Aliases for PDGFA Gene
Aliases for PDGFA Gene
External Ids for PDGFA Gene
- HGNC: 8799
- Entrez Gene: 5154
- Ensembl: ENSG00000197461
- OMIM: 173430
- UniProtKB: P04085
Previous GeneCards Identifiers for PDGFA Gene
- GC07U990063
- GC07Mh00634
- GC07M000503
- GC07M000536
- GC07M000455
Summaries for PDGFA Gene
-
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for PDGFA Gene
PDGFA (Platelet Derived Growth Factor Subunit A) is a Protein Coding gene. Diseases associated with PDGFA include Denys-Drash Syndrome and Wrinkles. Among its related pathways are Glioma and Immune response IL-23 signaling pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PDGFB.
UniProtKB/Swiss-Prot for PDGFA Gene
-
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
-
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFA Gene
Genomics for PDGFA Gene
Regulatory Elements for PDGFA Gene
Enhancers for PDGFA Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PDGFA on UCSC Golden Path with GeneCards custom track
Promoters for PDGFA Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PDGFA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PDGFA gene promoter:
Regulatory Element Products
Genomic Location for PDGFA Gene
- Chromosome:
- 7
- Start:
- 497,258 bp from pter
- End:
- 520,668 bp from pter
- Size:
- 23,411 bases
- Orientation:
- Minus strand
Genomic View for PDGFA Gene
Genes around PDGFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3 by Ensembl
- 7p22 by Entrez Gene
- 7p22 by HGNC
PDGFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDGFA Gene
Proteins for PDGFA Gene
-
Protein details for PDGFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04085-PDGFA_HUMAN
- Recommended name:
- Platelet-derived growth factor subunit A
- Protein Accession:
- P04085
- B5BU73
Protein attributes for PDGFA Gene
- Size:
- 211 amino acids
- Molecular mass:
- 24043 Da
- Quaternary structure:
-
- Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.
Protein Expression for PDGFA Gene
Post-translational modifications for PDGFA Gene
Other Protein References for PDGFA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PDGFA
- R&D Systems Antibodies for PDGFA (PDGF-AA)
- R&D Systems Antibodies for PDGFA (PDGF-A)
- R&D Systems Antibodies for PDGFA (PDGF)
- Novus Biologicals Antibodies for PDGFA
- Abcam antibodies for PDGF AA
-
Cloud-Clone Corp. Antibodies for PDGFA
- Invitrogen Antibodies for PDGFA
- antibodies-online Antibodies for PDGFA: See all 99
- GeneTex PDGFA antibody for PDGFA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDGFA
Protein Products
- EMD Millipore Purified and/or Recombinant PDGFA Protein
- R&D Systems Proteins and Enzymes for PDGFA (PDGF-AA)
- R&D Systems Proteins and Enzymes for PDGFA (PDGF)
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFA
- Origene Custom Protein Services for PDGFA
- ProSpec Recombinant Proteins for PDGFA
- eBioscience Mouse PDGF-AA Recombinant Protein 5 ug for PDGFA
- antibodies-online Proteins for PDGFA: See all 40
- Search antibodies-online for peptides
- GeneTex PDGF AA protein (GTX29702) for PDGFA
- GeneTex PDGF-AB Recombinant Protein (Active) (GTX47955-PRO) for PDGFA
- GeneTex PDGF-AA recombinant protein (GTX65194) for PDGFA
- Abcam proteins for PDGF AA
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for PDGFA (PDGF-AA)
-
Cloud-Clone Corp Assay Kits for PDGFA
- antibodies-online Kits for PDGFA: See all 51
No data available for DME Specific Peptides for PDGFA Gene
Domains & Families for PDGFA Gene
Protein Domains for PDGFA Gene
Suggested Antigen Peptide Sequences for PDGFA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04085UniProtKB/Swiss-Prot:
PDGFA_HUMAN :- The long form contains a basic insert which acts as a cell retention signal.
- Belongs to the PDGF/VEGF growth factor family.
- Domain:
-
- The long form contains a basic insert which acts as a cell retention signal.
- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
No data available for Gene Families for PDGFA Gene
Function for PDGFA Gene
Molecular function for PDGFA Gene
- GENATLAS Biochemistry:
- platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also involved in transformation process
- UniProtKB/Swiss-Prot Function:
- Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
LifeMap Function Summary for PDGFA Gene
During embryonic development, PDGFA as signaling molecule is secreted from the following cells
- Epiblast
- Somite
It affects the following cells:
- Primitive Streak
-
Neural Tube
- Oligodendrocyte Precursor Cells (Lateral Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Caudal Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Anterior Entopeduncular Area)
- Oligodendrocyte Precursor Cells (Motor Neural Progenitor Domain)
- Oligodendrocyte Precursor Cells (Medial Ganglionic Eminence)
- Somite
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005161 | platelet-derived growth factor receptor binding | IPI | 2536956 |
Phenotypes for PDGFA Gene
- MGI mutant phenotypes for PDGFA:
-
inferred from 2 alleles
- mortality/aging
- reproductive system phenotype
- cardiovascular system phenotype
- integument phenotype
- growth/size/body region phenotype
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- respiratory system phenotype
- embryo phenotype
- nervous system phenotype
- muscle phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for PDGFA:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance
- Increased cell number in S
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Models for PDGFA Gene
- MGI Knock Outs for PDGFA:
-
- Pdgfa tm1Cbet
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
- Search ViGene Biosciences for PDGFA
CRISPR Products
-
OriGene CRISPR knockouts for PDGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
- GenScript: Design CRISPR guide RNA sequences for PDGFA
miRNA for PDGFA Gene
- miRTarBase miRNAs that target PDGFA
-
- hsa-let-7d-5p (MIRT005549)
- hsa-mir-221-3p (MIRT053724)
- hsa-mir-29b-3p (MIRT438915)
- hsa-mir-514b-3p (MIRT622846)
- hsa-mir-514a-3p (MIRT622847)
- hsa-mir-6809-3p (MIRT622848)
- hsa-mir-6833-3p (MIRT622849)
- hsa-mir-4768-5p (MIRT622850)
- hsa-mir-4753-3p (MIRT622851)
- hsa-mir-6873-3p (MIRT622852)
- hsa-mir-130b-5p (MIRT622853)
- hsa-mir-6817-3p (MIRT622854)
- hsa-mir-7110-3p (MIRT622855)
- hsa-mir-1273g-5p (MIRT655310)
- hsa-mir-203a-5p (MIRT655311)
miRNA Products
- Search ViGene Biosciences for PDGFA
Clone Products
- OriGene clones in human for PDGFA
- OriGene ORF clones in human,mouse,rat for PDGFA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDGFA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PDGFA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12981 ) for PDGFA
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDGFA Gene
Localization for PDGFA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDGFA Gene
- Secreted. Note=Released by platelets upon wounding.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| plasma membrane | 1 |
No data available for Gene Ontology (GO) - Cellular Components for PDGFA Gene
Pathways & Interactions for PDGFA Gene
More details on SuperPathways for PDGFA| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interleukin-3, 5 and GM-CSF signaling |
.95
|
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 3 | PI3K events in ERBB4 signaling |
.82
|
|
| 4 | GPCR Pathway |
.73
.62
|
.55
|
| 5 | ERK Signaling |
.61
.58
|
.49
|
Pathways by source for PDGFA Gene
6 BioSystems pathways for PDGFA Gene
84 Reactome pathways for PDGFA Gene
1 PharmGKB pathway for PDGFA Gene
17 KEGG pathways for PDGFA Gene
3 GeneGo (Thomson Reuters) pathways for PDGFA Gene
2 R&D Systems pathways for PDGFA Gene
Interacting Proteins for PDGFA Gene
Selected Interacting proteins:
ENSP00000346508
P04085-PDGFA_HUMAN
for PDGFA Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0001525 | angiogenesis | ISS | -- |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001775 | cell activation | TAS | 10508235 |
Drugs & Compounds for PDGFA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sunitinib | Approved, Investigational | Pharma | inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor | 490 | |
| Nintedanib (BIBF 1120) | Pharma | VEGFR/PDGFR/FGFR inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AG 18 |
