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Aliases for UFM1 Gene

Aliases for UFM1 Gene

  • Ubiquitin-Fold Modifier 1 2 3 5
  • C13orf20 3 4
  • Chromosome 13 Open Reading Frame 20 2
  • BM-002 3

External Ids for UFM1 Gene

Previous HGNC Symbols for UFM1 Gene

  • C13orf20

Previous GeneCards Identifiers for UFM1 Gene

  • GC13P037822
  • GC13P038923
  • GC13P019722

Summaries for UFM1 Gene

Entrez Gene Summary for UFM1 Gene

  • UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]

GeneCards Summary for UFM1 Gene

UFM1 (Ubiquitin-Fold Modifier 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UFM1 Gene

  • Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).

Gene Wiki entry for UFM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFM1 Gene

Genomics for UFM1 Gene

Regulatory Elements for UFM1 Gene

Enhancers for UFM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UFM1 on UCSC Golden Path with GeneCards custom track

Promoters for UFM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UFM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UFM1 Gene

Chromosome:
13
Start:
38,349,771 bp from pter
End:
38,363,619 bp from pter
Size:
13,849 bases
Orientation:
Plus strand

Genomic View for UFM1 Gene

Genes around UFM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UFM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UFM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFM1 Gene

Proteins for UFM1 Gene

  • Protein details for UFM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61960-UFM1_HUMAN
    Recommended name:
    Ubiquitin-fold modifier 1
    Protein Accession:
    P61960
    Secondary Accessions:
    • Q14346
    • Q5VXS0
    • Q6IAG6
    • Q9CPX2
    • Q9NZF2

    Protein attributes for UFM1 Gene

    Size:
    85 amino acids
    Molecular mass:
    9118 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UFM1 Gene

    Alternative splice isoforms for UFM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UFM1 Gene

Proteomics data for UFM1 Gene at MOPED

Post-translational modifications for UFM1 Gene

  • Ubiquitination at Lys 19
  • Modification sites at PhosphoSitePlus

Other Protein References for UFM1 Gene

Antibody Products

No data available for DME Specific Peptides for UFM1 Gene

Domains & Families for UFM1 Gene

Protein Domains for UFM1 Gene

Suggested Antigen Peptide Sequences for UFM1 Gene

Graphical View of Domain Structure for InterPro Entry

P61960

UniProtKB/Swiss-Prot:

UFM1_HUMAN :
  • Belongs to the UFM1 family.
Family:
  • Belongs to the UFM1 family.
genes like me logo Genes that share domains with UFM1: view

No data available for Gene Families for UFM1 Gene

Function for UFM1 Gene

Molecular function for UFM1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).
UniProtKB/Swiss-Prot Induction:
Up-regulated by thapsigargin.
genes like me logo Genes that share phenotypes with UFM1: view

Animal Model Products

miRNA for UFM1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UFM1 Gene

Localization for UFM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UFM1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFM1 Gene COMPARTMENTS Subcellular localization image for UFM1 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15071506
genes like me logo Genes that share ontologies with UFM1: view

Pathways & Interactions for UFM1 Gene

SuperPathways for UFM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:0071569 protein ufmylation IDA 15071506
genes like me logo Genes that share ontologies with UFM1: view

No data available for Pathways by source and SIGNOR curated interactions for UFM1 Gene

Drugs & Compounds for UFM1 Gene

No Compound Related Data Available

Transcripts for UFM1 Gene

Unigene Clusters for UFM1 Gene

Ubiquitin-fold modifier 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UFM1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for UFM1 Gene

GeneLoc Exon Structure for
UFM1
ECgene alternative splicing isoforms for
UFM1

Expression for UFM1 Gene

mRNA expression in normal human tissues for UFM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UFM1 Gene

This gene is overexpressed in Oral epithelium (9.2) and Salivary gland (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFM1 Gene



SOURCE GeneReport for Unigene cluster for UFM1 Gene Hs.643655

genes like me logo Genes that share expression patterns with UFM1: view

Protein tissue co-expression partners for UFM1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UFM1 Gene

Orthologs for UFM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UFM1 35
  • 94.51 (n)
  • 98.82 (a)
dog
(Canis familiaris)
Mammalia UFM1 35
  • 96.86 (n)
  • 100 (a)
UFM1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufm1 35
  • 89.8 (n)
  • 100 (a)
Ufm1 16
Ufm1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UFM1 35
  • 100 (n)
  • 100 (a)
UFM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufm1 35
  • 88.63 (n)
  • 98.82 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UFM1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves UFM1 35
  • 84.71 (n)
  • 95.29 (a)
UFM1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UFM1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1490 35
ufm1 35
  • 84.31 (n)
  • 94.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ufm1 35
  • 82.33 (n)
  • 98.8 (a)
ufm1 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta UFM1_ANOGA 35
  • 70.73 (n)
  • 89.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34191 35
  • 69.88 (n)
  • 87.95 (a)
CG34191 36
  • 84 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-277 35
  • 69.11 (n)
  • 90.24 (a)
ufm-1 36
  • 79 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77710 35
  • 69.44 (n)
  • 83.33 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7864 35
rice
(Oryza sativa)
Liliopsida Os.5520 35
Os01g0962400 35
  • 66.27 (n)
  • 82.14 (a)
corn
(Zea mays)
Liliopsida Zm.16801 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5990 36
  • 85 (a)
OneToOne
Species with no ortholog for UFM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UFM1 Gene

ENSEMBL:
Gene Tree for UFM1 (if available)
TreeFam:
Gene Tree for UFM1 (if available)

Paralogs for UFM1 Gene

Pseudogenes.org Pseudogenes for UFM1 Gene

genes like me logo Genes that share paralogs with UFM1: view

No data available for Paralogs for UFM1 Gene

Variants for UFM1 Gene

Sequence variations from dbSNP and Humsavar for UFM1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs11693 -- 38,362,951(+) CATGC(A/G)TTATT nc-transcript-variant, utr-variant-3-prime
rs1011484 -- 38,348,675(+) TCAGT(A/T)GGCTG upstream-variant-2KB
rs1032753 -- 38,347,932(-) TTGTG(A/G)AGGGA upstream-variant-2KB
rs1330959 -- 38,350,749(+) GTAGC(A/G)AAGAA intron-variant
rs1553300 -- 38,349,426(-) GCTTA(A/C)TTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UFM1 Gene

Variant ID Type Subtype PubMed ID
nsv900005 CNV Loss 21882294
nsv900006 CNV Loss 21882294

Variation tolerance for UFM1 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UFM1 Gene

HapMap Linkage Disequilibrium report
UFM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFM1 Gene

Disorders for UFM1 Gene

Relevant External Links for UFM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UFM1

No disorders were found for UFM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UFM1 Gene

Publications for UFM1 Gene

  1. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M. … Tanaka K. (EMBO J. 2004) 2 3 4 67
  2. Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. (PMID: 16527251) Sasakawa H. … Kato K. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1). (PMID: 24726913) Homrich M. … Diestel S. (Exp. Cell Res. 2014) 3

Products for UFM1 Gene

Sources for UFM1 Gene

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