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Aliases for SARAF Gene

Aliases for SARAF Gene

  • Store-Operated Calcium Entry-Associated Regulatory Factor 2 3 5
  • SOCE-Associated Regulatory Factor 2 3 4
  • Transmembrane Protein 66 2 3 4
  • HBV X-Transactivated Gene 3 Protein 3 4
  • HBV XAg-Transactivated Protein 3 3 4
  • TMEM66 3 4
  • XTP3 3 4
  • Testicular Secretory Protein Li 59 3
  • SARAF Short Isoform 3
  • SARAF Long Isoform 3
  • Protein FOAP-7 4
  • HSPC035 3
  • FOAP-7 3

External Ids for SARAF Gene

Previous HGNC Symbols for SARAF Gene

  • TMEM66

Summaries for SARAF Gene

GeneCards Summary for SARAF Gene

SARAF (Store-Operated Calcium Entry-Associated Regulatory Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SARAF Gene

  • Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

Gene Wiki entry for SARAF Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARAF Gene

Genomics for SARAF Gene

Regulatory Elements for SARAF Gene

Promoters for SARAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SARAF on UCSC Golden Path with GeneCards custom track

Genomic Location for SARAF Gene

Chromosome:
8
Start:
30,063,012 bp from pter
End:
30,083,208 bp from pter
Size:
20,197 bases
Orientation:
Minus strand

Genomic View for SARAF Gene

Genes around SARAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SARAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SARAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARAF Gene

Proteins for SARAF Gene

  • Protein details for SARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY9-SARAF_HUMAN
    Recommended name:
    Store-operated calcium entry-associated regulatory factor
    Protein Accession:
    Q96BY9
    Secondary Accessions:
    • B3KQQ4
    • B7Z9J1
    • D3DSU7
    • H9MHJ8
    • H9MHJ9
    • Q53HE8
    • Q9UNZ3
    • Q9Y683

    Protein attributes for SARAF Gene

    Size:
    339 amino acids
    Molecular mass:
    36975 Da
    Quaternary structure:
    • Interacts with STIM1.
    SequenceCaution:
    • Sequence=AAD44487.1; Type=Frameshift; Positions=28; Evidence={ECO:0000305};

    Alternative splice isoforms for SARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SARAF Gene

Proteomics data for SARAF Gene at MOPED

Post-translational modifications for SARAF Gene

  • Ubiquitination at Lys 43, Lys 65, Lys 79, Lys 86, Lys 106, Lys 109, Lys 145, and Lys 326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SARAF Gene

Domains & Families for SARAF Gene

Protein Domains for SARAF Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96BY9

UniProtKB/Swiss-Prot:

SARAF_HUMAN :
  • The cytoplasmic C-terminal region mediates interaction with STIM1, while the N-terminal lumenal region mediates regulation of SOCE activity.
  • Belongs to the SARAF family.
Domain:
  • The cytoplasmic C-terminal region mediates interaction with STIM1, while the N-terminal lumenal region mediates regulation of SOCE activity.
Family:
  • Belongs to the SARAF family.
genes like me logo Genes that share domains with SARAF: view

No data available for Gene Families for SARAF Gene

Function for SARAF Gene

Molecular function for SARAF Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
genes like me logo Genes that share phenotypes with SARAF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SARAF Gene

Localization for SARAF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARAF Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.
Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SARAF Gene

Pathways & Interactions for SARAF Gene

SuperPathways for SARAF Gene

No Data Available

Interacting Proteins for SARAF Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256255%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000158771%0d%0a9606.ENSP00000300737%0d%0a9606.ENSP00000328216%0d%0a9606.ENSP00000290649%0d%0a
Selected Interacting proteins: Q96BY9-SARAF_HUMAN ENSP00000256255 for SARAF Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for SARAF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SARAF Gene

Drugs & Compounds for SARAF Gene

No Compound Related Data Available

Transcripts for SARAF Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SARAF Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - -
SP10: -
SP11:

ExUns: 9d · 9e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SARAF Gene

GeneLoc Exon Structure for
SARAF
ECgene alternative splicing isoforms for
SARAF

Expression for SARAF Gene

mRNA expression in normal human tissues for SARAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SARAF Gene

This gene is overexpressed in Bone (48.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SARAF Gene



mRNA Expression by UniProt/SwissProt for SARAF Gene

Q96BY9-SARAF_HUMAN
Tissue specificity: Highly expressed in macrophages.
genes like me logo Genes that share expression patterns with SARAF: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SARAF Gene

Orthologs for SARAF Gene

This gene was present in the common ancestor of animals.

Orthologs for SARAF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM66 35
  • 83.82 (n)
  • 82.64 (a)
TMEM66 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM66 35
  • 87.46 (n)
  • 87.14 (a)
TMEM66 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem66 35
  • 82.09 (n)
  • 83.5 (a)
Saraf 16
Tmem66 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM66 35
  • 99.31 (n)
  • 98.82 (a)
TMEM66 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem66 35
  • 79.4 (n)
  • 79.94 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM66 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM66 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM66 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2119 35
zebrafish
(Danio rerio)
Actinopterygii tmem66 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T06D8.9 35
  • 48.85 (n)
  • 44.66 (a)
T06D8.9 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for SARAF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SARAF Gene

ENSEMBL:
Gene Tree for SARAF (if available)
TreeFam:
Gene Tree for SARAF (if available)

Paralogs for SARAF Gene

Pseudogenes.org Pseudogenes for SARAF Gene

genes like me logo Genes that share paralogs with SARAF: view

No data available for Paralogs for SARAF Gene

Variants for SARAF Gene

Sequence variations from dbSNP and Humsavar for SARAF Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11538828 - 30,073,927(-) ATACC(A/C)CAAAA intron-variant, reference, missense
rs7036 -- 30,063,490(+) TATTA(C/T)AGTCT utr-variant-3-prime
rs9130 -- 30,063,309(+) TTTTC(C/T)ACCTT utr-variant-3-prime
rs11020 -- 30,063,320(+) TTCCT(A/C)CAGAA utr-variant-3-prime
rs984285 -- 30,077,234(-) aagtg(A/T)tctgc intron-variant

Variation tolerance for SARAF Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SARAF Gene

HapMap Linkage Disequilibrium report
SARAF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SARAF Gene

Disorders for SARAF Gene

Relevant External Links for SARAF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SARAF

No disorders were found for SARAF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SARAF Gene

Publications for SARAF Gene

  1. SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling. (PMID: 22464749) Palty R. … Reuveny E. (Cell 2012) 2 3 4 67
  2. The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function. (PMID: 23816623) Jha A. … Muallem S. (J. Cell Biol. 2013) 2 3
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum. (PMID: 23867461) Huang C.H. … Chen X. (J. Biol. Chem. 2013) 3

Products for SARAF Gene

Sources for SARAF Gene

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