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Aliases for SLC25A37 Gene

Aliases for SLC25A37 Gene

  • Solute Carrier Family 25 Member 37 2 3 4 5
  • Mitochondrial Solute Carrier Protein 2 3 4
  • Mitochondrial Iron Transporter 1 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 37 2 3
  • Mitoferrin-1 2 3
  • Mitoferrin 2 3
  • MFRN 3 4
  • MSCP 3 4
  • Solute Carrier Family 25, Member 37 2
  • Predicted Protein Of HQ2217 3
  • PRO1278 3
  • PRO1584 3
  • PRO2217 3
  • HT015 3
  • MFRN1 3
  • MSC 3

External Ids for SLC25A37 Gene

Previous GeneCards Identifiers for SLC25A37 Gene

  • GC08P023443
  • GC08P023444
  • GC08P023386
  • GC08P021931

Summaries for SLC25A37 Gene

Entrez Gene Summary for SLC25A37 Gene

  • SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC25A37 Gene

SLC25A37 (Solute Carrier Family 25 Member 37) is a Protein Coding gene. Among its related pathways are Mitochondrial iron-sulfur cluster biogenesis and Metabolism. GO annotations related to this gene include iron ion transmembrane transporter activity. An important paralog of this gene is SLC25A28.

UniProtKB/Swiss-Prot for SLC25A37 Gene

  • Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Gene Wiki entry for SLC25A37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A37 Gene

Genomics for SLC25A37 Gene

Regulatory Elements for SLC25A37 Gene

Enhancers for SLC25A37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G023550 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +24.2 24248 5.7 ATF1 PKNOX1 SIN3A BRCA1 ZNF2 YY1 GATA2 ZNF143 FOS ZNF263 SLC25A37 ENTPD4 ENSG00000253390 EGR3 ENSG00000253200 TNFRSF10B GC08M023551
GH08G023557 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +31.3 31288 4.8 ELF3 FOXA2 ZSCAN4 ZNF48 ZSCAN9 RAD21 RARA YY1 GATA2 FOS SLC25A37 ENSG00000253200 C8orf58 ENTPD4 LOC107986927 ENSG00000253390 NKX3-1 RNU4-71P EGR3 TNFRSF10C
GH08G023489 1.2 ENCODE dbSUPER 24.5 -38.8 -38797 1.0 ATF1 ARNT CREB3L1 SIN3A TCF12 MCM3 NCOA1 NFYC JUNB TBX21 SLC25A37 ENSG00000253390 ENTPD4 NKX3-1 LOC105379327 LOC646708
GH08G023506 1.4 Ensembl ENCODE dbSUPER 19.8 -21.5 -21467 1.6 TBP HDAC1 PKNOX1 FOXA2 SIN3A RAD21 YY1 GATA2 RCOR1 RELB SLC25A37 LOC105379327
GH08G023497 1.1 FANTOM5 dbSUPER 18.7 -32.4 -32426 0.1 ESRRA ZBTB21 INSM2 SIN3A ZIC2 TEAD3 FOSL1 ZFHX2 GLIS2 ZNF366 SLC25A37 ENSG00000253390 ENTPD4 TNFRSF10C LOC105379327
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A37 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222243 595 1601 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS ZNF263 SP3 ZHX2

Genomic Location for SLC25A37 Gene

Chromosome:
8
Start:
23,528,805 bp from pter
End:
23,575,463 bp from pter
Size:
46,659 bases
Orientation:
Plus strand

Genomic View for SLC25A37 Gene

Genes around SLC25A37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A37 Gene

Proteins for SLC25A37 Gene

  • Protein details for SLC25A37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ2-MFRN1_HUMAN
    Recommended name:
    Mitoferrin-1
    Protein Accession:
    Q9NYZ2
    Secondary Accessions:
    • A2RU93
    • Q53FT7
    • Q69YJ8
    • Q969S1
    • Q9P0J2

    Protein attributes for SLC25A37 Gene

    Size:
    338 amino acids
    Molecular mass:
    37323 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64141.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305}; Sequence=CAH10415.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A37 Gene

Post-translational modifications for SLC25A37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A37 Gene

Domains & Families for SLC25A37 Gene

Gene Families for SLC25A37 Gene

Protein Domains for SLC25A37 Gene

Suggested Antigen Peptide Sequences for SLC25A37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYZ2

UniProtKB/Swiss-Prot:

