Aliases for REV1 Gene
External Ids for REV1 Gene
Previous HGNC Symbols for REV1 Gene
Previous GeneCards Identifiers for REV1 Gene
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]
GeneCards Summary for REV1 Gene
REV1 (REV1, Polymerase (DNA Directed)) is a Protein Coding gene. Diseases associated with REV1 include tick infestation and primary bacterial infectious disease. Among its related pathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include magnesium ion binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH.
UniProtKB/Swiss-Prot for REV1 Gene
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.