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Aliases for EVL Gene

Aliases for EVL Gene

  • Enah/Vasp-Like 2 3
  • Ena/Vasodilator-Stimulated Phosphoprotein-Like 3 4
  • RNB6 3 4
  • Ena/VASP-Like Protein 3
  • UEVLD 6
  • UEV3 6
  • ATTP 6

External Ids for EVL Gene

Previous GeneCards Identifiers for EVL Gene

  • GC14P094253
  • GC14P098428
  • GC14P098521
  • GC14P099601
  • GC14P100990
  • GC14P100999
  • GC14P080713
  • GC14P101018
  • GC14P101029
  • GC14P101045
  • GC14P101073
  • GC14P101110
  • GC14P101159
  • GC14P101219

Summaries for EVL Gene

GeneCards Summary for EVL Gene

EVL (Enah/Vasp-Like) is a Protein Coding gene. Diseases associated with EVL include esophageal varix and hypersplenism. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is SPRED1.

UniProtKB/Swiss-Prot for EVL Gene

  • Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization

Gene Wiki entry for EVL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVL Gene

Genomics for EVL Gene

Regulatory Elements for EVL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EVL Gene

Start:
99,971,449 bp from pter
End:
100,144,236 bp from pter
Size:
172,788 bases
Orientation:
Plus strand

Genomic View for EVL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVL Gene

Proteins for EVL Gene

  • Protein details for EVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI08-EVL_HUMAN
    Recommended name:
    Ena/VASP-like protein
    Protein Accession:
    Q9UI08
    Secondary Accessions:
    • A8K105
    • B7Z3I5
    • O95884
    • Q7Z522
    • Q8TBV1
    • Q9UF25
    • Q9UIC2

    Protein attributes for EVL Gene

    Size:
    416 amino acids
    Molecular mass:
    44620 Da
    Quaternary structure:
    • Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A. Interacts, via the Pro-rich region, with the C-terminal SH3 domain of DNMBP. Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich domain of Listeria monocytogenes actA (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of ZYX.
    Miscellaneous:
    • Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes.

    Alternative splice isoforms for EVL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVL Gene

Proteomics data for EVL Gene at MOPED

Post-translational modifications for EVL Gene

  • Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC.
  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EVL Gene

Domains for EVL Gene

Protein Domains for EVL Gene

Graphical View of Domain Structure for InterPro Entry

Q9UI08

UniProtKB/Swiss-Prot:

EVL_HUMAN :
  • Q9UI08
Domain:
  • The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization
  • Contains 1 WH1 domain.
Family:
  • Belongs to the Ena/VASP family.
genes like me logo Genes that share domains with EVL: view

No data available for Gene Families for EVL Gene

Function for EVL Gene

Molecular function for EVL Gene

UniProtKB/Swiss-Prot Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization

Gene Ontology (GO) - Molecular Function for EVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 10993894
GO:0005522 profilin binding ISS --
GO:0017124 SH3 domain binding ISS --
genes like me logo Genes that share ontologies with EVL: view
genes like me logo Genes that share phenotypes with EVL: view

Animal Models for EVL Gene

MGI Knock Outs for EVL:

Animal Model Products

CRISPR Products

miRNA for EVL Gene

miRTarBase miRNAs that target EVL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EVL Gene

Localization for EVL Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVL Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EVL Gene COMPARTMENTS Subcellular localization image for EVL gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for EVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EVL: view

Pathways for EVL Gene

genes like me logo Genes that share pathways with EVL: view

Pathways by source for EVL Gene

1 Cell Signaling Technology pathway for EVL Gene

Gene Ontology (GO) - Biological Process for EVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization TAS 9268706
GO:0007166 cell surface receptor signaling pathway NAS 10993894
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007399 nervous system development NAS 10993894
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with EVL: view

Transcripts for EVL Gene

Unigene Clusters for EVL Gene

Enah/Vasp-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18: - -
SP19: -

ExUns: 17b ^ 18a · 18b · 18c · 18d ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b
SP1: - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for EVL Gene

GeneLoc Exon Structure for
EVL
ECgene alternative splicing isoforms for
EVL

Expression for EVL Gene

mRNA expression in normal human tissues for EVL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EVL Gene

SOURCE GeneReport for Unigene cluster for EVL Gene Hs.125867

genes like me logo Genes that share expressions with EVL: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EVL Gene

Orthologs for EVL Gene

This gene was present in the common ancestor of animals.

Orthologs for EVL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVL 35
  • 99.36 (n)
  • 99.76 (a)
EVL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EVL 35
  • 90.19 (n)
  • 94.02 (a)
EVL 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EVL 35
  • 91.23 (n)
  • 94.74 (a)
EVL 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Evl 35
  • 89.83 (n)
  • 94.43 (a)
Evl 16
Evl 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EVL 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EVL 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves EVL 35
  • 76.34 (n)
  • 83.93 (a)
EVL 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EVL 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii evla 36
  • 40 (a)
OneToMany
evlb 36
  • 60 (a)
OneToMany
idibd2260 35
fruit fly
(Drosophila melanogaster)
Insecta ena 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-34 36
  • 25 (a)
OneToMany
Species with no ortholog for EVL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EVL Gene

ENSEMBL:
Gene Tree for EVL (if available)
TreeFam:
Gene Tree for EVL (if available)

Paralogs for EVL Gene

Paralogs for EVL Gene

genes like me logo Genes that share paralogs with EVL: view

Variants for EVL Gene

Sequence variations from dbSNP and Humsavar for EVL Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs726514 -- 100,126,622(-) GGCCC(C/T)GGCTT intron-variant
rs734407 -- 100,022,201(-) GCCTA(C/T)AGGCA intron-variant
rs736510 -- 100,065,147(+) ACCTG(G/T)CCCCT upstream-variant-2KB, intron-variant
rs736511 -- 100,065,057(-) TGTTA(C/T)AGAAA upstream-variant-2KB, intron-variant
rs745909 -- 100,022,906(-) CCACG(C/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EVL Gene

Variant ID Type Subtype PubMed ID
dgv142n21 CNV Loss 19592680
nsv832874 CNV Loss 17160897
nsv527130 CNV Loss 19592680
nsv526793 CNV Loss 19592680
nsv902225 CNV Loss 21882294
nsv524413 CNV Loss 19592680
nsv902226 CNV Loss 21882294

Relevant External Links for EVL Gene

HapMap Linkage Disequilibrium report
EVL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVL Gene

Disorders for EVL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for EVL Gene including...

Search for EVL Gene in MalaCards »

(4) University of Copenhagen DISEASES for EVL Gene

Relevant External Links for EVL

Genetic Association Database (GAD)
EVL
Human Genome Epidemiology (HuGE) Navigator
EVL
genes like me logo Genes that share disorders with EVL: view

No data available for UniProtKB/Swiss-Prot for EVL Gene

Publications for EVL Gene

  1. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PMID: 10993894) Klostermann A. … Behl C. (J. Biol. Chem. 2000) 2 3 4 23
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. (PMID: 10945997) Lambrechts A. … Gertler F.B. (J. Biol. Chem. 2000) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. (PMID: 15469845) Krause M. … Gertler F.B. (Dev. Cell 2004) 3 4

Products for EVL Gene

Sources for EVL Gene

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