Aliases for ATP6V1D Gene
- ATPase H+ Transporting V1 Subunit D 2 3
- ATPase, H+ Transporting, Lysosomal 34kDa, V1 Subunit D 2 3 5
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 2 3
- V-ATPase 28 KDa Accessory Protein 3 4
- Vacuolar Proton Pump Subunit D 3 4
- V-ATPase Subunit D 3 4
- ATP6M 3 4
- VATD 3 4
- H(+)-Transporting Two-Sector ATPase, Subunit M 3
External Ids for ATP6V1D Gene
Previous HGNC Symbols for ATP6V1D Gene
Previous GeneCards Identifiers for ATP6V1D Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V1D Gene
ATP6V1D (ATPase H+ Transporting V1 Subunit D) is a Protein Coding gene. Among its related pathways are Synaptic vesicle cycle and Immune System. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.
UniProtKB/Swiss-Prot for ATP6V1D Gene
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.