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Aliases for PDE6G Gene

Aliases for PDE6G Gene

  • Phosphodiesterase 6G 2 3 5
  • Phosphodiesterase 6G, CGMP-Specific, Rod, Gamma 2 3
  • GMP-PDE Gamma 3 4
  • PDEG 3 4
  • Rod CG-PDE G 3
  • EC 63
  • EC 4
  • RP57 3

External Ids for PDE6G Gene

Previous HGNC Symbols for PDE6G Gene

  • PDEG

Previous GeneCards Identifiers for PDE6G Gene

  • GC17U990070
  • GC17M080177
  • GC17M080313
  • GC17M077227
  • GC17M079617
  • GC17M075063

Summaries for PDE6G Gene

Entrez Gene Summary for PDE6G Gene

  • This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

GeneCards Summary for PDE6G Gene

PDE6G (Phosphodiesterase 6G) is a Protein Coding gene. Diseases associated with PDE6G include retinitis pigmentosa 57 and pde6g-related retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include enzyme inhibitor activity and 3,5-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE6H.

UniProtKB/Swiss-Prot for PDE6G Gene

  • Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Tocris Summary for PDE6G Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE6G Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE6G Gene

Genomics for PDE6G Gene

Regulatory Elements for PDE6G Gene

Genomic Location for PDE6G Gene

81,650,459 bp from pter
81,663,112 bp from pter
12,654 bases
Minus strand

Genomic View for PDE6G Gene

Genes around PDE6G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE6G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE6G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE6G Gene

Proteins for PDE6G Gene

  • Protein details for PDE6G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma
    Protein Accession:
    Secondary Accessions:
    • Q3KP63
    • Q7Z3U8

    Protein attributes for PDE6G Gene

    87 amino acids
    Molecular mass:
    9643 Da
    Quaternary structure:
    • Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
    • Sequence=CAD97656.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW89666.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE6G Gene

neXtProt entry for PDE6G Gene

Proteomics data for PDE6G Gene at MOPED

Selected DME Specific Peptides for PDE6G Gene

Post-translational modifications for PDE6G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE6G Gene

Domains & Families for PDE6G Gene

Gene Families for PDE6G Gene

Protein Domains for PDE6G Gene

Suggested Antigen Peptide Sequences for PDE6G Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the rod/cone cGMP-PDE gamma subunit family.
  • Belongs to the rod/cone cGMP-PDE gamma subunit family.
genes like me logo Genes that share domains with PDE6G: view

Function for PDE6G Gene

Molecular function for PDE6G Gene

GENATLAS Biochemistry:
cGMP specific nucleotide phosphodiesterase,class VI,gamma subunit,rod photoreceptor
UniProtKB/Swiss-Prot CatalyticActivity:
Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate.
UniProtKB/Swiss-Prot Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Enzyme Numbers (IUBMB) for PDE6G Gene

Gene Ontology (GO) - Molecular Function for PDE6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16357825
genes like me logo Genes that share ontologies with PDE6G: view
genes like me logo Genes that share phenotypes with PDE6G: view

Human Phenotype Ontology for PDE6G Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PDE6G Gene

MGI Knock Outs for PDE6G:

Animal Model Products

miRNA for PDE6G Gene

miRTarBase miRNAs that target PDE6G

No data available for Transcription Factor Targets and HOMER Transcription for PDE6G Gene

Localization for PDE6G Gene

Subcellular locations from

Jensen Localization Image for PDE6G Gene COMPARTMENTS Subcellular localization image for PDE6G gene
Compartment Confidence
plasma membrane 4
cytosol 2
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PDE6G Gene

Pathways & Interactions for PDE6G Gene

genes like me logo Genes that share pathways with PDE6G: view

Pathways by source for PDE6G Gene

2 KEGG pathways for PDE6G Gene
1 Qiagen pathway for PDE6G Gene

Gene Ontology (GO) - Biological Process for PDE6G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process IEA --
GO:0016056 rhodopsin mediated signaling pathway TAS --
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with PDE6G: view

No data available for SIGNOR curated interactions for PDE6G Gene

Drugs & Compounds for PDE6G Gene

(8) Drugs for PDE6G Gene - From: HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vardenafil Approved Pharma Target, allosteric modulator PDE5 inhibitor 0
sildenafil Approved, Investigational Pharma Inhibition, Inhibitor, Target, inhibitor 0
Adenosine monophosphate Approved Nutra 0
Dipyridamole Approved Pharma Inhibition, Inhibitor Adenosine transport inhibitor 76
3-ISOBUTYL-1-METHYLXANTHINE Experimental Pharma Target 0

