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Aliases for ZBTB7A Gene

Aliases for ZBTB7A Gene

  • Zinc Finger And BTB Domain Containing 7A 2 3 2
  • FBI1 3 4 6
  • LRF 3 4 6
  • Factor That Binds To Inducer Of Short Transcripts Protein 1 3 4
  • POZ And Krueppel Erythroid Myeloid Ontogenic Factor 3 4
  • HIV-1 Inducer Of Short Transcripts Binding Protein 2 3
  • POK Erythroid Myeloid Ontogenic Factor 3 4
  • Leukemia/Lymphoma-Related Factor 3 4
  • Factor Binding IST Protein 1 3 4
  • TTF-I-Interacting Peptide 21 3 4
  • HIV-1 1st-Binding Protein 1 3 4
  • Zinc Finger Protein 857A 3 4
  • Lymphoma Related Factor 2 3
  • Pokemon 3 4
  • ZNF857A 3 4
  • ZBTB7 3 4
  • FBI-1 3 4
  • TIP21 3 4
  • Zinc Finger And BTB Domain Containing 7A, HIV-1 Inducer Of Short Transcripts Binding Protein 3
  • Zinc Finger And BTB Domain-Containing Protein 7A 3
  • Zinc Finger And BTB Domain Containing 7 2

External Ids for ZBTB7A Gene

Previous Symbols for ZBTB7A Gene

  • ZBTB7

Summaries for ZBTB7A Gene

GeneCards Summary for ZBTB7A Gene

ZBTB7A (Zinc Finger And BTB Domain Containing 7A) is a Protein Coding gene. Diseases associated with ZBTB7A include hiv-1. GO annotations related to this gene include histone acetyltransferase binding. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB7A Gene

  • Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Gene Wiki entry for ZBTB7A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7A Gene

Genomics for ZBTB7A Gene

Genomic Location for ZBTB7A Gene

Start:
4,044,364 bp from pter
End:
4,066,945 bp from pter
Size:
22,582 bases
Orientation:
Minus strand

Genomic View for ZBTB7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7A Gene

Regulatory Elements for ZBTB7A Gene

Proteins for ZBTB7A Gene

  • Protein details for ZBTB7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95365-ZBT7A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7A
    Protein Accession:
    O95365
    Secondary Accessions:
    • D6W619
    • O00456
    • Q14D41
    • Q5XG86

    Protein attributes for ZBTB7A Gene

    Size:
    584 amino acids
    Molecular mass:
    61439 Da
    Quaternary structure:
    • Interacts with BCL6.
    SequenceCaution:
    • Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB7A Gene

neXtProt entry for ZBTB7A Gene

Proteomics data for ZBTB7A Gene at MOPED

Post-translational modifications for ZBTB7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB7A Gene

Domains for ZBTB7A Gene

Gene Families for ZBTB7A Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB7A Gene

UniProtKB/Swiss-Prot:

ZBT7A_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • O95365
Similarity:
  • Contains 4 C2H2-type zinc fingers.:
    • O95365
genes like me logo Genes that share domains with ZBTB7A: view

Function for ZBTB7A Gene

Molecular function for ZBTB7A Gene

UniProtKB/Swiss-Prot Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Gene Ontology (GO) - Molecular Function for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS 15337766
GO:0005515 protein binding IPI 24514149
GO:0035035 histone acetyltransferase binding ISS 15337766
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view

Phenotypes for ZBTB7A Gene

genes like me logo Genes that share phenotypes with ZBTB7A: view

Animal Models for ZBTB7A Gene

MGI Knock Outs for ZBTB7A:

miRNA for ZBTB7A Gene

miRTarBase miRNAs that target ZBTB7A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZBTB7A Gene

Localization for ZBTB7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB7A Gene COMPARTMENTS Subcellular localization image for ZBTB7A gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view

Pathways for ZBTB7A Gene

SuperPathways for ZBTB7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated ISS 15337766
genes like me logo Genes that share ontologies with ZBTB7A: view

No data available for Pathways by source for ZBTB7A Gene

Compounds for ZBTB7A Gene

(1) Novoseek inferred chemical compound relationships for ZBTB7A Gene

Compound -log(P) Hits PubMed IDs
zinc 43 4
genes like me logo Genes that share compounds with ZBTB7A: view

Transcripts for ZBTB7A Gene

Unigene Clusters for ZBTB7A Gene

Zinc finger and BTB domain containing 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7A Gene

