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Aliases for REV1 Gene

Aliases for REV1 Gene

  • REV1, Polymerase (DNA Directed) 2 3
  • Rev1-Like Terminal Deoxycytidyl Transferase 3 4
  • Alpha Integrin-Binding Protein 80 3 4
  • AIBP80 3 4
  • REV1L 3 4
  • REV1 Homolog (S. Cerevisiae) 2
  • REV1 (Yeast Homolog)- Like 2
  • DNA Repair Protein REV1 3
  • REV1-Like (Yeast) 2
  • REV1 Homolog 3
  • REV1- Like 3
  • EC 2.7.7.- 4
  • REV1L, 6

External Ids for REV1 Gene

Previous Symbols for REV1 Gene

  • REV1L

Summaries for REV1 Gene

Entrez Gene Summary for REV1 Gene

  • This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for REV1 Gene

REV1 (REV1, Polymerase (DNA Directed)) is a Protein Coding gene. Among its related pathways are DNA Repair and Fanconi anemia pathway (KEGG). GO annotations related to this gene include magnesium ion binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH.

UniProtKB/Swiss-Prot for REV1 Gene

  • Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Gene Wiki entry for REV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REV1 Gene

Genomics for REV1 Gene

Genomic Location for REV1 Gene

Start:
99,400,475 bp from pter
End:
99,490,035 bp from pter
Size:
89,561 bases
Orientation:
Minus strand

Genomic View for REV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REV1 Gene

Regulatory Elements for REV1 Gene

Proteins for REV1 Gene

  • Protein details for REV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBZ9-REV1_HUMAN
    Recommended name:
    DNA repair protein REV1
    Protein Accession:
    Q9UBZ9
    Secondary Accessions:
    • O95941
    • Q53SI7
    • Q9C0J4
    • Q9NUP2

    Protein attributes for REV1 Gene

    Size:
    1251 amino acids
    Molecular mass:
    138248 Da
    Quaternary structure:
    • Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. May bind ITGA3. Interacts with FAAP20/C1orf86.
    SequenceCaution:
    • Sequence=AAK43708.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REV1 Gene

    Alternative splice isoforms for REV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REV1 Gene

Proteomics data for REV1 Gene at MOPED

Post-translational modifications for REV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REV1 Gene

No data available for DME Specific Peptides for REV1 Gene

Domains for REV1 Gene

Gene Families for REV1 Gene

HGNC:
  • POL :DNA polymerases

Suggested Antigen Peptide Sequences for REV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBZ9

UniProtKB/Swiss-Prot:

REV1_HUMAN
Domain:
  • The C-terminal domain is necessary for protein interactions:
    • Q9UBZ9
  • Contains 1 BRCT domain.:
    • Q9UBZ9
  • Contains 1 umuC domain.:
    • Q9UBZ9
Family:
  • Belongs to the DNA polymerase type-Y family.:
    • Q9UBZ9
genes like me logo Genes that share domains with REV1: view

Function for REV1 Gene

Molecular function for REV1 Gene

UniProtKB/Swiss-Prot Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Enzyme Numbers (IUBMB) for REV1 Gene

Gene Ontology (GO) - Molecular Function for REV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003684 damaged DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding IPI 11485998
GO:0016779 nucleotidyltransferase activity --
genes like me logo Genes that share ontologies with REV1: view
genes like me logo Genes that share phenotypes with REV1: view

Animal Models for REV1 Gene

MGI Knock Outs for REV1:

miRNA for REV1 Gene

miRTarBase miRNAs that target REV1

No data available for Transcription Factor Targeting and HOMER Transcription for REV1 Gene

Localization for REV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REV1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REV1 Gene COMPARTMENTS Subcellular localization image for REV1 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for REV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with REV1: view

Pathways for REV1 Gene

genes like me logo Genes that share pathways with REV1: view

Pathways by source for REV1 Gene

Gene Ontology (GO) - Biological Process for REV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication TAS 10536157
GO:0006281 DNA repair TAS --
GO:0009411 response to UV IDA 11485998
GO:0019985 translesion synthesis TAS --
GO:0042276 error-prone translesion synthesis TAS 11485998
genes like me logo Genes that share ontologies with REV1: view

Compounds for REV1 Gene

(2) Novoseek inferred chemical compound relationships for REV1 Gene

Compound -log(P) Hits PubMed IDs
dcmp 73.5 2
cisplatin 18.4 5
genes like me logo Genes that share compounds with REV1: view

