Aliases for LARS Gene
External Ids for LARS Gene
Previous GeneCards Identifiers for LARS Gene
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for LARS Gene
LARS (Leucyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with LARS include acute infantile liver failure-multisystemic involvement syndrome and infantile liver failure syndrome 1. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and aminoacyl-tRNA editing activity.
UniProtKB/Swiss-Prot for LARS Gene
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.