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Aliases for MRPS17 Gene

Aliases for MRPS17 Gene

  • Mitochondrial Ribosomal Protein S17 2 3 5
  • MRP-S17 3 4
  • RPMS17 3 4
  • S17mt 3 4
  • 28S Ribosomal Protein S17 2
  • Mitochondrial 2
  • HSPC011 3

External Ids for MRPS17 Gene

Previous GeneCards Identifiers for MRPS17 Gene

  • GC07P055483
  • GC07P055727
  • GC07P055761
  • GC07P055793
  • GC07P055987
  • GC07P055834
  • GC07P056019
  • GC07P055952

Summaries for MRPS17 Gene

Entrez Gene Summary for MRPS17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS17 Gene

MRPS17 (Mitochondrial Ribosomal Protein S17) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome and rRNA binding. An important paralog of this gene is ENSG00000249773.

Gene Wiki entry for MRPS17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS17 Gene

Genomics for MRPS17 Gene

Regulatory Elements for MRPS17 Gene

Enhancers for MRPS17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS17 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS17 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MRPS17 gene promoter:

Genomic Location for MRPS17 Gene

55,951,819 bp from pter
55,956,501 bp from pter
4,683 bases
Plus strand

Genomic View for MRPS17 Gene

Genes around MRPS17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS17 Gene

Proteins for MRPS17 Gene

  • Protein details for MRPS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S17, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q86X15

    Protein attributes for MRPS17 Gene

    130 amino acids
    Molecular mass:
    14502 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS17 Gene

neXtProt entry for MRPS17 Gene

Proteomics data for MRPS17 Gene at MOPED

Post-translational modifications for MRPS17 Gene

  • Ubiquitination at Lys 41
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS17 Gene

Domains & Families for MRPS17 Gene

Gene Families for MRPS17 Gene

Protein Domains for MRPS17 Gene

Suggested Antigen Peptide Sequences for MRPS17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S17P family.
  • Belongs to the ribosomal protein S17P family.
genes like me logo Genes that share domains with MRPS17: view

Function for MRPS17 Gene

genes like me logo Genes that share phenotypes with MRPS17: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS17 Gene

Localization for MRPS17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS17 Gene


Subcellular locations from

Jensen Localization Image for MRPS17 Gene COMPARTMENTS Subcellular localization image for MRPS17 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS17: view

Pathways & Interactions for MRPS17 Gene

genes like me logo Genes that share pathways with MRPS17: view

Gene Ontology (GO) - Biological Process for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0006996 organelle organization TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS17: view

No data available for SIGNOR curated interactions for MRPS17 Gene

Drugs & Compounds for MRPS17 Gene

No Compound Related Data Available

Transcripts for MRPS17 Gene

mRNA/cDNA for MRPS17 Gene

Unigene Clusters for MRPS17 Gene

Mitochondrial ribosomal protein S17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS17 Gene

No ASD Table

Relevant External Links for MRPS17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS17 Gene

mRNA expression in normal human tissues for MRPS17 Gene

mRNA differential expression in normal tissues according to GTEx for MRPS17 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for MRPS17 Gene

This gene is overexpressed in Lung (24.8), Liver (10.9), and Cervix (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS17 Gene

SOURCE GeneReport for Unigene cluster for MRPS17 Gene Hs.44298

genes like me logo Genes that share expression patterns with MRPS17: view

Protein tissue co-expression partners for MRPS17 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS17 Gene

Orthologs for MRPS17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS17 35
  • 87.18 (n)
  • 86.92 (a)
-- 36
  • 81 (a)
MRPS17 36
  • 82 (a)
(Canis familiaris)
Mammalia MRPS17 35
  • 87.69 (n)
  • 88.46 (a)
-- 36
  • 74 (a)
(Mus musculus)
Mammalia Mrps17 35
  • 79.77 (n)
  • 86.32 (a)
Mrps17 16
Mrps17 36
  • 87 (a)
(Pan troglodytes)
Mammalia MRPS17 35
  • 99.23 (n)
  • 98.46 (a)
MRPS17 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Mrps17 35
  • 81.1 (n)
  • 84.25 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
(Gallus gallus)
Aves MRPS17 35
  • 74.74 (n)
  • 79.69 (a)
MRPS17 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps17 35
  • 68.52 (n)
  • 70.63 (a)
Str.1461 35
African clawed frog
(Xenopus laevis)
Amphibia mrps17-prov 35
(Danio rerio)
Actinopterygii zgc:110031 35
  • 67.19 (n)
  • 77.34 (a)
MRPS17 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.271 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS17 36
  • 23 (a)
Species with no ortholog for MRPS17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS17 Gene

Gene Tree for MRPS17 (if available)
Gene Tree for MRPS17 (if available)

Paralogs for MRPS17 Gene

Paralogs for MRPS17 Gene

genes like me logo Genes that share paralogs with MRPS17: view

Variants for MRPS17 Gene

Sequence variations from dbSNP and Humsavar for MRPS17 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1047693 -- 55,955,246(+) TTTTT(C/T)TAAGT utr-variant-3-prime
rs12669185 -- 55,952,704(+) cactc(C/T)agact intron-variant
rs12670669 -- 55,951,251(+) gaggc(A/G)gaggt upstream-variant-2KB
rs12671091 -- 55,950,973(+) tgata(C/T)ttttc upstream-variant-2KB
rs13227582 -- 55,954,628(+) CTTGG(C/G/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS17 Gene

Variant ID Type Subtype PubMed ID
esv28230 CNV Gain+Loss 19812545
esv2734447 CNV Deletion 23290073
dgv1201e199 CNV Deletion 23128226
nsv888064 CNV Gain 21882294
esv2734448 CNV Deletion 23290073

Variation tolerance for MRPS17 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS17 Gene

Disorders for MRPS17 Gene

Relevant External Links for MRPS17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS17 Gene

Publications for MRPS17 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for MRPS17 Gene

Sources for MRPS17 Gene