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Aliases for GET4 Gene

Aliases for GET4 Gene

  • Golgi To ER Traffic Protein 4 2 3 5
  • Transmembrane Domain Recognition Complex 35 KDa Subunit 3 4
  • Transmembrane Domain Recognition Complex, 35kDa 2 3
  • Conserved Edge Protein 2 3
  • C7orf20 3 4
  • TRC35 3 4
  • CEE 3 4
  • Golgi To ER Traffic Protein 4 Homolog (S. Cerevisiae) 2
  • Golgi To ER Traffic Protein 4 Homolog 3
  • Chromosome 7 Open Reading Frame 20 2
  • Conserved Edge Expressed Protein 3
  • Conserved Edge-Expressed Protein 4
  • CGI-20 Protein 2
  • H_NH1244M04.5 3
  • CGI-20 3

External Ids for GET4 Gene

Previous HGNC Symbols for GET4 Gene

  • C7orf20

Previous GeneCards Identifiers for GET4 Gene

  • GC07P000916

Summaries for GET4 Gene

GeneCards Summary for GET4 Gene

GET4 (Golgi To ER Traffic Protein 4) is a Protein Coding gene. Diseases associated with GET4 include Louping Ill and Postmenopausal Atrophic Vaginitis.

UniProtKB/Swiss-Prot for GET4 Gene

  • As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Gene Wiki entry for GET4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GET4 Gene

Genomics for GET4 Gene

Regulatory Elements for GET4 Gene

Enhancers for GET4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G000971 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +99.7 99692 8.8 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 ENSG00000225146 C7orf50 COX19 LOC101927021 GPER1
GH07G000537 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -337.4 -337442 3.5 PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B GLIS2 GATA2 ZNF143 FOS SP5 PDGFA GET4 PRKAR1B DNAAF5 GC07P000552 TRBV5-8
GH07G000511 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -360.3 -360262 9.2 PKNOX1 MLX SIN3A ARID4B DMAP1 ZNF2 ZNF143 FOS ZNF263 SP3 HRAT92 PDGFA GET4 GC07P000522 TRBV7-8
GH07G000968 0.7 dbSUPER 5.4 +92.8 92783 1.7 KLF1 MNT PAX8 FOXA1 POLR2A TARDBP GLIS1 KLF9 KDM1A HNRNPL CYP2W1 ENSG00000225146 GPR146 C7orf50 COX19 GET4 LOC105375120 PIR60263
GH07G000501 1.5 FANTOM5 ENCODE dbSUPER 2.2 -370.8 -370761 9.3 HNRNPUL1 MLX ARID4B ZNF48 YY1 ZNF121 ELK1 FOS SP5 PPARG HRAT92 PDGFA GET4 CYP2W1 TRBV6-9 ENSG00000234471
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GET4 on UCSC Golden Path with GeneCards custom track

Promoters for GET4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207497 448 2001 MLX CREB3L1 AGO1 ZFP64 YY1 ZNF143 SP3 NFYC ZFP41 ZNF610

Genomic Location for GET4 Gene

Chromosome:
7
Start:
876,552 bp from pter
End:
896,436 bp from pter
Size:
19,885 bases
Orientation:
Plus strand

Genomic View for GET4 Gene

Genes around GET4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GET4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GET4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GET4 Gene

Proteins for GET4 Gene

  • Protein details for GET4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5D6-GET4_HUMAN
    Recommended name:
    Golgi to ER traffic protein 4 homolog
    Protein Accession:
    Q7L5D6
    Secondary Accessions:
    • A4D2Q1
    • B3KNC7
    • Q9UFC9
    • Q9Y309

    Protein attributes for GET4 Gene

    Size:
    327 amino acids
    Molecular mass:
    36504 Da
    Quaternary structure:
    • Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083). Interacts with BAG6; the interaction is direct and localizes BAG6 to the cytosol (PubMed:21636303).

    Alternative splice isoforms for GET4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GET4 Gene

Post-translational modifications for GET4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GET4 Gene

No data available for DME Specific Peptides for GET4 Gene

Domains & Families for GET4 Gene

Protein Domains for GET4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GET4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L5D6

UniProtKB/Swiss-Prot:

GET4_HUMAN :
  • Belongs to the GET4 family.
Family:
  • Belongs to the GET4 family.
genes like me logo Genes that share domains with GET4: view

No data available for Gene Families for GET4 Gene

Function for GET4 Gene

Molecular function for GET4 Gene

UniProtKB/Swiss-Prot Function:
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Gene Ontology (GO) - Molecular Function for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0051087 chaperone binding IPI 25535373
genes like me logo Genes that share ontologies with GET4: view
genes like me logo Genes that share phenotypes with GET4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GET4 Gene

Localization for GET4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GET4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GET4 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 21636303
GO:0005829 cytosol IDA,IEA 20676083
GO:0071818 BAT3 complex IDA 20676083
genes like me logo Genes that share ontologies with GET4: view

