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Aliases for PDPK1 Gene

Aliases for PDPK1 Gene

  • 3-Phosphoinositide Dependent Protein Kinase 1 2 3
  • PDK1 3 4 6
  • EC 2.7.11.1 4 64
  • 3-Phosphoinositide-Dependent Protein Kinase 2 Pseudogene 3
  • 3-Phosphoinositide Dependent Protein Kinase-1 3
  • 3-Phosphoinositide-Dependent Protein Kinase 1 3
  • PkB Kinase Like Gene 1 3
  • PkB Kinase 2
  • EC 2.7.11 64
  • PRO0461 3
  • PDPK2P 3
  • PDPK2 3
  • HPDK1 4

External Ids for PDPK1 Gene

Summaries for PDPK1 Gene

GeneCards Summary for PDPK1 Gene

PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein serine/threonine kinase activity and insulin receptor binding.

UniProtKB/Swiss-Prot for PDPK1 Gene

  • Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.

Tocris Summary for PDPK1 Gene

  • Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main effector of PDK1.

Gene Wiki entry for PDPK1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDPK1 Gene

Genomics for PDPK1 Gene

Genomic Location for PDPK1 Gene

Start:
2,537,964 bp from pter
End:
2,603,190 bp from pter
Size:
65,227 bases
Orientation:
Plus strand

Genomic View for PDPK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDPK1 Gene

Regulatory Elements for PDPK1 Gene

Proteins for PDPK1 Gene

  • Protein details for PDPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15530-PDPK1_HUMAN
    Recommended name:
    3-phosphoinositide-dependent protein kinase 1
    Protein Accession:
    O15530
    Secondary Accessions:
    • H0Y4Z0
    • Q59EH6
    • Q6FI20
    • Q8IV52
    • Q9BRD5

    Protein attributes for PDPK1 Gene

    Size:
    556 amino acids
    Molecular mass:
    63152 Da
    Quaternary structure:
    • Homodimer in its autoinhibited state. Active as monomer. Interacts with NPRL2, PPARG, PAK1, PTK2B, GRB14, PKN1 (via C-terminus), STRAP and IKKB. The Tyr-9 phosphorylated form interacts with SRC, RASA1 and CRK (via their SH2 domains). Interacts with SGK3 in a phosphorylation-dependent manner. The tyrosine-phosphorylated form interacts with PTPN6. The Ser-241 phosphorylated form interacts with YWHAH and YWHAQ. Binds INSR in response to insulin. Interacts (via PH domain) with SMAD3, SMAD4 and SMAD7. Interacts with PKN2; the interaction stimulates PDPK1 autophosphorylation, its PI(3,4,5)P3-dependent kinase activity toward Ser-473 of AKT1 but also activates its kinase activity toward PRKCD and PRKCZ.
    SequenceCaution:
    • Sequence=BAD93072.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDPK1 Gene

    Alternative splice isoforms for PDPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDPK1 Gene

Proteomics data for PDPK1 Gene at MOPED

Post-translational modifications for PDPK1 Gene

  • Autophosphorylated; autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2.
  • Monoubiquitinated in the kinase domain, deubiquitinated by USP4
  • Phosphorylation on Ser-241 in the activation loop is required for full activity. PDPK1 itself can autophosphorylate Ser-241, leading to its own activation. Autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2 (By similarity). Tyr-9 phosphorylation is critical for stabilization of both PDPK1 and the PDPK1/SRC complex via HSP90-mediated protection of PDPK1 degradation. Angiotensin II stimulates the tyrosine phosphorylation of PDPK1 in vascular smooth muscle in a calcium- and SRC-dependent manner. Phosphorylated on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin. Palmitate negatively regulates autophosphorylation at Ser-241 and palmitate-induced phosphorylation at Ser-529 and Ser-501 by PKC/PRKCQ negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylation at Thr-354 by MELK partially inhibits kinase activity, the inhibition is cooperatively enhanced by phosphorylation at Ser-394 and Ser-398 by MAP3K5.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys304, Lys323, and Lys441

Domains for PDPK1 Gene

UniProtKB/Swiss-Prot:

PDPK1_HUMAN
Domain:
  • The PH domain plays a pivotal role in the localization and nuclear import of PDPK1 and is also essential for its homodimerization:
    • O15530
  • Contains 1 PH domain.:
    • O15530
  • Contains 1 protein kinase domain.:
    • O15530
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.:
    • O15530
genes like me logo Genes that share domains with PDPK1: view

