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Aliases for IP6K2 Gene

Aliases for IP6K2 Gene

  • Inositol Hexakisphosphate Kinase 2 2 3
  • Inositol Hexaphosphate Kinase 2 2 3
  • EC 2.7.4.21 4 63
  • IHPK2 3 4
  • PiUS 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • P(I)-Uptake Stimulator 4
  • Pi Uptake Stimulator 3
  • Insp6 Kinase 2 3
  • InsP6 Kinase 2 4

External Ids for IP6K2 Gene

Previous HGNC Symbols for IP6K2 Gene

  • IHPK2

Previous GeneCards Identifiers for IP6K2 Gene

  • GC03M048700

Summaries for IP6K2 Gene

Entrez Gene Summary for IP6K2 Gene

  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for IP6K2 Gene

IP6K2 (Inositol Hexakisphosphate Kinase 2) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K1.

UniProtKB/Swiss-Prot for IP6K2 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Gene Wiki entry for IP6K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K2 Gene

Genomics for IP6K2 Gene

Genomic Location for IP6K2 Gene

Chromosome:
3
Start:
48,688,003 bp from pter
End:
48,740,353 bp from pter
Size:
52,351 bases
Orientation:
Minus strand

Genomic View for IP6K2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IP6K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K2 Gene

Proteins for IP6K2 Gene

  • Protein details for IP6K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHH9-IP6K2_HUMAN
    Recommended name:
    Inositol hexakisphosphate kinase 2
    Protein Accession:
    Q9UHH9
    Secondary Accessions:
    • A8K3B1
    • B4E3G6
    • G8JLL6
    • Q6P0N8
    • Q9BSZ6
    • Q9BUW3
    • Q9H4P7
    • Q9NT63
    • Q9UFU6

    Protein attributes for IP6K2 Gene

    Size:
    426 amino acids
    Molecular mass:
    49186 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IP6K2 Gene

neXtProt entry for IP6K2 Gene

Proteomics data for IP6K2 Gene at MOPED

Selected DME Specific Peptides for IP6K2 Gene

Post-translational modifications for IP6K2 Gene

  • Ubiquitination at Lys 15, Lys 42, Lys 182, Lys 202, Lys 222, and Lys 286
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for IP6K2 Gene

Protein Domains for IP6K2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UHH9

UniProtKB/Swiss-Prot:

IP6K2_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K2: view

No data available for Gene Families for IP6K2 Gene

Function for IP6K2 Gene

Molecular function for IP6K2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Enzyme Numbers (IUBMB) for IP6K2 Gene

Gene Ontology (GO) - Molecular Function for IP6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA --
GO:0052723 inositol hexakisphosphate 1-kinase activity IEA --
genes like me logo Genes that share ontologies with IP6K2: view
genes like me logo Genes that share phenotypes with IP6K2: view

Animal Models for IP6K2 Gene

MGI Knock Outs for IP6K2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IP6K2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for IP6K2 Gene

Localization for IP6K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IP6K2 Gene COMPARTMENTS Subcellular localization image for IP6K2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for IP6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11502751
GO:0005654 nucleoplasm TAS --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with IP6K2: view

Pathways & Interactions for IP6K2 Gene

genes like me logo Genes that share pathways with IP6K2: view

Gene Ontology (GO) - Biological Process for IP6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006817 phosphate ion transport IEA --
GO:0016310 phosphorylation --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0030308 negative regulation of cell growth IMP 11337497
GO:0043065 positive regulation of apoptotic process IMP 11337497
genes like me logo Genes that share ontologies with IP6K2: view

No data available for SIGNOR curated interactions for IP6K2 Gene

Drugs & Compounds for IP6K2 Gene

(1) Additional Compounds for IP6K2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phytate
genes like me logo Genes that share compounds with IP6K2: view

Transcripts for IP6K2 Gene

Unigene Clusters for IP6K2 Gene

Inositol hexakisphosphate kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IP6K2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a ·
SP1: - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - -
SP23: - - - - - - - - - - -
SP24: - - - - - -
SP25:
SP26: - - - - - -
SP27: - - - - - - - - - - - - - - - - -
SP28: - - - - -
SP29: - - - - - - - - - - - - - - - - -
SP30: - - - - - - - - - - - - - - -
SP31: - - - - - - - - - - - - - - - - -
SP32: - - - - - - - - - - - - - -
SP33: -
SP34: - - - - - - -
SP35: - - - - - - -
SP36: - - - -

