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Aliases for KLF13 Gene

Aliases for KLF13 Gene

  • Kruppel-Like Factor 13 2 3 5
  • Novel Sp1-Like Zinc Finger Transcription Factor 1 3 4
  • Transcription Factor BTEB3 3 4
  • Transcription Factor NSLP1 3 4
  • BTE-Binding Protein 3 3 4
  • RFLAT-1 3 4
  • BTEB3 3 4
  • NSLP1 3 4
  • RANTES Factor Of Late Activated T Lymphocytes-1 3
  • RANTES Factor Of Late Activated T-Lymphocytes 1 4
  • Basic Transcription Element Binding Protein 3 3
  • Basic Transcription Element-Binding Protein 3 4
  • RFLAT1 3
  • FKLF2 3

External Ids for KLF13 Gene

Previous GeneCards Identifiers for KLF13 Gene

  • GC15M027358
  • GC15P024375
  • GC15P029199
  • GC15P029335
  • GC15P028915
  • GC15P031619
  • GC15P008795

Summaries for KLF13 Gene

Entrez Gene Summary for KLF13 Gene

  • KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KLF13 Gene

KLF13 (Kruppel-Like Factor 13) is a Protein Coding gene. Diseases associated with KLF13 include Chromosome 15Q13.3 Microdeletion Syndrome. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for KLF13 Gene

  • Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.

Gene Wiki entry for KLF13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF13 Gene

Genomics for KLF13 Gene

Regulatory Elements for KLF13 Gene

Enhancers for KLF13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLF13 on UCSC Golden Path with GeneCards custom track

Promoters for KLF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF13 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF13 Gene

Chromosome:
15
Start:
31,326,855 bp from pter
End:
31,435,665 bp from pter
Size:
108,811 bases
Orientation:
Plus strand

Genomic View for KLF13 Gene

Genes around KLF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF13 Gene

Proteins for KLF13 Gene

  • Protein details for KLF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y9-KLF13_HUMAN
    Recommended name:
    Krueppel-like factor 13
    Protein Accession:
    Q9Y2Y9
    Secondary Accessions:
    • Q9Y356

    Protein attributes for KLF13 Gene

    Size:
    288 amino acids
    Molecular mass:
    31180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF13 Gene

Proteomics data for KLF13 Gene at MOPED

Post-translational modifications for KLF13 Gene

Other Protein References for KLF13 Gene

No data available for DME Specific Peptides for KLF13 Gene

Domains & Families for KLF13 Gene

Protein Domains for KLF13 Gene

Suggested Antigen Peptide Sequences for KLF13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y9

UniProtKB/Swiss-Prot:

KLF13_HUMAN :
  • The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF13: view

Function for KLF13 Gene

Molecular function for KLF13 Gene

UniProtKB/Swiss-Prot Function:
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.

Gene Ontology (GO) - Molecular Function for KLF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF13: view
genes like me logo Genes that share phenotypes with KLF13: view

Animal Models for KLF13 Gene

MGI Knock Outs for KLF13:

Animal Model Products

miRNA for KLF13 Gene

miRTarBase miRNAs that target KLF13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF13 Gene

Localization for KLF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF13 Gene COMPARTMENTS Subcellular localization image for KLF13 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for KLF13 Gene

Pathways & Interactions for KLF13 Gene

SuperPathways for KLF13 Gene

No Data Available

SIGNOR curated interactions for KLF13 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF13 Gene

None

No data available for Pathways by source for KLF13 Gene

Drugs & Compounds for KLF13 Gene

(3) Drugs for KLF13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLF13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLF13: view

Transcripts for KLF13 Gene

Unigene Clusters for KLF13 Gene

Kruppel-like factor 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF13 Gene

No ASD Table

Relevant External Links for KLF13 Gene

GeneLoc Exon Structure for
KLF13
ECgene alternative splicing isoforms for
KLF13

Expression for KLF13 Gene

mRNA expression in normal human tissues for KLF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.3), Retina (11.4), Lung (9.1), and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF13 Gene



