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Aliases for AIG1 Gene

Aliases for AIG1 Gene

  • Androgen Induced 1 2 3 5
  • AIG-1 3 4
  • Androgen-Induced Gene 1 Protein 3
  • DJ95L4.1 3

External Ids for AIG1 Gene

Previous GeneCards Identifiers for AIG1 Gene

  • GC06P143315
  • GC06P143362
  • GC06P143423
  • GC06P140946

Summaries for AIG1 Gene

GeneCards Summary for AIG1 Gene

AIG1 (Androgen Induced 1) is a Protein Coding gene. An important paralog of this gene is ADTRP.

UniProtKB/Swiss-Prot for AIG1 Gene

  • May play a role in androgen-regulated growth of hair follicles.

Gene Wiki entry for AIG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIG1 Gene

Genomics for AIG1 Gene

Regulatory Elements for AIG1 Gene

Enhancers for AIG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G143058 1.7 Ensembl ENCODE dbSUPER 11.2 +2.9 2940 7.0 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 VDAC1P8 AIG1 LTV1 HIVEP2 ENSG00000232618 ENSG00000227192 ENSG00000225752
GH06G142940 1.7 Ensembl ENCODE dbSUPER 10.2 -114.9 -114884 8.3 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 GLIS1 NBN VDAC1P8 ENSG00000270890 ENSG00000233138 AIG1 FUCA2 ENSG00000232618 LOC105369170
GH06G143222 1.2 Ensembl ENCODE 10.5 +165.2 165172 4.9 FOXA2 PKNOX1 YY1 TCF12 ZNF121 ZNF766 GATA2 ZHX2 PPARG TBX21 AIG1 ENSG00000217495 ENSG00000225752
GH06G143106 1 ENCODE 10.7 +48.2 48186 2.3 FOXA2 ARID4B ZNF48 ZNF2 YY1 ZNF143 MXD4 PPARG KAT8 SSRP1 AIG1 ENSG00000225752 ENSG00000217495
GH06G143176 0.9 Ensembl ENCODE 9.8 +117.4 117388 1.4 CTCF CBX3 TAL1 ZIC2 RAD21 CHAMP1 NFIC ZNF316 GATA2 GLIS1 AIG1 PHACTR2 LOC100131471 ENSG00000225752 ENSG00000217495
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AIG1 on UCSC Golden Path with GeneCards custom track

Promoters for AIG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000204263 1437 2001 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for AIG1 Gene

Chromosome:
6
Start:
143,059,363 bp from pter
End:
143,340,343 bp from pter
Size:
280,981 bases
Orientation:
Plus strand

Genomic View for AIG1 Gene

Genes around AIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIG1 Gene

Proteins for AIG1 Gene

  • Protein details for AIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVV5-AIG1_HUMAN
    Recommended name:
    Androgen-induced gene 1 protein
    Protein Accession:
    Q9NVV5
    Secondary Accessions:
    • B4DPX2
    • C9J569
    • Q5T2H2
    • Q6N047
    • Q7Z378
    • Q8TB14
    • Q9Y3A9
    • Q9Y5B4

    Protein attributes for AIG1 Gene

    Size:
    245 amino acids
    Molecular mass:
    28222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34098.1; Type=Frameshift; Positions=182, 193, 223; Evidence={ECO:0000305}; Sequence=CAE45823.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AIG1 Gene

neXtProt entry for AIG1 Gene

Post-translational modifications for AIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AIG1 Gene

Domains & Families for AIG1 Gene

Protein Domains for AIG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AIG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVV5

UniProtKB/Swiss-Prot:

AIG1_HUMAN :
  • Belongs to the AIG1 family.
Family:
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with AIG1: view

No data available for Gene Families for AIG1 Gene

Function for AIG1 Gene

Molecular function for AIG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in androgen-regulated growth of hair follicles.
UniProtKB/Swiss-Prot Induction:
By dihydrotestosterone (DHT).

