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Aliases for RHCG Gene

Aliases for RHCG Gene

  • Rh Family, C Glycoprotein 2 3
  • RHGK 3 4 6
  • Rhesus Blood Group Family Type C Glycoprotein 3 4
  • Rhesus Blood Group, C Glycoprotein 2 3
  • Rh Family Type C Glycoprotein 3 4
  • Tumor-Related Protein DRC2 3 4
  • Rh Glycoprotein Kidney 3 4
  • Rh Type C Glycoprotein 3 4
  • C15orf6 3 4
  • PDRC2 3 4
  • Chromosome 15 Open Reading Frame 6 2
  • Ammonium Transporter Rh Type C 3
  • SLC42A3 3
  • CDRC2 4

External Ids for RHCG Gene

Previous Symbols for RHCG Gene

  • C15orf6

Summaries for RHCG Gene

GeneCards Summary for RHCG Gene

RHCG (Rh Family, C Glycoprotein) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ankyrin binding. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot for RHCG Gene

  • Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene Wiki entry for RHCG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHCG Gene

Genomics for RHCG Gene

Genomic Location for RHCG Gene

89,471,398 bp from pter
89,496,613 bp from pter
25,216 bases
Minus strand

Genomic View for RHCG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHCG Gene

Regulatory Elements for RHCG Gene

Proteins for RHCG Gene

  • Protein details for RHCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ammonium transporter Rh type C
    Protein Accession:
    Secondary Accessions:
    • A8K4D4
    • Q6X3Y4

    Protein attributes for RHCG Gene

    479 amino acids
    Molecular mass:
    53179 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for RHCG Gene

neXtProt entry for RHCG Gene

Proteomics data for RHCG Gene at MOPED

Post-translational modifications for RHCG Gene

Other Protein References for RHCG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHCG Gene

Domains for RHCG Gene

Gene Families for RHCG Gene


  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.:
    • Q9UBD6
genes like me logo Genes that share domains with RHCG: view

Function for RHCG Gene

Molecular function for RHCG Gene

UniProtKB/Swiss-Prot Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene Ontology (GO) - Molecular Function for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008519 ammonium transmembrane transporter activity IGI 11062476
GO:0030506 ankyrin binding IDA 12719424
genes like me logo Genes that share ontologies with RHCG: view
genes like me logo Genes that share phenotypes with RHCG: view

Animal Models for RHCG Gene

MGI Knock Outs for RHCG:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RHCG Gene

Localization for RHCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHCG Gene

Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RHCG Gene COMPARTMENTS Subcellular localization image for RHCG gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10852913
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IDA 16928804
genes like me logo Genes that share ontologies with RHCG: view

Pathways for RHCG Gene

genes like me logo Genes that share pathways with RHCG: view

Interacting Proteins for RHCG Gene

Gene Ontology (GO) - Biological Process for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006873 cellular ion homeostasis IDA 14761968
GO:0006885 regulation of pH IEA --
GO:0015696 ammonium transport IGI 11062476
GO:0015837 amine transport NAS 10852913
GO:0030855 epithelial cell differentiation NAS 12204676
genes like me logo Genes that share ontologies with RHCG: view

Compounds for RHCG Gene

(1) HMDB Compounds for RHCG Gene

Compound Synonyms Cas Number PubMed IDs
  • NH3

(1) IUPHAR Ligand for RHCG Gene

Ligand Type Action Affinity Pubmed IDs
[14C]methylamine None None

(3) Novoseek inferred chemical compound relationships for RHCG Gene

Compound -log(P) Hits PubMed IDs
amtb 90.9 1
methylammonium 90.3 1
ammonium 78.7 19
genes like me logo Genes that share compounds with RHCG: view

Transcripts for RHCG Gene

Unigene Clusters for RHCG Gene

Rh family, C glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHCG Gene

No ASD Table

Relevant External Links for RHCG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHCG Gene

mRNA expression in normal human tissues for RHCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHCG Gene

