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Aliases for JKAMP Gene

Aliases for JKAMP Gene

  • JNK1/MAPK8-Associated Membrane Protein 2 3
  • JAMP 3 4 6
  • Jun N-Terminal Kinase 1-Associated Membrane Protein 2 3
  • Medulloblastoma Antigen MU-MB-50.4 3 4
  • C14orf100 3 4
  • Chromosome 14 Open Reading Frame 100 2
  • JNK1-Associated Membrane Protein 4
  • JNK-Associated Membrane Protein 3
  • C24orf100 6
  • HSPC213 3
  • HSPC327 3
  • CDA06 3

External Ids for JKAMP Gene

Previous Symbols for JKAMP Gene

  • C14orf100

Summaries for JKAMP Gene

GeneCards Summary for JKAMP Gene

JKAMP (JNK1/MAPK8-Associated Membrane Protein) is a Protein Coding gene. Diseases associated with JKAMP include medulloblastoma. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for JKAMP Gene

  • May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).

Gene Wiki entry for JKAMP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JKAMP Gene

Genomics for JKAMP Gene

Genomic Location for JKAMP Gene

Start:
59,484,443 bp from pter
End:
59,505,410 bp from pter
Size:
20,968 bases
Orientation:
Plus strand

Genomic View for JKAMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JKAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JKAMP Gene

No data available for Regulatory Elements for JKAMP Gene

Proteins for JKAMP Gene

  • Protein details for JKAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P055-JKAMP_HUMAN
    Recommended name:
    JNK1/MAPK8-associated membrane protein
    Protein Accession:
    Q9P055
    Secondary Accessions:
    • B4DP67
    • Q6FIB6
    • Q6IAJ2
    • Q7Z5D4
    • Q86SY6
    • Q9H0Q6
    • Q9H2W0
    • Q9HAH5
    • Q9P0R3

    Protein attributes for JKAMP Gene

    Size:
    326 amino acids
    Molecular mass:
    36751 Da
    Quaternary structure:
    • Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1L (By similarity).
    Miscellaneous:
    • Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen
    SequenceCaution:
    • Sequence=AAF29005.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF36133.1; Type=Frameshift; Positions=105, 124; Evidence={ECO:0000305};

    Alternative splice isoforms for JKAMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JKAMP Gene

Proteomics data for JKAMP Gene at MOPED

Post-translational modifications for JKAMP Gene

  • Ubiquitinated by RNF5 via Lys-63-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD (By similarity).
  • Ubiquitination at Lys16

No data available for DME Specific Peptides for JKAMP Gene

Domains for JKAMP Gene

Protein Domains for JKAMP Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with JKAMP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for JKAMP Gene

Function for JKAMP Gene

Molecular function for JKAMP Gene

UniProtKB/Swiss-Prot Function: May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).

Gene Ontology (GO) - Molecular Function for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 19269966
genes like me logo Genes that share ontologies with JKAMP: view
genes like me logo Genes that share phenotypes with JKAMP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for JKAMP Gene

Localization for JKAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for JKAMP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JKAMP Gene COMPARTMENTS Subcellular localization image for JKAMP gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with JKAMP: view

Pathways for JKAMP Gene

SuperPathways for JKAMP Gene

No Data Available

Gene Ontology (GO) - Biological Process for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IDA 19269966
genes like me logo Genes that share ontologies with JKAMP: view

No data available for Pathways by source for JKAMP Gene

Transcripts for JKAMP Gene

Unigene Clusters for JKAMP Gene

JNK1/MAPK8-associated membrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JKAMP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10:

Relevant External Links for JKAMP Gene

GeneLoc Exon Structure for
JKAMP
ECgene alternative splicing isoforms for
JKAMP

Expression for JKAMP Gene

mRNA expression in normal human tissues for JKAMP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JKAMP Gene

SOURCE GeneReport for Unigene cluster for JKAMP Gene Hs.446850

genes like me logo Genes that share expressions with JKAMP: view

Orthologs for JKAMP Gene

This gene was present in the common ancestor of animals.

Orthologs for JKAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JKAMP 36
  • 99.79 (n)
  • 100 (a)
JKAMP 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JAMP 37
  • 98 (a)
OneToOne
JKAMP 36
  • 92.98 (n)
  • 98.03 (a)
dog
(Canis familiaris)
Mammalia JKAMP 36
  • 93.89 (n)
  • 98.39 (a)
JKAMP 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4931417E11Rik 37
  • 72 (a)
OneToMany
Jkamp 36
  • 87.57 (n)
  • 97.43 (a)
Jkamp 16
Jkamp 37
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia JKAMP 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JKAMP 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jkamp 36
  • 87.78 (n)
  • 97.43 (a)
chicken
(Gallus gallus)
Aves JKAMP 36
  • 76.13 (n)
  • 85.16 (a)
JKAMP 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JKAMP 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22554 36
tropical clawed frog
(Silurana tropicalis)
Amphibia jkamp 36
  • 72.67 (n)
  • 80.71 (a)
Str.15301 36
zebrafish
(Danio rerio)
Actinopterygii jkamp 36
  • 71.74 (n)
  • 82.2 (a)
jkamp 37
  • 83 (a)
OneToOne
zgc63678 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001461 36
  • 54.05 (n)
  • 47.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2126 36
  • 50.88 (n)
  • 44.56 (a)
CG2126 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea jamp-1 36
  • 44.82 (n)
  • 34.81 (a)
jamp-1 37
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for JKAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JKAMP Gene

ENSEMBL:
Gene Tree for JKAMP (if available)
TreeFam:
Gene Tree for JKAMP (if available)

Paralogs for JKAMP Gene

Pseudogenes.org Pseudogenes for JKAMP Gene

genes like me logo Genes that share paralogs with JKAMP: view

No data available for Paralogs for JKAMP Gene

Variants for JKAMP Gene

Sequence variations from dbSNP and Humsavar for JKAMP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7560 -- 59,504,321(+) CTTGC(G/T)TCTCT utr-variant-3-prime, downstream-variant-500B
rs13704 -- 59,504,337(-) AACAG(A/C)TGAAC utr-variant-3-prime, downstream-variant-500B
rs1253108 -- 59,486,637(+) TGCCA(A/G)ATGCT intron-variant
rs1253109 -- 59,486,661(+) CAATT(A/T)TTTTT intron-variant
rs1253110 -- 59,487,263(+) TTGTT(C/T)ATGTT intron-variant

Relevant External Links for JKAMP Gene

HapMap Linkage Disequilibrium report
JKAMP

No data available for Structural Variations from Database of Genomic Variants (DGV) for JKAMP Gene

Disorders for JKAMP Gene

(1) MalaCards Diseases for JKAMP Gene

Search for JKAMP Gene in MalaCards »

Relevant External Links for JKAMP

Genetic Association Database (GAD)
JKAMP
Human Genome Epidemiology (HuGE) Navigator
JKAMP
genes like me logo Genes that share disorders with JKAMP: view

No data available for UniProtKB/Swiss-Prot for JKAMP Gene

Publications for JKAMP Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PMID: 12800201) Behrends U. … Mautner J. (Int. J. Cancer 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for JKAMP Gene

Sources for JKAMP Gene

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