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Aliases for WNT16 Gene

Aliases for WNT16 Gene

  • Wnt Family Member 16 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 16 2

External Ids for WNT16 Gene

Previous GeneCards Identifiers for WNT16 Gene

  • GC07P119443
  • GC07P120506
  • GC07P120519
  • GC07P120559
  • GC07P120752
  • GC07P120965
  • GC07P115328

Summaries for WNT16 Gene

Entrez Gene Summary for WNT16 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT16 Gene

WNT16 (Wnt Family Member 16) is a Protein Coding gene. Diseases associated with WNT16 include Nodular Basal Cell Carcinoma and Basal Cell Carcinoma. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT7B.

UniProtKB/Swiss-Prot for WNT16 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT16 Gene

Additional gene information for WNT16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT16 Gene

Genomics for WNT16 Gene

GeneHancer (GH) Regulatory Elements for WNT16 Gene

Promoters and enhancers for WNT16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I121328 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +4.4 4360 2.1 MZF1 ZNF335 GLIS2 ZNF366 SCRT2 KLF7 ZNF548 EGR2 ZNF362 USF2 WNT16 ING3 FAM3C
GH07I121301 Enhancer 1 Ensembl ENCODE 25.4 -23.1 -23084 2.1 LEF1 BACH1 EBF1 BATF ZIC2 IRF4 ZNF664 POLR2B POLR2A NFATC1 WNT16 RNU6-517P GC07M121195
GH07I121543 Enhancer 1.1 Ensembl ENCODE 11.3 +220.1 220138 4.2 CLOCK ATF1 BATF IRF4 RAD21 RFX5 ARID2 ZNF143 ATF7 RCOR1 FAM3C CYCSP19 WNT16 LOC105375478 ENSG00000227743
GH07I121547 Enhancer 0.7 ENCODE 11.3 +222.3 222325 0.2 CTCF ATF1 BACH1 RAD21 RFX5 CC2D1A ZNF664 FOXK2 ARID2 ZNF143 WNT16 LOC105375478 ENSG00000227743
GH07I121350 Enhancer 0.5 dbSUPER 12.4 +28.5 28506 6.3 CTCF IKZF1 SCRT2 KLF4 BATF FAM3C WNT16 CYCSP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WNT16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT16 gene promoter:

Genomic Locations for WNT16 Gene

Genomic Locations for WNT16 Gene
chr7:121,325,367-121,341,104
(GRCh38/hg38)
Size:
15,738 bases
Orientation:
Plus strand
chr7:120,965,421-120,981,158
(GRCh37/hg19)

Genomic View for WNT16 Gene

Genes around WNT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT16 Gene

Proteins for WNT16 Gene

  • Protein details for WNT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBV4-WNT16_HUMAN
    Recommended name:
    Protein Wnt-16
    Protein Accession:
    Q9UBV4
    Secondary Accessions:
    • Q2M3G1
    • Q9Y5C0

    Protein attributes for WNT16 Gene

    Size:
    365 amino acids
    Molecular mass:
    40690 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT16 Gene

Post-translational modifications for WNT16 Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at isoforms=2143, posLast=189189, and isoforms=2311

Other Protein References for WNT16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT16 Gene

Domains & Families for WNT16 Gene

Gene Families for WNT16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WNT16 Gene

Suggested Antigen Peptide Sequences for WNT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBV4

UniProtKB/Swiss-Prot:

WNT16_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT16: view

Function for WNT16 Gene

Molecular function for WNT16 Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Phenotypes From GWAS Catalog for WNT16 Gene

Gene Ontology (GO) - Molecular Function for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT16: view

Phenotypes for WNT16 Gene

genes like me logo Genes that share phenotypes with WNT16: view

Animal Models for WNT16 Gene

MGI Knock Outs for WNT16:

Clone Products

  • Addgene plasmids for WNT16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT16 Gene

Localization for WNT16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT16 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT16 gene
Compartment Confidence
extracellular 5
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 10500199
GO:0005737 cytoplasm IDA 17200136
genes like me logo Genes that share ontologies with WNT16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT16 Gene