|
118409-57-7 |
|
|
||
| DMPQ dihydrochloride |
|
1123491-15-5 |
|
|
||
| SU 16f |
|
251356-45-3 |
|
|
||
| SU 6668 |
|
252916-29-3 |
|
|
(5) Tocris Compounds for PDGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG 18 | EGFR/PDGFR-kinase inhibitor | 118409-57-7 |
| DMPQ dihydrochloride | Potent, selective inhibitor of PDGFRbeta | 1123491-15-5 |
| SU 16f | Potent and selective PDGFRbeta inhibitor | 251356-45-3 |
| SU 6668 | PDGFR, VEGFR and FGFR inhibitor | 252916-29-3 |
| Sunitinib malate | Potent VEGFR, PDGFRbeta and KIT inhibitor | 341031-54-7 |
(1) ApexBio Compounds for PDGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Nintedanib (BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | 928326-83-4 |
Drug Products
- ApexBio compounds for PDGFA
Transcripts for PDGFA Gene
mRNA/cDNA for PDGFA Gene
- (7) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PDGFA Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
- GenScript: Design CRISPR guide RNA sequences for PDGFA
miRNA Products
- Search ViGene Biosciences for PDGFA
Clone Products
- OriGene clones in human for PDGFA
- OriGene ORF clones in human,mouse,rat for PDGFA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PDGFA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12981 ) for PDGFA
Expression for PDGFA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Mature Endothelial Cells Corneal Endothelium
- Conjunctival Epithelium
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Mural Trophectoderm Cells Mural Trophectoderm
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Kidney (Urinary System)
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Corneal Endothelium
- Angioblasts Embryonic Blood Islands
- Fibroblasts (Uncategorized)
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Hypoblast (Extraembryonic Tissues)
- Parietal Endoderm Cells Hypoblast
-
Ovary (Reproductive System)
- Primary Oocyte Primordial Follicle
-
Gonad
- Primary Oocyte Primordial Follicle
-
Blood (Hematopoietic System)
- Megakaryocytes Hematopoietic Bone Marrow
-
Heart (Cardiovascular System)
- Epicardial Progenitors Cells Epicardium
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Blood Islands
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Gut Tube (Gastrointestinal Tract)
- NULL (Integumentary System)
- Uncategorized
- Dermis (Integumentary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for PDGFA Gene
This gene is overexpressed in Artery - Aorta (x4.4).
This gene is overexpressed in Peripheral blood mononuclear cells (57.2) and Islet of Langerhans (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFA Gene
SOURCE GeneReport for Unigene cluster for PDGFA Gene Hs.535898
Primer Products
-
OriGene qPCR primer pairs and template standards for PDGFA
-
OriGene qPCR primer pairs for PDGFA
No data available for mRNA Expression by UniProt/SwissProt for PDGFA Gene
Orthologs for PDGFA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PDGFA 35 |
|
||
| PDGFA 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PDGFA 35 |
|
||
| PDGFA 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pdgfa 35 |
|
||
| Pdgfa 16 |
|
||||
| Pdgfa 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PDGFA 35 |
|
||
| PDGFA 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pdgfa 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PDGFA 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PDGFA 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PDGFA 35 |
|
||
| PDGF-A 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PDGFA 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pdgfa 35 |
|
||
| Str.20307 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | PDGFA 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pdgfa 35 |
|
||
| pdgfaa 35 |
|
||||
| pdgfaa 36 |
|
OneToMany | |||
| pdgfab 36 |
|
OneToMany |
- Species with no ortholog for PDGFA:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PDGFA Gene
(1) SIMAP similar genes for PDGFA Gene using alignment to 4 proteins:
Variants for PDGFA Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1129401 | -- | 512,409(+) | GTGGC(A/G)TGGAC | reference, synonymous-codon | |
| rs1129403 | -- | 497,345(+) | TATTA(A/G)GTAAA | utr-variant-3-prime | |
| rs1129404 | -- | 497,301(+) | CAAAA(A/G)AAGAA | utr-variant-3-prime | |
