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Aliases for SLC25A39 Gene

Aliases for SLC25A39 Gene

  • Solute Carrier Family 25 Member 39 2 3 5
  • Solute Carrier Family 25, Member 39 2
  • CGI-69 3
  • CGI69 3

External Ids for SLC25A39 Gene

Previous GeneCards Identifiers for SLC25A39 Gene

  • GC17M039753
  • GC17M042396
  • GC17M038161

Summaries for SLC25A39 Gene

Entrez Gene Summary for SLC25A39 Gene

  • This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis. [provided by RefSeq, Mar 2016]

GeneCards Summary for SLC25A39 Gene

SLC25A39 (Solute Carrier Family 25 Member 39) is a Protein Coding gene. An important paralog of this gene is SLC25A40.

UniProtKB/Swiss-Prot for SLC25A39 Gene

  • Required for normal heme biosynthesis.

Gene Wiki entry for SLC25A39 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A39 Gene

Genomics for SLC25A39 Gene

Regulatory Elements for SLC25A39 Gene

Enhancers for SLC25A39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G044323 1.7 FANTOM5 ENCODE dbSUPER 22.4 -0.6 -625 3.8 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 SLC4A1 SLC25A39 UBTF ASB16-AS1 ITGA2B TMUB2 ENSG00000267211
GH17G044337 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.6 -14.8 -14843 3.9 HDGF PKNOX1 CEBPG ZIC2 TCF12 ZNF121 GATA3 ZNF366 POLR2A RFX1 SLC25A39 RUNDC3A-AS1 GRN TMUB2 ENSG00000267211
GH17G044344 1.8 FANTOM5 ENCODE dbSUPER 15.4 -22.3 -22288 5.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 DHX8 SLC25A39 MEOX1 EFTUD2 RUNDC3A-AS1 ASB16-AS1 UBTF RUNDC3A RNU6-453P ENSG00000221496
GH17G044541 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 -220.3 -220345 8.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A SLC30A9 ZNF766 ZNF143 FOS GPATCH8 MEIOC FAM171A2 SLC25A39 TMUB2 FZD2 GRN ADAM11 TMEM101 GJC1
GH17G044332 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -9.0 -9031 2.6 SIN3A ZNF121 NFIC ZNF585B ZNF341 NR2C1 KDM1A ZNF600 SPI1 TCF7L2 SLC25A39 GRN TMUB2 ENSG00000267211
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A39 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094748 -630 3401 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for SLC25A39 Gene

Chromosome:
17
Start:
44,319,625 bp from pter
End:
44,324,870 bp from pter
Size:
5,246 bases
Orientation:
Minus strand

Genomic View for SLC25A39 Gene

Genes around SLC25A39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A39 Gene

Proteins for SLC25A39 Gene

  • Protein details for SLC25A39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZJ4-S2539_HUMAN
    Recommended name:
    Solute carrier family 25 member 39
    Protein Accession:
    Q9BZJ4
    Secondary Accessions:
    • A8JZZ2
    • D3DX51
    • D3DX54
    • Q4V9M1
    • Q9P182
    • Q9UF66
    • Q9Y379

    Protein attributes for SLC25A39 Gene

    Size:
    359 amino acids
    Molecular mass:
    39249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A39 Gene

Post-translational modifications for SLC25A39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A39 Gene

Domains & Families for SLC25A39 Gene

Gene Families for SLC25A39 Gene

Protein Domains for SLC25A39 Gene

Suggested Antigen Peptide Sequences for SLC25A39 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZJ4

UniProtKB/Swiss-Prot:

S2539_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A39: view

Function for SLC25A39 Gene

Molecular function for SLC25A39 Gene

UniProtKB/Swiss-Prot Function:
Required for normal heme biosynthesis.

