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Aliases for SLC25A39 Gene

Aliases for SLC25A39 Gene

  • Solute Carrier Family 25 Member 39 2 3 5
  • Solute Carrier Family 25, Member 39 2
  • CGI-69 3
  • CGI69 3

External Ids for SLC25A39 Gene

Previous GeneCards Identifiers for SLC25A39 Gene

  • GC17M039753
  • GC17M042396
  • GC17M038161

Summaries for SLC25A39 Gene

Entrez Gene Summary for SLC25A39 Gene

  • This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis. [provided by RefSeq, Mar 2016]

GeneCards Summary for SLC25A39 Gene

SLC25A39 (Solute Carrier Family 25 Member 39) is a Protein Coding gene. An important paralog of this gene is SLC25A40.

UniProtKB/Swiss-Prot for SLC25A39 Gene

  • Required for normal heme biosynthesis.

Gene Wiki entry for SLC25A39 Gene

Additional gene information for SLC25A39 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A39 Gene

Genomics for SLC25A39 Gene

GeneHancer (GH) Regulatory Elements for SLC25A39 Gene

Promoters and enhancers for SLC25A39 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I044323 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 572.4 -0.6 -624 3.8 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 SLC25A39 SLC4A1 UBTF ASB16-AS1 ITGA2B TMUB2 ENSG00000267211 GC17P044298 GC17P044299
GH17I044344 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.4 -22.3 -22288 5.5 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 POLR2B GRN UBTF SLC25A39 MEOX1 C17orf53 RUNDC3A-AS1 TMUB2 MAP3K14-AS1 LSM12 RUNDC3A
GH17I044337 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18.6 -14.8 -14843 3.9 ZNF362 HLF DACH1 CBFA2T3 ZIC2 TCF12 ZFP69B ZNF335 GATA3 ZNF692 SLC25A39 RUNDC3A-AS1 GRN TMUB2 ENSG00000267211
GH17I044541 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 -220.3 -220344 8.1 HDGF SIN3A ETS1 TCF12 GLIS2 ZNF143 FOS ATF7 REST SMARCA4 GPATCH8 MEIOC FAM171A2 SLC25A39 TMUB2 FZD2 GRN ADAM11 TMEM101 GJC1
GH17I044314 Enhancer 1 Ensembl ENCODE 17.1 +9.2 9197 2.5 PKNOX1 ZNF76 SIN3A YBX1 ZNF335 GLIS2 SP3 CEBPB ZNF398 REST RUNDC3A-AS1 SLC25A39 UBTF ASB16-AS1 DHX8 TMUB2 GPATCH8 LINC00910 GC17M044320 RUNDC3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A39 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A39 gene promoter:

Genomic Locations for SLC25A39 Gene

Genomic Locations for SLC25A39 Gene
chr17:44,319,625-44,324,870
(GRCh38/hg38)
Size:
5,246 bases
Orientation:
Minus strand
chr17:42,396,993-42,402,238
(GRCh37/hg19)

Genomic View for SLC25A39 Gene

Genes around SLC25A39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A39 Gene

Proteins for SLC25A39 Gene

  • Protein details for SLC25A39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZJ4-S2539_HUMAN
    Recommended name:
    Solute carrier family 25 member 39
    Protein Accession:
    Q9BZJ4
    Secondary Accessions:
    • A8JZZ2
    • D3DX51
    • D3DX54
    • Q4V9M1
    • Q9P182
    • Q9UF66
    • Q9Y379

    Protein attributes for SLC25A39 Gene

    Size:
    359 amino acids
    Molecular mass:
    39249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A39 Gene

Post-translational modifications for SLC25A39 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A39 Gene

Domains & Families for SLC25A39 Gene

Gene Families for SLC25A39 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A39 Gene

Suggested Antigen Peptide Sequences for SLC25A39 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZJ4

UniProtKB/Swiss-Prot:

S2539_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A39: view

Function for SLC25A39 Gene

Molecular function for SLC25A39 Gene

UniProtKB/Swiss-Prot Function:
Required for normal heme biosynthesis.

