Aliases for SARAF Gene
External Ids for SARAF Gene
Previous HGNC Symbols for SARAF Gene
GeneCards Summary for SARAF Gene
SARAF (Store-Operated Calcium Entry Associated Regulatory Factor) is a Protein Coding gene.
UniProtKB/Swiss-Prot for SARAF Gene
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.