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Aliases for ZBTB7A Gene

Aliases for ZBTB7A Gene

  • Zinc Finger And BTB Domain Containing 7A 2 3 5
  • Zinc Finger And BTB Domain Containing 7A, HIV-1 Inducer Of Short Transcripts Binding Protein 2 3
  • Factor That Binds To Inducer Of Short Transcripts Protein 1 3 4
  • POZ And Krueppel Erythroid Myeloid Ontogenic Factor 3 4
  • POK Erythroid Myeloid Ontogenic Factor 3 4
  • Leukemia/Lymphoma-Related Factor 3 4
  • Factor Binding IST Protein 1 3 4
  • TTF-I-Interacting Peptide 21 3 4
  • HIV-1 1st-Binding Protein 1 3 4
  • Zinc Finger Protein 857A 3 4
  • Lymphoma Related Factor 2 3
  • Pokemon 3 4
  • ZNF857A 3 4
  • ZBTB7 3 4
  • FBI-1 3 4
  • TIP21 3 4
  • FBI1 3 4
  • LRF 3 4
  • HIV-1 Inducer Of Short Transcripts Binding Protein 3
  • Zinc Finger And BTB Domain-Containing Protein 7A 3
  • Zinc Finger And BTB Domain Containing 7 2

External Ids for ZBTB7A Gene

Previous HGNC Symbols for ZBTB7A Gene

  • ZBTB7

Previous GeneCards Identifiers for ZBTB7A Gene

  • GC19M004000
  • GC19M004001
  • GC19M003809

Summaries for ZBTB7A Gene

GeneCards Summary for ZBTB7A Gene

ZBTB7A (Zinc Finger And BTB Domain Containing 7A) is a Protein Coding gene. GO annotations related to this gene include histone acetyltransferase binding. An important paralog of this gene is ZBTB7C.

UniProtKB/Swiss-Prot for ZBTB7A Gene

  • Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Gene Wiki entry for ZBTB7A Gene

Additional gene information for ZBTB7A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7A Gene

Genomics for ZBTB7A Gene

Regulatory Elements for ZBTB7A Gene

Enhancers for ZBTB7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H004086 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -21.8 -21813 5 PKNOX1 PTBP1 MAX ZNF121 CTBP1 GATA3 POLR2A SCRT2 ZNF600 RUNX3 ZBTB7A ENSG00000267980 MAP2K2
GH19H004042 1 ENCODE dbSUPER 13.2 +23.8 23760 2 SMARCE1 MAZ ESRRA ZNF687 NFIB SIN3A DPF2 ZBTB7B ZNF217 HIC1 ZBTB7A EEF2 ENSG00000267980 NFIC ENSG00000268670 GC19M003988
GH19H004030 0.8 dbSUPER 11.9 +32.9 32928 7 HDGF PTBP1 NFIB SUZ12 ZSCAN4 CDC5L ZIC2 ZKSCAN1 HIC1 ZFHX2 ZBTB7A CCDC94 ENSG00000267030 CACTIN-AS1 C19orf71 NFIC TBXA2R PIP5K1C ENSG00000267980 GC19M003988
GH19H004056 1.8 FANTOM5 ENCODE dbSUPER 4.6 +3.7 3714 12 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS SP3 SEMA6B CACTIN-AS1 PIAS4 CACTIN NFIC ZBTB7A PLIN5 UBXN6 SIRT6 ATCAY
GH19H004044 0.5 dbSUPER 13.2 +21.3 21271 2 ZBTB10 SSRP1 ZNF366 PRDM1 ZBTB7A EEF2 SNORD37 ENSG00000268670 GC19M003988
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB7A on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106148 945 4401 PKNOX1 ARID4B SIN3A ETS1 ZNF766 GLIS2 ELK1 ZNF143 FOS RUNX3

Genomic Location for ZBTB7A Gene

Chromosome:
19
Start:
4,043,303 bp from pter
End:
4,066,945 bp from pter
Size:
23,643 bases
Orientation:
Minus strand

Genomic View for ZBTB7A Gene

Genes around ZBTB7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7A Gene

Proteins for ZBTB7A Gene

  • Protein details for ZBTB7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95365-ZBT7A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7A
    Protein Accession:
    O95365
    Secondary Accessions:
    • D6W619
    • O00456
    • Q14D41
    • Q5XG86

    Protein attributes for ZBTB7A Gene

    Size:
    584 amino acids
    Molecular mass:
    61439 Da
    Quaternary structure:
    • Interacts with BCL6.
    SequenceCaution:
    • Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB7A Gene

neXtProt entry for ZBTB7A Gene

Post-translational modifications for ZBTB7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB7A Gene

Antibody Products

  • R&D Systems Antibodies for ZBTB7A (ZBTB7A/Pokemon)
  • Cell Signaling Technology (CST) Antibodies for ZBTB7A (FBI1)

No data available for DME Specific Peptides for ZBTB7A Gene

Domains & Families for ZBTB7A Gene

Gene Families for ZBTB7A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB7A Gene

Suggested Antigen Peptide Sequences for ZBTB7A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB7A: view

