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Aliases for IL23A Gene

Aliases for IL23A Gene

  • Interleukin 23 Subunit Alpha 2 3 5
  • Interleukin 23, Alpha Subunit P19 2 3
  • Interleukin-23 Subunit P19 3 4
  • IL-23 Subunit Alpha 3 4
  • IL-23p19 3 4
  • IL-23-A 3 4
  • SGRF 3 4
  • Interleukin-Six, G-CSF Related Factor 3
  • JKA3 Induced Upon T-Cell Activation 3
  • Interleukin 23 P19 Subunit 3
  • G-CSF Related Factor 2
  • Interleukin-Six 2
  • IL23P19 3
  • IL-23A 3
  • IL-23 3
  • P19 3

External Ids for IL23A Gene

Previous GeneCards Identifiers for IL23A Gene

  • GC12M056592
  • GC12P056443
  • GC12P055019
  • GC12P055020
  • GC12P055021
  • GC12P056732
  • GC12P053771

Summaries for IL23A Gene

Entrez Gene Summary for IL23A Gene

  • This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL23A Gene

IL23A (Interleukin 23 Subunit Alpha) is a Protein Coding gene. Diseases associated with IL23A include rheumatoid arthritis and multiple sclerosis, disease progression, modifier of. Among its related pathways are PEDF Induced Signaling and Allograft rejection. GO annotations related to this gene include cytokine activity and interleukin-23 receptor binding.

UniProtKB/Swiss-Prot for IL23A Gene

  • Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene Wiki entry for IL23A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL23A Gene

Genomics for IL23A Gene

Regulatory Elements for IL23A Gene

Enhancers for IL23A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL23A on UCSC Golden Path with GeneCards custom track

Promoters for IL23A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL23A on UCSC Golden Path with GeneCards custom track

Genomic Location for IL23A Gene

Chromosome:
12
Start:
56,334,158 bp from pter
End:
56,340,410 bp from pter
Size:
6,253 bases
Orientation:
Plus strand

Genomic View for IL23A Gene

Genes around IL23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL23A Gene

Proteins for IL23A Gene

  • Protein details for IL23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPF7-IL23A_HUMAN
    Recommended name:
    Interleukin-23 subunit alpha
    Protein Accession:
    Q9NPF7
    Secondary Accessions:
    • Q6NZ80
    • Q6NZ82
    • Q9H2A5

    Protein attributes for IL23A Gene

    Size:
    189 amino acids
    Molecular mass:
    20730 Da
    Quaternary structure:
    • Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

    Three dimensional structures from OCA and Proteopedia for IL23A Gene

neXtProt entry for IL23A Gene

Proteomics data for IL23A Gene at MOPED

Post-translational modifications for IL23A Gene

No Post-translational modifications

Other Protein References for IL23A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL23A Gene

Domains & Families for IL23A Gene

Gene Families for IL23A Gene

Protein Domains for IL23A Gene

Suggested Antigen Peptide Sequences for IL23A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPF7

UniProtKB/Swiss-Prot:

IL23A_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL23A: view

Function for IL23A Gene

Molecular function for IL23A Gene

UniProtKB/Swiss-Prot Function:
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.
genes like me logo Genes that share phenotypes with IL23A: view

Animal Models for IL23A Gene

MGI Knock Outs for IL23A:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL23A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL23A Gene

Localization for IL23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL23A Gene

Secreted. Note=Secreted upon association with IL12B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL23A Gene COMPARTMENTS Subcellular localization image for IL23A gene
Compartment Confidence
extracellular 5
cytosol 2
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IL23A Gene

Pathways & Interactions for IL23A Gene

genes like me logo Genes that share pathways with IL23A: view

SIGNOR curated interactions for IL23A Gene

Activates:

Gene Ontology (GO) - Biological Process for IL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002230 positive regulation of defense response to virus by host IEA,ISS --
GO:0002827 positive regulation of T-helper 1 type immune response IEA,TAS 16751425
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with IL23A: view

Drugs & Compounds for IL23A Gene

(6) Drugs for IL23A Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ustekinumab Approved, Investigational Pharma antibody 77
ABT-874 Investigational Pharma Target 0
BRIAKINUMAB Pharma 0
CNTO 1275 Pharma 0

(4) Additional Compounds for IL23A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL23A: view

Transcripts for IL23A Gene

Unigene Clusters for IL23A Gene

Interleukin 23, alpha subunit p19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL23A Gene

No ASD Table

Relevant External Links for IL23A Gene

GeneLoc Exon Structure for
IL23A
ECgene alternative splicing isoforms for
IL23A

Expression for IL23A Gene

mRNA expression in normal human tissues for IL23A Gene

mRNA differential expression in normal tissues according to GTEx for IL23A Gene

This gene is overexpressed in Testis (x10.4).

SOURCE GeneReport for Unigene cluster for IL23A Gene Hs.98309

mRNA Expression by UniProt/SwissProt for IL23A Gene

Q9NPF7-IL23A_HUMAN
Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
genes like me logo Genes that share expression patterns with IL23A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL23A Gene

Orthologs for IL23A Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL23A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL23A 35
  • 86.77 (n)
  • 82.54 (a)
IL23A 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL23A 35
  • 88.36 (n)
  • 88.89 (a)
IL23A 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il23a 35
  • 82.09 (n)
  • 75 (a)
Il23a 16
Il23a 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL23A 35
  • 100 (n)
  • 100 (a)
IL23A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il23a 35
  • 84.57 (n)
  • 79.79 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia IL23A 36
  • 46 (a)
OneToOne
Species with no ortholog for IL23A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL23A Gene

ENSEMBL:
Gene Tree for IL23A (if available)
TreeFam:
Gene Tree for IL23A (if available)

Paralogs for IL23A Gene

No data available for Paralogs for IL23A Gene

Variants for IL23A Gene

Sequence variations from dbSNP and Humsavar for IL23A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12816666 -- 56,336,266(+) tcaag(A/G)ccagc intron-variant
rs7308517 -- 56,336,848(+) GTTCC(A/T)GCCAC intron-variant
rs13378047 -- 56,340,174(+) CCCCA(A/G/T)GCACC utr-variant-3-prime
rs79813541 -- 56,337,913(+) AACAA(A/G)CTGAA intron-variant, upstream-variant-2KB
rs79957405 -- 56,340,630(+) TGGGA(A/T)CATAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IL23A Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for IL23A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL23A Gene

HapMap Linkage Disequilibrium report
IL23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL23A Gene

Disorders for IL23A Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL23A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
- elite association - COSMIC cancer census association via MalaCards
Search IL23A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL23A

Genetic Association Database (GAD)
IL23A
Human Genome Epidemiology (HuGE) Navigator
IL23A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL23A
genes like me logo Genes that share disorders with IL23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL23A Gene

Publications for IL23A Gene

  1. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. (PMID: 11114383) Oppmann B. … Kastelein R.A. (Immunity 2000) 2 3 4 23 67
  2. Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with BehAset's disease. (PMID: 19915944) Habibagahi Z. … Heidari M. (Mod Rheumatol 2010) 3 23
  3. CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals. (PMID: 20071030) Sender L.Y. … Waibler Z. (Mol. Immunol. 2010) 3 23
  4. IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity. (PMID: 20428758) Fukuda M. … Sakashita H. (Int. J. Oncol. 2010) 3 23
  5. Elevated expression of IL-12 and IL-23 in patients with aplastic anemia. (PMID: 18190588) Gu Y. … Xu C. (Int J Lab Hematol 2009) 3 23

Products for IL23A Gene

Sources for IL23A Gene

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