| rs12720022 | -- | 515,993(-) | TGCTA(C/G)CAAAA | intron-variant | |
| rs12720023 | -- | 515,990(-) | TACCA(A/G)AAGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7074n71 | CNV | Loss | 21882294 |
| dgv7078n71 | CNV | Loss | 21882294 |
| nsv887128 | CNV | Loss | 21882294 |
| esv2733620 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.69;
14.65% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PDGFA Gene
Disorders for PDGFA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| denys-drash syndrome |
|
|
| wrinkles |
|
|
| pulmonary fibrosis, idiopathic |
|
|
| essential thrombocythemia |
|
|
| mesothelioma, somatic |
|
Search PDGFA in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PDGFA
No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFA Gene
Publications for PDGFA Gene
- Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PMID: 1612586) Bonthron D. … Speleman F. (Genomics 1992) 3 4 23 67
- The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PMID: 1505216) Stenman G. … Betsholtz C. (Cytogenet. Cell Genet. 1992) 2 3 23
- Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. (PMID: 19707201) Martinho O. … Reis R.M. (Br. J. Cancer 2009) 3 23
- Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries. (PMID: 18326546) Pinkas H. … Abir R. (Mol. Hum. Reprod. 2008) 3 23
- High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. (PMID: 18592007) Hoffmann A.C. … Danenberg P.V. (Neoplasia 2008) 3 23
Products for PDGFA Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PDGFA
- EMD Millipore Purified and/or Recombinant PDGFA Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for PDGFA (PDGF)
- R&D Systems Antibodies for PDGFA (PDGF-A)
- R&D Systems Antibodies for PDGFA (PDGF-AA)
- R&D Systems Proteins and Enzymes for PDGFA (PDGF)
- R&D Systems Proteins and Enzymes for PDGFA (PDGF-AA)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for PDGFA (PDGF-AA)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PDGFA
- Origene Custom Protein Services for PDGFA
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for PDGFA
- Browse OriGene Inhibitory RNA Products For PDGFA
- OriGene qPCR primer pairs for PDGFA
- OriGene qPCR primer pairs and template standards for PDGFA
- OriGene CRISPR knockouts for PDGFA
- OriGene clones in human for PDGFA
- OriGene ORF clones in human,mouse,rat for PDGFA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for PDGFA
- GenScript Custom Assay Services for PDGFA
- GenScript Custom overexpressing Cell Line Services for PDGFA
- GenScript: Design CRISPR guide RNA sequences for PDGFA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PDGFA
- Novus Biologicals Antibodies for PDGFA
- Novus Biologicals proteins and lysates for PDGFA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PDGF AA
- Abcam proteins for PDGF AA
- Abcam assays for PDGF AA
- Abcam assays for PDGF-AA
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for PDGFA
- Cloud-Clone Corp. Antibodies for PDGFA
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp Assay Kits for PDGFA
- Invitrogen Antibodies for PDGFA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for PDGFA
- eBioscience Mouse PDGF-AA Recombinant Protein 5 ug for PDGFA
- Search eBioscience for PDGFA related elisas
- eBioscience FlowRNA Probe Sets (VA1-12981 ) for PDGFA
- antibodies-online Antibodies for PDGFA: See all 99
- antibodies-online Kits for PDGFA: See all 51
- antibodies-online Proteins for PDGFA: See all 40
- Search antibodies-online for peptides
- GeneTex PDGFA antibody for PDGFA
- GeneTex PDGF AA protein (GTX29702) for PDGFA
- GeneTex PDGF-AB Recombinant Protein (Active) (GTX47955-PRO) for PDGFA
- GeneTex PDGF-AA recombinant protein (GTX65194) for PDGFA
- ViGene Biosciences adenoviral particle packaged cDNA for PDGFA gene
- ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
- ViGene Biosciences lentiviral particle packaged cDNA for PDGFA gene
- ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
- ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
- ViGene Biosciences ready-to-package AAV shRNAs for PDGFA gene
- Search ViGene Biosciences for PDGFA
- Search ViGene Biosciences for PDGFA
- Santa Cruz Biotechnology (SCBT) Antibodies for PDGFA
- Search Santa Cruz Biotechnology (SCBT) for PDGFA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDGFA
Sources for PDGFA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon