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Aliases for AIG1 Gene

Aliases for AIG1 Gene

  • Androgen-Induced 1 2 3
  • AIG-1 3 4
  • Androgen-Induced Gene 1 Protein 3
  • DJ95L4.1 3

External Ids for AIG1 Gene

Previous GeneCards Identifiers for AIG1 Gene

  • GC06P143315
  • GC06P143362
  • GC06P143423
  • GC06P140946

Summaries for AIG1 Gene

GeneCards Summary for AIG1 Gene

AIG1 (Androgen-Induced 1) is a Protein Coding gene. Diseases associated with AIG1 include amebiasis. An important paralog of this gene is ADTRP.

UniProtKB/Swiss-Prot for AIG1 Gene

  • May play a role in androgen-regulated growth of hair follicles

Gene Wiki entry for AIG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIG1 Gene

Genomics for AIG1 Gene

Regulatory Elements for AIG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AIG1 Gene

143,059,363 bp from pter
143,340,343 bp from pter
280,981 bases
Plus strand

Genomic View for AIG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIG1 Gene

Proteins for AIG1 Gene

  • Protein details for AIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Androgen-induced gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • B4DPX2
    • C9J569
    • Q5T2H2
    • Q6N047
    • Q7Z378
    • Q8TB14
    • Q9Y3A9
    • Q9Y5B4

    Protein attributes for AIG1 Gene

    245 amino acids
    Molecular mass:
    28222 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34098.1; Type=Frameshift; Positions=182, 193, 223; Evidence={ECO:0000305}; Sequence=CAE45823.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AIG1 Gene

neXtProt entry for AIG1 Gene

Proteomics data for AIG1 Gene at MOPED

Post-translational modifications for AIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AIG1 Gene

Domains for AIG1 Gene

Protein Domains for AIG1 Gene


Suggested Antigen Peptide Sequences for AIG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AIG1 family.
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with AIG1: view

No data available for Gene Families for AIG1 Gene

Function for AIG1 Gene

Molecular function for AIG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in androgen-regulated growth of hair follicles
UniProtKB/Swiss-Prot Induction:
By dihydrotestosterone (DHT).

Gene Ontology (GO) - Molecular Function for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with AIG1: view

Phenotypes for AIG1 Gene

GenomeRNAi human phenotypes for AIG1:
genes like me logo Genes that share phenotypes with AIG1: view

Animal Model Products

miRNA for AIG1 Gene

miRTarBase miRNAs that target AIG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AIG1 Gene

Localization for AIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIG1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for AIG1 Gene COMPARTMENTS Subcellular localization image for AIG1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AIG1: view

Pathways for AIG1 Gene

SuperPathways for AIG1 Gene

No Data Available

Interacting Proteins for AIG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350509 Q9NVV5-AIG1_HUMAN for AIG1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for AIG1 Gene


No data available for Pathways by source for AIG1 Gene

Transcripts for AIG1 Gene

Unigene Clusters for AIG1 Gene

Androgen-induced 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIG1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for AIG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AIG1 Gene

mRNA expression in normal human tissues for AIG1 Gene

mRNA differential expression in normal tissues according to GTEx for AIG1 Gene

This gene is overexpressed in Liver (4.7).

Protein differential expression in normal tissues for AIG1 Gene

This gene is overexpressed in Ovary (12.8) and Liver (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AIG1 Gene

SOURCE GeneReport for Unigene cluster for AIG1 Gene Hs.567501

mRNA Expression by UniProt/SwissProt for AIG1 Gene

Tissue specificity: Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.
genes like me logo Genes that share expressions with AIG1: view

Expression partners for AIG1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AIG1 Gene

Orthologs for AIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AIG1 35
  • 93.98 (n)
  • 96.64 (a)
AIG1 36
  • 97 (a)
(Canis familiaris)
Mammalia AIG1 35
  • 91.52 (n)
  • 94.83 (a)
AIG1 36
  • 91 (a)
(Mus musculus)
Mammalia Aig1 35
  • 88.99 (n)
  • 95.15 (a)
Aig1 16
Aig1 36
  • 82 (a)
(Pan troglodytes)
Mammalia AIG1 35
  • 97.74 (n)
  • 97.29 (a)
AIG1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Aig1 35
  • 88.16 (n)
  • 92.98 (a)
(Monodelphis domestica)
Mammalia AIG1 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia AIG1 36
  • 89 (a)
(Gallus gallus)
Aves AIG1 35
  • 79.39 (n)
  • 82.46 (a)
AIG1 36
  • 88 (a)
(Anolis carolinensis)
Reptilia AIG1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo15a 35
  • 74.63 (n)
  • 78.76 (a)
(Danio rerio)
Actinopterygii aig1 35
  • 70.18 (n)
  • 75.88 (a)
aig1 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008626 35
  • 54.05 (n)
  • 44.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11601 36
  • 27 (a)
CG3625 36
  • 33 (a)
CG6149 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for AIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIG1 Gene

Gene Tree for AIG1 (if available)
Gene Tree for AIG1 (if available)

Paralogs for AIG1 Gene

Paralogs for AIG1 Gene

(1) SIMAP similar genes for AIG1 Gene using alignment to 8 proteins: Pseudogenes for AIG1 Gene

genes like me logo Genes that share paralogs with AIG1: view

Variants for AIG1 Gene

Sequence variations from dbSNP and Humsavar for AIG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9908 -- 143,340,029(+) GAGAA(A/C)TATGT utr-variant-3-prime
rs16640 -- 143,065,487(+) TCACT(-/CATTCACT)AGCAA intron-variant
rs200150 -- 143,088,531(+) GAAAC(A/G)TGTAG intron-variant
rs200151 -- 143,097,311(+) tccta(C/T)acccc intron-variant
rs200152 -- 143,071,498(-) ttccg(A/G)taaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AIG1 Gene

Variant ID Type Subtype PubMed ID
esv2659568 CNV Deletion 23128226
esv275228 CNV Gain+Loss 21479260
esv2664367 CNV Deletion 23128226
esv29171 CNV Loss 19812545

Relevant External Links for AIG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIG1 Gene

Disorders for AIG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AIG1 Gene in MalaCards »

(1) Disease for AIG1 Gene

(1) University of Copenhagen DISEASES for AIG1 Gene

Relevant External Links for AIG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AIG1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for AIG1 Gene

Publications for AIG1 Gene

  1. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. (PMID: 11266118) Seo J. … Kim M. (Mol. Cells 2001) 2 3 4 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for AIG1 Gene

Sources for AIG1 Gene

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