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Aliases for HDAC7 Gene

Aliases for HDAC7 Gene

  • Histone Deacetylase 7 2 3 5
  • Histone Deacetylase 7A 2 3 4
  • EC 3.5.1.98 4 63
  • HDAC7A 3 4
  • HD7A 3 4
  • HD7 3 4

External Ids for HDAC7 Gene

Previous HGNC Symbols for HDAC7 Gene

  • HDAC7A

Previous GeneCards Identifiers for HDAC7 Gene

  • GC12M046463
  • GC12M048176
  • GC12M045207

Summaries for HDAC7 Gene

Entrez Gene Summary for HDAC7 Gene

  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HDAC7 Gene

HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is HDAC10.

UniProtKB/Swiss-Prot for HDAC7 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Tocris Summary for HDAC7 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC7 Gene

Genomics for HDAC7 Gene

Regulatory Elements for HDAC7 Gene

Genomic Location for HDAC7 Gene

Chromosome:
12
Start:
47,782,722 bp from pter
End:
47,833,132 bp from pter
Size:
50,411 bases
Orientation:
Minus strand

Genomic View for HDAC7 Gene

Genes around HDAC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC7 Gene

Proteins for HDAC7 Gene

  • Protein details for HDAC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUI4-HDAC7_HUMAN
    Recommended name:
    Histone deacetylase 7
    Protein Accession:
    Q8WUI4
    Secondary Accessions:
    • B3KY08
    • B4DWI0
    • B4E0Q5
    • Q6P1W9
    • Q6W9G7
    • Q7Z4K2
    • Q7Z5I1
    • Q96K01
    • Q9BR73
    • Q9H7L0
    • Q9NW41
    • Q9NWA9
    • Q9NYK9
    • Q9UFU7

    Protein attributes for HDAC7 Gene

    Size:
    952 amino acids
    Molecular mass:
    102927 Da
    Quaternary structure:
    • Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15 (By similarity). Interacts with PML (isoform PML-4). Interacts with FOXP3.
    Miscellaneous:
    • Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor.
    SequenceCaution:
    • Sequence=AAF63491.1; Type=Frameshift; Positions=877; Evidence={ECO:0000305}; Sequence=BAA91474.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91545.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15759.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55363.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC56929.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDAC7 Gene

    Alternative splice isoforms for HDAC7 Gene

neXtProt entry for HDAC7 Gene

Proteomics data for HDAC7 Gene at MOPED

Post-translational modifications for HDAC7 Gene

  • May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HDAC7 (HDAC7)

Domains & Families for HDAC7 Gene

Gene Families for HDAC7 Gene

Suggested Antigen Peptide Sequences for HDAC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUI4

UniProtKB/Swiss-Prot:

HDAC7_HUMAN :
  • The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Domain:
  • The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC7: view

Function for HDAC7 Gene

Molecular function for HDAC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Enzyme Numbers (IUBMB) for HDAC7 Gene

Gene Ontology (GO) - Molecular Function for HDAC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA --
genes like me logo Genes that share ontologies with HDAC7: view
genes like me logo Genes that share phenotypes with HDAC7: view

Animal Models for HDAC7 Gene

MGI Knock Outs for HDAC7:

Animal Model Products

miRNA for HDAC7 Gene

miRTarBase miRNAs that target HDAC7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC7 Gene

Localization for HDAC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC7 Gene

Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC7 Gene COMPARTMENTS Subcellular localization image for HDAC7 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HDAC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16980613
genes like me logo Genes that share ontologies with HDAC7: view

Pathways & Interactions for HDAC7 Gene

genes like me logo Genes that share pathways with HDAC7: view

SIGNOR curated interactions for HDAC7 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HDAC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007043 cell-cell junction assembly IEA --
GO:0007219 Notch signaling pathway TAS --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with HDAC7: view

Drugs & Compounds for HDAC7 Gene

(25) Drugs for HDAC7 Gene - From: DGIdb, Tocris, ApexBio, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Belinostat Approved, Investigational Pharma Inhibitor Histone deacetylase (HDAC)inhibitors 41
Valproic Acid Approved, Investigational Pharma inhibitor HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 311
Vorinostat Approved, Investigational Pharma inhibitor HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 238
7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide Experimental Pharma Target 0
MGCD-0103 Investigational Pharma inhibitor 0