Pathways & Interactions for GET4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0051220 cytoplasmic sequestering of protein IMP 21636303
GO:0071816 tail-anchored membrane protein insertion into ER membrane IMP 20676083
GO:1904378 maintenance of unfolded protein involved in ERAD pathway IMP 21636303
genes like me logo Genes that share ontologies with GET4: view

No data available for Pathways by source and SIGNOR curated interactions for GET4 Gene

Transcripts for GET4 Gene

Unigene Clusters for GET4 Gene

Golgi to ER traffic protein 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GET4 Gene

No ASD Table

Relevant External Links for GET4 Gene

GeneLoc Exon Structure for
GET4
ECgene alternative splicing isoforms for
GET4

Expression for GET4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GET4 Gene

Protein differential expression in normal tissues from HIPED for GET4 Gene

This gene is overexpressed in Bone (24.0) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GET4 Gene



Protein tissue co-expression partners for GET4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GET4 Gene:

GET4

SOURCE GeneReport for Unigene cluster for GET4 Gene:

Hs.107387

Evidence on tissue expression from TISSUES for GET4 Gene

  • Nervous system(4)
  • Eye(2.6)
  • Blood(2.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with GET4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GET4 Gene

Orthologs for GET4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GET4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GET4 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia GET4 34 35
  • 89.83 (n)
oppossum
(Monodelphis domestica)
Mammalia GET4 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GET4 34 35
  • 87.74 (n)
rat
(Rattus norvegicus)
Mammalia Get4 34
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Get4 34 16 35
  • 86.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GET4 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GET4 34 35
  • 75.66 (n)
lizard
(Anolis carolinensis)
Reptilia GET4 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia get4 34
  • 74.71 (n)
Str.1674 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26196 34
zebrafish
(Danio rerio)
Actinopterygii get4 34 35
  • 75.13 (n)
wufd15h01 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000119 34
  • 57.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9853 34 35
  • 52.43 (n)
worm
(Caenorhabditis elegans)
Secernentea cee-1 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GET4 34 35 37
  • 40.79 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20295g 34
  • 39.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63220 34
  • 44.08 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01190 34
  • 43.5 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes get4 34
  • 43.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2033 35
  • 38 (a)
OneToOne
Species where no ortholog for GET4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GET4 Gene

ENSEMBL:
Gene Tree for GET4 (if available)
TreeFam:
Gene Tree for GET4 (if available)

Paralogs for GET4 Gene

No data available for Paralogs for GET4 Gene

Variants for GET4 Gene

Sequence variations from dbSNP and Humsavar for GET4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000164185 -- 895,898(+) GAACA(C/T)GGGGT utr-variant-3-prime
rs1000288672 -- 876,243(+) CCAGT(C/G)CCGGC upstream-variant-2KB
rs1000322171 -- 886,836(+) GCGAG(C/T)ACACG intron-variant
rs1000400193 -- 880,982(+) GCCTC(A/G)GCCTC intron-variant
rs1000416128 -- 877,869(+) CCCCC(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GET4 Gene

Variant ID Type Subtype PubMed ID
dgv11111n54 CNV loss 21841781
esv1624512 CNV deletion 17803354
esv1790011 CNV deletion 17803354
esv24184 CNV gain+loss 19812545
esv25170 CNV loss 19812545
esv2733671 CNV deletion 23290073
esv2733673 CNV deletion 23290073
esv2733674 CNV deletion 23290073
esv2733675 CNV deletion 23290073
esv3571557 CNV loss 25503493
nsv1122151 CNV deletion 24896259
nsv1144159 CNV deletion 24896259
nsv464244 CNV loss 19166990
nsv464245 CNV gain 19166990
nsv473647 CNV novel sequence insertion 20440878
nsv509182 CNV insertion 20534489
nsv5611 CNV insertion 18451855
nsv605698 CNV loss 21841781
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605701 CNV gain 21841781
nsv605702 CNV loss 21841781
nsv950784 CNV deletion 24416366

Variation tolerance for GET4 Gene

Residual Variation Intolerance Score: 7.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GET4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GET4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GET4 Gene

Disorders for GET4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GET4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
louping ill
postmenopausal atrophic vaginitis
  • atrophic vaginitis
erysipeloid
  • infection due to erysipelothrix rhusiopathiae
hemophagocytic lymphohistiocytosis, familial, 3
  • familial hemophagocytic lymphohistiocytosis 3
- elite association - COSMIC cancer census association via MalaCards
Search GET4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GET4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GET4
genes like me logo Genes that share disorders with GET4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GET4 Gene

Publications for GET4 Gene

  1. A ribosome-associating factor chaperones tail-anchored membrane proteins. (PMID: 20676083) Mariappan M. … Hegde R.S. (Nature 2010) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. (PMID: 21636303) Wang Q. … Ye Y. (Mol. Cell 2011) 3 4 64
  4. Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. (PMID: 20106980) Chang Y.W. … Wang C. (J. Biol. Chem. 2010) 2 3 64
  5. Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development. (PMID: 18249086) Fernandes J.M.O. … Johnston I.A. (Genomics 2008) 3 4 64

Products for GET4 Gene

Sources for GET4 Gene

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