
- hsa-mir-27b-3p (MIRT472141)
- hsa-mir-190a-3p (MIRT522254)
- hsa-mir-5011-5p (MIRT522255)
- hsa-mir-1277-5p (MIRT522256)
- hsa-mir-3121-3p (MIRT522257)
- hsa-mir-548c-3p (MIRT522258)
- hsa-mir-574-5p (MIRT627953)
- hsa-mir-6818-5p (MIRT627954)
- hsa-mir-664b-3p (MIRT627955)
- hsa-mir-579-3p (MIRT627956)
- hsa-mir-5696 (MIRT627957)
- hsa-mir-6867-5p (MIRT627958)
- hsa-mir-1304-3p (MIRT627959)
- hsa-mir-153-5p (MIRT627960)
- hsa-mir-1250-3p (MIRT627961)
- hsa-mir-1285-5p (MIRT627962)
- hsa-mir-216a-5p (MIRT627963)
- hsa-mir-6802-5p (MIRT701392)
- hsa-mir-6800-5p (MIRT701393)
- hsa-mir-6822-3p (MIRT701394)
- hsa-mir-3622b-5p (MIRT701395)
- hsa-mir-6770-5p (MIRT701396)
- hsa-mir-1253 (MIRT701397)
- hsa-mir-6741-3p (MIRT701398)
- hsa-mir-135a-3p (MIRT701399)
- hsa-mir-6865-5p (MIRT701400)
- hsa-mir-6815-5p (MIRT701401)
- hsa-mir-3158-3p (MIRT701402)
- hsa-mir-4446-3p (MIRT701403)
- hsa-mir-5088-5p (MIRT701404)
- hsa-mir-944 (MIRT701405)
miRNA Products
- Search ViGene Biosciences for NLK
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for NLK
- Browse OriGene Inhibitory RNA Products For NLK
-
ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
Clone Products
- OriGene clones in human for NLK
- OriGene ORF clones in human,mouse,rat for NLK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NLK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for NLK
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for NLK gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NLK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLK Gene
Localization for NLK Gene
Subcellular locations from UniProtKB/Swiss-Prot for NLK Gene
- Nucleus. Cytoplasm. Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for NLK Gene
More details on SuperPathways for NLK| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK signaling pathway | ||
| 2 | Wnt signaling pathway (KEGG) | ||
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.42
|
|
| 4 | Adherens junction | ||
| 5 | FoxO signaling pathway |
Pathways by source for NLK Gene
1 Sino Biological pathway for NLK Gene
1 GeneTex pathway for NLK Gene
7 BioSystems pathways for NLK Gene
4 Reactome pathways for NLK Gene
4 KEGG pathways for NLK Gene
2 R&D Systems pathways for NLK Gene
1 Qiagen pathway for NLK Gene
Interacting Proteins for NLK Gene
Selected Interacting proteins:
Q9UBE8-NLK_HUMAN
ENSP00000384625
for NLK Gene via
MINT
STRING
UniProtKB
I2D
SIGNOR curated interactions for NLK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA,ISS | -- |
| GO:0006468 | protein phosphorylation | IEA,ISS | -- |
| GO:0018107 | peptidyl-threonine phosphorylation | IEA,ISS | -- |
| GO:0030178 | negative regulation of Wnt signaling pathway | IEA,ISS | -- |
| GO:0046777 | protein autophosphorylation | IEA | -- |
Drugs & Compounds for NLK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Nutra | 0 |
Transcripts for NLK Gene
mRNA/cDNA for NLK Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (185) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NLK
-
Santa Cruz Biotechnology (SCBT) CRISPR for NLK
- GenScript: Design CRISPR guide RNA sequences for NLK
miRNA Products
- Search ViGene Biosciences for NLK
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for NLK
- Browse OriGene Inhibitory RNA Products For NLK
-
ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
Clone Products
- OriGene clones in human for NLK
- OriGene ORF clones in human,mouse,rat for NLK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NLK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for NLK
Flow Cytometry Products
Expression for NLK Gene
mRNA differential expression in normal tissues according to GTEx for NLK Gene
This gene is overexpressed in Brain - Cortex (x5.0) and Brain - Frontal Cortex (BA9) (x5.0).