This gene is overexpressed in Esophagus - Mucosa (29.3), Vagina (10.4), Cervix - Ectocervix (6.6), and Minor Salivary Gland (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHCG Gene

SOURCE GeneReport for Unigene cluster for RHCG Gene Hs.459284

mRNA Expression by UniProt/SwissProt for RHCG Gene

Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.
genes like me logo Genes that share expressions with RHCG: view

Orthologs for RHCG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHCG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHCG 36
  • 99.23 (n)
  • 99.16 (a)
  • 88 (a)
(Bos Taurus)
Mammalia RHCG 36
  • 83.22 (n)
  • 76.81 (a)
  • 76 (a)
(Canis familiaris)
Mammalia RHCG 36
  • 85.74 (n)
  • 81.66 (a)
  • 81 (a)
(Mus musculus)
Mammalia Rhcg 36
  • 81.42 (n)
  • 77.87 (a)
Rhcg 16
Rhcg 37
  • 75 (a)
(Monodelphis domestica)
Mammalia RHCG 37
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RHCG 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Rhcg 36
  • 81.7 (n)
  • 78.91 (a)
(Gallus gallus)
Aves RHCG 36
  • 73.09 (n)
  • 74.84 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia RHCG 37
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhcg 36
  • 64.51 (n)
  • 66.52 (a)
(Danio rerio)
Actinopterygii rhcga 36
  • 67.12 (n)
  • 68.1 (a)
rhcga 37
  • 62 (a)
rhcgb 37
  • 62 (a)
rhcgl1 37
  • 62 (a)
wufj85f07 36
fruit fly
(Drosophila melanogaster)
Insecta Rh50 37
  • 40 (a)
Rh50 38
  • 42 (a)
(Caenorhabditis elegans)
Secernentea rhr-1 37
  • 38 (a)
rhr-2 37
  • 37 (a)
rhr-1 38
  • 40 (a)
rhr-2 38
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13103 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
CSA.7075 37
  • 46 (a)
CSA.7848 37
  • 42 (a)
Species with no ortholog for RHCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHCG Gene

Gene Tree for RHCG (if available)
Gene Tree for RHCG (if available)

Paralogs for RHCG Gene

Paralogs for RHCG Gene

Selected SIMAP similar genes for RHCG Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RHCG: view

Variants for RHCG Gene

Sequence variations from dbSNP and Humsavar for RHCG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs893719 -- 89,494,408(-) GTGCT(C/G)GTAGT intron-variant
rs893720 -- 89,494,002(-) GGCCA(A/C)TGGAG intron-variant
rs893721 -- 89,486,603(-) CACAC(A/T)CACTC intron-variant
rs1122571 -- 89,495,365(-) CGCCT(A/T)TATCA intron-variant
rs1347926 -- 89,479,853(-) TCAAA(A/T)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHCG Gene

Variant ID Type Subtype PubMed ID
esv34025 CNV Loss 18971310
nsv457245 CNV Loss 19166990
esv2750003 CNV Deletion 23290073

Relevant External Links for RHCG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RHCG Gene

(1) Novoseek inferred disease relationships for RHCG Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 11.3 1

Relevant External Links for RHCG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RHCG: view

No data available for UniProtKB/Swiss-Prot for RHCG Gene

Publications for RHCG Gene

  1. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. (PMID: 11062476) Marini A.-M. … Cherif-Zahar B. (Nat. Genet. 2000) 3 4 23
  2. RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PMID: 12204676) Chen B.-S. … Wang M.-R. (Eur. J. Cancer 2002) 3 4 23
  3. NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PMID: 14761968) Bakouh N. … Planelles G. (J. Biol. Chem. 2004) 3 4 23
  4. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PMID: 16477434) Marini A.-M. … Andre B. (Curr. Genet. 2006) 3 4 23
  5. Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PMID: 16580862) Zidi-Yahiaoui N. … Mouro-Chanteloup I. (Transfus. Clin. Biol. 2006) 3 4 23

Products for RHCG Gene

Sources for RHCG Gene

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