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Aliases for DPH5 Gene

Aliases for DPH5 Gene

  • Diphthamide Biosynthesis 5 2 3
  • Diphthamide Biosynthesis Methyltransferase 3 4
  • EC 2.1.1.98 4 64
  • HSPC143 3 6
  • DPH5 Homolog (S. Cerevisiae) 2
  • Diphthine Synthase 3
  • Protein X 0011 3
  • DPH5 Homolog 3
  • AD-018 3
  • CGI-30 3
  • NPD015 3

External Ids for DPH5 Gene

Summaries for DPH5 Gene

Entrez Gene Summary for DPH5 Gene

  • This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPH5 Gene

DPH5 (Diphthamide Biosynthesis 5) is a Protein Coding gene. Among its related pathways are diphthamide biosynthesis. GO annotations related to this gene include diphthine synthase activity.

UniProtKB/Swiss-Prot for DPH5 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

Gene Wiki entry for DPH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPH5 Gene

Genomics for DPH5 Gene

Genomic Location for DPH5 Gene

Start:
100,989,623 bp from pter
End:
101,026,088 bp from pter
Size:
36,466 bases
Orientation:
Minus strand

Genomic View for DPH5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPH5 Gene

Regulatory Elements for DPH5 Gene

Proteins for DPH5 Gene

  • Protein details for DPH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2P9-DPH5_HUMAN
    Recommended name:
    Diphthine synthase
    Protein Accession:
    Q9H2P9
    Secondary Accessions:
    • A8JZY6
    • D3DT62
    • Q9P017
    • Q9P0I4
    • Q9Y319

    Protein attributes for DPH5 Gene

    Size:
    285 amino acids
    Molecular mass:
    31651 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DPH5 Gene

neXtProt entry for DPH5 Gene

Proteomics data for DPH5 Gene at MOPED

Selected DME Specific Peptides for DPH5 Gene

Post-translational modifications for DPH5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPH5 Gene

Domains for DPH5 Gene

Protein Domains for DPH5 Gene

UniProtKB/Swiss-Prot:

DPH5_HUMAN
Family:
  • Belongs to the diphthine synthase family.:
    • Q9H2P9
genes like me logo Genes that share domains with DPH5: view

No data available for Gene Families for DPH5 Gene

Function for DPH5 Gene

Molecular function for DPH5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] = 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine-[translation elongation factor 2]
UniProtKB/Swiss-Prot Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

Enzyme Numbers (IUBMB) for DPH5 Gene

Gene Ontology (GO) - Molecular Function for DPH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004164 diphthine synthase activity NAS 15485916
GO:0008168 methyltransferase activity --
genes like me logo Genes that share ontologies with DPH5: view

miRNA for DPH5 Gene

miRTarBase miRNAs that target DPH5

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPH5 Gene

Localization for DPH5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPH5 Gene COMPARTMENTS Subcellular localization image for DPH5 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for DPH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPH5: view

Pathways for DPH5 Gene

SuperPathways for DPH5 Gene

Superpath Contained pathways
1 diphthamide biosynthesis
genes like me logo Genes that share pathways with DPH5: view

Pathways by source for DPH5 Gene

1 BioSystems pathway for DPH5 Gene

UniProtKB/Swiss-Prot Q9H2P9-DPH5_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis

Gene Ontology (GO) - Biological Process for DPH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine TAS --
GO:0032259 methylation IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with DPH5: view

Compounds for DPH5 Gene

(4) HMDB Compounds for DPH5 Gene

Compound Synonyms Cas Number PubMed IDs
2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine
  • [3-[[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]]-1-carboxy- propyl]-methyl-ammonium
Not Available
2-(3-Carboxy-3-aminopropyl)-L-histidine
  • 2-(3-amino-3-carboxypropyl)-L-histidine
Not Available
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(1) Drugbank Compounds for DPH5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-Adenosyl-L-Homocysteine
979-92-0 target
genes like me logo Genes that share compounds with DPH5: view

