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Aliases for CHMP3 Gene

Aliases for CHMP3 Gene

  • Charged Multivesicular Body Protein 3 2 3 5
  • Vacuolar Protein Sorting-Associated Protein 24 3 4
  • Neuroendocrine Differentiation Factor 3 4
  • Chromatin-Modifying Protein 3 3 4
  • VPS24 3 4
  • NEDF 3 4
  • Vacuolar Protein Sorting 24 Homolog (S. Cerevisiae) 2
  • Vacuolar Protein Sorting 24 (Yeast) 2
  • Vacuolar Protein Sorting 24 Homolog 3
  • CHMP Family, Member 3 3
  • 25.1 Protein 3
  • CGI-149 3
  • CGI149 4
  • HVps24 4

External Ids for CHMP3 Gene

Previous HGNC Symbols for CHMP3 Gene

  • VPS24

Previous GeneCards Identifiers for CHMP3 Gene

  • GC02M086730

Summaries for CHMP3 Gene

Entrez Gene Summary for CHMP3 Gene

  • This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CHMP3 Gene

CHMP3 (Charged Multivesicular Body Protein 3) is a Protein Coding gene. Diseases associated with CHMP3 include hiv-1. Among its related pathways are HIV Life Cycle and Infectious disease. GO annotations related to this gene include protein homodimerization activity and ubiquitin-specific protease binding. An important paralog of this gene is RNF103-CHMP3.

UniProtKB/Swiss-Prot for CHMP3 Gene

  • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

Gene Wiki entry for CHMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP3 Gene

Genomics for CHMP3 Gene

Regulatory Elements for CHMP3 Gene

Promoters for CHMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHMP3 Gene

Chromosome:
2
Start:
86,503,430 bp from pter
End:
86,563,497 bp from pter
Size:
60,068 bases
Orientation:
Minus strand

Genomic View for CHMP3 Gene

Genes around CHMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP3 Gene

Proteins for CHMP3 Gene

  • Protein details for CHMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3E7-CHMP3_HUMAN
    Recommended name:
    Charged multivesicular body protein 3
    Protein Accession:
    Q9Y3E7
    Secondary Accessions:
    • A8K3W0
    • B4DG34
    • B8ZZM0
    • B8ZZX5
    • Q3ZTS9
    • Q53S71
    • Q53SU5
    • Q9NZ51

    Protein attributes for CHMP3 Gene

    Size:
    222 amino acids
    Molecular mass:
    25073 Da
    Quaternary structure:
    • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Forms a metastable monomer in solution; its core structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes into a flat lattice via two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. May interact with IGFBP7; the relevance of such interaction however remains unclear. Interacts with CHMP2A. Interacts with CHMP4A; the interaction requires the release of CHMP4A autoinhibition. Interacts with VPS4A. Interacts with STAMBP; the interaction appears to relieve the autoinhibition of CHMP3. Interacts with VTA1.
    Miscellaneous:
    • Its overexpression strongly inhibits HIV-1 release.

    Three dimensional structures from OCA and Proteopedia for CHMP3 Gene

    Alternative splice isoforms for CHMP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP3 Gene

Proteomics data for CHMP3 Gene at MOPED

Post-translational modifications for CHMP3 Gene

  • Ubiquitination at Lys 179
  • Modification sites at PhosphoSitePlus

Other Protein References for CHMP3 Gene

No data available for DME Specific Peptides for CHMP3 Gene

Domains & Families for CHMP3 Gene

Protein Domains for CHMP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3E7

UniProtKB/Swiss-Prot:

CHMP3_HUMAN :
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
  • Belongs to the SNF7 family.
Domain:
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP3: view

Function for CHMP3 Gene

Molecular function for CHMP3 Gene

UniProtKB/Swiss-Prot Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

Gene Ontology (GO) - Molecular Function for CHMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
genes like me logo Genes that share ontologies with CHMP3: view

Phenotypes for CHMP3 Gene

MGI mutant phenotypes for CHMP3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CHMP3: view

Animal Models for CHMP3 Gene

MGI Knock Outs for CHMP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHMP3 Gene

Localization for CHMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP3 Gene

Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane. Note=Localizes to the midbody of dividing cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP3 Gene COMPARTMENTS Subcellular localization image for CHMP3 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
plasma membrane 5
lysosome 2
vacuole 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CHMP3: view

