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Aliases for SLC25A37 Gene

Aliases for SLC25A37 Gene

  • Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 37 2 3
  • MFRN 3 4 6
  • Mitochondrial Solute Carrier Protein 3 4
  • Solute Carrier Family 25, Member 37 2 3
  • Mitochondrial Iron Transporter 1 3 4
  • Mitoferrin 2 3
  • MFRN1 3 6
  • MSCP 3 4
  • Solute Carrier Family 25 Member 37 4
  • Predicted Protein Of HQ2217 3
  • Mitoferrin-1 3
  • PRO1278 3
  • PRO1584 3
  • PRO2217 3
  • HT015 3
  • MSC 3

External Ids for SLC25A37 Gene

Summaries for SLC25A37 Gene

Entrez Gene Summary for SLC25A37 Gene

  • SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC25A37 Gene

SLC25A37 (Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 37) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial Iron-Sulfur Cluster Biogenesis. GO annotations related to this gene include iron ion transmembrane transporter activity. An important paralog of this gene is SLC25A28.

UniProtKB/Swiss-Prot for SLC25A37 Gene

  • Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Gene Wiki entry for SLC25A37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A37 Gene

Genomics for SLC25A37 Gene

Genomic Location for SLC25A37 Gene

Start:
23,528,805 bp from pter
End:
23,575,463 bp from pter
Size:
46,659 bases
Orientation:
Plus strand

Genomic View for SLC25A37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A37 Gene

Regulatory Elements for SLC25A37 Gene

Proteins for SLC25A37 Gene

  • Protein details for SLC25A37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ2-MFRN1_HUMAN
    Recommended name:
    Mitoferrin-1
    Protein Accession:
    Q9NYZ2
    Secondary Accessions:
    • A2RU93
    • Q53FT7
    • Q69YJ8
    • Q969S1
    • Q9P0J2

    Protein attributes for SLC25A37 Gene

    Size:
    338 amino acids
    Molecular mass:
    37323 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64141.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305}; Sequence=CAH10415.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A37 Gene

Proteomics data for SLC25A37 Gene at MOPED

Post-translational modifications for SLC25A37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A37 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A37 Gene

Domains for SLC25A37 Gene

Gene Families for SLC25A37 Gene

Protein Domains for SLC25A37 Gene

UniProtKB/Swiss-Prot:

MFRN1_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q9NYZ2
Similarity:
  • Contains 3 Solcar repeats.:
    • Q9NYZ2
genes like me logo Genes that share domains with SLC25A37: view

Function for SLC25A37 Gene

Molecular function for SLC25A37 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Gene Ontology (GO) - Molecular Function for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005381 iron ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A37: view
genes like me logo Genes that share phenotypes with SLC25A37: view

Animal Models for SLC25A37 Gene

MGI Knock Outs for SLC25A37:

miRNA for SLC25A37 Gene

miRTarBase miRNAs that target SLC25A37

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC25A37 Gene

Localization for SLC25A37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A37 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A37 Gene COMPARTMENTS Subcellular localization image for SLC25A37 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A37: view

Pathways for SLC25A37 Gene

genes like me logo Genes that share pathways with SLC25A37: view

Pathways by source for SLC25A37 Gene

1 BioSystems pathway for SLC25A37 Gene
2 Reactome pathways for SLC25A37 Gene

Gene Ontology (GO) - Biological Process for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0034755 iron ion transmembrane transport IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0048250 mitochondrial iron ion transport IEA --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with SLC25A37: view

Compounds for SLC25A37 Gene

(2) HMDB Compounds for SLC25A37 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Iron
  • Armco iron
7439-89-6
genes like me logo Genes that share compounds with SLC25A37: view

Transcripts for SLC25A37 Gene

Unigene Clusters for SLC25A37 Gene

Solute carrier family 25 (mitochondrial iron transporter), member 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: -
SP7: - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: - -
SP11: - - - - - - - -
SP12:
SP13:

Relevant External Links for SLC25A37 Gene

GeneLoc Exon Structure for
SLC25A37
ECgene alternative splicing isoforms for
SLC25A37

Expression for SLC25A37 Gene

mRNA expression in normal human tissues for SLC25A37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A37 Gene