Gene Ontology (GO) - Molecular Function for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A39: view
genes like me logo Genes that share phenotypes with SLC25A39: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A39

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A39 Gene

Localization for SLC25A39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A39 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A39 gene
Compartment Confidence
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A39: view

Pathways & Interactions for SLC25A39 Gene

SuperPathways for SLC25A39 Gene

No Data Available

Interacting Proteins for SLC25A39 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366299%0d%0a9606.ENSP00000340989%0d%0a9606.ENSP00000306330%0d%0a9606.ENSP00000283195%0d%0a9606.ENSP00000386588%0d%0a9606.ENSP00000381253%0d%0a
Selected Interacting proteins: Q9BZJ4-S2539_HUMAN ENSP00000366299 for SLC25A39 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006783 heme biosynthetic process IEA --
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A39: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A39 Gene

Transcripts for SLC25A39 Gene

Unigene Clusters for SLC25A39 Gene

Solute carrier family 25, member 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A39 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - -
SP15: - -
SP16: - -
SP17: - - - - - - - - - -
SP18: - -
SP19:
SP20: - - - - - - - - - - - - - - - - - - - - - -
SP21:
SP22: - - - - -
SP23:
SP24: - - - - -

ExUns: 8f ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -
SP9: -
SP10: -
SP11: - -
SP12:
SP13: -
SP14: -
SP15: -
SP16: - - - -
SP17:
SP18: - -
SP19:
SP20: - -
SP21: - - - - - -
SP22:
SP23:
SP24:

Relevant External Links for SLC25A39 Gene

GeneLoc Exon Structure for
SLC25A39
ECgene alternative splicing isoforms for
SLC25A39

Expression for SLC25A39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A39 Gene

This gene is overexpressed in Whole Blood (x19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A39 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC25A39 Gene:

SLC25A39

SOURCE GeneReport for Unigene cluster for SLC25A39 Gene:

Hs.744880

mRNA Expression by UniProt/SwissProt for SLC25A39 Gene:

Q9BZJ4-S2539_HUMAN
Tissue specificity: Expressed in many tissues. Abundant in testis and kidney.

Evidence on tissue expression from TISSUES for SLC25A39 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Intestine(4.3)
  • Lung(3.8)
  • Eye(3.1)
  • Skin(3.1)
  • Kidney(2.8)
  • Blood(2.2)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SLC25A39: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A39 Gene

Orthologs for SLC25A39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A39 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToMany
SLC25A39 34
  • 89.85 (n)
-- 35
  • 59 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SLC25A39 34 35
  • 88.92 (n)
mouse
(Mus musculus)
Mammalia Slc25a39 34 16 35
  • 85.94 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a39 34
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A39 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A39 34 35
  • 69.71 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A39 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a39 34
  • 61.96 (n)
Str.3014 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2727 34
zebrafish
(Danio rerio)
Actinopterygii slc25a39 34 35
  • 63.14 (n)
zgc63736 34
fruit fly
(Drosophila melanogaster)
Insecta Shawn 35
  • 38 (a)
ManyToMany
CG2616 35
  • 33 (a)
ManyToMany
Tyler 35
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C16C10.1 35
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTM1 35 37
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MTM1 34
  • 45.81 (n)
rice
(Oryza sativa)
Liliopsida Os08g0386800 34
  • 48.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
Species where no ortholog for SLC25A39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A39 Gene

ENSEMBL:
Gene Tree for SLC25A39 (if available)
TreeFam:
Gene Tree for SLC25A39 (if available)

Paralogs for SLC25A39 Gene

Paralogs for SLC25A39 Gene

(1) SIMAP similar genes for SLC25A39 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for SLC25A39 Gene

genes like me logo Genes that share paralogs with SLC25A39: view

Variants for SLC25A39 Gene

Sequence variations from dbSNP and Humsavar for SLC25A39 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000425732 -- 44,321,930(+) CCAGG(A/C)GGACA intron-variant
rs1000457072 -- 44,322,117(+) GGTGG(G/T)GCACG intron-variant
rs1000509295 -- 44,322,232(+) TGACA(A/G)AGCGA intron-variant
rs1000657851 -- 44,326,694(+) TTGTC(A/G)GGGAG intron-variant, upstream-variant-2KB
rs1000759595 -- 44,326,846(+) GGAGG(-/C)CGGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A39 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv2061 CNV insertion 18451855
nsv510713 CNV deletion 20534489

Variation tolerance for SLC25A39 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A39 Gene

Human Gene Mutation Database (HGMD)
SLC25A39
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A39 Gene

Disorders for SLC25A39 Gene

Relevant External Links for SLC25A39

Genetic Association Database (GAD)
SLC25A39
Human Genome Epidemiology (HuGE) Navigator
SLC25A39
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A39

No disorders were found for SLC25A39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A39 Gene

Publications for SLC25A39 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69. (PMID: 11139402) Yu X.X. … Adams S.H. (Biochem. J. 2001) 3 4 64

Products for SLC25A39 Gene

Sources for SLC25A39 Gene

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