Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RHCG Gene

Aliases for RHCG Gene

  • Rh Family C Glycoprotein 2 3
  • Rhesus Blood Group Family Type C Glycoprotein 3 4
  • Rhesus Blood Group, C Glycoprotein 2 3
  • Rh Family Type C Glycoprotein 3 4
  • Tumor-Related Protein DRC2 3 4
  • Rh Family, C Glycoprotein 3 5
  • Rh Glycoprotein Kidney 3 4
  • Rh Type C Glycoprotein 3 4
  • C15orf6 3 4
  • PDRC2 3 4
  • RHGK 3 4
  • Chromosome 15 Open Reading Frame 6 2
  • SLC42A3 3
  • CDRC2 4

External Ids for RHCG Gene

Previous HGNC Symbols for RHCG Gene

  • C15orf6

Previous GeneCards Identifiers for RHCG Gene

  • GC15M086419
  • GC15M083380
  • GC15M087601
  • GC15M087744
  • GC15M087815
  • GC15M090014
  • GC15M066127

Summaries for RHCG Gene

GeneCards Summary for RHCG Gene

RHCG (Rh Family C Glycoprotein) is a Protein Coding gene. Diseases associated with RHCG include acute urate nephropathy and rh deficiency syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ankyrin binding and ammonium transmembrane transporter activity. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot for RHCG Gene

  • Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene Wiki entry for RHCG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHCG Gene

Genomics for RHCG Gene

Regulatory Elements for RHCG Gene

Enhancers for RHCG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHCG on UCSC Golden Path with GeneCards custom track

Promoters for RHCG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHCG on UCSC Golden Path with GeneCards custom track

Genomic Location for RHCG Gene

Chromosome:
15
Start:
89,471,398 bp from pter
End:
89,496,613 bp from pter
Size:
25,216 bases
Orientation:
Minus strand

Genomic View for RHCG Gene

Genes around RHCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHCG Gene

Proteins for RHCG Gene

  • Protein details for RHCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD6-RHCG_HUMAN
    Recommended name:
    Ammonium transporter Rh type C
    Protein Accession:
    Q9UBD6
    Secondary Accessions:
    • A8K4D4
    • Q6X3Y4

    Protein attributes for RHCG Gene

    Size:
    479 amino acids
    Molecular mass:
    53179 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for RHCG Gene

neXtProt entry for RHCG Gene

Proteomics data for RHCG Gene at MOPED

Post-translational modifications for RHCG Gene

Other Protein References for RHCG Gene

Antibody Products

No data available for DME Specific Peptides for RHCG Gene

Domains & Families for RHCG Gene

Gene Families for RHCG Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for RHCG Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBD6

UniProtKB/Swiss-Prot:

RHCG_HUMAN :
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Family:
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
genes like me logo Genes that share domains with RHCG: view

Function for RHCG Gene

Molecular function for RHCG Gene

UniProtKB/Swiss-Prot Function:
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
genes like me logo Genes that share phenotypes with RHCG: view

Animal Models for RHCG Gene

MGI Knock Outs for RHCG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHCG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHCG Gene

Localization for RHCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHCG Gene

Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHCG Gene COMPARTMENTS Subcellular localization image for RHCG gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016323 basolateral plasma membrane IDA 16928804
genes like me logo Genes that share ontologies with RHCG: view

Pathways & Interactions for RHCG Gene

genes like me logo Genes that share pathways with RHCG: view

Interacting Proteins for RHCG Gene

Gene Ontology (GO) - Biological Process for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006885 regulation of pH IEA --
GO:0015696 ammonium transport IEA,IGI 11062476
GO:0042592 homeostatic process NAS 10852913
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with RHCG: view

No data available for SIGNOR curated interactions for RHCG Gene

Drugs & Compounds for RHCG Gene

(2) Drugs for RHCG Gene - From: IUPHAR and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]methylamine Pharma 0

(3) Additional Compounds for RHCG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with RHCG: view

Transcripts for RHCG Gene

Unigene Clusters for RHCG Gene

Rh family, C glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHCG Gene

No ASD Table

Relevant External Links for RHCG Gene

GeneLoc Exon Structure for
RHCG
ECgene alternative splicing isoforms for
RHCG

Expression for RHCG Gene

mRNA expression in normal human tissues for RHCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHCG Gene

This gene is overexpressed in Esophagus - Mucosa (x29.3), Vagina (x10.4), Cervix - Ectocervix (x6.6), and Minor Salivary Gland (x5.4).

