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Aliases for ARMCX3 Gene

Aliases for ARMCX3 Gene

  • Armadillo Repeat Containing, X-Linked 3 2 3 5
  • ARM Protein Lost In Epithelial Cancers On Chromosome X 3 3 4
  • ALEX3 3 4
  • Arm Protein Lost In Epithelial Cancers, X Chromosome, 3 3
  • Armadillo Repeat-Containing X-Linked Protein 3 3
  • 1200004E24Rik 3
  • Protein ALEX3 4
  • DJ545K15.2 3
  • GASP6 3

External Ids for ARMCX3 Gene

Previous GeneCards Identifiers for ARMCX3 Gene

  • GC0XP099650
  • GC0XP100684
  • GC0XP100764
  • GC0XP100878
  • GC0XP090685

Summaries for ARMCX3 Gene

Entrez Gene Summary for ARMCX3 Gene

  • This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARMCX3 Gene

ARMCX3 (Armadillo Repeat Containing, X-Linked 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is ARMCX1.

UniProtKB/Swiss-Prot for ARMCX3 Gene

  • Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.

Gene Wiki entry for ARMCX3 Gene

Additional gene information for ARMCX3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX3 Gene

Genomics for ARMCX3 Gene

GeneHancer (GH) Regulatory Elements for ARMCX3 Gene

Promoters and enhancers for ARMCX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI101622 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.6 554 2.6 ATF1 ZNF133 SIN3A ZNF335 ZNF213 ZNF366 ATF7 IKZF2 CREM EGR2 ARMCX3 ARMCX3-AS1 BEX5 ARMCX6
GH0XI101658 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 15.6 +36.5 36503 2.3 MEIS2 PKNOX1 KLF1 USF1 ZBTB21 MAX SIN3A ZNF76 YY1 ZNF366 ARMCX2 ARMCX3 RNU6-30P RNU6-587P BEX5 GC0XP101635
GH0XI101619 Enhancer 1 FANTOM5 Ensembl ENCODE 19.2 -3.4 -3358 0.7 SIX4 PKNOX1 MAZ GLIS2 VEZF1 JUN ATF7 ARMCX6 ARMCX3 BTK
GH0XI101616 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 9.2 -5.1 -5121 1.8 ATF1 DMAP1 RAD21 YY1 CREM EGR2 ZBTB11 USF2 REST KAT8 ARMCX6 ARL13A ARMCX3 GC0XM101605
GH0XI101383 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 5.1 -237.4 -237447 3.6 HDGF HDAC1 PKNOX1 SMAD1 ZNF473 NFRKB IRF4 POLR2B EGR1 ETV6 BTK ARMCX4 ARL13A GLA BEX5 ARMCX3 TIMM8A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARMCX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARMCX3 gene promoter:

Genomic Locations for ARMCX3 Gene

Genomic Locations for ARMCX3 Gene
chrX:101,622,797-101,627,843
(GRCh38/hg38)
Size:
5,047 bases
Orientation:
Plus strand
chrX:100,877,787-100,882,833
(GRCh37/hg19)

Genomic View for ARMCX3 Gene

Genes around ARMCX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMCX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMCX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX3 Gene

Proteins for ARMCX3 Gene

  • Protein details for ARMCX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UH62-ARMX3_HUMAN
    Recommended name:
    Armadillo repeat-containing X-linked protein 3
    Protein Accession:
    Q9UH62
    Secondary Accessions:
    • Q53HC6
    • Q7LCF5
    • Q9NPE4

    Protein attributes for ARMCX3 Gene

    Size:
    379 amino acids
    Molecular mass:
    42501 Da
    Quaternary structure:
    • Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent. Interacts with SOX10.

neXtProt entry for ARMCX3 Gene

Post-translational modifications for ARMCX3 Gene

  • Ubiquitination at Lys170 and Lys182

Other Protein References for ARMCX3 Gene

No data available for DME Specific Peptides for ARMCX3 Gene

Domains & Families for ARMCX3 Gene

Gene Families for ARMCX3 Gene

Protein Domains for ARMCX3 Gene

Suggested Antigen Peptide Sequences for ARMCX3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UH62

UniProtKB/Swiss-Prot:

ARMX3_HUMAN :
  • Belongs to the eutherian X-chromosome-specific Armcx family.
Family:
  • Belongs to the eutherian X-chromosome-specific Armcx family.
genes like me logo Genes that share domains with ARMCX3: view

Function for ARMCX3 Gene

Molecular function for ARMCX3 Gene

UniProtKB/Swiss-Prot Function:
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.