ExUns: 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15:
SP16:
SP17: - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - -
SP23: - - - - - - - - - - - -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31: - - - - - - - - - - - -
SP32: - - - - - - - - - - - -
SP33:
SP34:
SP35:
SP36:

Relevant External Links for IP6K2 Gene

GeneLoc Exon Structure for
IP6K2
ECgene alternative splicing isoforms for
IP6K2

Expression for IP6K2 Gene

mRNA expression in normal human tissues for IP6K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IP6K2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IP6K2 Gene



SOURCE GeneReport for Unigene cluster for IP6K2 Gene Hs.595983

genes like me logo Genes that share expression patterns with IP6K2: view

Protein tissue co-expression partners for IP6K2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IP6K2 Gene

Orthologs for IP6K2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IP6K2 35
  • 90.59 (n)
  • 95.53 (a)
IP6K2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IP6K2 35
  • 92.39 (n)
  • 97.41 (a)
IP6K2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ip6k2 35
  • 92.08 (n)
  • 96.94 (a)
Ip6k2 16
Ip6k2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ip6k2 35
  • 91.53 (n)
  • 96.47 (a)
oppossum
(Monodelphis domestica)
Mammalia IP6K2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IP6K2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IP6K2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves IP6K2 35
  • 78.54 (n)
  • 86.08 (a)
IP6K2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IP6K2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ip6k2 35
  • 73.82 (n)
  • 80.42 (a)
Str.12613 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9227 35
zebrafish
(Danio rerio)
Actinopterygii ip6k2 35
  • 66.27 (n)
  • 68.18 (a)
ip6k2 36
  • 60 (a)
OneToMany
IP6K2 (2 of 2) 36
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010480 35
  • 54.34 (n)
  • 47.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10082 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30A10.3 36
  • 32 (a)
ManyToMany
T20F7.3 36
  • 26 (a)
ManyToMany
Y22D7AR.6 36
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for IP6K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IP6K2 Gene

ENSEMBL:
Gene Tree for IP6K2 (if available)
TreeFam:
Gene Tree for IP6K2 (if available)

Paralogs for IP6K2 Gene

Paralogs for IP6K2 Gene

genes like me logo Genes that share paralogs with IP6K2: view

Variants for IP6K2 Gene

Sequence variations from dbSNP and Humsavar for IP6K2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1048940 -- 48,688,274(-) GGAGT(A/C/G)AGCTT synonymous-codon, reference
rs1812510 -- 48,713,908(-) aactc(C/T)tgacc intron-variant
rs1960365 -- 48,713,936(-) tttca(C/T)catgt intron-variant
rs1987410 -- 48,714,009(-) ctccc(A/T)agtag intron-variant
rs3172494 -- 48,694,054(-) GAGGA(A/C)TGAGC intron-variant, utr-variant-3-prime, nc-transcript-variant, utr-variant-5-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IP6K2 Gene

Variant ID Type Subtype PubMed ID
nsv834685 CNV Loss 17160897
nsv876762 CNV Loss 21882294
nsv818138 CNV Gain 17921354
nsv508918 CNV Insertion 20534489

Variation tolerance for IP6K2 Gene

Residual Variation Intolerance Score: 17.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IP6K2 Gene

HapMap Linkage Disequilibrium report
IP6K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K2 Gene

Disorders for IP6K2 Gene

Relevant External Links for IP6K2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IP6K2
genes like me logo Genes that share disorders with IP6K2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K2 Gene

Publications for IP6K2 Gene

  1. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. (PMID: 18195352) Chakraborty A. … Snyder S.H. (Proc. Natl. Acad. Sci. U.S.A. 2008) 23 67
  2. Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. (PMID: 17379600) Morrison B.H. … Lindner D.J. (J. Biol. Chem. 2007) 23 67
  3. Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma. (PMID: 15634191) Morrison B.H. … Lindner D.J. (Biochem. J. 2005) 23 67
  4. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. (PMID: 15533939) Nagata E. … Snyder S.H. (J. Biol. Chem. 2005) 23 67
  5. Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. (PMID: 11896621) Morrison B.H. … Lindner D.J. (Oncogene 2002) 23 67

Products for IP6K2 Gene

Sources for IP6K2 Gene

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