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Aliases for GPR89B Gene

Aliases for GPR89B Gene

  • G Protein-Coupled Receptor 89B 2 3 5
  • G Protein-Coupled Receptor 89C 2 3
  • GPR89C 3 4
  • Putative NF-Kappa-B-Activating Protein 90 3
  • Putative MAPK-Activating Protein PM01 3
  • G Protein-Coupled Receptor 89 2
  • Putative Golgi PH Regulator C 3
  • Putative Protein GPR89C 3
  • Golgi PH Regulator A 3
  • Golgi PH Regulator B 3
  • Protein GPR89B 4
  • Protein GPR89 3
  • UNQ192 3
  • GPR89 3
  • SH120 3
  • GPHRB 4
  • GPHR 3

External Ids for GPR89B Gene

Previous HGNC Symbols for GPR89B Gene

  • GPR89
  • GPR89C

Previous GeneCards Identifiers for GPR89B Gene

  • GC01U901427
  • GC01P145868
  • GC01P147400
  • GC01M119728

Summaries for GPR89B Gene

GeneCards Summary for GPR89B Gene

GPR89B (G Protein-Coupled Receptor 89B) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89A.

UniProtKB/Swiss-Prot for GPR89B Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Wiki entry for GPR89B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89B Gene

Genomics for GPR89B Gene

Regulatory Elements for GPR89B Gene

Enhancers for GPR89B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G147484 0.3 FANTOM5 1.4 -443.3 -443343 0.2 GPR89B OR13Z3P PIR38166
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR89B on UCSC Golden Path with GeneCards custom track

Promoters for GPR89B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013141 507 1801 HDGF PKNOX1 ATF1 CREB3L1 SIN3A GLI4 ZNF2 ZBTB7B ZNF121 GLIS2

Transcription factor binding sites by QIAGEN in the GPR89B gene promoter:

Genomic Location for GPR89B Gene

Chromosome:
1
Start:
147,928,393 bp from pter
End:
147,993,521 bp from pter
Size:
65,129 bases
Orientation:
Plus strand

Genomic View for GPR89B Gene

Genes around GPR89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89B Gene

Proteins for GPR89B Gene

  • Protein details for GPR89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG08-GPHRB_HUMAN
    Recommended name:
    Golgi pH regulator B
    Protein Accession:
    P0CG08
    Secondary Accessions:
    • A6NKF9
    • A6NN37
    • B2RUV3
    • B3KMN3
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89B Gene

    Size:
    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Does not seem to be able to bind GTP.
    SequenceCaution:
    • Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys.; Evidence={ECO:0000305};

neXtProt entry for GPR89B Gene

Post-translational modifications for GPR89B Gene

  • Glycosylation at posLast=180180 and posLast=243243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89B Gene

Domains & Families for GPR89B Gene

Protein Domains for GPR89B Gene

Suggested Antigen Peptide Sequences for GPR89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG08

UniProtKB/Swiss-Prot:

GPHRB_HUMAN :
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
Family:
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89B: view

No data available for Gene Families for GPR89B Gene

Function for GPR89B Gene

Molecular function for GPR89B Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Ontology (GO) - Molecular Function for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IBA --
genes like me logo Genes that share ontologies with GPR89B: view
genes like me logo Genes that share phenotypes with GPR89B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89B Gene

Localization for GPR89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89B Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR89B gene
Compartment Confidence
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IBA --
genes like me logo Genes that share ontologies with GPR89B: view

Pathways & Interactions for GPR89B Gene

SuperPathways for GPR89B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015031 protein transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051452 intracellular pH reduction IBA --
genes like me logo Genes that share ontologies with GPR89B: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89B Gene

Drugs & Compounds for GPR89B Gene

No Compound Related Data Available

Transcripts for GPR89B Gene

Unigene Clusters for GPR89B Gene

G protein-coupled receptor 89B:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89B Gene

No ASD Table

Relevant External Links for GPR89B Gene

GeneLoc Exon Structure for
GPR89B
ECgene alternative splicing isoforms for
GPR89B

Expression for GPR89B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR89B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPR89B Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR89B Gene:

GPR89B

SOURCE GeneReport for Unigene cluster for GPR89B Gene:

Hs.645432

mRNA Expression by UniProt/SwissProt for GPR89B Gene:

P0CG08-GPHRB_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89B Gene

  • Nervous system(4.7)
  • Lung(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with GPR89B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89B Gene

Orthologs for GPR89B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR89B 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
LOC483157 34
  • 93.77 (n)
cow
(Bos Taurus)
Mammalia GPR89 34 35
  • 94.17 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpr89b 34
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Gpr89 34 16 35
  • 88.5 (n)
chicken
(Gallus gallus)
Aves GPR89 35
  • 95 (a)
OneToMany
GPR89B 34
  • 83.11 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 34
  • 79 (n)
zebrafish
(Danio rerio)
Actinopterygii GPR89A 35
  • 90 (a)
OneToMany
si:ch73-390b10.2 34
  • 77.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 34
  • 60.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 34 35
  • 59.22 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 34
  • 58.11 (n)
Y75B8A.16 35
  • 55 (a)
ManyToMany
C11H1.2 35
  • 53 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 34
  • 54.38 (n)
rice
(Oryza sativa)
Liliopsida Os04g0600800 34
  • 56.76 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1303 34
Species where no ortholog for GPR89B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89B Gene

ENSEMBL:
Gene Tree for GPR89B (if available)
TreeFam:
Gene Tree for GPR89B (if available)

Paralogs for GPR89B Gene

Paralogs for GPR89B Gene

(2) SIMAP similar genes for GPR89B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR89B: view

Variants for GPR89B Gene

Sequence variations from dbSNP and Humsavar for GPR89B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111351195 -- 147,931,479(+) GCATT(A/T)TGCTT intron-variant
rs111406915 -- 147,953,519(+) ATACA(C/T)ATGTC intron-variant
rs111483535 -- 147,945,521(+) AAAGC(A/G)TATGC intron-variant
rs111630648 -- 147,985,979(-) TTCTG(C/T)AAAGA intron-variant
rs112166383 -- 147,938,388(+) CTTTA(A/G)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89B Gene

Variant ID Type Subtype PubMed ID
dgv184n106 CNV deletion 24896259
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
nsv1000564 CNV gain 25217958
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1078214 CNV deletion 25765185
nsv1132304 CNV duplication 24896259
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv511130 CNV loss 21212237
nsv946274 CNV duplication 23825009
nsv946311 CNV duplication 23825009
nsv946312 CNV duplication 23825009
nsv951832 CNV deletion 24416366

Variation tolerance for GPR89B Gene

Gene Damage Index Score: 1.25; 25.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR89B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR89B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89B Gene

Disorders for GPR89B Gene

Relevant External Links for GPR89B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR89B

No disorders were found for GPR89B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89B Gene

Publications for GPR89B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y. … Kinoshita T. (Nat. Cell Biol. 2008) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for GPR89B Gene

Sources for GPR89B Gene

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