Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDC Gene

Aliases for PDC Gene

  • Phosducin 2 3
  • 33 KDa Phototransducing Protein 3 4
  • PHD 3 4
  • Phosducin-Like Orphan Protein 3
  • G Beta Gamma Binding Protein 3
  • Protein MEKA 4
  • PhLOP 3
  • PhLP 3
  • MEKA 3

External Ids for PDC Gene

Previous GeneCards Identifiers for PDC Gene

  • GC01M183938
  • GC01M181840
  • GC01M182932
  • GC01M183651
  • GC01M183144
  • GC01M184679
  • GC01M157647

Summaries for PDC Gene

Entrez Gene Summary for PDC Gene

  • This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDC Gene

PDC (Phosducin) is a Protein Coding gene. Diseases associated with PDC include paroxysmal nonkinesigenic dyskinesia and prostate cancer 1. Among its related pathways are Olfactory Signaling Pathway. GO annotations related to this gene include phospholipase inhibitor activity. An important paralog of this gene is PDCL.

UniProtKB/Swiss-Prot for PDC Gene

  • May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.

Gene Wiki entry for PDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDC Gene

Genomics for PDC Gene

Regulatory Elements for PDC Gene

Genomic Location for PDC Gene

Chromosome:
1
Start:
186,443,566 bp from pter
End:
186,461,122 bp from pter
Size:
17,557 bases
Orientation:
Minus strand

Genomic View for PDC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDC Gene

Proteins for PDC Gene

  • Protein details for PDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20941-PHOS_HUMAN
    Recommended name:
    Phosducin
    Protein Accession:
    P20941
    Secondary Accessions:
    • Q14816
    • Q9UP22
    • Q9UP23

    Protein attributes for PDC Gene

    Size:
    246 amino acids
    Molecular mass:
    28246 Da
    Quaternary structure:
    • Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with CRX.

    Alternative splice isoforms for PDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDC Gene

Proteomics data for PDC Gene at MOPED

Post-translational modifications for PDC Gene

  • Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDC Gene

Domains & Families for PDC Gene

Suggested Antigen Peptide Sequences for PDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20941

UniProtKB/Swiss-Prot:

PHOS_HUMAN :
  • Belongs to the phosducin family.
Family:
  • Belongs to the phosducin family.
genes like me logo Genes that share domains with PDC: view

No data available for Gene Families for PDC Gene

Function for PDC Gene

Molecular function for PDC Gene

GENATLAS Biochemistry:
phosducin,expressed in rod and cone photoreceptors and pinealocytes
UniProtKB/Swiss-Prot Function:
May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.

Gene Ontology (GO) - Molecular Function for PDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 7961975
genes like me logo Genes that share ontologies with PDC: view
genes like me logo Genes that share phenotypes with PDC: view

Animal Models for PDC Gene

MGI Knock Outs for PDC:

Animal Model Products

miRNA for PDC Gene

miRTarBase miRNAs that target PDC

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PDC Gene

Localization for PDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDC Gene

Cytoplasm, cytosol. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Nucleus. Note=Outer and inner segments of the rod cells.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDC Gene COMPARTMENTS Subcellular localization image for PDC gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PDC: view

Pathways & Interactions for PDC Gene

SuperPathways for PDC Gene

Superpath Contained pathways
1 Olfactory Signaling Pathway
genes like me logo Genes that share pathways with PDC: view

Pathways by source for PDC Gene

1 KEGG pathway for PDC Gene

Interacting Proteins for PDC Gene

Selected Interacting proteins: P20941-PHOS_HUMAN for PDC Gene via I2D

Gene Ontology (GO) - Biological Process for PDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 7961975
GO:0007601 visual perception IEA --
GO:0007602 phototransduction TAS 8288249
GO:0043086 negative regulation of catalytic activity TAS 7961975
genes like me logo Genes that share ontologies with PDC: view

No data available for SIGNOR curated interactions for PDC Gene

Drugs & Compounds for PDC Gene

(8) Drugs for PDC Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Morphine Approved, Investigational Pharma Partial agonist, Agonist 805
Norepinephrine Approved Pharma 206
cyclic amp Experimental Pharma 0
FARNESYL Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(6) Additional Compounds for PDC Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
gdp
gtp
Partial agonist, Agonist
LIPID
PGE1
genes like me logo Genes that share compounds with PDC: view

Transcripts for PDC Gene

mRNA/cDNA for PDC Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDC Gene

Phosducin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDC Gene

No ASD Table

Relevant External Links for PDC Gene

GeneLoc Exon Structure for
PDC
ECgene alternative splicing isoforms for
PDC

Expression for PDC Gene

mRNA expression in normal human tissues for PDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDC Gene

This gene is overexpressed in Brain - Cerebellum (x4.5) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for PDC Gene

This gene is overexpressed in Retina (44.9) and Liver (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDC Gene



SOURCE GeneReport for Unigene cluster for PDC Gene Hs.654381

genes like me logo Genes that share expression patterns with PDC: view

Protein tissue co-expression partners for PDC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PDC Gene

Orthologs for PDC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDC 35
  • 90.4 (n)
  • 88.07 (a)
PDC 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDC 35
  • 91.77 (n)
  • 89.71 (a)
PDC 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdc 35
  • 86.34 (n)
  • 88.93 (a)
Pdc 16
Pdc 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDC 35
  • 99.46 (n)
  • 99.19 (a)
PDC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdc 35
  • 86.59 (n)
  • 88.21 (a)
oppossum
(Monodelphis domestica)
Mammalia PDC 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDC 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDC 35
  • 76.15 (n)
  • 77.24 (a)
PDC 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDC 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdc 35
  • 69.97 (n)
  • 70.69 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26950 35
pdca 35
  • 66.82 (n)
  • 68.25 (a)
pdca 36
  • 62 (a)
OneToMany
pdcb 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7650 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mau-8 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for PDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDC Gene

ENSEMBL:
Gene Tree for PDC (if available)
TreeFam:
Gene Tree for PDC (if available)

Paralogs for PDC Gene

Paralogs for PDC Gene

(1) SIMAP similar genes for PDC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDC: view

Variants for PDC Gene

Variation tolerance for PDC Gene

Residual Variation Intolerance Score: 62.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDC Gene

HapMap Linkage Disequilibrium report
PDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for PDC Gene

Disorders for PDC Gene

MalaCards: The human disease database

(8) MalaCards diseases for PDC Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
paroxysmal nonkinesigenic dyskinesia
  • dystonia 8
prostate cancer 1
  • prostate cancer, hereditary, 1
usher syndrome type ii
  • ush 2
nasal cavity disease
  • nasal cavity disease nos
nose disease
  • nasal disorder
- elite association
Search PDC in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDC

Genetic Association Database (GAD)
PDC
Human Genome Epidemiology (HuGE) Navigator
PDC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDC
genes like me logo Genes that share disorders with PDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDC Gene

Publications for PDC Gene

  1. Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization. (PMID: 8288249) Sparkes R.S. … Bateman J.B. (Genomics 1993) 2 23 67
  2. NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes. (PMID: 20018744) Smrcka A.V. … Giralt E. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  3. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. (PMID: 19193988) Lou X. … Chen Y. (Acta Crystallogr. F 2009) 23 67
  4. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. (PMID: 19959875) Beetz N. … Hein L. (J. Clin. Invest. 2009) 23 67
  5. delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation. (PMID: 19362548) Heiss A. … Eisinger D.A. (Exp. Cell Res. 2009) 23 67

Products for PDC Gene

Sources for PDC Gene

Back to Top

Content