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Aliases for TRIM33 Gene

Aliases for TRIM33 Gene

  • Tripartite Motif Containing 33 2 3
  • TIF1G 3 4 6
  • RFG7 3 4 6
  • Transcriptional Intermediary Factor 1 Gamma 2 3
  • Tripartite Motif-Containing 33 2 3
  • RET-Fused Gene 7 Protein 3 4
  • Ectodermin Homolog 3 4
  • Protein Rfg7 3 4
  • TIF1-Gamma 3 4
  • PTC7 3 6
  • Transcription Intermediary Factor 1-Gamma 4
  • Tripartite Motif-Containing Protein 33 4
  • E3 Ubiquitin-Protein Ligase TRIM33 3
  • Ret-Fused Gene 7 2
  • EC 6.3.2.- 4
  • TIF1GAMMA 3
  • TIFGAMMA 3
  • KIAA1113 4
  • EC 6.3.2 64
  • ECTO 3
  • TF1G 3

External Ids for TRIM33 Gene

Summaries for TRIM33 Gene

Entrez Gene Summary for TRIM33 Gene

  • The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM33 Gene

TRIM33 (Tripartite Motif Containing 33) is a Protein Coding gene. Diseases associated with TRIM33 include thyroid carcinoma, papillary. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity and co-SMAD binding. An important paralog of this gene is TRIM28.

UniProtKB/Swiss-Prot for TRIM33 Gene

  • Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Gene Wiki entry for TRIM33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM33 Gene

Genomics for TRIM33 Gene

Genomic Location for TRIM33 Gene

Start:
114,392,777 bp from pter
End:
114,511,160 bp from pter
Size:
118,384 bases
Orientation:
Minus strand

Genomic View for TRIM33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM33 Gene

Regulatory Elements for TRIM33 Gene

Proteins for TRIM33 Gene

  • Protein details for TRIM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPN9-TRI33_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM33
    Protein Accession:
    Q9UPN9
    Secondary Accessions:
    • O95855
    • Q5TG72
    • Q5TG73
    • Q5TG74
    • Q9C017
    • Q9UJ79

    Protein attributes for TRIM33 Gene

    Size:
    1127 amino acids
    Molecular mass:
    122533 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling.
    SequenceCaution:
    • Sequence=AAD17259.1; Type=Frameshift; Positions=1114; Evidence={ECO:0000305}; Sequence=BAA83065.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM33 Gene

    Alternative splice isoforms for TRIM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM33 Gene

Proteomics data for TRIM33 Gene at MOPED

Post-translational modifications for TRIM33 Gene

Other Protein References for TRIM33 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TRIM33 Gene

Gene Families for TRIM33 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing
  • PHF :Zinc fingers, PHD-type
IUPHAR :

UniProtKB/Swiss-Prot:

TRI33_HUMAN
Domain:
  • Contains 1 bromo domain.:
    • Q9UPN9
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q9UPN9
Similarity:
  • Contains 2 B box-type zinc fingers.:
    • Q9UPN9
  • Contains 1 PHD-type zinc finger.:
    • Q9UPN9
  • Contains 1 RING-type zinc finger.:
    • Q9UPN9
genes like me logo Genes that share domains with TRIM33: view

Function for TRIM33 Gene

Molecular function for TRIM33 Gene

UniProtKB/Swiss-Prot Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Enzyme Numbers (IUBMB) for TRIM33 Gene

Gene Ontology (GO) - Molecular Function for TRIM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19135894
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM33: view
genes like me logo Genes that share phenotypes with TRIM33: view

Animal Models for TRIM33 Gene

MGI Knock Outs for TRIM33:

miRNA for TRIM33 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for TRIM33 Gene

Localization for TRIM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM33 Gene

Nucleus. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM33 Gene COMPARTMENTS Subcellular localization image for TRIM33 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TRIM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 19135894
GO:0005654 nucleoplasm TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TRIM33: view

