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Aliases for GPR89B Gene

Aliases for GPR89B Gene

  • G Protein-Coupled Receptor 89B 2 3 5
  • G Protein-Coupled Receptor 89C 2 3
  • GPR89C 3 4
  • Putative NF-Kappa-B-Activating Protein 90 3
  • Putative MAPK-Activating Protein PM01 3
  • G Protein-Coupled Receptor 89 2
  • Putative Golgi PH Regulator C 3
  • Putative Protein GPR89C 3
  • Golgi PH Regulator A 3
  • Protein GPR89B 4
  • Protein GPR89 3
  • UNQ192 3
  • GPR89 3
  • SH120 3
  • GPHRB 4
  • GPHR 3

External Ids for GPR89B Gene

Previous HGNC Symbols for GPR89B Gene

  • GPR89
  • GPR89C

Previous GeneCards Identifiers for GPR89B Gene

  • GC01U901427
  • GC01P145868
  • GC01P147400
  • GC01M119728

Summaries for GPR89B Gene

GeneCards Summary for GPR89B Gene

GPR89B (G Protein-Coupled Receptor 89B) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89A.

UniProtKB/Swiss-Prot for GPR89B Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Wiki entry for GPR89B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89B Gene

Genomics for GPR89B Gene

Regulatory Elements for GPR89B Gene

Enhancers for GPR89B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR89B on UCSC Golden Path with GeneCards custom track

Promoters for GPR89B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR89B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPR89B gene promoter:

Genomic Location for GPR89B Gene

Chromosome:
1
Start:
147,928,393 bp from pter
End:
147,993,521 bp from pter
Size:
65,129 bases
Orientation:
Plus strand

Genomic View for GPR89B Gene

Genes around GPR89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89B Gene

Proteins for GPR89B Gene

  • Protein details for GPR89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG08-GPHRB_HUMAN
    Recommended name:
    Golgi pH regulator B
    Protein Accession:
    P0CG08
    Secondary Accessions:
    • A6NKF9
    • A6NN37
    • B2RUV3
    • B3KMN3
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89B Gene

    Size:
    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Does not seem to be able to bind GTP.
    SequenceCaution:
    • Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys.; Evidence={ECO:0000305};

neXtProt entry for GPR89B Gene

Proteomics data for GPR89B Gene at MOPED

Post-translational modifications for GPR89B Gene

  • Glycosylation at Asn 180 and Asn 243
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR89B Gene

No data available for DME Specific Peptides for GPR89B Gene

Domains & Families for GPR89B Gene

Protein Domains for GPR89B Gene

Suggested Antigen Peptide Sequences for GPR89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG08

UniProtKB/Swiss-Prot:

GPHRB_HUMAN :
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
Family:
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89B: view

No data available for Gene Families for GPR89B Gene

Function for GPR89B Gene

Molecular function for GPR89B Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.
genes like me logo Genes that share phenotypes with GPR89B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89B Gene

Localization for GPR89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89B Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GPR89B: view

No data available for Subcellular locations from COMPARTMENTS for GPR89B Gene

Pathways & Interactions for GPR89B Gene

SuperPathways for GPR89B Gene

No Data Available

Interacting Proteins for GPR89B Gene

Gene Ontology (GO) - Biological Process for GPR89B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPR89B Gene

Drugs & Compounds for GPR89B Gene

No Compound Related Data Available

Transcripts for GPR89B Gene

Unigene Clusters for GPR89B Gene

G protein-coupled receptor 89B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89B Gene

No ASD Table

Relevant External Links for GPR89B Gene

GeneLoc Exon Structure for
GPR89B
ECgene alternative splicing isoforms for
GPR89B

Expression for GPR89B Gene

mRNA expression in normal human tissues for GPR89B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPR89B Gene



SOURCE GeneReport for Unigene cluster for GPR89B Gene Hs.645432

mRNA Expression by UniProt/SwissProt for GPR89B Gene

P0CG08-GPHRB_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with GPR89B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for GPR89B Gene

Orthologs for GPR89B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR89 35
  • 94.17 (n)
  • 99.05 (a)
GPR89 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC483157 35
  • 93.77 (n)
  • 98.46 (a)
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gpr89 35
  • 88.5 (n)
  • 96.92 (a)
Gpr89 16
Gpr89 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GPR89B 35
  • 99.78 (n)
  • 100 (a)
GPR89B 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpr89b 35
  • 89.23 (n)
  • 96.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPR89B 35
  • 83.11 (n)
  • 95.15 (a)
GPR89 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 35
  • 79 (n)
  • 92.95 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-390b10.2 35
  • 77.61 (n)
  • 90.31 (a)
GPR89A 36
  • 90 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 35
  • 60.94 (n)
  • 63.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 35
  • 59.22 (n)
  • 57.56 (a)
CG8090 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 35
  • 58.11 (n)
  • 57.95 (a)
C11H1.2 36
  • 53 (a)
ManyToMany
Y75B8A.16 36
  • 55 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 35
  • 54.38 (n)
  • 46.48 (a)
rice
(Oryza sativa)
Liliopsida Os04g0600800 35
  • 56.76 (n)
  • 46.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1303 35
Species with no ortholog for GPR89B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89B Gene

ENSEMBL:
Gene Tree for GPR89B (if available)
TreeFam:
Gene Tree for GPR89B (if available)

Paralogs for GPR89B Gene

Paralogs for GPR89B Gene

(2) SIMAP similar genes for GPR89B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR89B: view

Variants for GPR89B Gene

Sequence variations from dbSNP and Humsavar for GPR89B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1967015 -- 147,947,164(+) acccc(A/G)tctgt intron-variant
rs2797009 -- 147,957,977(+) GAGAA(C/T)GGTGT intron-variant
rs2797069 -- 147,951,446(+) GAAAA(A/G)GTGAC intron-variant
rs2797070 -- 147,951,482(+) GCCTG(G/T)CTATT intron-variant
rs2797071 -- 147,951,690(+) Tgact(G/T)ctagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89B Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
nsv511130 CNV Loss 21212237
nsv872268 CNV Gain 21882294

Variation tolerance for GPR89B Gene

Gene Damage Index Score: 1.25; 25.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR89B Gene

HapMap Linkage Disequilibrium report
GPR89B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89B Gene

Disorders for GPR89B Gene

Relevant External Links for GPR89B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR89B

No disorders were found for GPR89B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89B Gene

Publications for GPR89B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y. … Kinoshita T. (Nat. Cell Biol. 2008) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for GPR89B Gene

Sources for GPR89B Gene

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