No ASD Table

Relevant External Links for ZBTB7A Gene

GeneLoc Exon Structure for
ZBTB7A
ECgene alternative splicing isoforms for
ZBTB7A

Expression for ZBTB7A Gene

mRNA expression in normal human tissues for ZBTB7A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB7A Gene

SOURCE GeneReport for Unigene cluster for ZBTB7A Gene Hs.591384

mRNA Expression by UniProt/SwissProt for ZBTB7A Gene

O95365-ZBT7A_HUMAN
Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassles corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).
genes like me logo Genes that share expressions with ZBTB7A: view

Orthologs for ZBTB7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB7A 36
  • 99.83 (n)
  • 100 (a)
ZBTB7A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB7A 36
  • 89.48 (n)
  • 93.28 (a)
ZBTB7A 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB7A 36
  • 92.84 (n)
  • 94.58 (a)
ZBTB7A 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb7a 36
  • 85.2 (n)
  • 90.59 (a)
Zbtb7a 16
Zbtb7a 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB7A 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB7A 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb7a 36
  • 84.49 (n)
  • 89.88 (a)
chicken
(Gallus gallus)
Aves ZBTB7A 36
  • 75.26 (n)
  • 74.21 (a)
ZBTB7A 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB7A 37
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb7a 36
  • 62.53 (n)
  • 58.17 (a)
zbtb7a 37
  • 45 (a)
OneToOne
Species with no ortholog for ZBTB7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7A Gene

ENSEMBL:
Gene Tree for ZBTB7A (if available)
TreeFam:
Gene Tree for ZBTB7A (if available)

Paralogs for ZBTB7A Gene

Paralogs for ZBTB7A Gene

Selected SIMAP similar genes for ZBTB7A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB7A: view

Variants for ZBTB7A Gene

Sequence variations from dbSNP and Humsavar for ZBTB7A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13437 -- 4,045,520(+) CATCC(C/G/T)GTAGA utr-variant-3-prime
rs350834 -- 4,067,993(-) CCCCC(C/G)CCCCC upstream-variant-2KB
rs350840 -- 4,064,420(-) CACCC(C/G)CCATG intron-variant, upstream-variant-2KB
rs350841 -- 4,063,069(-) TAAAC(C/T)GCCCT intron-variant
rs350842 -- 4,061,783(+) ATGGG(A/C/G/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7A Gene

Variant ID Type Subtype PubMed ID
dgv3665n71 CNV Loss 21882294
nsv910783 CNV Loss 21882294
dgv3666n71 CNV Loss 21882294
dgv3667n71 CNV Loss 21882294
esv2717979 CNV Deletion 23290073
dgv3669n71 CNV Loss 21882294
nsv470115 CNV Loss 18288195
dgv3670n71 CNV Loss 21882294
dgv3671n71 CNV Loss 21882294
nsv828402 CNV Gain 20364138
dgv3672n71 CNV Loss 21882294
dgv3673n71 CNV Loss 21882294
esv2671159 CNV Deletion 23128226
nsv828403 CNV Loss 20364138
esv2717990 CNV Deletion 23290073
esv2670713 CNV Deletion 23128226
esv26783 CNV Loss 19812545

Relevant External Links for ZBTB7A Gene

HapMap Linkage Disequilibrium report
ZBTB7A

Disorders for ZBTB7A Gene

(1) MalaCards Diseases for ZBTB7A Gene

Search for ZBTB7A Gene in MalaCards »

(1) Novoseek inferred disease relationships for ZBTB7A Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 13.9 2
genes like me logo Genes that share disorders with ZBTB7A: view

No data available for UniProtKB/Swiss-Prot for ZBTB7A Gene

Publications for ZBTB7A Gene

  1. FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (PMID: 9973611) Morrison D.J. … Hernandez N. (Nucleic Acids Res. 1999) 2 3 4 23
  2. Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. (PMID: 17189472) Stogios P.J. … Prive G.G. (Protein Sci. 2007) 3 4 23
  3. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. (PMID: 9927193) Davies J.M. … Zelent A. (Oncogene 1999) 2 3 4
  4. Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4. (PMID: 18368381) Laudes M. … Krone W. (J. Mol. Med. 2008) 3 23
  5. Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN). (PMID: 18682402) Choi W.I. … Hur M.W. (J. Biol. Chem. 2008) 3 23

Products for ZBTB7A Gene

Sources for ZBTB7A Gene

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