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Aliases for ARMCX3 Gene

Aliases for ARMCX3 Gene

  • Armadillo Repeat Containing, X-Linked 3 2 3 5
  • ARM Protein Lost In Epithelial Cancers On Chromosome X 3 3 4
  • ALEX3 3 4
  • Arm Protein Lost In Epithelial Cancers, X Chromosome, 3 3
  • Armadillo Repeat-Containing X-Linked Protein 3 3
  • 1200004E24Rik 3
  • Protein ALEX3 4
  • DJ545K15.2 3
  • GASP6 3

External Ids for ARMCX3 Gene

Previous GeneCards Identifiers for ARMCX3 Gene

  • GC0XP099650
  • GC0XP100684
  • GC0XP100764
  • GC0XP100878
  • GC0XP090685

Summaries for ARMCX3 Gene

Entrez Gene Summary for ARMCX3 Gene

  • This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARMCX3 Gene

ARMCX3 (Armadillo Repeat Containing, X-Linked 3) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ARMCX1.

Gene Wiki entry for ARMCX3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX3 Gene

Genomics for ARMCX3 Gene

Regulatory Elements for ARMCX3 Gene

Enhancers for ARMCX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG101619 1.2 FANTOM5 Ensembl ENCODE 19.1 -3.4 -3358 0.7 SIX4 PKNOX1 MAZ JUN ZBTB7A JUND GLIS2 CEBPA TRIM28 ARMCX3 BTK ARMCX6
GH0XG101658 0.8 ENCODE 15.6 +36.5 36504 2.3 TBP PKNOX1 KLF1 FOXA2 USF1 ZBTB21 ZSCAN4 SIN3A MAX ZNF76 ARMCX3 RNU6-30P RNU6-587P BEX5 ARMCX2 GC0XP101635
GH0XG101799 0.9 Ensembl ENCODE 11.6 +176.7 176732 0.3 CTCF MAZ ZNF654 PKNOX1 TRIM22 RAD21 ZBTB40 ZNF518A GABPA PBX2 ARMCX2 ARMCX6 ARMCX3-AS1 ARMCX3 GK4P NXF5
GH0XG101616 0.9 ENCODE 9.2 -5.1 -5122 1.8 ATF1 CREB3L1 DMAP1 RAD21 YY1 KLF13 CREM EGR2 ZHX2 USF2 ARMCX3 ARMCX6 GC0XM101605
GH0XG101383 1.2 FANTOM5 ENCODE 5.1 -237.4 -237447 3.6 HDAC1 HDGF TBP PKNOX1 CBX3 TBL1XR1 ZNF473 NFRKB EGR1 ETV6 ARMCX4 GLA BTK BEX5 ARMCX3 TIMM8A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARMCX3 on UCSC Golden Path with GeneCards custom track

Promoters for ARMCX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247643 903 1801 ATF1 ZNF133 SIN3A ZNF766 ZNF366 IKZF2 CREM EGR2 SP3 SMAD5

Genomic Location for ARMCX3 Gene

Chromosome:
X
Start:
101,622,797 bp from pter
End:
101,627,843 bp from pter
Size:
5,047 bases
Orientation:
Plus strand

Genomic View for ARMCX3 Gene

Genes around ARMCX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMCX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMCX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX3 Gene

Proteins for ARMCX3 Gene

  • Protein details for ARMCX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UH62-ARMX3_HUMAN
    Recommended name:
    Armadillo repeat-containing X-linked protein 3
    Protein Accession:
    Q9UH62
    Secondary Accessions:
    • Q53HC6
    • Q7LCF5
    • Q9NPE4

    Protein attributes for ARMCX3 Gene

    Size:
    379 amino acids
    Molecular mass:
    42501 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARMCX3 Gene

Post-translational modifications for ARMCX3 Gene

  • Ubiquitination at posLast=170170 and posLast=182182
  • Modification sites at PhosphoSitePlus