(5) Additional Compounds for PDE6G Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
Etazolate hydrochloride
Ro 20-1724
genes like me logo Genes that share compounds with PDE6G: view

Transcripts for PDE6G Gene

Unigene Clusters for PDE6G Gene

Phosphodiesterase 6G, cGMP-specific, rod, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE6G Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for PDE6G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE6G Gene

mRNA expression in normal human tissues for PDE6G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE6G Gene

This gene is overexpressed in Spleen (x12.1) and Whole Blood (x10.3).

Protein differential expression in normal tissues from HIPED for PDE6G Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDE6G Gene

SOURCE GeneReport for Unigene cluster for PDE6G Gene Hs.654482

genes like me logo Genes that share expression patterns with PDE6G: view

Protein tissue co-expression partners for PDE6G Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PDE6G Gene

Orthologs for PDE6G Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDE6G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDE6G 36
  • 98 (a)
PDE6G 35
  • 91.57 (n)
  • 97.7 (a)
(Canis familiaris)
Mammalia PDE6G 35
  • 91.57 (n)
  • 97.7 (a)
PDE6G 36
  • 98 (a)
(Mus musculus)
Mammalia Pde6g 16
Pde6g 36
  • 97 (a)
Pde6g 35
  • 89.66 (n)
  • 96.55 (a)
(Monodelphis domestica)
Mammalia PDE6G 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia PDE6G 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Pde6g 35
  • 88.89 (n)
  • 96.55 (a)
(Gallus gallus)
Aves PDE6G 35
  • 82.76 (n)
  • 90.8 (a)
PDE6G 36
  • 91 (a)
(Anolis carolinensis)
Reptilia PDE6G 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pde6g 35
  • 82.76 (n)
  • 94.25 (a)
(Danio rerio)
Actinopterygii pde6g 36
  • 93 (a)
pde6g 35
pde6g 35
  • 80.08 (n)
  • 93.1 (a)
Species with no ortholog for PDE6G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE6G Gene

Gene Tree for PDE6G (if available)
Gene Tree for PDE6G (if available)

Paralogs for PDE6G Gene

Paralogs for PDE6G Gene

(1) SIMAP similar genes for PDE6G Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDE6G: view

Variants for PDE6G Gene

Sequence variations from dbSNP and Humsavar for PDE6G Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_009294 -
rs3432 -- 81,650,504(-) CAGCC(C/T)GCCCT nc-transcript-variant, utr-variant-3-prime
rs8477 -- 81,651,029(-) CCACT(A/G)TGCTC nc-transcript-variant, utr-variant-3-prime
rs8908 -- 81,650,841(-) GGAGA(C/T)ACAGG nc-transcript-variant, utr-variant-3-prime
rs1126818 -- 81,650,800(-) TTGGT(C/T)GGTCT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDE6G Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
esv2716457 CNV Deletion 23290073

Variation tolerance for PDE6G Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE6G Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE6G Gene

Disorders for PDE6G Gene

MalaCards: The human disease database

(7) MalaCards diseases for PDE6G Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 57
  • rp57
pde6g-related retinitis pigmentosa
  • retinitis pigmentosa 57
retinitis pigmentosa
  • retinitis pigmentosa 1
retinitis pigmentosa 66
  • rp66
acid-labile subunit, deficiency of
  • acid-labile subunit deficiency
- elite association - COSMIC cancer census association via MalaCards
Search PDE6G in MalaCards View complete list of genes associated with diseases


  • Retinitis pigmentosa 57 (RP57) [MIM:613582]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269 PubMed:20655036}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PDE6G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PDE6G: view

No data available for Genatlas for PDE6G Gene

Publications for PDE6G Gene

  1. Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa. (PMID: 8125719) Hahn L.B. … Dryja T.P. (Invest. Ophthalmol. Vis. Sci. 1994) 3 4 23 67
  2. Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. (PMID: 18779324) Zhang X.J. … Cote R.H. (J. Biol. Chem. 2008) 25 26
  3. Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina. (PMID: 2161380) Tuteja N. … Farber D.B. (Gene 1990) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. (PMID: 20979602) Nikolova S. … Pullamsetti S.S. (Respir. Res. 2010) 3

Products for PDE6G Gene

Sources for PDE6G Gene

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