Function for PDPK1 Gene

Molecular function for PDPK1 Gene

GENATLAS Biochemistry: 3-phosphoinositide (PtdIns(3,4,5)P3,PtdIns(3,4)P2)-dependent kinase 1,ubiquitously expressed,homolog to Drosophila DSTPK61 kinase,likely mediating the activation of protein-kinase B AKT/PKB by insulin or growth factors
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Homodimerization regulates its activity by maintaining the kinase in an autoinhibitory conformation. NPRL2 down-regulates its activity by interfering with tyrosine phosphorylation at the Tyr-9, Tyr-373 and Tyr-376 residues. The 14-3-3 protein YWHAQ acts as a negative regulator by association with the residues surrounding the Ser-241 residue. STRAP positively regulates its activity by enhancing its autophosphorylation and by stimulating its dissociation from YWHAQ. SMAD2, SMAD3, SMAD4 and SMAD7 also positively regulate its activity by stimulating its dissociation from YWHAQ. Activated by phosphorylation on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.
UniProtKB/Swiss-Prot Induction: Stimulated by insulin, and the oxidants hydrogen peroxide and peroxovanadate

Enzyme Numbers (IUBMB) for PDPK1 Gene

Gene Ontology (GO) - Molecular Function for PDPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004676 3-phosphoinositide-dependent protein kinase activity IDA 9368760
GO:0004713 protein tyrosine kinase activity --
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with PDPK1: view
genes like me logo Genes that share phenotypes with PDPK1: view

Animal Models for PDPK1 Gene

MGI Knock Outs for PDPK1:

No data available for Transcription Factor Targeting and HOMER Transcription for PDPK1 Gene

Localization for PDPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDPK1 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDPK1 Gene COMPARTMENTS Subcellular localization image for PDPK1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PDPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with PDPK1: view

Pathways for PDPK1 Gene

SuperPathways for PDPK1 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 IL-9 Signaling Pathways
4 Insulin receptor signalling cascade
5 IL-2 Pathway
genes like me logo Genes that share pathways with PDPK1: view

Pathways by source for PDPK1 Gene

Gene Ontology (GO) - Biological Process for PDPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0003323 type B pancreatic cell development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PDPK1: view

Compounds for PDPK1 Gene

(4) ApexBio Compounds for PDPK1 Gene

Compound Action Cas Number
BX-912 BX-912 is a PDK-1 inhibitor. [702674-56-4]
NVP-BAG956 potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor [853910-02-8]
OSU-03012 (AR-12) OSU 03012 is a potent inhibitor of PDK1 (IC50 = 5 uM). [742112-33-0]
PDK1 inhibitor An potent and selective inhibitor of PDK1 with potential as anticancer agent. [1001409-50-2]

(4) Tocris Compounds for PDPK1 Gene

Compound Action Cas Number
BAG 956 Dual PI 3-kinase and PDK1 inhibitor [853910-02-8]
BX 795 PDK1 inhibitor [702675-74-9]
GSK 2334470 Highly potent, selective PDK1 inhibitor [1227911-45-6]
PS 48 PDK1 activator [1180676-32-7]

(3) HMDB Compounds for PDPK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Celecoxib
  • Celebrex
169590-42-5

(41) Novoseek inferred chemical compound relationships for PDPK1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 79.2 33
phosphatidylinositol-3,4,5-trisphosphate 78.4 9
phosphoinositide 78 52
threonine 71.1 19
7-hydroxystaurosporine 70.8 4
genes like me logo Genes that share compounds with PDPK1: view

Transcripts for PDPK1 Gene

Unigene Clusters for PDPK1 Gene

3-phosphoinositide dependent protein kinase-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDPK1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - - - -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7: - -
SP8: - - -

Relevant External Links for PDPK1 Gene

GeneLoc Exon Structure for
PDPK1
ECgene alternative splicing isoforms for
PDPK1

Expression for PDPK1 Gene

mRNA expression in normal human tissues for PDPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDPK1 Gene

SOURCE GeneReport for Unigene cluster for PDPK1 Gene Hs.459691

mRNA Expression by UniProt/SwissProt for PDPK1 Gene

O15530-PDPK1_HUMAN
Tissue specificity: Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast.
genes like me logo Genes that share expressions with PDPK1: view

