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Aliases for WNT16 Gene

Aliases for WNT16 Gene

  • Wingless-Type MMTV Integration Site Family, Member 16 2 3

External Ids for WNT16 Gene

Previous GeneCards Identifiers for WNT16 Gene

  • GC07P119443
  • GC07P120506
  • GC07P120519
  • GC07P120559
  • GC07P120752
  • GC07P120965
  • GC07P115328

Summaries for WNT16 Gene

Entrez Gene Summary for WNT16 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT16 Gene

WNT16 (Wingless-Type MMTV Integration Site Family, Member 16) is a Protein Coding gene. Diseases associated with WNT16 include osteoporotic fracture and coffin-siris syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT16 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT16 Gene

Genomics for WNT16 Gene

Regulatory Elements for WNT16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT16 Gene

Start:
121,325,367 bp from pter
End:
121,341,104 bp from pter
Size:
15,738 bases
Orientation:
Plus strand

Genomic View for WNT16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT16 Gene

Proteins for WNT16 Gene

  • Protein details for WNT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBV4-WNT16_HUMAN
    Recommended name:
    Protein Wnt-16
    Protein Accession:
    Q9UBV4
    Secondary Accessions:
    • Q2M3G1
    • Q9Y5C0

    Protein attributes for WNT16 Gene

    Size:
    365 amino acids
    Molecular mass:
    40690 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT16 Gene

Proteomics data for WNT16 Gene at MOPED

Post-translational modifications for WNT16 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn143, Asn189, and Asn311
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT16 Gene

Domains for WNT16 Gene

Gene Families for WNT16 Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT16 Gene

Suggested Antigen Peptide Sequences for WNT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBV4

UniProtKB/Swiss-Prot:

WNT16_HUMAN :
  • Q9UBV4
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT16: view

Function for WNT16 Gene

Molecular function for WNT16 Gene

UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Ontology (GO) - Molecular Function for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT16: view

Phenotypes for WNT16 Gene

MGI mutant phenotypes for WNT16:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with WNT16: view

Animal Model Products

CRISPR Products

miRNA for WNT16 Gene

miRTarBase miRNAs that target WNT16

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WNT16 Gene

Localization for WNT16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT16 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT16 Gene COMPARTMENTS Subcellular localization image for WNT16 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 10500199
GO:0005737 cytoplasm IDA 17200136
genes like me logo Genes that share ontologies with WNT16: view

Pathways for WNT16 Gene

genes like me logo Genes that share pathways with WNT16: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003408 optic cup formation involved in camera-type eye development ISS 16258938
GO:0007275 multicellular organismal development --
GO:0010628 positive regulation of gene expression IMP 16007226
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 19951988
GO:0016055 Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with WNT16: view

Transcripts for WNT16 Gene

mRNA/cDNA for WNT16 Gene

(9) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT16 Gene

Wingless-type MMTV integration site family, member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT16

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WNT16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT16 Gene

No ASD Table

Relevant External Links for WNT16 Gene

GeneLoc Exon Structure for
WNT16
ECgene alternative splicing isoforms for
WNT16

Expression for WNT16 Gene

mRNA expression in normal human tissues for WNT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT16 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.1), Vagina (8.2), Skin - Sun Exposed (Lower leg) (8.0), and Cervix - Ectocervix (5.7).

SOURCE GeneReport for Unigene cluster for WNT16 Gene Hs.272375

mRNA Expression by UniProt/SwissProt for WNT16 Gene

Q9UBV4-WNT16_HUMAN
Tissue specificity: Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas
genes like me logo Genes that share expressions with WNT16: view

In Situ Assay Products

No data available for Protein expression for WNT16 Gene

Orthologs for WNT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT16 35
  • 99.18 (n)
  • 99.18 (a)
WNT16 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT16 35
  • 92.73 (n)
  • 94.75 (a)
WNT16 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT16 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt16 35
  • 88 (n)
  • 90.93 (a)
Wnt16 16
Wnt16 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT16 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT16 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt16 35
  • 87.27 (n)
  • 90.38 (a)
chicken
(Gallus gallus)
Aves WNT16 35
  • 78.6 (n)
  • 85.99 (a)
WNT16 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT16 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt16 35
  • 73.08 (n)
  • 76.92 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt16 35
  • 64.86 (n)
  • 68.29 (a)
wnt16 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 37
  • 48 (a)
Wnt4 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-20 35
  • 50.96 (n)
  • 43.63 (a)
lin-44 37
  • 31 (a)
egl-20 37
  • 41 (a)
mom-2 37
  • 31 (a)
Species with no ortholog for WNT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT16 Gene

ENSEMBL:
Gene Tree for WNT16 (if available)
TreeFam:
Gene Tree for WNT16 (if available)

Paralogs for WNT16 Gene

Paralogs for WNT16 Gene

Selected SIMAP similar genes for WNT16 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WNT16: view

Variants for WNT16 Gene

Sequence variations from dbSNP and Humsavar for WNT16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2536188 -- 121,333,842(-) ATAAC(A/G)TGAGT intron-variant
rs2536189 -- 121,333,567(-) TCTCA(C/G)TCATT intron-variant
rs2536190 -- 121,332,807(-) TAAGA(C/T)ACTGA intron-variant
rs2536191 -- 121,327,584(-) TCACC(A/G)GAGGT intron-variant, upstream-variant-2KB
rs2536192 -- 121,327,159(-) ACTGA(A/T)CCAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WNT16 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
dgv2132e1 CNV Complex 17122850
esv269393 CNV Insertion 20981092

Relevant External Links for WNT16 Gene

HapMap Linkage Disequilibrium report
WNT16
Human Gene Mutation Database (HGMD)
WNT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT16 Gene

Disorders for WNT16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for WNT16 Gene including...

Search for WNT16 Gene in MalaCards »

(1) University of Copenhagen DISEASES for WNT16 Gene

Relevant External Links for WNT16

Genetic Association Database (GAD)
WNT16
Human Genome Epidemiology (HuGE) Navigator
WNT16
genes like me logo Genes that share disorders with WNT16: view

No data available for UniProtKB/Swiss-Prot for WNT16 Gene

Publications for WNT16 Gene

  1. Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. (PMID: 11095990) Fear M.W. … Barnes M.R. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. (PMID: 10500199) McWhirter J.R. … Murre C. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  3. The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. (PMID: 16769578) Casagrande G. … Basso G. (Haematologica 2006) 3 23
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WNT16 Gene

  • Addgene plasmids for WNT16

Sources for WNT16 Gene

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