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Aliases for UBE2J1 Gene

Aliases for UBE2J1 Gene

  • Ubiquitin-Conjugating Enzyme E2, J1 2 3
  • Ubiquitin-Conjugating Enzyme E2, J1 (UBC6 Homolog, Yeast) 2 3
  • Yeast Ubiquitin-Conjugating Enzyme UBC6 Homolog E 3 4
  • Non-Canonical Ubiquitin-Conjugating Enzyme 1 3 4
  • HSUBC6e 3 4
  • NCUBE-1 3 4
  • NCUBE1 3 4
  • Ubiquitin-Conjugating Enzyme E2, J1, U 3
  • Ubiquitin-Conjugating Enzyme E2 J1 3
  • EC 4
  • HSU93243 3
  • HSPC153 3
  • HSPC205 3
  • CGI-76 3
  • UBC6E 3
  • Ubc6p 3
  • UBC6 3

External Ids for UBE2J1 Gene

Previous GeneCards Identifiers for UBE2J1 Gene

  • GC06M090003
  • GC06M090032
  • GC06M090031
  • GC06M090093
  • GC06M087253
  • GC06M090037

Summaries for UBE2J1 Gene

Entrez Gene Summary for UBE2J1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J1 Gene

UBE2J1 (Ubiquitin-Conjugating Enzyme E2, J1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2J2.

UniProtKB/Swiss-Prot for UBE2J1 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Gene Wiki entry for UBE2J1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2J1 Gene

Genomics for UBE2J1 Gene

Regulatory Elements for UBE2J1 Gene

Genomic Location for UBE2J1 Gene

89,326,625 bp from pter
89,352,900 bp from pter
26,276 bases
Minus strand

Genomic View for UBE2J1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J1 Gene

Proteins for UBE2J1 Gene

  • Protein details for UBE2J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J1
    Protein Accession:
    Secondary Accessions:
    • A8K3F9
    • Q53F25
    • Q5W0N4
    • Q9BZ32
    • Q9NQL3
    • Q9NY66
    • Q9P011
    • Q9P0S0
    • Q9UF10

    Protein attributes for UBE2J1 Gene

    318 amino acids
    Molecular mass:
    35199 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34071.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF36125.1; Type=Frameshift; Positions=119; Evidence={ECO:0000305};

neXtProt entry for UBE2J1 Gene

Proteomics data for UBE2J1 Gene at MOPED

Post-translational modifications for UBE2J1 Gene

  • Ubiquitination at Lys186
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2J1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UBE2J1 Gene

Domains for UBE2J1 Gene

Gene Families for UBE2J1 Gene

  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2J1 Gene

Suggested Antigen Peptide Sequences for UBE2J1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y385
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2J1: view

Function for UBE2J1 Gene

Molecular function for UBE2J1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Enzyme Numbers (IUBMB) for UBE2J1 Gene

Gene Ontology (GO) - Molecular Function for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IPI 11439185
genes like me logo Genes that share ontologies with UBE2J1: view

Phenotypes for UBE2J1 Gene

GenomeRNAi human phenotypes for UBE2J1:
genes like me logo Genes that share phenotypes with UBE2J1: view

Animal Model Products

miRNA for UBE2J1 Gene

miRTarBase miRNAs that target UBE2J1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2J1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2J1 Gene

Localization for UBE2J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for UBE2J1 Gene COMPARTMENTS Subcellular localization image for UBE2J1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBE2J1: view

Pathways for UBE2J1 Gene

genes like me logo Genes that share pathways with UBE2J1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9Y385-UB2J1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 21245296
genes like me logo Genes that share ontologies with UBE2J1: view

Compounds for UBE2J1 Gene

(4) HMDB Compounds for UBE2J1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with UBE2J1: view

Transcripts for UBE2J1 Gene

mRNA/cDNA for UBE2J1 Gene

Unigene Clusters for UBE2J1 Gene

Ubiquitin-conjugating enzyme E2, J1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2J1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: -
SP4: - -
SP5: -

Relevant External Links for UBE2J1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2J1 Gene

mRNA expression in normal human tissues for UBE2J1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2J1 Gene

This gene is overexpressed in Whole Blood (4.4).

Protein differential expression in normal tissues for UBE2J1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.1) and Stomach (10.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2J1 Gene

SOURCE GeneReport for Unigene cluster for UBE2J1 Gene Hs.163776

genes like me logo Genes that share expressions with UBE2J1: view

Expression partners for UBE2J1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UBE2J1 Gene

Orthologs for UBE2J1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2J1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBE2J1 35
  • 93.19 (n)
  • 95.6 (a)
UBE2J1 36
  • 93 (a)
(Canis familiaris)
Mammalia UBE2J1 35
  • 92.26 (n)
  • 95.16 (a)
UBE2J1 36
  • 93 (a)
(Mus musculus)
Mammalia Ube2j1 35
  • 88.16 (n)
  • 92.45 (a)
Ube2j1 16
Ube2j1 36
  • 92 (a)
(Pan troglodytes)
Mammalia UBE2J1 35
  • 99.69 (n)
  • 99.69 (a)
UBE2J1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ube2j1 35
  • 91.55 (n)
  • 97.65 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2J1 36
  • 79 (a)
(Gallus gallus)
Aves UBE2J1 35
  • 73.8 (n)
  • 77.74 (a)
UBE2J1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia UBE2J1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2j1 35
  • 70.47 (n)
  • 74.39 (a)
(Danio rerio)
Actinopterygii Dr.28798 35
ube2j1 35
  • 61.08 (n)
  • 68.39 (a)
ube2j1 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea ubc-6 35
  • 60.43 (n)
  • 62.03 (a)
ubc-6 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1220 36
  • 55 (a)
Species with no ortholog for UBE2J1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2J1 Gene

Gene Tree for UBE2J1 (if available)
Gene Tree for UBE2J1 (if available)

Paralogs for UBE2J1 Gene

Paralogs for UBE2J1 Gene

Selected SIMAP similar genes for UBE2J1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBE2J1: view

Variants for UBE2J1 Gene

Sequence variations from dbSNP and Humsavar for UBE2J1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8099 - 89,342,397(-) TGATG(G/T)AGGAG reference, missense
rs1358851 -- 89,348,072(+) GGCAA(C/G)CGGGC intron-variant
rs1998576 -- 89,333,418(+) AAGCC(A/G)TTACT intron-variant
rs3822871 -- 89,329,706(-) GCAAA(C/T)GAATA reference, synonymous-codon
rs6931561 -- 89,329,237(+) AGTTT(C/T)GCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2J1 Gene

Variant ID Type Subtype PubMed ID
esv27467 CNV Loss 19812545

Relevant External Links for UBE2J1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2J1 Gene

Disorders for UBE2J1 Gene

Relevant External Links for UBE2J1

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for UBE2J1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for UBE2J1 Gene

Publications for UBE2J1 Gene

  1. Identification of a family of non-canonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. (PMID: 10708578) Lester D.H. … Houston B. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. (PMID: 11406589) Walter J. … Sommer T. (EMBO J. 2001) 3 23
  3. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PMID: 22607976) Sato T. … Kai H. (Mol. Cell 2012) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for UBE2J1 Gene

Sources for UBE2J1 Gene

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