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Aliases for ARMCX3 Gene

Aliases for ARMCX3 Gene

  • Armadillo Repeat Containing, X-Linked 3 2 3
  • ALEX3 3 4 6
  • ARM Protein Lost In Epithelial Cancers On Chromosome X 3 3 4
  • Arm Protein Lost In Epithelial Cancers, X Chromosome, 3 3
  • Armadillo Repeat-Containing X-Linked Protein 3 3
  • 1200004E24Rik 3
  • Protein ALEX3 4
  • DJ545K15.2 3
  • GASP6 3

External Ids for ARMCX3 Gene

Previous GeneCards Identifiers for ARMCX3 Gene

  • GC0XP099650
  • GC0XP100684
  • GC0XP100764
  • GC0XP100878
  • GC0XP090685

Summaries for ARMCX3 Gene

Entrez Gene Summary for ARMCX3 Gene

  • This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARMCX3 Gene

ARMCX3 (Armadillo Repeat Containing, X-Linked 3) is a Protein Coding gene. An important paralog of this gene is ARMCX6.

Gene Wiki entry for ARMCX3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX3 Gene

Genomics for ARMCX3 Gene

Regulatory Elements for ARMCX3 Gene

Genomic Location for ARMCX3 Gene

101,622,797 bp from pter
101,627,843 bp from pter
5,047 bases
Plus strand

Genomic View for ARMCX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARMCX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX3 Gene

Proteins for ARMCX3 Gene

  • Protein details for ARMCX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing X-linked protein 3
    Protein Accession:
    Secondary Accessions:
    • Q53HC6
    • Q7LCF5
    • Q9NPE4

    Protein attributes for ARMCX3 Gene

    379 amino acids
    Molecular mass:
    42501 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARMCX3 Gene

Proteomics data for ARMCX3 Gene at MOPED

Post-translational modifications for ARMCX3 Gene

  • Ubiquitination at Lys170 and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for ARMCX3 Gene

Antibody Products

No data available for DME Specific Peptides for ARMCX3 Gene

Domains for ARMCX3 Gene

Gene Families for ARMCX3 Gene

  • ARMC :Armadillo repeat containing

Protein Domains for ARMCX3 Gene

Suggested Antigen Peptide Sequences for ARMCX3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UH62
  • Contains 3 ARM repeats.
genes like me logo Genes that share domains with ARMCX3: view

Function for ARMCX3 Gene

Gene Ontology (GO) - Molecular Function for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARMCX3: view

Animal Model Products

miRNA for ARMCX3 Gene

miRTarBase miRNAs that target ARMCX3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARMCX3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARMCX3 Gene

Localization for ARMCX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ARMCX3 Gene COMPARTMENTS Subcellular localization image for ARMCX3 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031307 integral component of mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with ARMCX3: view

Pathways for ARMCX3 Gene

SuperPathways for ARMCX3 Gene

No Data Available

Interacting Proteins for ARMCX3 Gene

Gene Ontology (GO) - Biological Process for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034613 cellular protein localization IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARMCX3: view

No data available for Pathways by source for ARMCX3 Gene

Transcripts for ARMCX3 Gene

Unigene Clusters for ARMCX3 Gene

Armadillo repeat containing, X-linked 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARMCX3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: - -

Relevant External Links for ARMCX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMCX3 Gene

mRNA expression in normal human tissues for ARMCX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ARMCX3 Gene

This gene is overexpressed in Bone (33.1) and Adrenal (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARMCX3 Gene

SOURCE GeneReport for Unigene cluster for ARMCX3 Gene Hs.592225

genes like me logo Genes that share expressions with ARMCX3: view

Expression partners for ARMCX3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARMCX3 Gene

Orthologs for ARMCX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARMCX3 35
  • 93.32 (n)
  • 95.25 (a)
  • 95 (a)
(Canis familiaris)
Mammalia ARMCX3 35
  • 93.32 (n)
  • 94.72 (a)
  • 95 (a)
(Mus musculus)
Mammalia Armcx3 35
  • 90.15 (n)
  • 96.57 (a)
Armcx3 16
Armcx3 36
  • 97 (a)
(Pan troglodytes)
Mammalia ARMCX3 35
  • 99.91 (n)
  • 99.74 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Armcx3 35
  • 90.24 (n)
  • 95.25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
(Gallus gallus)
Aves -- 36
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
(Danio rerio)
Actinopterygii ARMCX3 36
  • 30 (a)
Species with no ortholog for ARMCX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX3 Gene

Gene Tree for ARMCX3 (if available)
Gene Tree for ARMCX3 (if available)

Paralogs for ARMCX3 Gene

Paralogs for ARMCX3 Gene

Selected SIMAP similar genes for ARMCX3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARMCX3: view

Variants for ARMCX3 Gene

Sequence variations from dbSNP and Humsavar for ARMCX3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6995 -- 101,626,444(+) TGTGT(A/G)TCATC utr-variant-3-prime
rs1058663 -- 101,626,485(+) AAAAA(A/G)AAGAA utr-variant-3-prime
rs1058664 -- 101,626,496(+) AGAAA(A/G)AAACC utr-variant-3-prime
rs1058670 -- 101,627,506(+) AAAAA(A/G)AAAAG utr-variant-3-prime
rs1058683 -- 101,627,715(+) CGAGC(A/C)CCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARMCX3 Gene

Variant ID Type Subtype PubMed ID
nsv7452 OTHER Inversion 18451855
nsv524711 CNV Gain 19592680
nsv522728 CNV Gain 19592680
nsv207 OTHER Inversion 15895083

Relevant External Links for ARMCX3 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMCX3 Gene

Disorders for ARMCX3 Gene

No disorders were found for ARMCX3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARMCX3 Gene

Publications for ARMCX3 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PMID: 11162520) Kurochkin I.V. … Nomura H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for ARMCX3 Gene

Sources for ARMCX3 Gene

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