Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LARS Gene

Aliases for LARS Gene

  • Leucyl-TRNA Synthetase 4 2 3
  • EC 6.1.1.4 4 63
  • LEURS 3 4
  • LFIS 3 6
  • Leucyl-TRNA Synthetase, Cytoplasmic 3
  • Cytoplasmic Leucyl-TRNA Synthetase 3
  • Leucine TRNA Ligase 1, Cytoplasmic 3
  • Leucine--TRNA Ligase, Cytoplasmic 3
  • Cytosolic Leucyl-TRNA Synthetase 3
  • Proliferation-Inducing Gene 44 3
  • Leucine TRNA Ligase 1 2
  • Leucine-TRNA Ligase 3
  • Leucine Translase 3
  • Cytoplasmic 2
  • KIAA1352 4
  • EC 6.1.1 63
  • HSPC192 3
  • Hr025Cl 3
  • ILFS1 3
  • LARS1 3
  • PIG44 3
  • RNTLS 3
  • LEUS 3
  • LRS 3

External Ids for LARS Gene

Previous GeneCards Identifiers for LARS Gene

  • GC05M145468
  • GC05M146077
  • GC05M145521
  • GC05M145473
  • GC05M140639

Summaries for LARS Gene

Entrez Gene Summary for LARS Gene

  • This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for LARS Gene

LARS (Leucyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with LARS include infantile liver failure syndrome 1 and acute infantile liver failure-multisystemic involvement syndrome. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include aminoacyl-tRNA editing activity and leucine-tRNA ligase activity.

UniProtKB/Swiss-Prot for LARS Gene

  • Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.

Gene Wiki entry for LARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARS Gene

Genomics for LARS Gene

Regulatory Elements for LARS Gene

Genomic Location for LARS Gene

Start:
146,113,026 bp from pter
End:
146,182,731 bp from pter
Size:
69,706 bases
Orientation:
Minus strand

Genomic View for LARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARS Gene

Proteins for LARS Gene

  • Protein details for LARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J5-SYLC_HUMAN
    Recommended name:
    Leucine--tRNA ligase, cytoplasmic
    Protein Accession:
    Q9P2J5
    Secondary Accessions:
    • A2RRR4
    • A7E266
    • B4DJ10
    • Q2TU79
    • Q9NSE1

    Protein attributes for LARS Gene

    Size:
    1176 amino acids
    Molecular mass:
    134466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92590.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARS Gene

    Alternative splice isoforms for LARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LARS Gene

Proteomics data for LARS Gene at MOPED

Post-translational modifications for LARS Gene

  • Ubiquitination at Lys39, Lys45, Lys155, Lys193, Lys278, Lys341, Lys659, Lys716, Lys719, Lys733, Lys814, and Lys832
  • Modification sites at PhosphoSitePlus

Other Protein References for LARS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for LARS Gene

Gene Families for LARS Gene

HGNC:
  • aaRS1 :Aminoacyl tRNA synthetases / Class I

Graphical View of Domain Structure for InterPro Entry

Q9P2J5

UniProtKB/Swiss-Prot:

SYLC_HUMAN :
  • Q9P2J5
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with LARS: view

Function for LARS Gene

Molecular function for LARS Gene

GENATLAS Biochemistry:
leucyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
UniProtKB/Swiss-Prot EnzymeRegulation:
(5-fluoro-1,3-dihydro-1-hydroxy-1,2-benzoxaborole) inhibits LARS by forming a covalent adduct with the 3 adenosine of tRNA(Leu) at the editing site, thus locking the enzyme in an inactive conformation
UniProtKB/Swiss-Prot Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.

Enzyme Numbers (IUBMB) for LARS Gene

Gene Ontology (GO) - Molecular Function for LARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0002161 aminoacyl-tRNA editing activity IEA --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004823 leucine-tRNA ligase activity TAS --
GO:0004825 NOT methionine-tRNA ligase activity IBA --
genes like me logo Genes that share ontologies with LARS: view
genes like me logo Genes that share phenotypes with LARS: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for LARS Gene

Localization for LARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LARS Gene COMPARTMENTS Subcellular localization image for LARS gene
Compartment Confidence
cytosol 4
chloroplast 2
mitochondrion 2
nucleus 2
extracellular 1
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LARS: view

Pathways for LARS Gene

genes like me logo Genes that share pathways with LARS: view

Pathways by source for LARS Gene

1 KEGG pathway for LARS Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006429 leucyl-tRNA aminoacylation IBA --
GO:0006431 NOT methionyl-tRNA aminoacylation IBA --
GO:0006450 regulation of translational fidelity IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with LARS: view

Compounds for LARS Gene

(6) HMDB Compounds for LARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
104404-17-3
L-Leucine
  • (2S)-2-Amino-4-methylpentanoate
61-90-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2

(1) Drugbank Compounds for LARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Leucine
  • (2S)-2-Amino-4-methylpentanoic acid
61-90-5 target

(5) Novoseek inferred chemical compound relationships for LARS Gene

Compound -log(P) Hits PubMed IDs
trna(leu) 94.1 9
leucine-trna 88 3
anticodon 75.7 3
trna 74.3 15
leucine 59.7 5
genes like me logo Genes that share compounds with LARS: view