No data available for UniProtKB/Swiss-Prot for ZBTB7A Gene

Function for ZBTB7A Gene

Molecular function for ZBTB7A Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Phenotypes From GWAS Catalog for ZBTB7A Gene

Gene Ontology (GO) - Molecular Function for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding ISS 15337766
GO:0005515 protein binding IPI 24514149
genes like me logo Genes that share ontologies with ZBTB7A: view
genes like me logo Genes that share phenotypes with ZBTB7A: view

Animal Models for ZBTB7A Gene

MGI Knock Outs for ZBTB7A:

Animal Model Products

CRISPR Products

miRNA for ZBTB7A Gene

miRTarBase miRNAs that target ZBTB7A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB7A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB7A Gene

Localization for ZBTB7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB7A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view

Pathways & Interactions for ZBTB7A Gene

SuperPathways for ZBTB7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB7A Gene

Drugs & Compounds for ZBTB7A Gene

(1) Drugs for ZBTB7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB7A: view

Transcripts for ZBTB7A Gene

Unigene Clusters for ZBTB7A Gene

Zinc finger and BTB domain containing 7A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB7A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7A Gene

No ASD Table

Relevant External Links for ZBTB7A Gene

GeneLoc Exon Structure for
ZBTB7A
ECgene alternative splicing isoforms for
ZBTB7A

Expression for ZBTB7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB7A Gene

Protein differential expression in normal tissues from HIPED for ZBTB7A Gene

This gene is overexpressed in Pancreas (14.7), Adrenal (13.0), and Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB7A Gene



Protein tissue co-expression partners for ZBTB7A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB7A Gene:

ZBTB7A

SOURCE GeneReport for Unigene cluster for ZBTB7A Gene:

Hs.591384

mRNA Expression by UniProt/SwissProt for ZBTB7A Gene:

O95365-ZBT7A_HUMAN
Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassles corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).

Evidence on tissue expression from TISSUES for ZBTB7A Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with ZBTB7A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB7A Gene

Orthologs for ZBTB7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB7A 33 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia ZBTB7A 33 34
  • 92.84 (n)
cow
(Bos Taurus)
Mammalia ZBTB7A 33 34
  • 89.48 (n)
mouse
(Mus musculus)
Mammalia Zbtb7a 33 16 34
  • 85.2 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb7a 33
  • 84.49 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB7A 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB7A 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB7A 33 34
  • 75.26 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB7A 34
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb7a 33 34
  • 62.53 (n)
Species where no ortholog for ZBTB7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7A Gene

ENSEMBL:
Gene Tree for ZBTB7A (if available)
TreeFam:
Gene Tree for ZBTB7A (if available)

Paralogs for ZBTB7A Gene

Paralogs for ZBTB7A Gene

(6) SIMAP similar genes for ZBTB7A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB7A: view

Variants for ZBTB7A Gene

Sequence variations from dbSNP and Humsavar for ZBTB7A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000102457 -- 4,058,684(+) CCCTC(C/T)TGTCC intron-variant
rs1000194530 -- 4,044,031(+) GTTGC(C/T)GGGCG utr-variant-3-prime
rs1000233927 -- 4,054,955(+) CCGTG(C/T)AGGCG reference, missense
rs1000352683 -- 4,048,300(+) ATCCC(C/T)GCCCA intron-variant
rs1000381452 -- 4,063,255(+) CACAG(C/T)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7A Gene

Variant ID Type Subtype PubMed ID
dgv6231n54 CNV gain+loss 21841781
esv2670713 CNV deletion 23128226
esv2671159 CNV deletion 23128226
esv26783 CNV loss 19812545
esv2717979 CNV deletion 23290073
esv2717990 CNV deletion 23290073
nsv1071500 CNV deletion 25765185
nsv1121966 CNV deletion 24896259
nsv1126508 CNV deletion 24896259
nsv1133440 CNV deletion 24896259
nsv1136269 CNV deletion 24896259
nsv470115 CNV loss 18288195
nsv578435 CNV loss 21841781
nsv578436 CNV loss 21841781
nsv578441 CNV gain+loss 21841781
nsv828402 CNV gain 20364138
nsv828403 CNV loss 20364138
nsv953949 CNV deletion 24416366

Variation tolerance for ZBTB7A Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7A Gene

Disorders for ZBTB7A Gene

Relevant External Links for ZBTB7A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB7A

No disorders were found for ZBTB7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB7A Gene

Publications for ZBTB7A Gene

  1. FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (PMID: 9973611) Morrison DJ … Hernandez N (Nucleic acids research 1999) 2 3 4 22 60
  2. Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. (PMID: 17189472) Stogios PJ … Privé GG (Protein science : a publication of the Protein Society 2007) 3 4 22 60
  3. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. (PMID: 9927193) Davies JM … Zelent A (Oncogene 1999) 2 3 4 60
  4. Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A). (PMID: 19471103) Choi WI … Hur MW (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009) 3 22 60
  5. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors. (PMID: 18801742) Jeon BN … Hur MW (The Journal of biological chemistry 2008) 3 22 60

Products for ZBTB7A Gene

Sources for ZBTB7A Gene

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