Aliases for PDE6G Gene
External Ids for PDE6G Gene
Previous HGNC Symbols for PDE6G Gene
Previous GeneCards Identifiers for PDE6G Gene
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
GeneCards Summary for PDE6G Gene
PDE6G (Phosphodiesterase 6G) is a Protein Coding gene. Diseases associated with PDE6G include Retinitis Pigmentosa 57 and Pde6g-Related Retinitis Pigmentosa. Among its related pathways are Phototransduction and Metabolism of fat-soluble vitamins. GO annotations related to this gene include enzyme inhibitor activity and 3,5-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE6H.
UniProtKB/Swiss-Prot for PDE6G Gene
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.