Gene Ontology (GO) - Molecular Function for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with AIG1: view
genes like me logo Genes that share phenotypes with AIG1: view

Animal Model Products

CRISPR Products

miRNA for AIG1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIG1 Gene

Localization for AIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIG1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIG1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AIG1: view

Pathways & Interactions for AIG1 Gene

No Data Available

Interacting Proteins for AIG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350509%0d%0a9606.ENSP00000321239%0d%0a9606.ENSP00000362217%0d%0a
Selected Interacting proteins: Q9NVV5-AIG1_HUMAN ENSP00000350509 for AIG1 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for AIG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AIG1 Gene

Transcripts for AIG1 Gene

Unigene Clusters for AIG1 Gene

Androgen-induced 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIG1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for AIG1 Gene

GeneLoc Exon Structure for
AIG1
ECgene alternative splicing isoforms for
AIG1

Expression for AIG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AIG1 Gene

mRNA differential expression in normal tissues according to GTEx for AIG1 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for AIG1 Gene

This gene is overexpressed in Ovary (12.8) and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AIG1 Gene



Protein tissue co-expression partners for AIG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AIG1 Gene:

AIG1

SOURCE GeneReport for Unigene cluster for AIG1 Gene:

Hs.567501

mRNA Expression by UniProt/SwissProt for AIG1 Gene:

Q9NVV5-AIG1_HUMAN
Tissue specificity: Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.

Evidence on tissue expression from TISSUES for AIG1 Gene

  • Skin(4.3)
  • Nervous system(3.4)
  • Liver(2.2)
  • Kidney(2.1)
  • Spleen(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with AIG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AIG1 Gene

Orthologs for AIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIG1 34 35
  • 97.74 (n)
cow
(Bos Taurus)
Mammalia AIG1 34 35
  • 93.98 (n)
dog
(Canis familiaris)
Mammalia AIG1 34 35
  • 91.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AIG1 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aig1 34 16 35
  • 88.99 (n)
rat
(Rattus norvegicus)
Mammalia Aig1 34
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia AIG1 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves AIG1 34 35
  • 79.39 (n)
lizard
(Anolis carolinensis)
Reptilia AIG1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo15a 34
  • 74.63 (n)
zebrafish
(Danio rerio)
Actinopterygii aig1 34 35
  • 70.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008626 34
  • 54.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3625 35
  • 33 (a)
ManyToMany
CG6149 35
  • 32 (a)
ManyToMany
CG11601 35
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for AIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIG1 Gene

ENSEMBL:
Gene Tree for AIG1 (if available)
TreeFam:
Gene Tree for AIG1 (if available)

Paralogs for AIG1 Gene

Paralogs for AIG1 Gene

(1) SIMAP similar genes for AIG1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for AIG1 Gene

genes like me logo Genes that share paralogs with AIG1: view

Variants for AIG1 Gene

Sequence variations from dbSNP and Humsavar for AIG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000000816 -- 143,288,462(+) TGTTT(C/T)CACTT intron-variant
rs1000008913 -- 143,154,915(+) TGATC(G/T)CGGTG intron-variant
rs1000038448 -- 143,240,562(+) CCAAT(C/T)TTTGC intron-variant
rs1000042624 -- 143,217,507(+) GTTAT(A/G)TCTTT intron-variant
rs1000056236 -- 143,211,167(+) TGACA(-/GAGT)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AIG1 Gene

Variant ID Type Subtype PubMed ID
esv2659568 CNV deletion 23128226
esv2664367 CNV deletion 23128226
esv275228 CNV gain+loss 21479260
esv29171 CNV loss 19812545
esv3412403 CNV insertion 20981092
esv3540580 CNV deletion 23714750
esv3571432 CNV loss 25503493
esv3576234 CNV gain 25503493
esv3611090 CNV loss 21293372
esv3611092 CNV loss 21293372
esv3611093 CNV loss 21293372
nsv476666 CNV novel sequence insertion 20440878
nsv476772 CNV novel sequence insertion 20440878
nsv478750 CNV novel sequence insertion 20440878
nsv949863 CNV duplication 24416366
nsv965775 CNV duplication 23825009

Variation tolerance for AIG1 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AIG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIG1 Gene

Disorders for AIG1 Gene

Relevant External Links for AIG1

Genetic Association Database (GAD)
AIG1
Human Genome Epidemiology (HuGE) Navigator
AIG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AIG1

No disorders were found for AIG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIG1 Gene

Publications for AIG1 Gene

  1. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. (PMID: 11266118) Seo J. … Kim M. (Mol. Cells 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for AIG1 Gene

Sources for AIG1 Gene

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