Protein differential expression in normal tissues from HIPED for RHCG Gene

This gene is overexpressed in Cervix (21.5), Saliva (18.0), Urine (17.2), and Esophagus (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHCG Gene



SOURCE GeneReport for Unigene cluster for RHCG Gene Hs.459284

mRNA Expression by UniProt/SwissProt for RHCG Gene

Q9UBD6-RHCG_HUMAN
Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.
genes like me logo Genes that share expression patterns with RHCG: view

Protein tissue co-expression partners for RHCG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RHCG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHCG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RHCG 35
  • 83.22 (n)
  • 76.81 (a)
RHCG 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHCG 35
  • 85.74 (n)
  • 81.66 (a)
RHCG 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhcg 35
  • 81.42 (n)
  • 77.87 (a)
Rhcg 16
Rhcg 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RHCG 35
  • 99.23 (n)
  • 99.16 (a)
RHCG 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhcg 35
  • 81.7 (n)
  • 78.91 (a)
oppossum
(Monodelphis domestica)
Mammalia RHCG 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHCG 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHCG 35
  • 73.09 (n)
  • 74.84 (a)
RHCG 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHCG 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhcg 35
  • 64.51 (n)
  • 66.52 (a)
zebrafish
(Danio rerio)
Actinopterygii rhcga 35
  • 67.12 (n)
  • 68.1 (a)
wufj85f07 35
rhcga 36
  • 62 (a)
OneToMany
rhcgb 36
  • 62 (a)
OneToMany
rhcgl1 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rh50 37
  • 42 (a)
Rh50 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rhr-1 37
  • 40 (a)
rhr-2 37
  • 38 (a)
rhr-1 36
  • 38 (a)
ManyToMany
rhr-2 36
  • 37 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13103 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
CSA.7075 36
  • 46 (a)
ManyToMany
CSA.7848 36
  • 42 (a)
ManyToMany
Species with no ortholog for RHCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHCG Gene

ENSEMBL:
Gene Tree for RHCG (if available)
TreeFam:
Gene Tree for RHCG (if available)

Paralogs for RHCG Gene

Paralogs for RHCG Gene

(10) SIMAP similar genes for RHCG Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RHCG: view

Variants for RHCG Gene

Sequence variations from dbSNP and Humsavar for RHCG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs17807723 - 89,480,327(+) GTTGC(A/G)TCGGT nc-transcript-variant, reference, missense
rs4932134 -- 89,483,254(+) GGCAA(C/T)AGCAA intron-variant
rs4932135 -- 89,483,329(+) TGAGC(C/T)TCAGT intron-variant
rs4988760 -- 89,486,601(+) GAGAG(A/T)GTGTG intron-variant
rs4988762 -- 89,486,605(+) GTGTG(A/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHCG Gene

Variant ID Type Subtype PubMed ID
esv34025 CNV Loss 18971310
nsv457245 CNV Loss 19166990
esv2750003 CNV Deletion 23290073

Variation tolerance for RHCG Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHCG Gene

HapMap Linkage Disequilibrium report
RHCG
Human Gene Mutation Database (HGMD)
RHCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHCG Gene

Disorders for RHCG Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHCG Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute urate nephropathy
  • uric acid nephrolithiasis
rh deficiency syndrome
  • rh-null syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RHCG in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHCG

Genetic Association Database (GAD)
RHCG
Human Genome Epidemiology (HuGE) Navigator
RHCG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHCG
genes like me logo Genes that share disorders with RHCG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHCG Gene

Publications for RHCG Gene

  1. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PMID: 10852913) Liu Z. … Huang C.-H. (J. Biol. Chem. 2000) 2 3 4 67
  2. Functional reconstitution into liposomes of purified human RhCG ammonia channel. (PMID: 20126667) Mouro-Chanteloup I. … Ripoche P. (PLoS ONE 2010) 3 23
  3. Function of human Rh based on structure of RhCG at 2.1 A. (PMID: 20457942) Gruswitz F. … Stroud R.M. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  4. RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. (PMID: 19357182) Brown A.C. … Toye A.M. (Am. J. Physiol. Renal Physiol. 2009) 3 23
  5. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PMID: 16477434) Marini A.-M. … Andre B. (Curr. Genet. 2006) 3 23

Products for RHCG Gene

Sources for RHCG Gene

Content