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Aliases for PDC Gene

Aliases for PDC Gene

  • Phosducin 2 3
  • 33 KDa Phototransducing Protein 3 4
  • PHD 3 4
  • Phosducin-Like Orphan Protein 3
  • G Beta Gamma Binding Protein 3
  • Protein MEKA 4
  • PhLOP 3
  • PhLP 3
  • MEKA 3

External Ids for PDC Gene

Previous GeneCards Identifiers for PDC Gene

  • GC01M183938
  • GC01M181840
  • GC01M182932
  • GC01M183651
  • GC01M183144
  • GC01M184679
  • GC01M157647

Summaries for PDC Gene

Entrez Gene Summary for PDC Gene

  • This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDC Gene

PDC (Phosducin) is a Protein Coding gene. Diseases associated with PDC include paroxysmal nonkinesigenic dyskinesia and prostate cancer 1. Among its related pathways are Olfactory Signaling Pathway. GO annotations related to this gene include phospholipase inhibitor activity. An important paralog of this gene is PDCL.

UniProtKB/Swiss-Prot for PDC Gene

  • May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.

Gene Wiki entry for PDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDC Gene

Genomics for PDC Gene

Regulatory Elements for PDC Gene

Genomic Location for PDC Gene

Start:
186,443,566 bp from pter
End:
186,461,122 bp from pter
Size:
17,557 bases
Orientation:
Minus strand

Genomic View for PDC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDC Gene

Proteins for PDC Gene

  • Protein details for PDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20941-PHOS_HUMAN
    Recommended name:
    Phosducin
    Protein Accession:
    P20941
    Secondary Accessions:
    • Q14816
    • Q9UP22
    • Q9UP23

    Protein attributes for PDC Gene

    Size:
    246 amino acids
    Molecular mass:
    28246 Da
    Quaternary structure:
    • Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with CRX.

    Alternative splice isoforms for PDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDC Gene

Proteomics data for PDC Gene at MOPED

Post-translational modifications for PDC Gene

  • Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDC Gene

Domains for PDC Gene

Suggested Antigen Peptide Sequences for PDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20941

UniProtKB/Swiss-Prot:

PHOS_HUMAN :
  • P20941
Family:
  • Belongs to the phosducin family.
genes like me logo Genes that share domains with PDC: view

No data available for Gene Families for PDC Gene

Function for PDC Gene

Molecular function for PDC Gene

GENATLAS Biochemistry: phosducin,expressed in rod and cone photoreceptors and pinealocytes
UniProtKB/Swiss-Prot Function: May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.

Gene Ontology (GO) - Molecular Function for PDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 7961975
genes like me logo Genes that share ontologies with PDC: view
genes like me logo Genes that share phenotypes with PDC: view

Animal Models for PDC Gene

MGI Knock Outs for PDC:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PDC Gene

Localization for PDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDC Gene

Cytoplasm, cytosol. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Nucleus. Note=Outer and inner segments of the rod cells.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDC Gene COMPARTMENTS Subcellular localization image for PDC gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PDC: view

Pathways for PDC Gene

SuperPathways for PDC Gene

Superpath Contained pathways
1 Olfactory Signaling Pathway
genes like me logo Genes that share pathways with PDC: view

Pathways by source for PDC Gene

1 KEGG pathway for PDC Gene

Interacting Proteins for PDC Gene

Selected Interacting proteins: P20941-PHOS_HUMAN for PDC Gene via I2D

Gene Ontology (GO) - Biological Process for PDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 7961975
GO:0007601 visual perception IEA --
GO:0007602 phototransduction TAS 8288249
GO:0043086 negative regulation of catalytic activity TAS 7961975
genes like me logo Genes that share ontologies with PDC: view

Compounds for PDC Gene

(2) HMDB Compounds for PDC Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for PDC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
FARNESYL
target