Transcripts for LARS Gene

Unigene Clusters for LARS Gene

Leucyl-tRNA synthetase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LARS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8: -

ExUns: 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6: - -
SP7:
SP8:

Relevant External Links for LARS Gene

GeneLoc Exon Structure for
LARS
ECgene alternative splicing isoforms for
LARS

Expression for LARS Gene

mRNA expression in normal human tissues for LARS Gene

Protein differential expression in normal tissues for LARS Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.4) and Lymph node (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LARS Gene

SOURCE GeneReport for Unigene cluster for LARS Gene Hs.432674

genes like me logo Genes that share expressions with LARS: view

Expression partners for LARS Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LARS Gene

Orthologs for LARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LARS 35
  • 91.01 (n)
  • 92.18 (a)
LARS 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LARS 35
  • 92.38 (n)
  • 94.98 (a)
LARS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lars 35
  • 85.97 (n)
  • 90.22 (a)
Lars 16
Lars 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LARS 35
  • 99.35 (n)
  • 99.57 (a)
LARS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lars 35
  • 86.9 (n)
  • 90.14 (a)
oppossum
(Monodelphis domestica)
Mammalia LARS 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARS 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARS 35
  • 79.11 (n)
  • 87.07 (a)
LARS 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARS 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lars 35
  • 75.88 (n)
  • 83.67 (a)
Str.5585 35
zebrafish
(Danio rerio)
Actinopterygii larsb 35
  • 71.02 (n)
  • 79.63 (a)
wufb36b12 35
larsa 36
  • 79 (a)
OneToMany
larsa 36
  • 76 (a)
OneToMany
larsb 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008297 35
  • 58.48 (n)
  • 59.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33123 35
  • 59.98 (n)
  • 59.64 (a)
CG33123 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lars-1 35
  • 59.57 (n)
  • 57.5 (a)
lars-1 36
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL088W 35
  • 54.2 (n)
  • 48.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06105g 35
  • 53.83 (n)
  • 48.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC60 35
  • 53.43 (n)
  • 46.76 (a)
CDC60 36
  • 45 (a)
OneToOne
CDC60 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09620 35
  • 56.22 (n)
  • 50.05 (a)
soybean
(Glycine max)
eudicotyledons Gma.978 35
barley
(Hordeum vulgare)
Liliopsida Hv.6307 35
rice
(Oryza sativa)
Liliopsida Os.24539 35
Os09g0503400 35
  • 57.78 (n)
  • 52.63 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7517 35
corn
(Zea mays)
Liliopsida Zm.12595 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11019 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09463 35
  • 51.34 (n)
  • 47.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lrs1 35
  • 56.88 (n)
  • 51.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9718 36
  • 63 (a)
OneToOne
Species with no ortholog for LARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LARS Gene

ENSEMBL:
Gene Tree for LARS (if available)
TreeFam:
Gene Tree for LARS (if available)

Paralogs for LARS Gene

Selected SIMAP similar genes for LARS Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LARS: view

No data available for Paralogs for LARS Gene

Variants for LARS Gene

Sequence variations from dbSNP and Humsavar for LARS Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10988 Benign, - 146,120,433(+) CTTGC(C/T)TGATT missense, reference
rs16742 -- 146,113,337(+) GGATT(-/AA)ATAGG utr-variant-3-prime
rs883639 -- 146,127,031(-) TGATA(C/T)ATGAT intron-variant
rs1054020 -- 146,145,585(+) GAAAA(C/T)TGACG intron-variant
rs1395275 -- 146,122,625(+) TATCA(C/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LARS Gene

Variant ID Type Subtype PubMed ID
nsv883006 CNV Loss 21882294
nsv428128 CNV Loss 18775914
dgv6355n71 CNV Loss 21882294
esv1264154 CNV Insertion 17803354

Relevant External Links for LARS Gene

HapMap Linkage Disequilibrium report
LARS
Human Gene Mutation Database (HGMD)
LARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARS Gene

Disorders for LARS Gene

(1) OMIM Diseases for LARS Gene (151350)

UniProtKB/Swiss-Prot

SYLC_HUMAN
  • Infantile liver failure syndrome 1 (ILFS1) [MIM:615438]: A life-threatening disorder of hepatic function that manifests with acute liver failure in the first few months of life. Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis. {ECO:0000269 PubMed:22607940}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LARS

Genetic Association Database (GAD)
LARS
Human Genome Epidemiology (HuGE) Navigator
LARS
genes like me logo Genes that share disorders with LARS: view

No data available for Novoseek inferred disease relationships and Genatlas for LARS Gene

Publications for LARS Gene

  1. Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles. (PMID: 19426743) Seiradake E. … Cusack S. (J. Mol. Biol. 2009) 3 4 23
  2. Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. (PMID: 18446061) Shin S.H. … Chung Y.J. (Exp. Mol. Med. 2008) 3 23
  3. Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells. (PMID: 6933703) Giles R.E. … Ruddle F.H. (Somatic Cell Genet. 1980) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Identification of a mutation in LARS as a novel cause of infantile hepatopathy. (PMID: 22607940) Casey J.P. … Ennis S. (Mol. Genet. Metab. 2012) 3 4

Products for LARS Gene

  • Addgene plasmids for LARS

Sources for LARS Gene

Back to Top

Content