Pathways & Interactions for WNT16 Gene

genes like me logo Genes that share pathways with WNT16: view

SIGNOR curated interactions for WNT16 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003408 optic cup formation involved in camera-type eye development ISS 16258938
GO:0007275 multicellular organism development IEA --
GO:0010628 positive regulation of gene expression IMP 16007226
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 19951988
GO:0016055 Wnt signaling pathway TAS,IBA --
genes like me logo Genes that share ontologies with WNT16: view

Drugs & Compounds for WNT16 Gene

No Compound Related Data Available

Transcripts for WNT16 Gene

mRNA/cDNA for WNT16 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT16 Gene

Wingless-type MMTV integration site family, member 16:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT16

Alternative Splicing Database (ASD) splice patterns (SP) for WNT16 Gene

No ASD Table

Relevant External Links for WNT16 Gene

GeneLoc Exon Structure for
WNT16
ECgene alternative splicing isoforms for
WNT16

Expression for WNT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT16 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.1), Vagina (x8.2), Skin - Sun Exposed (Lower leg) (x8.0), and Cervix - Ectocervix (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of WNT16 Gene:

WNT16

SOURCE GeneReport for Unigene cluster for WNT16 Gene:

Hs.272375

mRNA Expression by UniProt/SwissProt for WNT16 Gene:

Q9UBV4-WNT16_HUMAN
Tissue specificity: Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas.
genes like me logo Genes that share expression patterns with WNT16: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT16 Gene

Orthologs for WNT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT16 33 34
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia WNT16 33 34
  • 92.73 (n)
mouse
(Mus musculus)
Mammalia Wnt16 33 16 34
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia Wnt16 33
  • 87.27 (n)
dog
(Canis familiaris)
Mammalia WNT16 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT16 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT16 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT16 33 34
  • 78.6 (n)
lizard
(Anolis carolinensis)
Reptilia WNT16 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt16 33
  • 73.08 (n)
zebrafish
(Danio rerio)
Actinopterygii wnt16 33 34
  • 64.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 35
  • 48 (a)
Wnt4 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-20 35 33
  • 50.96 (n)
lin-44 35
  • 31 (a)
mom-2 35
  • 31 (a)
Species where no ortholog for WNT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT16 Gene

ENSEMBL:
Gene Tree for WNT16 (if available)
TreeFam:
Gene Tree for WNT16 (if available)

Paralogs for WNT16 Gene

Paralogs for WNT16 Gene

genes like me logo Genes that share paralogs with WNT16: view

Variants for WNT16 Gene

Sequence variations from dbSNP and Humsavar for WNT16 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_036289 A colorectal cancer sample p.Val126Met
rs1000064365 -- 121,329,914(+) A/G intron_variant
rs1000300224 -- 121,323,968(+) C/T upstream_transcript_variant
rs1000461599 -- 121,323,683(+) G/A upstream_transcript_variant
rs1000891167 -- 121,326,003(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT16 Gene

Variant ID Type Subtype PubMed ID
esv2759558 CNV loss 17122850
esv3364873 CNV insertion 20981092
nsv1034353 CNV loss 25217958
nsv7405 OTHER inversion 18451855

Variation tolerance for WNT16 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT16 Gene

Human Gene Mutation Database (HGMD)
WNT16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT16 Gene

Disorders for WNT16 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WNT16 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nodular basal cell carcinoma
  • basal cell carcinoma, nodular
basal cell carcinoma
  • basal cell cancer
coffin-siris syndrome 1
  • css1
- elite association - COSMIC cancer census association via MalaCards
Search WNT16 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WNT16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT16 Gene

Publications for WNT16 Gene

  1. Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. (PMID: 11095990) Fear MW … Barnes MR (Biochemical and biophysical research communications 2000) 3 4 22 58
  2. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. (PMID: 10500199) McWhirter JR … Murre C (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 58
  3. The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. (PMID: 16769578) Casagrande G … Basso G (Haematologica 2006) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for WNT16 Gene

Sources for WNT16 Gene

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