Phenotypes for ARMCX3 Gene

genes like me logo Genes that share phenotypes with ARMCX3: view

Animal Model Products

CRISPR Products

miRNA for ARMCX3 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMCX3 Gene

Localization for ARMCX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX3 Gene

Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMCX3 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARMCX3: view

Pathways & Interactions for ARMCX3 Gene

SuperPathways for ARMCX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034613 cellular protein localization IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ARMCX3: view

No data available for Pathways by source and SIGNOR curated interactions for ARMCX3 Gene

Drugs & Compounds for ARMCX3 Gene

No Compound Related Data Available

Transcripts for ARMCX3 Gene

Unigene Clusters for ARMCX3 Gene

Armadillo repeat containing, X-linked 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: - -
SP8:
SP9:

Relevant External Links for ARMCX3 Gene

GeneLoc Exon Structure for
ARMCX3
ECgene alternative splicing isoforms for
ARMCX3

Expression for ARMCX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMCX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMCX3 Gene

This gene is overexpressed in Bone (33.1) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARMCX3 Gene



Protein tissue co-expression partners for ARMCX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMCX3 Gene:

ARMCX3

SOURCE GeneReport for Unigene cluster for ARMCX3 Gene:

Hs.592225

Evidence on tissue expression from TISSUES for ARMCX3 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
  • Liver(4.3)
  • Bone marrow(4.2)
  • Eye(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ARMCX3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMCX3 Gene

Orthologs for ARMCX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMCX3 33 34
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia ARMCX3 33 34
  • 93.32 (n)
dog
(Canis familiaris)
Mammalia ARMCX3 33 34
  • 93.32 (n)
rat
(Rattus norvegicus)
Mammalia Armcx3 33
  • 90.24 (n)
mouse
(Mus musculus)
Mammalia Armcx3 33 16 34
  • 90.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 34
  • 30 (a)
OneToMany
Species where no ortholog for ARMCX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX3 Gene

ENSEMBL:
Gene Tree for ARMCX3 (if available)
TreeFam:
Gene Tree for ARMCX3 (if available)

Paralogs for ARMCX3 Gene

Paralogs for ARMCX3 Gene

(7) SIMAP similar genes for ARMCX3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARMCX3: view

Variants for ARMCX3 Gene

Sequence variations from dbSNP and Humsavar for ARMCX3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000301038 -- 101,624,715(+) A/G intron_variant
rs1000578063 -- 101,623,053(+) G/A upstream_transcript_variant
rs1000630204 -- 101,622,703(+) G/T upstream_transcript_variant
rs1001870399 -- 101,624,131(+) C/G intron_variant
rs1003142103 -- 101,622,066(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMCX3 Gene

Variant ID Type Subtype PubMed ID
nsv207 OTHER inversion 15895083
nsv522728 CNV gain 19592680
nsv524711 CNV gain 19592680
nsv7452 OTHER inversion 18451855

Variation tolerance for ARMCX3 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMCX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMCX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMCX3 Gene

Disorders for ARMCX3 Gene

Additional Disease Information for ARMCX3

No disorders were found for ARMCX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMCX3 Gene

Publications for ARMCX3 Gene

  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PMID: 11162520) Kurochkin IV … Nomura H (Biochemical and biophysical research communications 2001) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PMID: 22569362) López-Doménech G … Soriano E (Nature communications 2012) 2 3 58
  4. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. (PMID: 19304657) Mou Z … Gardner PD (The Journal of biological chemistry 2009) 2 3 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for ARMCX3 Gene

Sources for ARMCX3 Gene

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