SOURCE GeneReport for Unigene cluster for KLF13 Gene Hs.525752

mRNA Expression by UniProt/SwissProt for KLF13 Gene

Q9Y2Y9-KLF13_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with KLF13: view

Protein tissue co-expression partners for KLF13 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for KLF13 Gene

Orthologs for KLF13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF13 35
  • 91.64 (n)
  • 90.94 (a)
mouse
(Mus musculus)
Mammalia Klf13 35
  • 91.52 (n)
  • 94.7 (a)
Klf13 16
Klf13 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF13 35
  • 99.07 (n)
  • 99.31 (a)
KLF13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf13 35
  • 93.75 (n)
  • 98.96 (a)
dog
(Canis familiaris)
Mammalia KLF13 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF13 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF13 35
  • 60.36 (n)
  • 63.27 (a)
KLF13 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF13 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf13 35
  • 65.76 (n)
  • 70.7 (a)
zebrafish
(Danio rerio)
Actinopterygii klf13 35
  • 64.91 (n)
  • 65.45 (a)
wufi22b08 35
klf13 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EP2237 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea Y40B1A.4 37
  • 66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 36
  • 14 (a)
OneToMany
Species with no ortholog for KLF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF13 Gene

ENSEMBL:
Gene Tree for KLF13 (if available)
TreeFam:
Gene Tree for KLF13 (if available)

Paralogs for KLF13 Gene

Paralogs for KLF13 Gene

genes like me logo Genes that share paralogs with KLF13: view

Variants for KLF13 Gene

Sequence variations from dbSNP and Humsavar for KLF13 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs5014835 -- 31,341,323(-) CCCCT(C/G)CTACT intron-variant
rs5811634 -- 31,335,472(+) GTGTG(-/TGTGTA)TGGTG intron-variant
rs5811637 -- 31,351,794(+) ATCTT(-/G)AGGTC intron-variant
rs5811639 -- 31,353,426(+) GGGCT(-/G)GGCAA intron-variant
rs5811640 -- 31,388,606(+) AAAAA(-/A)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF13 Gene

Variant ID Type Subtype PubMed ID
nsv903831 CNV Gain 21882294
nsv903838 CNV Loss 21882294
esv34100 CNV Loss 18971310
nsv456747 CNV Loss 19166990
nsv903840 CNV Loss 21882294
nsv511044 OTHER Inversion 20534489
nsv516681 CNV Loss 19592680
dgv2308n71 CNV Loss 21882294
nsv827280 CNV Gain 20364138
esv29856 CNV Loss 19812545
nsv456748 CNV Loss 19166990

Variation tolerance for KLF13 Gene

Gene Damage Index Score: 1.65; 31.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLF13 Gene

Disorders for KLF13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q13.3 microdeletion syndrome
  • 15q13.3 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search KLF13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF13

Genetic Association Database (GAD)
KLF13
Human Genome Epidemiology (HuGE) Navigator
KLF13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF13
genes like me logo Genes that share disorders with KLF13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF13 Gene

Publications for KLF13 Gene

  1. Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. (PMID: 10415854) Cook T. … Urrutia R. (Ann. N. Y. Acad. Sci. 1999) 2 3 4 67
  2. Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells. (PMID: 18056793) Natesampillai S. … Veldhuis J.D. (Am. J. Physiol. Endocrinol. Metab. 2008) 3 23
  3. Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. (PMID: 17513757) Huang B. … Krensky A.M. (J. Immunol. 2007) 3 23
  4. A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function. (PMID: 16303770) Natesampillai S. … Veldhuis J.D. (J. Biol. Chem. 2006) 3 23
  5. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PMID: 12036432) Kaczynski J.A. … Urrutia R. (Biochem. J. 2002) 3 23

Products for KLF13 Gene

Sources for KLF13 Gene

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