Phenotypes From GWAS Catalog for SLC25A39 Gene

Gene Ontology (GO) - Molecular Function for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A39: view
genes like me logo Genes that share phenotypes with SLC25A39: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A39 Gene

Localization for SLC25A39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A39 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A39 gene
Compartment Confidence
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with SLC25A39: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC25A39 Gene

Pathways & Interactions for SLC25A39 Gene

SuperPathways for SLC25A39 Gene

No Data Available

Interacting Proteins for SLC25A39 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366299%0d%0a9606.ENSP00000340989%0d%0a9606.ENSP00000306330%0d%0a9606.ENSP00000283195%0d%0a9606.ENSP00000016946%0d%0a9606.ENSP00000327583%0d%0a
Selected Interacting proteins: ENSP00000366299 Q9BZJ4-S2539_HUMAN for SLC25A39 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006783 heme biosynthetic process IEA --
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A39: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A39 Gene

Drugs & Compounds for SLC25A39 Gene

No Compound Related Data Available

Transcripts for SLC25A39 Gene

Unigene Clusters for SLC25A39 Gene

Solute carrier family 25, member 39:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A39 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - -
SP15: - -
SP16: - -
SP17: - - - - - - - - - -
SP18: - -
SP19:
SP20: - - - - - - - - - - - - - - - - - - - - - -
SP21:
SP22: - - - - -
SP23:
SP24: - - - - -

ExUns: 8f ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -
SP9: -
SP10: -
SP11: - -
SP12:
SP13: -
SP14: -
SP15: -
SP16: - - - -
SP17:
SP18: - -
SP19:
SP20: - -
SP21: - - - - - -
SP22:
SP23:
SP24:

Relevant External Links for SLC25A39 Gene

GeneLoc Exon Structure for
SLC25A39
ECgene alternative splicing isoforms for
SLC25A39

Expression for SLC25A39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A39 Gene

This gene is overexpressed in Whole Blood (x19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A39 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC25A39 Gene:

SLC25A39

SOURCE GeneReport for Unigene cluster for SLC25A39 Gene:

Hs.744880

mRNA Expression by UniProt/SwissProt for SLC25A39 Gene:

Q9BZJ4-S2539_HUMAN
Tissue specificity: Expressed in many tissues. Abundant in testis and kidney.

Evidence on tissue expression from TISSUES for SLC25A39 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Intestine(4.3)
  • Lung(3.8)
  • Eye(3.1)
  • Skin(3.1)
  • Kidney(2.8)
  • Blood(2.2)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SLC25A39: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A39 Gene

Orthologs for SLC25A39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A39 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToMany
SLC25A39 33
  • 89.85 (n)
-- 34
  • 59 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SLC25A39 33 34
  • 88.92 (n)
mouse
(Mus musculus)
Mammalia Slc25a39 33 16 34
  • 85.94 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a39 33
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A39 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A39 33 34
  • 69.71 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A39 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a39 33
  • 61.96 (n)
Str.3014 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2727 33
zebrafish
(Danio rerio)
Actinopterygii slc25a39 33 34
  • 63.14 (n)
zgc63736 33
fruit fly
(Drosophila melanogaster)
Insecta Shawn 34
  • 38 (a)
ManyToMany
CG2616 34
  • 33 (a)
ManyToMany
Tyler 34
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C16C10.1 34
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTM1 34 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MTM1 33
  • 45.81 (n)
rice
(Oryza sativa)
Liliopsida Os08g0386800 33
  • 48.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Species where no ortholog for SLC25A39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A39 Gene

ENSEMBL:
Gene Tree for SLC25A39 (if available)
TreeFam:
Gene Tree for SLC25A39 (if available)

Paralogs for SLC25A39 Gene

Paralogs for SLC25A39 Gene

(1) SIMAP similar genes for SLC25A39 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for SLC25A39 Gene

genes like me logo Genes that share paralogs with SLC25A39: view

Variants for SLC25A39 Gene

Sequence variations from dbSNP and Humsavar for SLC25A39 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000425732 -- 44,321,930(-) C/A/T intron_variant
rs1000457072 -- 44,322,117(-) T/G intron_variant
rs1000509295 -- 44,322,232(-) G/A intron_variant
rs1000657851 -- 44,326,694(-) A/G upstream_transcript_variant
rs1000759595 -- 44,326,847(-) C/CC upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A39 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv2061 CNV insertion 18451855
nsv510713 CNV deletion 20534489

Variation tolerance for SLC25A39 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A39 Gene

Human Gene Mutation Database (HGMD)
SLC25A39
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A39 Gene

Disorders for SLC25A39 Gene

Additional Disease Information for SLC25A39

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A39 Gene

Publications for SLC25A39 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69. (PMID: 11139402) Yu XX … Adams SH (The Biochemical journal 2001) 3 4 58

Products for SLC25A39 Gene

Sources for SLC25A39 Gene

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