Transcripts for REV1 Gene

Unigene Clusters for REV1 Gene

REV1, polymerase (DNA directed):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REV1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18 ^
SP1: - - -
SP2:
SP3: - - -
SP4:
SP5: -
SP6: - - - - - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for REV1 Gene

GeneLoc Exon Structure for
REV1
ECgene alternative splicing isoforms for
REV1

Expression for REV1 Gene

mRNA expression in normal human tissues for REV1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REV1 Gene

SOURCE GeneReport for Unigene cluster for REV1 Gene Hs.443077

mRNA Expression by UniProt/SwissProt for REV1 Gene

Q9UBZ9-REV1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with REV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for REV1 Gene

Orthologs for REV1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REV1 35
  • 99.49 (n)
  • 99.6 (a)
REV1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REV1 35
  • 81.61 (n)
  • 81.66 (a)
REV1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REV1 35
  • 90.79 (n)
  • 89.83 (a)
REV1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rev1 35
  • 85.6 (n)
  • 84.26 (a)
Rev1 16
Rev1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia REV1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REV1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rev1 35
  • 84.67 (n)
  • 82.38 (a)
chicken
(Gallus gallus)
Aves REV1 35
  • 78.52 (n)
  • 78.46 (a)
REV1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REV1 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32799 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rev1 35
  • 67.81 (n)
  • 67.13 (a)
zebrafish
(Danio rerio)
Actinopterygii rev1 35
  • 58.3 (n)
  • 56.42 (a)
rev1 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005939 35
  • 47.55 (n)
  • 40.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rev1 35
  • 50.68 (n)
  • 46.79 (a)
Rev1 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rev-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REV1 36
  • 24 (a)
OneToMany
REV1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for REV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REV1 Gene

ENSEMBL:
Gene Tree for REV1 (if available)
TreeFam:
Gene Tree for REV1 (if available)

Paralogs for REV1 Gene

Paralogs for REV1 Gene

Pseudogenes.org Pseudogenes for REV1 Gene

genes like me logo Genes that share paralogs with REV1: view

Variants for REV1 Gene

Sequence variations from dbSNP and Humsavar for REV1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs717454 -- 99,406,310(-) CATCA(A/G)TGTGG intron-variant
rs737094 -- 99,472,616(-) AAGAT(C/T)CTGTC intron-variant, upstream-variant-2KB
rs769105 -- 99,461,504(-) TGCCT(C/T)GCTTT intron-variant
rs896248 -- 99,462,013(+) TTCCT(A/G)AACTG intron-variant
rs896249 -- 99,472,750(+) AACCA(A/G)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REV1 Gene

Variant ID Type Subtype PubMed ID
nsv524466 CNV Loss 19592680
esv2658486 CNV Deletion 23128226
nsv874700 CNV Loss 21882294
esv2555492 CNV Deletion 19546169
nsv821279 CNV Deletion 20802225
nsv829580 CNV Loss 20364138
esv2052109 CNV Deletion 18987734
nsv511799 CNV Loss 21212237
esv4405 CNV Deletion 18987735
esv2720432 CNV Deletion 23290073
esv27651 CNV Gain+Loss 19812545
dgv84e180 CNV Gain 20482838
nsv829582 CNV Gain+Loss 20364138
esv33974 CNV Gain+Loss 17666407

Relevant External Links for REV1 Gene

HapMap Linkage Disequilibrium report
REV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REV1 Gene

Disorders for REV1 Gene

(2) University of Copenhagen DISEASES for REV1 Gene

Relevant External Links for REV1

Genetic Association Database (GAD)
REV1
Human Genome Epidemiology (HuGE) Navigator
REV1
genes like me logo Genes that share disorders with REV1: view

No data available for UniProtKB/Swiss-Prot for REV1 Gene

Publications for REV1 Gene

  1. The human REV1 gene codes for a DNA template-dependent dCMP transferase. (PMID: 10536157) Lin W. … Wang Z. (Nucleic Acids Res. 1999) 2 3 4 23
  2. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins. (PMID: 12529368) Masuda Y. … Kamiya K. (J. Biol. Chem. 2003) 3 4 23
  3. Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. (PMID: 11278384) Masuda Y. … Kamiya K. (J. Biol. Chem. 2001) 3 4 23
  4. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. (PMID: 11485998) Murakumo Y. … Takahashi M. (J. Biol. Chem. 2001) 3 4 23
  5. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. (PMID: 10760286) Gibbs P.E.M. … Maher V.M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23

Products for REV1 Gene

Sources for REV1 Gene

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