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Aliases for IP6K2 Gene

Aliases for IP6K2 Gene

  • Inositol Hexakisphosphate Kinase 2 2 3 5
  • Inositol Hexaphosphate Kinase 2 2 3
  • EC 2.7.4.21 4 56
  • IHPK2 3 4
  • PiUS 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • P(I)-Uptake Stimulator 4
  • Pi Uptake Stimulator 3
  • Insp6 Kinase 2 3
  • InsP6 Kinase 2 4

External Ids for IP6K2 Gene

Previous HGNC Symbols for IP6K2 Gene

  • IHPK2

Previous GeneCards Identifiers for IP6K2 Gene

  • GC03M048700

Summaries for IP6K2 Gene

Entrez Gene Summary for IP6K2 Gene

  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for IP6K2 Gene

IP6K2 (Inositol Hexakisphosphate Kinase 2) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K1.

UniProtKB/Swiss-Prot for IP6K2 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Gene Wiki entry for IP6K2 Gene

Additional gene information for IP6K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K2 Gene

Genomics for IP6K2 Gene

GeneHancer (GH) Regulatory Elements for IP6K2 Gene

Promoters and enhancers for IP6K2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I048714 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.3 +23.9 23905 3.2 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 YBX1 YY1 ETS1 IP6K2 WDR6 NCKIPSD DHX30 NICN1 PRKAR2A PRKAR2A-AS1 ENSG00000235236 QARS MST1
GH03I048693 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 568.6 +45.5 45508 2.6 KLF1 MAX ZNF76 FEZF1 YY1 ZNF335 ZFHX2 POLR2A ZBTB48 EGR1 IP6K2 WDR6 COL7A1 PFKFB4 UCN2 PRKAR2A PRKAR2A-AS1 QRICH1 QARS NCKIPSD
GH03I048738 Enhancer 1.3 Ensembl ENCODE dbSUPER 554.6 +0.6 645 3 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ATF7 RXRA IP6K2 WDR6 NCKIPSD
GH03I048741 Enhancer 0.4 ENCODE dbSUPER 550.8 -1.0 -1029 0.2 IP6K2 PIR40170
GH03I049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.4 -605.7 -605697 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A USP4 AMT QRICH1 ENSG00000235236 RBM6 ATRIP RBM5 WDR6 IP6K2 ENSG00000230454
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IP6K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IP6K2 gene promoter:

Genomic Locations for IP6K2 Gene

Genomic Locations for IP6K2 Gene
chr3:48,688,003-48,740,353
(GRCh38/hg38)
Size:
52,351 bases
Orientation:
Minus strand
chr3:48,725,436-48,777,786
(GRCh37/hg19)

Genomic View for IP6K2 Gene

Genes around IP6K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IP6K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IP6K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K2 Gene

Proteins for IP6K2 Gene

  • Protein details for IP6K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHH9-IP6K2_HUMAN
    Recommended name:
    Inositol hexakisphosphate kinase 2
    Protein Accession:
    Q9UHH9
    Secondary Accessions:
    • A8K3B1
    • B4E3G6
    • G8JLL6
    • Q6P0N8
    • Q9BSZ6
    • Q9BUW3
    • Q9H4P7
    • Q9NT63
    • Q9UFU6

    Protein attributes for IP6K2 Gene

    Size:
    426 amino acids
    Molecular mass:
    49186 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IP6K2 Gene

neXtProt entry for IP6K2 Gene

Selected DME Specific Peptides for IP6K2 Gene

Q9UHH9:
  • SYRFYSSS
  • VDNSDCEPKSK
  • CGMQVYQ
  • LDLKMGTRQ
  • VDVRMIDFAH

Post-translational modifications for IP6K2 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 615, posLast=4242, isoforms=182, posLast=202202, isoforms=222, and isoforms=286

Domains & Families for IP6K2 Gene

Gene Families for IP6K2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IP6K2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UHH9

UniProtKB/Swiss-Prot:

IP6K2_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K2: view

Function for IP6K2 Gene

Molecular function for IP6K2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Enzyme Numbers (IUBMB) for IP6K2 Gene

Phenotypes From GWAS Catalog for IP6K2 Gene

Gene Ontology (GO) - Molecular Function for IP6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity TAS --
GO:0000828 inositol hexakisphosphate kinase activity IDA,TAS --
GO:0000829 inositol heptakisphosphate kinase activity TAS --
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005515 protein binding IPI 18195352
genes like me logo Genes that share ontologies with IP6K2: view
genes like me logo Genes that share phenotypes with IP6K2: view

Animal Models for IP6K2 Gene

MGI Knock Outs for IP6K2:

Animal Model Products

Clone Products

  • Addgene plasmids for IP6K2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IP6K2 Gene

Localization for IP6K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IP6K2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IP6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA,IDA 11502751
GO:0005654 nucleoplasm TAS --
GO:0030054 cell junction IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with IP6K2: view

Pathways & Interactions for IP6K2 Gene

genes like me logo Genes that share pathways with IP6K2: view

Gene Ontology (GO) - Biological Process for IP6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006817 phosphate ion transport IEA --
GO:0016310 phosphorylation IEA --
GO:0030308 negative regulation of cell growth IMP 11337497
GO:0032958 inositol phosphate biosynthetic process IEA --
GO:0043065 positive regulation of apoptotic process IMP 11337497
genes like me logo Genes that share ontologies with IP6K2: view

No data available for SIGNOR curated interactions for IP6K2 Gene

Drugs & Compounds for IP6K2 Gene

(1) Additional Compounds for IP6K2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IP6K2: view

Transcripts for IP6K2 Gene

Unigene Clusters for IP6K2 Gene

Inositol hexakisphosphate kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for IP6K2

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a ·
SP1: - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - -
SP23: - - - - - - - - - - -
SP24: - - - - - -
SP25:
SP26: - - - - - -
SP27: - - - - - - - - - - - - - - - - -
SP28: - - - - -
SP29: - - - - - - - - - - - - - - - - -
SP30: - - - - - - - - - - - - - - -
SP31: - - - - - - - - - - - - - - - - -
SP32: - - - - - - - - - - - - - -
SP33: -
SP34: - - - - - - -
SP35: - - - - - - -
SP36: - - - -

ExUns: 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15:
SP16:
SP17: - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - -
SP23: - - - - - - - - - - - -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31: - - - - - - - - - - - -
SP32: - - - - - - - - - - - -
SP33:
SP34:
SP35:
SP36:

Relevant External Links for IP6K2 Gene

GeneLoc Exon Structure for
IP6K2
ECgene alternative splicing isoforms for
IP6K2

Expression for IP6K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IP6K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IP6K2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IP6K2 Gene



Protein tissue co-expression partners for IP6K2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IP6K2 Gene:

IP6K2

SOURCE GeneReport for Unigene cluster for IP6K2 Gene:

Hs.595983

Evidence on tissue expression from TISSUES for IP6K2 Gene

  • Nervous system(5)
  • Lung(4.7)
  • Skin(4.4)
  • Eye(2.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with IP6K2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IP6K2 Gene

Orthologs for IP6K2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IP6K2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IP6K2 33 34
  • 92.39 (n)
mouse
(Mus musculus)
Mammalia Ip6k2 33 16 34
  • 92.08 (n)
rat
(Rattus norvegicus)
Mammalia Ip6k2 33
  • 91.53 (n)
cow
(Bos Taurus)
Mammalia IP6K2 33 34
  • 90.59 (n)
oppossum
(Monodelphis domestica)
Mammalia IP6K2 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IP6K2 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves IP6K2 33 34
  • 78.54 (n)
lizard
(Anolis carolinensis)
Reptilia IP6K2 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ip6k2 33
  • 73.82 (n)
Str.12613 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9227 33
zebrafish
(Danio rerio)
Actinopterygii ip6k2 33 34
  • 66.27 (n)
IP6K2 (2 of 2) 34
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010480 33
  • 54.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10082 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30A10.3 34
  • 32 (a)
ManyToMany
Y22D7AR.6 34
  • 31 (a)
ManyToMany
T20F7.3 34
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
Species where no ortholog for IP6K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IP6K2 Gene

ENSEMBL:
Gene Tree for IP6K2 (if available)
TreeFam:
Gene Tree for IP6K2 (if available)

Paralogs for IP6K2 Gene

Paralogs for IP6K2 Gene

genes like me logo Genes that share paralogs with IP6K2: view

Variants for IP6K2 Gene

Sequence variations from dbSNP and Humsavar for IP6K2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000036948 -- 48,711,108(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000107236 -- 48,704,045(-) T/C intron_variant
rs1000149928 -- 48,717,731(-) G/A/T upstream_transcript_variant
rs1000227203 -- 48,716,040(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000475268 -- 48,689,559(-) A/G coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for IP6K2 Gene

Variant ID Type Subtype PubMed ID
nsv1114375 CNV deletion 24896259
nsv1131699 CNV deletion 24896259
nsv1139112 CNV deletion 24896259
nsv508918 CNV insertion 20534489
nsv590247 CNV loss 21841781
nsv590248 CNV loss 21841781
nsv818138 CNV gain 17921354
nsv834685 CNV loss 17160897

Variation tolerance for IP6K2 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IP6K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IP6K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K2 Gene

Disorders for IP6K2 Gene

Additional Disease Information for IP6K2

No disorders were found for IP6K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K2 Gene

Publications for IP6K2 Gene

  1. Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. (PMID: 10574768) Saiardi A … Snyder SH (Current biology : CB 1999) 2 3 4 58
  2. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. (PMID: 18195352) Chakraborty A … Snyder SH (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22 58
  3. Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. (PMID: 17379600) Morrison BH … Lindner DJ (The Journal of biological chemistry 2007) 3 22 58
  4. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. (PMID: 15533939) Nagata E … Snyder SH (The Journal of biological chemistry 2005) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for IP6K2 Gene

Sources for IP6K2 Gene

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