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Aliases for GPR89B Gene

Aliases for GPR89B Gene

  • G Protein-Coupled Receptor 89B 2 3
  • G Protein-Coupled Receptor 89C 2 3
  • GPHR 3 6
  • Putative NF-Kappa-B-Activating Protein 90 3
  • Putative MAPK-Activating Protein PM01 3
  • G Protein-Coupled Receptor 89 2
  • Putative Golgi PH Regulator C 3
  • Putative Protein GPR89C 3
  • Golgi PH Regulator A 3
  • Golgi PH Regulator B 3
  • Protein GPR89B 4
  • Protein GPR89 3
  • UNQ192 3
  • GPR89C 3
  • SH120 3
  • GPR89 3
  • GPHRB 4

External Ids for GPR89B Gene

Previous HGNC Symbols for GPR89B Gene

  • GPR89
  • GPR89C

Previous GeneCards Identifiers for GPR89B Gene

  • GC01U901427
  • GC01P145868
  • GC01P147400
  • GC01M119728

Summaries for GPR89B Gene

GeneCards Summary for GPR89B Gene

GPR89B (G Protein-Coupled Receptor 89B) is a Protein Coding gene. GO annotations related to this gene include voltage-gated ion channel activity. An important paralog of this gene is GPR89A.

UniProtKB/Swiss-Prot for GPR89B Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Wiki entry for GPR89B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89B Gene

Genomics for GPR89B Gene

Regulatory Elements for GPR89B Gene

Transcription factor binding sites by QIAGEN in the GPR89B gene promoter:

Genomic Location for GPR89B Gene

147,928,393 bp from pter
147,993,521 bp from pter
65,129 bases
Plus strand

Genomic View for GPR89B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89B Gene

Proteins for GPR89B Gene

  • Protein details for GPR89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi pH regulator B
    Protein Accession:
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89B Gene

    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    • Does not seem to be able to bind GTP
    • Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys.; Evidence={ECO:0000305};

neXtProt entry for GPR89B Gene

Proteomics data for GPR89B Gene at MOPED

Post-translational modifications for GPR89B Gene

Other Protein References for GPR89B Gene

No data available for DME Specific Peptides for GPR89B Gene

Domains for GPR89B Gene

Protein Domains for GPR89B Gene

Suggested Antigen Peptide Sequences for GPR89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89B: view

No data available for Gene Families for GPR89B Gene

Function for GPR89B Gene

Molecular function for GPR89B Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Ontology (GO) - Molecular Function for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity --
genes like me logo Genes that share ontologies with GPR89B: view
genes like me logo Genes that share phenotypes with GPR89B: view

Animal Model Products

CRISPR Products

miRNA for GPR89B Gene

miRTarBase miRNAs that target GPR89B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89B Gene

Localization for GPR89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89B Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR89B Gene COMPARTMENTS Subcellular localization image for GPR89B gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane --
GO:0032580 Golgi cisterna membrane --
genes like me logo Genes that share ontologies with GPR89B: view

Pathways for GPR89B Gene

SuperPathways for GPR89B Gene

No Data Available

Interacting Proteins for GPR89B Gene

Gene Ontology (GO) - Biological Process for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction --
GO:0015031 protein transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling --
genes like me logo Genes that share ontologies with GPR89B: view

No data available for Pathways by source for GPR89B Gene

Transcripts for GPR89B Gene

Unigene Clusters for GPR89B Gene

G protein-coupled receptor 89B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR89B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89B Gene

No ASD Table

Relevant External Links for GPR89B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR89B Gene

mRNA expression in normal human tissues for GPR89B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPR89B Gene

SOURCE GeneReport for Unigene cluster for GPR89B Gene Hs.645432

mRNA Expression by UniProt/SwissProt for GPR89B Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with GPR89B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for GPR89B Gene

Orthologs for GPR89B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR89 35
  • 94.17 (n)
  • 99.05 (a)
GPR89 36
  • 96 (a)
(Canis familiaris)
Mammalia LOC483157 35
  • 93.77 (n)
  • 98.46 (a)
-- 36
  • 98 (a)
(Mus musculus)
Mammalia Gpr89 35
  • 88.5 (n)
  • 96.92 (a)
Gpr89 16
Gpr89 36
  • 97 (a)
(Pan troglodytes)
Mammalia GPR89B 35
  • 99.78 (n)
  • 100 (a)
GPR89B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr89b 35
  • 89.23 (n)
  • 96.92 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
(Gallus gallus)
Aves GPR89B 35
  • 83.11 (n)
  • 95.15 (a)
GPR89 36
  • 95 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 35
  • 79 (n)
  • 92.95 (a)
(Danio rerio)
Actinopterygii si:ch73-390b10.2 35
  • 77.61 (n)
  • 90.31 (a)
GPR89A 36
  • 90 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 35
  • 60.94 (n)
  • 63.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 35
  • 59.22 (n)
  • 57.56 (a)
CG8090 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 35
  • 58.11 (n)
  • 57.95 (a)
C11H1.2 36
  • 53 (a)
Y75B8A.16 36
  • 55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 35
  • 54.38 (n)
  • 46.48 (a)
(Oryza sativa)
Liliopsida Os04g0600800 35
  • 56.76 (n)
  • 46.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1303 35
Species with no ortholog for GPR89B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89B Gene

Gene Tree for GPR89B (if available)
Gene Tree for GPR89B (if available)

Paralogs for GPR89B Gene

Paralogs for GPR89B Gene

(2) SIMAP similar genes for GPR89B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR89B: view

Variants for GPR89B Gene

Sequence variations from dbSNP and Humsavar for GPR89B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4281364 -- 147,929,524(+) TCCCC(C/T)CATCT intron-variant
rs4489616 -- 147,929,650(+) GATTC(A/C)GTTTT intron-variant
rs4508071 -- 147,929,566(+) TTTTT(A/G)CTTGT intron-variant
rs4600097 -- 147,929,600(+) CAGAA(A/G)CAGTT intron-variant
rs4950508 -- 147,940,175(+) aaggc(A/G)ggcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89B Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
nsv511130 CNV Loss 21212237
nsv872268 CNV Gain 21882294

Relevant External Links for GPR89B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89B Gene

Disorders for GPR89B Gene

No disorders were found for GPR89B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GPR89B Gene

Publications for GPR89B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y. … Kinoshita T. (Nat. Cell Biol. 2008) 3 4
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for GPR89B Gene

Sources for GPR89B Gene

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