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Aliases for AIG1 Gene

Aliases for AIG1 Gene

  • Androgen-Induced 1 2 3 5
  • AIG-1 3 4
  • DJ95L4.1 3

External Ids for AIG1 Gene

Previous GeneCards Identifiers for AIG1 Gene

  • GC06P143315
  • GC06P143362
  • GC06P143423
  • GC06P140946

Summaries for AIG1 Gene

GeneCards Summary for AIG1 Gene

AIG1 (Androgen-Induced 1) is a Protein Coding gene. An important paralog of this gene is ADTRP.

UniProtKB/Swiss-Prot for AIG1 Gene

  • May play a role in androgen-regulated growth of hair follicles.

Gene Wiki entry for AIG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIG1 Gene

Genomics for AIG1 Gene

Regulatory Elements for AIG1 Gene

Promoters for AIG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AIG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AIG1 Gene

Chromosome:
6
Start:
143,059,363 bp from pter
End:
143,340,343 bp from pter
Size:
280,981 bases
Orientation:
Plus strand

Genomic View for AIG1 Gene

Genes around AIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIG1 Gene

Proteins for AIG1 Gene

  • Protein details for AIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVV5-AIG1_HUMAN
    Recommended name:
    Androgen-induced gene 1 protein
    Protein Accession:
    Q9NVV5
    Secondary Accessions:
    • B4DPX2
    • C9J569
    • Q5T2H2
    • Q6N047
    • Q7Z378
    • Q8TB14
    • Q9Y3A9
    • Q9Y5B4

    Protein attributes for AIG1 Gene

    Size:
    245 amino acids
    Molecular mass:
    28222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34098.1; Type=Frameshift; Positions=182, 193, 223; Evidence={ECO:0000305}; Sequence=CAE45823.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AIG1 Gene

neXtProt entry for AIG1 Gene

Proteomics data for AIG1 Gene at MOPED

Post-translational modifications for AIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AIG1 Gene

Domains & Families for AIG1 Gene

Protein Domains for AIG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AIG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVV5

UniProtKB/Swiss-Prot:

AIG1_HUMAN :
  • Belongs to the AIG1 family.
Family:
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with AIG1: view

No data available for Gene Families for AIG1 Gene

Function for AIG1 Gene

Molecular function for AIG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in androgen-regulated growth of hair follicles.
UniProtKB/Swiss-Prot Induction:
By dihydrotestosterone (DHT).
genes like me logo Genes that share phenotypes with AIG1: view

Animal Model Products

miRNA for AIG1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIG1 Gene

Localization for AIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIG1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIG1 Gene COMPARTMENTS Subcellular localization image for AIG1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for AIG1 Gene

Pathways & Interactions for AIG1 Gene

SuperPathways for AIG1 Gene

No Data Available

Interacting Proteins for AIG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350509%0d%0a9606.ENSP00000321239%0d%0a
Selected Interacting proteins: ENSP00000350509 Q9NVV5-AIG1_HUMAN for AIG1 Gene via STRING I2D UniProtKB

Gene Ontology (GO) - Biological Process for AIG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AIG1 Gene

Drugs & Compounds for AIG1 Gene

No Compound Related Data Available

Transcripts for AIG1 Gene

Unigene Clusters for AIG1 Gene

Androgen-induced 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AIG1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for AIG1 Gene

GeneLoc Exon Structure for
AIG1
ECgene alternative splicing isoforms for
AIG1

Expression for AIG1 Gene

mRNA expression in normal human tissues for AIG1 Gene

mRNA differential expression in normal tissues according to GTEx for AIG1 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for AIG1 Gene

This gene is overexpressed in Ovary (12.8) and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AIG1 Gene



SOURCE GeneReport for Unigene cluster for AIG1 Gene Hs.567501

mRNA Expression by UniProt/SwissProt for AIG1 Gene

Q9NVV5-AIG1_HUMAN
Tissue specificity: Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.
genes like me logo Genes that share expression patterns with AIG1: view

Protein tissue co-expression partners for AIG1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AIG1 Gene

Orthologs for AIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIG1 36
  • 99 (a)
OneToOne
AIG1 35
  • 97.74 (n)
  • 97.29 (a)
cow
(Bos Taurus)
Mammalia AIG1 35
  • 93.98 (n)
  • 96.64 (a)
AIG1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIG1 36
  • 91 (a)
OneToOne
AIG1 35
  • 91.52 (n)
  • 94.83 (a)
mouse
(Mus musculus)
Mammalia Aig1 16
Aig1 36
  • 82 (a)
OneToOne
Aig1 35
  • 88.99 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia AIG1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIG1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aig1 35
  • 88.16 (n)
  • 92.98 (a)
chicken
(Gallus gallus)
Aves AIG1 35
  • 79.39 (n)
  • 82.46 (a)
AIG1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIG1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo15a 35
  • 74.63 (n)
  • 78.76 (a)
zebrafish
(Danio rerio)
Actinopterygii aig1 35
  • 70.18 (n)
  • 75.88 (a)
aig1 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008626 35
  • 54.05 (n)
  • 44.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11601 36
  • 27 (a)
ManyToMany
CG3625 36
  • 33 (a)
ManyToMany
CG6149 36
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for AIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIG1 Gene

ENSEMBL:
Gene Tree for AIG1 (if available)
TreeFam:
Gene Tree for AIG1 (if available)

Paralogs for AIG1 Gene

Paralogs for AIG1 Gene

(1) SIMAP similar genes for AIG1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for AIG1 Gene

genes like me logo Genes that share paralogs with AIG1: view

Variants for AIG1 Gene

Sequence variations from dbSNP and Humsavar for AIG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1053193 - 143,284,161(+) ACCAT(C/G)AGTAT intron-variant, reference, missense
rs200150 -- 143,088,531(+) GAAAC(A/G)TGTAG intron-variant
rs451823 -- 143,059,062(+) cacac(C/T)aatca upstream-variant-2KB
rs1058963 -- 143,189,620(+) CCCTA(C/T)TATCT intron-variant, utr-variant-3-prime
rs1124210 -- 143,334,471(+) AGGGT(A/G)TTAGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AIG1 Gene

Variant ID Type Subtype PubMed ID
esv2659568 CNV Deletion 23128226
esv275228 CNV Gain+Loss 21479260
esv2664367 CNV Deletion 23128226
esv29171 CNV Loss 19812545

Variation tolerance for AIG1 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AIG1 Gene

HapMap Linkage Disequilibrium report
AIG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIG1 Gene

Disorders for AIG1 Gene

Relevant External Links for AIG1

Genetic Association Database (GAD)
AIG1
Human Genome Epidemiology (HuGE) Navigator
AIG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AIG1

No disorders were found for AIG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIG1 Gene

Publications for AIG1 Gene

  1. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. (PMID: 11266118) Seo J. … Kim M. (Mol. Cells 2001) 2 3 4 23 67
  2. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. (PMID: 22076464) Ellinghaus E. … Franke A. (Leukemia 2012) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway. (PMID: 21622095) Wu G. … Huo K. (Front Biosci (Elite Ed) 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for AIG1 Gene

Sources for AIG1 Gene

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