This gene is overexpressed in Whole Blood (32.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A37 Gene

SOURCE GeneReport for Unigene cluster for SLC25A37 Gene Hs.596025

genes like me logo Genes that share expressions with SLC25A37: view

Orthologs for SLC25A37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A37 36
  • 99.61 (n)
  • 99.7 (a)
SLC25A37 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A37 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A37 36
  • 92.09 (n)
  • 92.88 (a)
SLC25A37 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a37 36
  • 88.36 (n)
  • 91.42 (a)
Slc25a37 16
Slc25a37 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A37 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A37 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a37 36
  • 87.48 (n)
  • 92.31 (a)
chicken
(Gallus gallus)
Aves SLC25A37 36
  • 74.61 (n)
  • 78.15 (a)
SLC25A37 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A37 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a37 36
  • 73.27 (n)
  • 74.83 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a37 36
  • 71.68 (n)
  • 74.58 (a)
slc25a37 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006030 36
  • 62.68 (n)
  • 57.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta mfrn 36
  • 60.45 (n)
  • 56.27 (a)
mfrn 37
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mfn-1 36
  • 54.12 (n)
  • 55.25 (a)
mfn-1 37
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR260W 36
  • 49.65 (n)
  • 42.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS3 37
  • 39 (a)
ManyToMany
MRS4 36
  • 47.2 (n)
  • 42.31 (a)
MRS4 37
  • 39 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15445g 36
  • 49.54 (n)
  • 43.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30160 36
  • 45.95 (n)
  • 42.14 (a)
rice
(Oryza sativa)
Liliopsida Os03g0296800 36
  • 50.91 (n)
  • 43.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02423 36
  • 54.47 (n)
  • 46.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8C9.12c 36
  • 48.36 (n)
  • 44.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for SLC25A37:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A37 Gene

ENSEMBL:
Gene Tree for SLC25A37 (if available)
TreeFam:
Gene Tree for SLC25A37 (if available)

Paralogs for SLC25A37 Gene

Paralogs for SLC25A37 Gene

Selected SIMAP similar genes for SLC25A37 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A37: view

Variants for SLC25A37 Gene

Sequence variations from dbSNP and Humsavar for SLC25A37 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8346 -- 23,572,023(-) CACAG(C/T)CTTCC utr-variant-3-prime
rs8534 -- 23,574,819(+) TTGCA(C/T)GTACT utr-variant-3-prime
rs9462 -- 23,566,661(+) ATTAA(A/T)GATCA intron-variant, utr-variant-5-prime
rs10992 -- 23,566,245(+) GGGCC(A/G)GCCCA synonymous-codon, reference, utr-variant-5-prime
rs13261 -- 23,568,141(+) TCCCC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A37 Gene

Variant ID Type Subtype PubMed ID
nsv831268 CNV Gain 17160897
nsv508499 CNV Loss 20534489
esv2421786 CNV Deletion 20811451
esv22651 CNV Loss 19812545
esv1990641 CNV Deletion 18987734
nsv471717 CNV Loss 16327809
esv2736758 CNV Deletion 23290073
esv4817 CNV Deletion 18987735
esv2528186 CNV Deletion 19546169
nsv396338 CNV Loss 16902084
esv9692 CNV Loss 19470904
nsv819222 CNV Gain 19587683

Relevant External Links for SLC25A37 Gene

HapMap Linkage Disequilibrium report
SLC25A37

Disorders for SLC25A37 Gene

(1) University of Copenhagen DISEASES for SLC25A37 Gene

Relevant External Links for SLC25A37

Genetic Association Database (GAD)
SLC25A37
Human Genome Epidemiology (HuGE) Navigator
SLC25A37
genes like me logo Genes that share disorders with SLC25A37: view

No data available for UniProtKB/Swiss-Prot for SLC25A37 Gene

Publications for SLC25A37 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. (PMID: 11845285) Li Q.-Z. … She J.-X. (Mamm. Genome 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Mitoferrin is essential for erythroid iron assimilation. (PMID: 16511496) Shaw G.C. … Paw B.H. (Nature 2006) 2 3

Products for SLC25A37 Gene

Sources for SLC25A37 Gene

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