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Aliases for TAF9B Gene

Aliases for TAF9B Gene

  • TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
  • TAF9-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
  • Transcription-Associated Factor TAFII31L 3 4
  • Neuronal Cell Death-Related Protein 7 3 4
  • TAF9L 3 4
  • DN-7 3 4
  • Transcription Initiation Factor TFIID Subunit 9-Like 4
  • Transcription Initiation Factor IID, 31kD Subunit 3
  • Transcription Associated Factor TAFII31L 3
  • TBP-Associated Factor 9L 3
  • TAFII31L 3
  • TFIID-31 3
  • DN7 3

External Ids for TAF9B Gene

Previous HGNC Symbols for TAF9B Gene

  • TAF9L

Previous GeneCards Identifiers for TAF9B Gene

  • GC0XP9L0788
  • GC0XM077271
  • GC0XM077385
  • GC0XM070971

Summaries for TAF9B Gene

Entrez Gene Summary for TAF9B Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF9B Gene

TAF9B (TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa) is a Protein Coding gene. Among its related pathways are Infectious disease and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein heterodimerization activity and transcription corepressor activity. An important paralog of this gene is TAF9.

UniProtKB/Swiss-Prot for TAF9B Gene

  • Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Wiki entry for TAF9B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF9B Gene

Genomics for TAF9B Gene

Regulatory Elements for TAF9B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAF9B Gene

Chromosome:
X
Start:
78,129,748 bp from pter
End:
78,139,706 bp from pter
Size:
9,959 bases
Orientation:
Minus strand

Genomic View for TAF9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF9B Gene

Proteins for TAF9B Gene

  • Protein details for TAF9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBM6-TAF9B_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 9B
    Protein Accession:
    Q9HBM6
    Secondary Accessions:
    • B2RUZ9
    • Q9Y2S3

    Protein attributes for TAF9B Gene

    Size:
    251 amino acids
    Molecular mass:
    27622 Da
    Quaternary structure:
    • Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription.

neXtProt entry for TAF9B Gene

Proteomics data for TAF9B Gene at MOPED

Post-translational modifications for TAF9B Gene

  • Ubiquitination at Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF9B Gene

Domains & Families for TAF9B Gene

Protein Domains for TAF9B Gene

Suggested Antigen Peptide Sequences for TAF9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBM6

UniProtKB/Swiss-Prot:

TAF9B_HUMAN :
  • Belongs to the TAF9 family.
Family:
  • Belongs to the TAF9 family.
genes like me logo Genes that share domains with TAF9B: view

No data available for Gene Families for TAF9B Gene

Function for TAF9B Gene

Molecular function for TAF9B Gene

UniProtKB/Swiss-Prot Function:
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Ontology (GO) - Molecular Function for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IC 12837753
GO:0005515 protein binding IPI 15899866
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF9B: view

Phenotypes for TAF9B Gene

MGI mutant phenotypes for TAF9B:
inferred from 1 alleles
GenomeRNAi human phenotypes for TAF9B:
genes like me logo Genes that share phenotypes with TAF9B: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF9B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF9B Gene

Localization for TAF9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF9B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF9B Gene COMPARTMENTS Subcellular localization image for TAF9B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 15899866
GO:0033276 transcription factor TFTC complex IDA 15899866
genes like me logo Genes that share ontologies with TAF9B: view

Pathways & Interactions for TAF9B Gene

genes like me logo Genes that share pathways with TAF9B: view

Gene Ontology (GO) - Biological Process for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 12837753
GO:0006352 DNA-templated transcription, initiation --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF9B: view

No data available for SIGNOR curated interactions for TAF9B Gene

Drugs & Compounds for TAF9B Gene

No Compound Related Data Available

Transcripts for TAF9B Gene

mRNA/cDNA for TAF9B Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF9B Gene

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF9B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF9B Gene

No ASD Table

Relevant External Links for TAF9B Gene

GeneLoc Exon Structure for
TAF9B
ECgene alternative splicing isoforms for
TAF9B

Expression for TAF9B Gene

mRNA expression in normal human tissues for TAF9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF9B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.2), Placenta (9.8), and Fetal ovary (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF9B Gene



SOURCE GeneReport for Unigene cluster for TAF9B Gene Hs.592248

genes like me logo Genes that share expression patterns with TAF9B: view

Protein tissue co-expression partners for TAF9B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF9B Gene

Orthologs for TAF9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF9B 35
  • 93.89 (n)
  • 95.22 (a)
TAF9B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF9B 35
  • 94.38 (n)
  • 95.47 (a)
TAF9B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf9b 35
  • 91.3 (n)
  • 90.76 (a)
Taf9b 16
Taf9b 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF9B 35
  • 99.47 (n)
  • 99.6 (a)
TAF9B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf9b 35
  • 91.8 (n)
  • 90.57 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF9B 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF9 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii taf9 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta e(y)1 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-9 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF9 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for TAF9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAF9B Gene

ENSEMBL:
Gene Tree for TAF9B (if available)
TreeFam:
Gene Tree for TAF9B (if available)

Paralogs for TAF9B Gene

Paralogs for TAF9B Gene

(1) SIMAP similar genes for TAF9B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAF9B Gene

genes like me logo Genes that share paralogs with TAF9B: view

Variants for TAF9B Gene

Sequence variations from dbSNP and Humsavar for TAF9B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs10991 -- 78,130,251(+) TGATA(C/T)GAACA utr-variant-3-prime
rs2281382 -- 78,138,563(+) GGCCA(G/T)CCTGG intron-variant
rs2643581 -- 78,140,403(+) ACACC(C/T)TTCCC upstream-variant-2KB
rs2982583 -- 78,141,312(+) AAAAT(G/T)TAGCC upstream-variant-2KB
rs16978765 -- 78,134,625(+) GGTAC(A/C/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF9B Gene

Variant ID Type Subtype PubMed ID
nsv483140 CNV Gain 15286789

Variation tolerance for TAF9B Gene

Residual Variation Intolerance Score: 42.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF9B Gene

HapMap Linkage Disequilibrium report
TAF9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF9B Gene

Disorders for TAF9B Gene

Relevant External Links for TAF9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF9B
genes like me logo Genes that share disorders with TAF9B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF9B Gene

Publications for TAF9B Gene

  1. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. (PMID: 15899866) Frontini M. … Tora L. (Mol. Cell. Biol. 2005) 2 67
  2. In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. (PMID: 12837753) Chen Z. … Manley J.L. (J. Biol. Chem. 2003) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for TAF9B Gene

Sources for TAF9B Gene

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