(12) Novoseek inferred chemical compound relationships for PDC Gene

Compound -log(P) Hits PubMed IDs
etorphine 74.1 1
pge1 21.9 6
gdp 20.3 4
gtp 18.2 2
cyclic amp 16.1 2
genes like me logo Genes that share compounds with PDC: view

Transcripts for PDC Gene

mRNA/cDNA for PDC Gene

(9) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDC Gene

Phosducin:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDC Gene

No ASD Table

Relevant External Links for PDC Gene

GeneLoc Exon Structure for
PDC
ECgene alternative splicing isoforms for
PDC

Expression for PDC Gene

mRNA expression in normal human tissues for PDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDC Gene

This gene is overexpressed in Brain - Cerebellum (4.5) and Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PDC Gene

SOURCE GeneReport for Unigene cluster for PDC Gene Hs.654381

genes like me logo Genes that share expressions with PDC: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PDC Gene

Orthologs for PDC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDC 35
  • 99.46 (n)
  • 99.19 (a)
PDC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDC 35
  • 90.4 (n)
  • 88.07 (a)
PDC 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDC 35
  • 91.77 (n)
  • 89.71 (a)
PDC 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdc 35
  • 86.34 (n)
  • 88.93 (a)
Pdc 16
Pdc 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDC 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDC 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdc 35
  • 86.59 (n)
  • 88.21 (a)
chicken
(Gallus gallus)
Aves PDC 35
  • 76.15 (n)
  • 77.24 (a)
PDC 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDC 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdc 35
  • 69.97 (n)
  • 70.69 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26950 35
pdca 35
  • 66.82 (n)
  • 68.25 (a)
pdca 36
  • 62 (a)
OneToMany
pdcb 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7650 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mau-8 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for PDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDC Gene

ENSEMBL:
Gene Tree for PDC (if available)
TreeFam:
Gene Tree for PDC (if available)

Paralogs for PDC Gene

Paralogs for PDC Gene

Selected SIMAP similar genes for PDC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDC: view

Variants for PDC Gene

Sequence variations from dbSNP and Humsavar for PDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1799957 -- 186,462,213(-) TCTCT(G/T)TGAAA upstream-variant-2KB
rs1929093 -- 186,459,213(+) CCCTT(C/T)CTCCT intron-variant
rs1929096 -- 186,455,994(+) aaaaa(A/T)atata intron-variant
rs1972167 -- 186,455,683(-) cgcac(C/G)gccAC intron-variant
rs1988553 -- 186,455,685(-) tgcgc(A/C)ccgcc intron-variant

Relevant External Links for PDC Gene

HapMap Linkage Disequilibrium report
PDC
Locus Specific Mutation Databases (LSDB)
PDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PDC Gene

Disorders for PDC Gene

(3) University of Copenhagen DISEASES for PDC Gene

(3) Novoseek inferred disease relationships for PDC Gene

Disease -log(P) Hits PubMed IDs
retinitis pigmentosa 37 3
glioma 10.5 2
atrophy 2.46 2

Relevant External Links for PDC

Genetic Association Database (GAD)
PDC
Human Genome Epidemiology (HuGE) Navigator
PDC
genes like me logo Genes that share disorders with PDC: view

No data available for UniProtKB/Swiss-Prot for PDC Gene

Publications for PDC Gene

  1. Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization. (PMID: 8288249) Sparkes R.S. … Bateman J.B. (Genomics 1993) 2 3 23
  2. Mutation screening of the phosducin gene PDC in patients with retinitis pigmentosa and allied diseases. (PMID: 14758335) Nishiguchi K.M. … Dryja T.P. (Mol. Vis. 2004) 3 23 48
  3. Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments. (PMID: 11287646) Nakano K. … Bitensky M.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  4. Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding. (PMID: 11331285) Thulin C.D. … Willardson B.M. (J. Biol. Chem. 2001) 3 23
  5. SUMO-1 controls the protein stability and the biological function of phosducin. (PMID: 16421094) Klenk C. … Lohse M.J. (J. Biol. Chem. 2006) 3 23

Products for PDC Gene

Sources for PDC Gene

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