Aliases for PDE6G Gene
External Ids for PDE6G Gene
Previous HGNC Symbols for PDE6G Gene
Previous GeneCards Identifiers for PDE6G Gene
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
GeneCards Summary for PDE6G Gene
PDE6G (Phosphodiesterase 6G, CGMP-Specific, Rod, Gamma) is a Protein Coding gene. Diseases associated with PDE6G include pde6g-related retinitis pigmentosa and retinitis pigmentosa 57. Among its related pathways are Signaling by GPCR and Visual Cycle in Retinal Rods. GO annotations related to this gene include enzyme inhibitor activity and 3,5-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE6H.
UniProtKB/Swiss-Prot for PDE6G Gene
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.