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Aliases for ATP5F1 Gene

Aliases for ATP5F1 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit B1 2 3 5
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit B1 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B1 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit B1 2 3
  • ATPase Subunit B 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B, Isoform 1 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B 3
  • Cell Proliferation-Inducing Protein 47 3
  • ATP Synthase Subunit B, Mitochondrial 3
  • ATP Synthase B Chain, Mitochondrial 3
  • H+-ATP Synthase Subunit B 3
  • ATP Synthase Subunit B 4
  • PIG47 3

External Ids for ATP5F1 Gene

Previous GeneCards Identifiers for ATP5F1 Gene

  • GC01P112408
  • GC01P110863
  • GC01P111093
  • GC01P111290
  • GC01P111703
  • GC01P111793
  • GC01P111991
  • GC01P109863

Summaries for ATP5F1 Gene

Entrez Gene Summary for ATP5F1 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5F1 Gene

ATP5F1 (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit B1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5F1 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Wiki entry for ATP5F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5F1 Gene

Genomics for ATP5F1 Gene

Regulatory Elements for ATP5F1 Gene

Promoters for ATP5F1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP5F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP5F1 Gene

Chromosome:
1
Start:
111,448,864 bp from pter
End:
111,462,773 bp from pter
Size:
13,910 bases
Orientation:
Plus strand

Genomic View for ATP5F1 Gene

Genes around ATP5F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5F1 Gene

Proteins for ATP5F1 Gene

  • Protein details for ATP5F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24539-AT5F1_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit B1, mitochondrial
    Protein Accession:
    P24539
    Secondary Accessions:
    • Q9BQ68
    • Q9BRU8

    Protein attributes for ATP5F1 Gene

    Size:
    256 amino acids
    Molecular mass:
    28909 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5F1 Gene

Proteomics data for ATP5F1 Gene at MOPED

Post-translational modifications for ATP5F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5F1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATP5F1 Gene

Domains & Families for ATP5F1 Gene

Protein Domains for ATP5F1 Gene

Suggested Antigen Peptide Sequences for ATP5F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24539

UniProtKB/Swiss-Prot:

AT5F1_HUMAN :
  • Belongs to the eukaryotic ATPase B chain family.
Family:
  • Belongs to the eukaryotic ATPase B chain family.
genes like me logo Genes that share domains with ATP5F1: view

Function for ATP5F1 Gene

Molecular function for ATP5F1 Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,inner mitochondrial membrane (F0 segment),subunit b,isoform 1,complex V of oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Ontology (GO) - Molecular Function for ATP5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19016746
genes like me logo Genes that share ontologies with ATP5F1: view
genes like me logo Genes that share phenotypes with ATP5F1: view

Animal Models for ATP5F1 Gene

MGI Knock Outs for ATP5F1:

Animal Model Products

miRNA for ATP5F1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5F1 Gene

Localization for ATP5F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5F1 Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5F1 Gene COMPARTMENTS Subcellular localization image for ATP5F1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ATP5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005654 nucleoplasm IDA --
GO:0005759 mitochondrial matrix NAS 1831354
GO:0016021 integral component of membrane IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with ATP5F1: view

Pathways & Interactions for ATP5F1 Gene

genes like me logo Genes that share pathways with ATP5F1: view

Gene Ontology (GO) - Biological Process for ATP5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA,IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5F1: view

No data available for SIGNOR curated interactions for ATP5F1 Gene

Drugs & Compounds for ATP5F1 Gene

(2) Drugs for ATP5F1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved Pharma Inhibition, Pore Blocker Cytochrome P450 inhibitor; antifungal 26
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for ATP5F1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATP5F1: view

Transcripts for ATP5F1 Gene

Unigene Clusters for ATP5F1 Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5F1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
SP1: -
SP2:
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ATP5F1 Gene

GeneLoc Exon Structure for
ATP5F1
ECgene alternative splicing isoforms for
ATP5F1

Expression for ATP5F1 Gene

mRNA expression in normal human tissues for ATP5F1 Gene

mRNA differential expression in normal tissues according to GTEx for ATP5F1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for ATP5F1 Gene

This gene is overexpressed in Nasal epithelium (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5F1 Gene



SOURCE GeneReport for Unigene cluster for ATP5F1 Gene Hs.514870

genes like me logo Genes that share expression patterns with ATP5F1: view

Protein tissue co-expression partners for ATP5F1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATP5F1 Gene

Orthologs for ATP5F1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5F1 35
  • 99.74 (n)
  • 99.61 (a)
ATP5F1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5F1 36
  • 87 (a)
OneToOne
ATP5F1 35
  • 88.15 (n)
  • 86.72 (a)
dog
(Canis familiaris)
Mammalia LOC479901 35
  • 85.94 (n)
  • 85.16 (a)
ATP5F1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5f1 16
Atp5f1 36
  • 83 (a)
OneToOne
Atp5f1 35
  • 84.77 (n)
  • 82.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP5F1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5F1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5f1 35
  • 84.37 (n)
  • 82.03 (a)
chicken
(Gallus gallus)
Aves ATP5F1 36
  • 59 (a)
OneToOne
ATP5F1 35
  • 66.4 (n)
  • 62.1 (a)
lizard
(Anolis carolinensis)
Reptilia ATP5F1 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9224 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5f1 35
  • 63.71 (n)
  • 62.9 (a)
MGC75766 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9026 35
zebrafish
(Danio rerio)
Actinopterygii atp5f1 36
  • 58 (a)
OneToOne
atp5f1 35
  • 60.24 (n)
  • 58.23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001138 35
  • 49.72 (n)
  • 44.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-b 37
  • 46 (a)
ATPsyn-b 35
  • 53.37 (n)
  • 47.98 (a)
ATPsyn-b 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea asb-1 36
  • 18 (a)
OneToMany
asb-2 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP4 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7988 36
  • 27 (a)
OneToOne
Species with no ortholog for ATP5F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5F1 Gene

ENSEMBL:
Gene Tree for ATP5F1 (if available)
TreeFam:
Gene Tree for ATP5F1 (if available)

Paralogs for ATP5F1 Gene

genes like me logo Genes that share paralogs with ATP5F1: view

No data available for Paralogs for ATP5F1 Gene

Variants for ATP5F1 Gene

Sequence variations from dbSNP and Humsavar for ATP5F1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1264895 -, - 111,456,697(+) TGATA(C/T)GGAGA reference, missense
rs1264896 -- 111,452,946(-) AGATT(C/T)CTTCA intron-variant
rs6657730 -- 111,459,854(+) ACTGA(C/T)ATATT intron-variant
rs7520781 -- 111,456,962(+) TAGAA(A/T)CTATA intron-variant
rs7550945 -- 111,462,138(+) agata(C/T)ttgtg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATP5F1 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV Loss 19166990
esv268646 CNV Insertion 20981092

Variation tolerance for ATP5F1 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5F1 Gene

HapMap Linkage Disequilibrium report
ATP5F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5F1 Gene

Disorders for ATP5F1 Gene

Relevant External Links for ATP5F1

Genetic Association Database (GAD)
ATP5F1
Human Genome Epidemiology (HuGE) Navigator
ATP5F1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5F1

No disorders were found for ATP5F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5F1 Gene

Publications for ATP5F1 Gene

  1. Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria. (PMID: 1831354) Higuti T. … Ichirara A. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for ATP5F1 Gene

Sources for ATP5F1 Gene

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