Pathways for TRIM33 Gene

genes like me logo Genes that share pathways with TRIM33: view

Pathways by source for TRIM33 Gene

UniProtKB/Swiss-Prot Q9UPN9-TRI33_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TRIM33: view

Compounds for TRIM33 Gene

(4) HMDB Compounds for TRIM33 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with TRIM33: view

Transcripts for TRIM33 Gene

Unigene Clusters for TRIM33 Gene

Tripartite motif containing 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM33 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for TRIM33 Gene

GeneLoc Exon Structure for
TRIM33
ECgene alternative splicing isoforms for
TRIM33

Expression for TRIM33 Gene

mRNA expression in normal human tissues for TRIM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM33 Gene

SOURCE GeneReport for Unigene cluster for TRIM33 Gene Hs.26837

mRNA Expression by UniProt/SwissProt for TRIM33 Gene

Q9UPN9-TRI33_HUMAN
Tissue specificity: Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors
genes like me logo Genes that share expressions with TRIM33: view

Orthologs for TRIM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM33 36
  • 99.7 (n)
  • 99.82 (a)
TRIM33 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM33 36
  • 94.86 (n)
  • 97.66 (a)
TRIM33 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM33 36
  • 95.69 (n)
  • 98.78 (a)
TRIM33 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim33 36
  • 91.25 (n)
  • 95.67 (a)
Trim33 16
Trim33 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM33 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM33 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim33 36
  • 91.73 (n)
  • 96.39 (a)
chicken
(Gallus gallus)
Aves TRIM33 36
  • 83.26 (n)
  • 94.59 (a)
TRIM33 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM33 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32885 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10011 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1293 36
zebrafish
(Danio rerio)
Actinopterygii trim33 36
  • 64.46 (n)
  • 66.32 (a)
trim33 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 37
  • 16 (a)
OneToMany
bon 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea nhl-2 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 37
  • 24 (a)
OneToMany
Species with no ortholog for TRIM33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM33 Gene

ENSEMBL:
Gene Tree for TRIM33 (if available)
TreeFam:
Gene Tree for TRIM33 (if available)

Paralogs for TRIM33 Gene

Paralogs for TRIM33 Gene

Selected SIMAP similar genes for TRIM33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM33: view

Variants for TRIM33 Gene

Sequence variations from dbSNP and Humsavar for TRIM33 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2879 -- 114,392,931(+) TTAAA(A/T)AACCA utr-variant-3-prime
rs1113207 -- 114,490,890(+) GAAGG(C/T)GAAGG intron-variant
rs1125002 -- 114,395,553(-) GTGAG(A/G)AATAG utr-variant-3-prime
rs1146149 -- 114,457,356(-) ggtcc(A/C)aaaat intron-variant
rs2092510 -- 114,448,938(-) gtgtt(C/G)tttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM33 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv831104 CNV Loss 17160897
esv2474891 CNV Deletion 19546169
esv2102268 CNV Deletion 18987734
esv2716485 CNV Deletion 23290073

Relevant External Links for TRIM33 Gene

HapMap Linkage Disequilibrium report
TRIM33

Disorders for TRIM33 Gene

(1) OMIM Diseases for TRIM33 Gene (605769)

UniProtKB/Swiss-Prot

TRI33_HUMAN
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.

(1) Novoseek inferred disease relationships for TRIM33 Gene

Disease -log(P) Hits PubMed IDs
tumors 1.28 1

Relevant External Links for TRIM33

Genetic Association Database (GAD)
TRIM33
genes like me logo Genes that share disorders with TRIM33: view

Publications for TRIM33 Gene

  1. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PMID: 10022127) Venturini L. … De The H. (Oncogene 1999) 2 3 4 23
  2. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  3. Hetero-oligomerization among the TIF family of RBCC/TRIM domain- containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. (PMID: 12096914) Peng H. … Rauscher F.J. III (J. Mol. Biol. 2002) 3 4
  4. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. (PMID: 15820681) Dupont S. … Piccolo S. (Cell 2005) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TRIM33 Gene

Sources for TRIM33 Gene

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