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Aliases for WNT16 Gene

Aliases for WNT16 Gene

  • Wnt Family Member 16 2 3
  • Wingless-Type MMTV Integration Site Family, Member 16 2
  • Wingless-Type MMTV Integration Site Family Member 16 5

External Ids for WNT16 Gene

Previous GeneCards Identifiers for WNT16 Gene

  • GC07P119443
  • GC07P120506
  • GC07P120519
  • GC07P120559
  • GC07P120752
  • GC07P120965
  • GC07P115328

Summaries for WNT16 Gene

Entrez Gene Summary for WNT16 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT16 Gene

WNT16 (Wnt Family Member 16) is a Protein Coding gene. Diseases associated with WNT16 include osteoporotic fracture and coffin-siris syndrome. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathway (WikiPathways). GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT16 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT16 Gene

Genomics for WNT16 Gene

Regulatory Elements for WNT16 Gene

Genomic Location for WNT16 Gene

Chromosome:
7
Start:
121,325,367 bp from pter
End:
121,341,104 bp from pter
Size:
15,738 bases
Orientation:
Plus strand

Genomic View for WNT16 Gene

Genes around WNT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT16 Gene

Proteins for WNT16 Gene

  • Protein details for WNT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBV4-WNT16_HUMAN
    Recommended name:
    Protein Wnt-16
    Protein Accession:
    Q9UBV4
    Secondary Accessions:
    • Q2M3G1
    • Q9Y5C0

    Protein attributes for WNT16 Gene

    Size:
    365 amino acids
    Molecular mass:
    40690 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT16 Gene

Proteomics data for WNT16 Gene at MOPED

Post-translational modifications for WNT16 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 143, Asn 189, and Asn 311
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for WNT16

No data available for DME Specific Peptides for WNT16 Gene

Domains & Families for WNT16 Gene

Gene Families for WNT16 Gene

Protein Domains for WNT16 Gene

Suggested Antigen Peptide Sequences for WNT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBV4

UniProtKB/Swiss-Prot:

WNT16_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT16: view

Function for WNT16 Gene

Molecular function for WNT16 Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Ontology (GO) - Molecular Function for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with WNT16: view

Phenotypes for WNT16 Gene

genes like me logo Genes that share phenotypes with WNT16: view

Animal Models for WNT16 Gene

MGI Knock Outs for WNT16:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT16

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT16 Gene

Localization for WNT16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT16 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT16 Gene COMPARTMENTS Subcellular localization image for WNT16 gene
Compartment Confidence
extracellular 5
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with WNT16: view

Pathways & Interactions for WNT16 Gene

genes like me logo Genes that share pathways with WNT16: view

SIGNOR curated interactions for WNT16 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003408 optic cup formation involved in camera-type eye development ISS 16258938
GO:0007275 multicellular organism development IEA --
GO:0010628 positive regulation of gene expression IMP 16007226
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 19951988
GO:0016055 Wnt signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with WNT16: view

Drugs & Compounds for WNT16 Gene

No Compound Related Data Available

Transcripts for WNT16 Gene

mRNA/cDNA for WNT16 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT16 Gene

Wingless-type MMTV integration site family, member 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT16 Gene

No ASD Table

Relevant External Links for WNT16 Gene

GeneLoc Exon Structure for
WNT16
ECgene alternative splicing isoforms for
WNT16

Expression for WNT16 Gene

mRNA expression in normal human tissues for WNT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT16 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.1), Vagina (x8.2), Skin - Sun Exposed (Lower leg) (x8.0), and Cervix - Ectocervix (x5.7).

SOURCE GeneReport for Unigene cluster for WNT16 Gene Hs.272375

mRNA Expression by UniProt/SwissProt for WNT16 Gene

Q9UBV4-WNT16_HUMAN
Tissue specificity: Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas.
genes like me logo Genes that share expression patterns with WNT16: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for WNT16 Gene

Orthologs for WNT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT16 36
  • 99 (a)
OneToOne
WNT16 35
  • 99.18 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia WNT16 36
  • 94 (a)
OneToOne
WNT16 35
  • 92.73 (n)
  • 94.75 (a)
dog
(Canis familiaris)
Mammalia WNT16 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt16 16
Wnt16 35
  • 88 (n)
  • 90.93 (a)
Wnt16 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT16 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT16 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt16 35
  • 87.27 (n)
  • 90.38 (a)
chicken
(Gallus gallus)
Aves WNT16 35
  • 78.6 (n)
  • 85.99 (a)
WNT16 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT16 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt16 35
  • 73.08 (n)
  • 76.92 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt16 35
  • 64.86 (n)
  • 68.29 (a)
wnt16 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt4 37
  • 34 (a)
Wnt5 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-20 37
  • 41 (a)
lin-44 37
  • 31 (a)
mom-2 37
  • 31 (a)
egl-20 35
  • 50.96 (n)
  • 43.63 (a)
Species with no ortholog for WNT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT16 Gene

ENSEMBL:
Gene Tree for WNT16 (if available)
TreeFam:
Gene Tree for WNT16 (if available)

Paralogs for WNT16 Gene

Paralogs for WNT16 Gene

genes like me logo Genes that share paralogs with WNT16: view

Variants for WNT16 Gene

Sequence variations from dbSNP and Humsavar for WNT16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036289 A colorectal cancer sample
rs2908004 - 121,329,715(-) GCTCC(A/C/T)GCACT reference, missense
rs2707466 - 121,339,035(-) TCTTT(A/G)TTTTG reference, missense
rs2707470 -- 121,336,816(-) ATTAG(C/T)CACTT intron-variant
rs2707471 -- 121,336,623(-) TTAAT(A/G)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT16 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
dgv2132e1 CNV Complex 17122850
esv269393 CNV Insertion 20981092

Variation tolerance for WNT16 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT16 Gene

HapMap Linkage Disequilibrium report
WNT16
Human Gene Mutation Database (HGMD)
WNT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT16 Gene

Disorders for WNT16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WNT16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
osteoporotic fracture
  • osteoporotic fractures
coffin-siris syndrome
  • dwarfism-onychodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search WNT16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNT16

Genetic Association Database (GAD)
WNT16
Human Genome Epidemiology (HuGE) Navigator
WNT16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT16
genes like me logo Genes that share disorders with WNT16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT16 Gene

Publications for WNT16 Gene

  1. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. (PMID: 10500199) McWhirter J.R. … Murre C. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 67
  2. The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. (PMID: 16769578) Casagrande G. … Basso G. (Haematologica 2006) 3 23
  3. Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. (PMID: 11095990) Fear M.W. … Barnes M.R. (Biochem. Biophys. Res. Commun. 2000) 3 23
  4. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. (PMID: 24249740) Zhang L. … Deng H.W. (Hum. Mol. Genet. 2014) 3
  5. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. (PMID: 24945404) Kemp J.P. … Evans D.M. (PLoS Genet. 2014) 3

Products for WNT16 Gene

Sources for WNT16 Gene

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