Other Protein References for ARMCX3 Gene

Antibody Products

  • Abcam antibodies for ARMCX3

No data available for DME Specific Peptides for ARMCX3 Gene

Domains & Families for ARMCX3 Gene

Gene Families for ARMCX3 Gene

Protein Domains for ARMCX3 Gene

Suggested Antigen Peptide Sequences for ARMCX3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMCX3: view

No data available for UniProtKB/Swiss-Prot for ARMCX3 Gene

Function for ARMCX3 Gene

Phenotypes for ARMCX3 Gene

genes like me logo Genes that share phenotypes with ARMCX3: view

Animal Model Products

CRISPR Products

miRNA for ARMCX3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMCX3 Gene

Localization for ARMCX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMCX3 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with ARMCX3: view

Pathways & Interactions for ARMCX3 Gene

SuperPathways for ARMCX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMCX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034613 cellular protein localization IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARMCX3: view

No data available for Pathways by source and SIGNOR curated interactions for ARMCX3 Gene

Transcripts for ARMCX3 Gene

Unigene Clusters for ARMCX3 Gene

Armadillo repeat containing, X-linked 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: - -
SP8:
SP9:

Relevant External Links for ARMCX3 Gene

GeneLoc Exon Structure for
ARMCX3
ECgene alternative splicing isoforms for
ARMCX3

Expression for ARMCX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMCX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMCX3 Gene

This gene is overexpressed in Bone (33.1) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARMCX3 Gene



Protein tissue co-expression partners for ARMCX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMCX3 Gene:

ARMCX3

SOURCE GeneReport for Unigene cluster for ARMCX3 Gene:

Hs.592225

Evidence on tissue expression from TISSUES for ARMCX3 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
  • Liver(4.3)
  • Bone marrow(4.2)
  • Eye(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ARMCX3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMCX3 Gene

Orthologs for ARMCX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMCX3 34 35
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia ARMCX3 34 35
  • 93.32 (n)
dog
(Canis familiaris)
Mammalia ARMCX3 34 35
  • 93.32 (n)
rat
(Rattus norvegicus)
Mammalia Armcx3 34
  • 90.24 (n)
mouse
(Mus musculus)
Mammalia Armcx3 34 16 35
  • 90.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 35
  • 30 (a)
OneToMany
Species where no ortholog for ARMCX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX3 Gene

ENSEMBL:
Gene Tree for ARMCX3 (if available)
TreeFam:
Gene Tree for ARMCX3 (if available)

Paralogs for ARMCX3 Gene

Paralogs for ARMCX3 Gene

(7) SIMAP similar genes for ARMCX3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARMCX3: view

Variants for ARMCX3 Gene

Sequence variations from dbSNP and Humsavar for ARMCX3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000301038 -- 101,624,715(+) TCAAC(A/G)ATCTA intron-variant
rs1000578063 -- 101,623,053(+) AGGGG(A/G)GCGGG upstream-variant-2KB
rs1000630204 -- 101,622,703(+) CTGGG(G/T)GTGGG upstream-variant-2KB
rs1001870399 -- 101,624,131(+) ACTCT(C/G)CATGT intron-variant
rs1003142103 -- 101,622,066(+) AGGGG(A/G)TGTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARMCX3 Gene

Variant ID Type Subtype PubMed ID
nsv207 OTHER inversion 15895083
nsv522728 CNV gain 19592680
nsv524711 CNV gain 19592680
nsv7452 OTHER inversion 18451855

Variation tolerance for ARMCX3 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMCX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMCX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMCX3 Gene

Disorders for ARMCX3 Gene

Relevant External Links for ARMCX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARMCX3

No disorders were found for ARMCX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMCX3 Gene

Publications for ARMCX3 Gene

  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PMID: 11162520) Kurochkin I.V. … Nomura H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PMID: 22569362) LA^pez-DomAcnech G. … Soriano E. (Nat Commun 2012) 2 3 64
  4. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. (PMID: 19304657) Mou Z. … Gardner P.D. (J. Biol. Chem. 2009) 2 3 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for ARMCX3 Gene

Sources for ARMCX3 Gene

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