Transcripts for DPH5 Gene

Unigene Clusters for DPH5 Gene

DPH5 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPH5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13: - -

Relevant External Links for DPH5 Gene

GeneLoc Exon Structure for
DPH5
ECgene alternative splicing isoforms for
DPH5

Expression for DPH5 Gene

mRNA expression in normal human tissues for DPH5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPH5 Gene

SOURCE GeneReport for Unigene cluster for DPH5 Gene Hs.440776

genes like me logo Genes that share expressions with DPH5: view

Orthologs for DPH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPH5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH5 36
  • 99.3 (n)
  • 100 (a)
DPH5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPH5 36
  • 92.16 (n)
  • 94.39 (a)
DPH5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPH5 36
  • 91.64 (n)
  • 92.11 (a)
DPH5 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dph5 36
  • 87.19 (n)
  • 92.17 (a)
Dph5 16
Dph5 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPH5 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPH5 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dph5 36
  • 88.14 (n)
  • 92.17 (a)
chicken
(Gallus gallus)
Aves DPH5 36
  • 76.16 (n)
  • 80.78 (a)
gga-mir-1610 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPH5 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cgi-30-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dph5 36
  • 68.8 (n)
  • 73.31 (a)
Str.7197 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13925 36
zebrafish
(Danio rerio)
Actinopterygii dph5 36
  • 69.96 (n)
  • 78.75 (a)
dph5 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004412 36
  • 59.78 (n)
  • 63.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dph5 36
  • 59.9 (n)
  • 63.47 (a)
Dph5 37
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0491.7 36
  • 61.09 (n)
  • 63.94 (a)
B0491.7 37
  • 62 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR123W 36
  • 55.56 (n)
  • 61.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPH5 36
  • 58.43 (n)
  • 58.43 (a)
DPH5 37
  • 52 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22836g 36
  • 57.52 (n)
  • 61.28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31790 36
  • 63.77 (n)
  • 61.13 (a)
rice
(Oryza sativa)
Liliopsida Os03g0355800 36
  • 58.8 (n)
  • 60.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07266 36
  • 55.85 (n)
  • 60.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dph5 36
  • 58.58 (n)
  • 60.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14906 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToOne
Species with no ortholog for DPH5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPH5 Gene

ENSEMBL:
Gene Tree for DPH5 (if available)
TreeFam:
Gene Tree for DPH5 (if available)

Paralogs for DPH5 Gene

No data available for Paralogs for DPH5 Gene

Variants for DPH5 Gene

Sequence variations from dbSNP and Humsavar for DPH5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1188736 -- 101,020,021(-) TGCTA(A/G)AACCA intron-variant
rs2893311 -- 101,015,203(+) TATCT(A/G)GGGCA intron-variant
rs3835395 -- 101,022,560(-) TGATC(-/CTTC)ATTCT intron-variant
rs3887102 -- 101,015,221(-) atttt(A/G)tgagg intron-variant
rs4000624 -- 101,015,235(+) TTTCT(-/TAGA)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPH5 Gene

Variant ID Type Subtype PubMed ID
nsv522064 CNV Gain 19592680
esv2668878 CNV Deletion 23128226

Relevant External Links for DPH5 Gene

HapMap Linkage Disequilibrium report
DPH5

Disorders for DPH5 Gene

(1) University of Copenhagen DISEASES for DPH5 Gene

Relevant External Links for DPH5

Genetic Association Database (GAD)
DPH5
genes like me logo Genes that share disorders with DPH5: view

No data available for UniProtKB/Swiss-Prot for DPH5 Gene

Publications for DPH5 Gene

  1. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PMID: 15485916) Liu S. … Leppla S.H. (Mol. Cell. Biol. 2004) 2 3 23
  2. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. (PMID: 23486472) Wei H. … Pastan I. (J. Biol. Chem. 2013) 2 3 4
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4

Products for DPH5 Gene

Sources for DPH5 Gene

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