(2) Additional Compounds for HDAC7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NSC 3852
3565-26-2
Sodium 4-Phenylbutyrate
1716-12-7
genes like me logo Genes that share compounds with HDAC7: view

Transcripts for HDAC7 Gene

Unigene Clusters for HDAC7 Gene

Histone deacetylase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a ·
SP1: -
SP2: - - - - - -
SP3: - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: - -
SP15: - - - - - - - - -
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 33b ^ 34a · 34b · 34c · 34d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for HDAC7 Gene

GeneLoc Exon Structure for
HDAC7
ECgene alternative splicing isoforms for
HDAC7

Expression for HDAC7 Gene

mRNA expression in normal human tissues for HDAC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HDAC7 Gene

This gene is overexpressed in Prostate (39.9) and Urinary Bladder (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDAC7 Gene



SOURCE GeneReport for Unigene cluster for HDAC7 Gene Hs.200063

genes like me logo Genes that share expression patterns with HDAC7: view

Protein tissue co-expression partners for HDAC7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDAC7 Gene

Orthologs for HDAC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC7 35
  • 99.56 (n)
  • 99.39 (a)
HDAC7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC7 36
  • 91 (a)
OneToOne
HDAC7 35
  • 90.2 (n)
  • 92.14 (a)
dog
(Canis familiaris)
Mammalia HDAC7 35
  • 90.12 (n)
  • 93.54 (a)
HDAC7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac7 16
Hdac7 35
  • 87.08 (n)
  • 90.31 (a)
Hdac7 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC7 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdac7 35
  • 86.96 (n)
  • 89.59 (a)
chicken
(Gallus gallus)
Aves HDAC7 36
  • 66 (a)
OneToOne
HDAC7 35
  • 70.04 (n)
  • 69.16 (a)
lizard
(Anolis carolinensis)
Reptilia HDAC7 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac7 35
  • 63.57 (n)
  • 61.61 (a)
zebrafish
(Danio rerio)
Actinopterygii HDAC7 36
  • 40 (a)
OneToOne
LOC798603 35
  • 67.94 (n)
  • 66.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta HDAC4 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hda-4 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
CSA.5129 36
  • 21 (a)
ManyToMany
Species with no ortholog for HDAC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC7 Gene

ENSEMBL:
Gene Tree for HDAC7 (if available)
TreeFam:
Gene Tree for HDAC7 (if available)

Paralogs for HDAC7 Gene

Paralogs for HDAC7 Gene

genes like me logo Genes that share paralogs with HDAC7: view

Variants for HDAC7 Gene

Sequence variations from dbSNP and Humsavar for HDAC7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036043 A breast cancer sample
rs13632 -- 47,783,455(-) CAGCC(C/T)CAGGC utr-variant-3-prime
rs757344 -- 47,812,313(-) AAACC(A/G)GGCCA intron-variant
rs875023 -- 47,800,652(-) TGGAA(A/G)GACTG intron-variant
rs1006476 -- 47,785,564(+) ACAAG(C/T)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC7 Gene

Variant ID Type Subtype PubMed ID
nsv470289 CNV Gain 18288195
dgv94n21 CNV Loss 19592680
nsv899059 CNV Loss 21882294
nsv899060 CNV Loss 21882294
esv999028 CNV Deletion 20482838

Variation tolerance for HDAC7 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HDAC7 Gene

HapMap Linkage Disequilibrium report
HDAC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC7 Gene

Disorders for HDAC7 Gene

Relevant External Links for HDAC7

Genetic Association Database (GAD)
HDAC7
Human Genome Epidemiology (HuGE) Navigator
HDAC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HDAC7

No disorders were found for HDAC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDAC7 Gene

Publications for HDAC7 Gene

  1. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (PMID: 11466315) Fischle W. … Verdin E. (J. Biol. Chem. 2001) 3 4 23 67
  2. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. (PMID: 20224040) Margariti A. … Zeng L. (Circ. Res. 2010) 3 23
  3. Novel structural insights into class I and II histone deacetylases. (PMID: 19355988) Ficner R. (Curr Top Med Chem 2009) 3 23
  4. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. (PMID: 18509061) Wang S. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  5. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. (PMID: 18458084) Scott F.L. … Salvesen G.S. (J. Biol. Chem. 2008) 3 23

Products for HDAC7 Gene

Sources for HDAC7 Gene

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