Pathways & Interactions for CHMP3 Gene

genes like me logo Genes that share pathways with CHMP3: view

Pathways by source for CHMP3 Gene

1 BioSystems pathway for CHMP3 Gene
1 KEGG pathway for CHMP3 Gene

Gene Ontology (GO) - Biological Process for CHMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006914 autophagy TAS 20588296
GO:0006915 apoptotic process IEA --
GO:0006997 NOT nucleus organization IMP 20616062
GO:0007080 NOT mitotic metaphase plate congression IMP 20616062
genes like me logo Genes that share ontologies with CHMP3: view

No data available for SIGNOR curated interactions for CHMP3 Gene

Drugs & Compounds for CHMP3 Gene

No Compound Related Data Available

Transcripts for CHMP3 Gene

Unigene Clusters for CHMP3 Gene

Charged multivesicular body protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: -
SP11: - - - -
SP12: - -
SP13:

Relevant External Links for CHMP3 Gene

GeneLoc Exon Structure for
CHMP3
ECgene alternative splicing isoforms for
CHMP3

Expression for CHMP3 Gene

mRNA expression in normal human tissues for CHMP3 Gene

Protein differential expression in normal tissues from HIPED for CHMP3 Gene

This gene is overexpressed in Urine (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CHMP3 Gene



SOURCE GeneReport for Unigene cluster for CHMP3 Gene Hs.591582

mRNA Expression by UniProt/SwissProt for CHMP3 Gene

Q9Y3E7-CHMP3_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CHMP3: view

Protein tissue co-expression partners for CHMP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHMP3 Gene

Orthologs for CHMP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHMP3 35
  • 93.39 (n)
  • 98.65 (a)
CHMP3 36
  • 93 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Chmp3 35
  • 89.19 (n)
  • 95.95 (a)
Chmp3 16
Chmp3 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia VPS24 35
  • 99.4 (n)
  • 99.55 (a)
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Chmp3 35
  • 89.79 (n)
  • 96.85 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves CHMP3 35
  • 81.65 (n)
  • 91.28 (a)
-- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp3 35
  • 76.82 (n)
  • 83.64 (a)
zebrafish
(Danio rerio)
Actinopterygii chmp3 35
  • 74.66 (n)
  • 84.16 (a)
wufb47g01 35
chmp3 36
  • 79 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.878 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003507 35
  • 62.9 (n)
  • 61.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta vps24 35
  • 59.72 (n)
  • 60.65 (a)
vps24 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T27F7.1 35
  • 61.8 (n)
  • 63.48 (a)
vps-24 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR049C 35
  • 46.41 (n)
  • 30 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25366g 35
  • 46.22 (n)
  • 32.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS24 35
  • 44.53 (n)
  • 32.82 (a)
VPS24 36
  • 28 (a)
OneToMany
VPS24 38
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS24.1 35
  • 54.1 (n)
  • 44.57 (a)
rice
(Oryza sativa)
Liliopsida Os03g0108400 35
  • 53.18 (n)
  • 50.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01791 35
  • 46.28 (n)
  • 38.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for CHMP3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP3 Gene

ENSEMBL:
Gene Tree for CHMP3 (if available)
TreeFam:
Gene Tree for CHMP3 (if available)

Paralogs for CHMP3 Gene

Paralogs for CHMP3 Gene

(2) SIMAP similar genes for CHMP3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CHMP3 Gene

genes like me logo Genes that share paralogs with CHMP3: view

Variants for CHMP3 Gene

Variation tolerance for CHMP3 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHMP3 Gene

HapMap Linkage Disequilibrium report
CHMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for CHMP3 Gene

Disorders for CHMP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHMP3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search CHMP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHMP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHMP3
genes like me logo Genes that share disorders with CHMP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHMP3 Gene

Publications for CHMP3 Gene

  1. Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PMID: 11549700) Wilson E.M. … Rosenfeld R.G. (J. Clin. Endocrinol. Metab. 2001) 2 3 4 67
  2. Structural basis for ESCRT-III protein autoinhibition. (PMID: 19525971) Bajorek M. … Sundquist W.I. (Nat. Struct. Mol. Biol. 2009) 3 23
  3. Helical structures of ESCRT-III are disassembled by VPS4. (PMID: 18687924) Lata S. … Weissenhorn W. (Science 2008) 3 23
  4. AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes. (PMID: 17159328) Kyuuma M. … Tanaka N. (Cell Struct. Funct. 2007) 3 23
  5. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. (PMID: 15632132) Lin Y. … Hanson P.I. (J. Biol. Chem. 2005) 3 23

Products for CHMP3 Gene

Sources for CHMP3 Gene

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