This gene is overexpressed in Brain (49.1) and Retina (19.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLK Gene
SOURCE GeneReport for Unigene cluster for NLK Gene Hs.208759
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for NLK
-
OriGene qPCR primer pairs for NLK
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NLK Gene
Orthologs for NLK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | NLK 35 |
|
||
| NLK 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | NLK 35 |
|
||
| NLK 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Nlk 35 |
|
||
| Nlk 16 |
|
||||
| Nlk 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | NLK 35 |
|
||
| NLK 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Nlk 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NLK 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NLK 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NLK 35 |
|
||
| NLK 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | NLK 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nlk 35 |
|
||
| Str.7425 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | xnlk 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nlk2 35 |
|
||
| nlk2 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | nmo 37 |
|
|
|
| nmo 35 |
|
||||
| nmo 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005898 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | lit-1 35 |
|
||
| lit-1 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3781 36 |
|
OneToOne |
- Species with no ortholog for NLK:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NLK Gene
(47) SIMAP similar genes for NLK Gene using alignment to 3 proteins:
Variants for NLK Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11871287 | - | 28,122,674(+) | TCTGG(C/T)CTCTT | nc-transcript-variant, reference, missense | |
| VAR_042273 | A glioblastoma multiforme sample | ||||
| rs1242299 | -- | 28,189,182(+) | cccaa(A/G)catat | intron-variant | |
| rs2125844 | -- | 28,114,689(+) | tttca(C/T)gttta | intron-variant | |
| rs2125845 | -- | 28,158,156(-) | gctta(A/G/T)gtgtg | intron-variant |
Residual Variation Intolerance Score:
23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.59;
12.76% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NLK Gene
Disorders for NLK Gene
Relevant External Links for NLK
No disorders were found for NLK Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLK Gene
Publications for NLK Gene
- Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. (PMID: 10863097) Kehrer-Sawatzki H. … Krone W. (Gene 2000) 2 3 4 23 67
- Human SMAD4 is phosphorylated at Thr9 and Ser138 by interacting with NLK. (PMID: 19690946) Shi Y. … Huo K. (Mol. Cell. Biochem. 2010) 3 23
- Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. (PMID: 20061393) Kim S. … Chung J. (J. Biol. Chem. 2010) 3 23
- TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. (PMID: 20194509) Li M. … Li L. (J. Biol. Chem. 2010) 3 23
- Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma. (PMID: 20512928) Jung K.H. … Nam S.W. (J. Cell. Biochem. 2010) 3 23
Products for NLK Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NLK
- EMD Millipore Purified and/or Recombinant NLK Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NLK
- Search Origene for MassSpec and Protein Over-expression Lysates for NLK
- Origene Custom Protein Services for NLK
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for NLK
- Browse OriGene Inhibitory RNA Products For NLK
- OriGene qPCR primer pairs for NLK
- OriGene qPCR primer pairs and template standards for NLK
- OriGene CRISPR knockouts for NLK
- OriGene clones in human for NLK
- OriGene ORF clones in human,mouse,rat for NLK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for NLK
- GenScript Custom Assay Services for NLK
- GenScript Custom overexpressing Cell Line Services for NLK
- GenScript: Design CRISPR guide RNA sequences for NLK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NLK
- Sino Biological Human cDNA Clone for NLK
- Sino Biological Cell Lysates for NLK
- Sino Biological Recombinant Proteins for NLK
- 4000+ Proteins
- Search Sino Biological for antibodies, proteins & pathways
- Protein Production Services
- Transfection Reagents
- Protein A/G/L resins
- Isotyping reagents
- Novus Biologicals Antibodies for NLK
- Novus Biologicals proteins and lysates for NLK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for NLK
- antibodies-online Antibodies for NLK: See all 106
- antibodies-online Kits for NLK: See all 5
- antibodies-online Proteins for NLK: See all 9
- Search antibodies-online for peptides
- GeneTex NLK antibody for NLK
- Search GeneTex for Proteins for NLK
- ViGene Biosciences adenoviral particle packaged cDNA for NLK gene
- ViGene Biosciences lentiviral particle packaged cDNA for NLK gene
- ViGene Biosciences lentiviral particle packaged cDNA for NLK gene
- ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
- ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
- ViGene Biosciences ready-to-package AAV shRNAs for NLK gene
- Search ViGene Biosciences for NLK
- Search ViGene Biosciences for NLK
- Santa Cruz Biotechnology (SCBT) Antibodies for NLK
- Search Santa Cruz Biotechnology (SCBT) for NLK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NLK
Sources for NLK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon