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Aliases for TRIM33 Gene

Aliases for TRIM33 Gene

  • Tripartite Motif Containing 33 2 3
  • Transcriptional Intermediary Factor 1 Gamma 2 3
  • Tripartite Motif-Containing 33 2 3
  • RET-Fused Gene 7 Protein 3 4
  • Ectodermin Homolog 3 4
  • Protein Rfg7 3 4
  • TIF1-Gamma 3 4
  • TIF1G 3 4
  • RFG7 3 4
  • Transcription Intermediary Factor 1-Gamma 4
  • Tripartite Motif-Containing Protein 33 4
  • Ret-Fused Gene 7 2
  • EC 6.3.2.- 4
  • TIF1GAMMA 3
  • TIFGAMMA 3
  • KIAA1113 4
  • EC 6.3.2 63
  • ECTO 3
  • PTC7 3
  • TF1G 3

External Ids for TRIM33 Gene

Previous GeneCards Identifiers for TRIM33 Gene

  • GC01M115353
  • GC01M113822
  • GC01M114035
  • GC01M114238
  • GC01M114652
  • GC01M114935
  • GC01M112793

Summaries for TRIM33 Gene

Entrez Gene Summary for TRIM33 Gene

  • The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM33 Gene

TRIM33 (Tripartite Motif Containing 33) is a Protein Coding gene. Diseases associated with TRIM33 include differentiated thyroid carcinoma and endocervicitis. Among its related pathways are Signaling by GPCR and Wnt / Hedgehog / Notch. GO annotations related to this gene include ligase activity and R-SMAD binding. An important paralog of this gene is TRIM28.

UniProtKB/Swiss-Prot for TRIM33 Gene

  • Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Gene Wiki entry for TRIM33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM33 Gene

Genomics for TRIM33 Gene

Regulatory Elements for TRIM33 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM33 Gene

Chromosome:
1
Start:
114,392,777 bp from pter
End:
114,511,160 bp from pter
Size:
118,384 bases
Orientation:
Minus strand

Genomic View for TRIM33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM33 Gene

Proteins for TRIM33 Gene

  • Protein details for TRIM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPN9-TRI33_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM33
    Protein Accession:
    Q9UPN9
    Secondary Accessions:
    • O95855
    • Q5TG72
    • Q5TG73
    • Q5TG74
    • Q9C017
    • Q9UJ79

    Protein attributes for TRIM33 Gene

    Size:
    1127 amino acids
    Molecular mass:
    122533 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling.
    SequenceCaution:
    • Sequence=AAD17259.1; Type=Frameshift; Positions=1114; Evidence={ECO:0000305}; Sequence=BAA83065.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM33 Gene

    Alternative splice isoforms for TRIM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM33 Gene

Proteomics data for TRIM33 Gene at MOPED

Post-translational modifications for TRIM33 Gene

Other Protein References for TRIM33 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM33 (TIF1G)

Domains & Families for TRIM33 Gene

Suggested Antigen Peptide Sequences for TRIM33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPN9

UniProtKB/Swiss-Prot:

TRI33_HUMAN :
  • Contains 1 bromo domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Domain:
  • Contains 1 bromo domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM33: view

Function for TRIM33 Gene

Molecular function for TRIM33 Gene

UniProtKB/Swiss-Prot Function:
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Enzyme Numbers (IUBMB) for TRIM33 Gene

Gene Ontology (GO) - Molecular Function for TRIM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19135894
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM33: view
genes like me logo Genes that share phenotypes with TRIM33: view

Animal Models for TRIM33 Gene

MGI Knock Outs for TRIM33:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM33

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TRIM33 Gene

Localization for TRIM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM33 Gene

Nucleus. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM33 Gene COMPARTMENTS Subcellular localization image for TRIM33 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 3
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TRIM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 19135894
GO:0005654 nucleoplasm TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TRIM33: view

Pathways & Interactions for TRIM33 Gene

genes like me logo Genes that share pathways with TRIM33: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UPN9-TRI33_HUMAN

  • Pathway: Protein modification; protein ubiquitination

SIGNOR curated interactions for TRIM33 Gene

Activates:

Gene Ontology (GO) - Biological Process for TRIM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TRIM33: view

Drugs & Compounds for TRIM33 Gene

(3) Drugs for TRIM33 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for TRIM33 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TRIM33: view

Transcripts for TRIM33 Gene

Unigene Clusters for TRIM33 Gene

Tripartite motif containing 33:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM33

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM33 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for TRIM33 Gene

GeneLoc Exon Structure for
TRIM33
ECgene alternative splicing isoforms for
TRIM33

Expression for TRIM33 Gene

mRNA expression in normal human tissues for TRIM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM33 Gene

This gene is overexpressed in Stomach (9.8) and Bone (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM33 Gene



SOURCE GeneReport for Unigene cluster for TRIM33 Gene Hs.26837

mRNA Expression by UniProt/SwissProt for TRIM33 Gene

Q9UPN9-TRI33_HUMAN
Tissue specificity: Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors
genes like me logo Genes that share expression patterns with TRIM33: view

Protein tissue co-expression partners for TRIM33 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIM33 Gene

Orthologs for TRIM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM33 35
  • 94.86 (n)
  • 97.66 (a)
TRIM33 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM33 35
  • 95.69 (n)
  • 98.78 (a)
TRIM33 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim33 35
  • 91.25 (n)
  • 95.67 (a)
Trim33 16
Trim33 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM33 35
  • 99.7 (n)
  • 99.82 (a)
TRIM33 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim33 35
  • 91.73 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM33 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM33 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM33 35
  • 83.26 (n)
  • 94.59 (a)
TRIM33 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM33 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10011 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32885 35
zebrafish
(Danio rerio)
Actinopterygii trim33 35
  • 64.46 (n)
  • 66.32 (a)
trim33 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1293 35
fruit fly
(Drosophila melanogaster)
Insecta bon 37
  • 30 (a)
mei-P26 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-2 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 36
  • 24 (a)
OneToMany
Species with no ortholog for TRIM33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM33 Gene

ENSEMBL:
Gene Tree for TRIM33 (if available)
TreeFam:
Gene Tree for TRIM33 (if available)

Paralogs for TRIM33 Gene

Paralogs for TRIM33 Gene

(4) SIMAP similar genes for TRIM33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM33: view

Variants for TRIM33 Gene

Sequence variations from dbSNP and Humsavar for TRIM33 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2879 -- 114,392,931(+) TTAAA(A/T)AACCA utr-variant-3-prime
rs1113207 -- 114,490,890(+) GAAGG(C/T)GAAGG intron-variant
rs1125002 -- 114,395,553(-) GTGAG(A/G)AATAG utr-variant-3-prime
rs1146149 -- 114,457,356(-) ggtcc(A/C)aaaat intron-variant
rs2092510 -- 114,448,938(-) gtgtt(C/G)tttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM33 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv831104 CNV Loss 17160897
esv2474891 CNV Deletion 19546169
esv2102268 CNV Deletion 18987734
esv2716485 CNV Deletion 23290073

Variation tolerance for TRIM33 Gene

Residual Variation Intolerance Score: 5.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM33 Gene

HapMap Linkage Disequilibrium report
TRIM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM33 Gene

Disorders for TRIM33 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRIM33 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
endocervicitis
  • endocervicitis unspecified
hymenolepiasis
  • dwarf tapeworm infection
enterobiasis
  • threadworm infection
- elite association

UniProtKB/Swiss-Prot

TRI33_HUMAN
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.

Relevant External Links for TRIM33

Genetic Association Database (GAD)
TRIM33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM33
genes like me logo Genes that share disorders with TRIM33: view

No data available for Genatlas for TRIM33 Gene

Publications for TRIM33 Gene

  1. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PMID: 10022127) Venturini L. … De The H. (Oncogene 1999) 2 23 67
  2. Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. (PMID: 20124515) Randrianarison-Huetz V. … DumAcnil D. (Blood 2010) 23 67
  3. Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. (PMID: 19629168) Vincent D.F. … Bartholin L. (PLoS Genet. 2009) 23 67
  4. Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene. (PMID: 15256250) Yan K.P. … Losson R. (Gene 2004) 23 67
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 67

Products for TRIM33 Gene

Sources for TRIM33 Gene

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