Orthologs for PDPK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDPK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDPK1 36
  • 97.87 (n)
  • 97.07 (a)
PDPK1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDPK1 36
  • 88.97 (n)
  • 96.03 (a)
PDPK1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDPK1 36
  • 87.8 (n)
  • 95.08 (a)
PDPK1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdpk1 36
  • 88.37 (n)
  • 95.14 (a)
Pdpk1 16
Pdpk1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDPK1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDPK1 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdpk1 36
  • 88.79 (n)
  • 95.68 (a)
chicken
(Gallus gallus)
Aves PDPK1 36
  • 78.26 (n)
  • 89.86 (a)
PDPK1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDPK1 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15849 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pdpk1 36
  • 75.08 (n)
  • 86.17 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8413 36
zebrafish
(Danio rerio)
Actinopterygii Dr.14383 36
pdpk1a 37
  • 77 (a)
OneToMany
pdpk1b 36
  • 71.97 (n)
  • 80.87 (a)
pdpk1b 37
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001471 36
  • 52.9 (n)
  • 49.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pdk1 36
  • 53.56 (n)
  • 51.4 (a)
Pdk1 37
  • 29 (a)
OneToOne
Pk61C 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea pdk-1 36
  • 50.85 (n)
  • 43.27 (a)
pdk-1 37
  • 32 (a)
OneToOne
W04B5.5 38
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKH1 37
  • 25 (a)
OneToMany
PKH2 37
  • 18 (a)
OneToMany
PKH3 37
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PDK1 36
  • 51.12 (n)
  • 44.32 (a)
rice
(Oryza sativa)
Liliopsida Os01g0872800 36
  • 49.61 (n)
  • 43.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7527 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
CSA.3862 37
  • 49 (a)
OneToMany
Species with no ortholog for PDPK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDPK1 Gene

ENSEMBL:
Gene Tree for PDPK1 (if available)
TreeFam:
Gene Tree for PDPK1 (if available)

Paralogs for PDPK1 Gene

Pseudogenes.org Pseudogenes for PDPK1 Gene

genes like me logo Genes that share paralogs with PDPK1: view

No data available for Paralogs for PDPK1 Gene

Variants for PDPK1 Gene

Sequence variations from dbSNP and Humsavar for PDPK1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10866 -- 2,597,875(+) GGGAA(C/T)GCAGA utr-variant-3-prime
rs758319 -- 2,557,939(+) AAAAT(C/T)CTTGG reference, synonymous-codon
rs1005273 -- 2,595,964(-) GATGT(C/T)TGATG intron-variant
rs1011200 -- 2,559,888(+) TGAGC(C/T)GGAGG intron-variant
rs2019741 -- 2,584,427(+) agtgg(C/T)gcgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDPK1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2545n71 CNV Loss 21882294
nsv905139 CNV Loss 21882294
dgv2569n71 CNV Loss 21882294
dgv2570n71 CNV Loss 21882294
nsv905149 CNV Loss 21882294
nsv905152 CNV Loss 21882294
nsv905153 CNV Loss 21882294
dgv793e1 CNV Complex 17122850
nsv833122 CNV Loss 17160897
dgv2571n71 CNV Loss 21882294
nsv7275 OTHER Inversion 18451855
esv22359 CNV Gain 19812545
nsv833123 CNV Gain+Loss 17160897
nsv9333 CNV Loss 18304495
esv33514 CNV Gain+Loss 17666407
esv29849 CNV Gain+Loss 19812545
esv2750386 CNV Deletion 23290073
esv8446 CNV Loss 19470904
nsv510672 CNV Loss 20534489

Relevant External Links for PDPK1 Gene

HapMap Linkage Disequilibrium report
PDPK1

Disorders for PDPK1 Gene

(14) Novoseek inferred disease relationships for PDPK1 Gene

Disease -log(P) Hits PubMed IDs
cancer 36.3 18
tumors 24.3 23
glioblastoma 16.6 2
retinoblastoma 15.3 1
prostate cancer 13.2 1

Relevant External Links for PDPK1

Genetic Association Database (GAD)
PDPK1
Human Genome Epidemiology (HuGE) Navigator
PDPK1
genes like me logo Genes that share disorders with PDPK1: view

No data available for UniProtKB/Swiss-Prot for PDPK1 Gene

Publications for PDPK1 Gene

  1. 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. (PMID: 9368760) Alessi D.R. … Bownes M. (Curr. Biol. 1997) 3 4 23
  2. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. (PMID: 9637919) Anderson K.E. … Hawkins P.T. (Curr. Biol. 1998) 3 4 23
  3. Phosphorylation of Ser-241 is essential for the activity of 3- phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. (PMID: 10455013) Casamayor A. … Alessi D.R. (Biochem. J. 1999) 3 4 23
  4. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3- phosphoinositide-dependent protein kinase-1. (PMID: 10480933) Jensen C.J. … Froedin M. (J. Biol. Chem. 1999) 3 4 23
  5. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. (PMID: 9768361) Chou M.M. … Toker A. (Curr. Biol. 1998) 3 4 23

Products for PDPK1 Gene

  • Addgene plasmids for PDPK1

Sources for PDPK1 Gene

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