MFRN1_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A37: view

Function for SLC25A37 Gene

Molecular function for SLC25A37 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Gene Ontology (GO) - Molecular Function for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005381 iron ion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A37: view
genes like me logo Genes that share phenotypes with SLC25A37: view

Animal Models for SLC25A37 Gene

MGI Knock Outs for SLC25A37:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A37 Gene

Localization for SLC25A37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A37 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A37 gene
Compartment Confidence
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IBA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A37: view

Pathways & Interactions for SLC25A37 Gene

genes like me logo Genes that share pathways with SLC25A37: view

Pathways by source for SLC25A37 Gene

2 Reactome pathways for SLC25A37 Gene

Interacting Proteins for SLC25A37 Gene

Gene Ontology (GO) - Biological Process for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034755 iron ion transmembrane transport IEA --
GO:0048250 mitochondrial iron ion transport IBA --
GO:0055072 iron ion homeostasis IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A37: view

No data available for SIGNOR curated interactions for SLC25A37 Gene

Drugs & Compounds for SLC25A37 Gene

(1) Drugs for SLC25A37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(1) Additional Compounds for SLC25A37 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SLC25A37: view

Transcripts for SLC25A37 Gene

Unigene Clusters for SLC25A37 Gene

Solute carrier family 25 (mitochondrial iron transporter), member 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: -
SP7: - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: - -
SP11: - - - - - - - -
SP12:
SP13:

Relevant External Links for SLC25A37 Gene

GeneLoc Exon Structure for
SLC25A37
ECgene alternative splicing isoforms for
SLC25A37

Expression for SLC25A37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A37 Gene

This gene is overexpressed in Whole Blood (x32.6).

Protein differential expression in normal tissues from HIPED for SLC25A37 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A37 Gene



Protein tissue co-expression partners for SLC25A37 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A37 Gene:

SLC25A37

SOURCE GeneReport for Unigene cluster for SLC25A37 Gene:

Hs.596025

Evidence on tissue expression from TISSUES for SLC25A37 Gene

  • Nervous system(4.6)
  • Adrenal gland(4.3)
  • Lymph node(4.2)
  • Pancreas(4.2)
  • Eye(3.1)
  • Lung(3)
  • Liver(2.6)
  • Blood(2.4)
  • Intestine(2.4)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with SLC25A37: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A37 Gene

Orthologs for SLC25A37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A37 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia SLC25A37 34 35
  • 92.09 (n)
cow
(Bos Taurus)
Mammalia SLC25A37 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a37 34 16 35
  • 88.36 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a37 34
  • 87.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A37 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A37 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A37 34 35
  • 74.61 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A37 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a37 34
  • 73.27 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a37 34 35
  • 71.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006030 34
  • 62.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta mfrn 34 35
  • 60.45 (n)
worm
(Caenorhabditis elegans)
Secernentea mfn-1 34 35
  • 54.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR260W 34
  • 49.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15445g 34
  • 49.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS4 34 35
  • 47.2 (n)
MRS3 35
  • 39 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30160 34
  • 45.95 (n)
rice
(Oryza sativa)
Liliopsida Os03g0296800 34
  • 50.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02423 34
  • 54.47 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8C9.12c 34
  • 48.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for SLC25A37 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A37 Gene

ENSEMBL:
Gene Tree for SLC25A37 (if available)
TreeFam:
Gene Tree for SLC25A37 (if available)

Paralogs for SLC25A37 Gene

Paralogs for SLC25A37 Gene

(2) SIMAP similar genes for SLC25A37 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A37: view

Variants for SLC25A37 Gene

Sequence variations from dbSNP and Humsavar for SLC25A37 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000106566 -- 23,575,951(+) TGAAG(C/T)CCTTG downstream-variant-500B
rs1000169121 -- 23,565,181(+) TACTT(G/T)ATTCA intron-variant
rs1000212422 -- 23,538,881(+) AGCCT(A/C)CAGGG intron-variant, upstream-variant-2KB
rs1000221708 -- 23,528,955(+) CTCCC(A/C)CTCCC utr-variant-5-prime
rs1000311635 -- 23,570,745(+) TAAGG(C/T)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A37 Gene

Variant ID Type Subtype PubMed ID
dgv3794n106 CNV deletion 24896259
esv1990641 CNV deletion 18987734
esv22651 CNV loss 19812545
esv2421786 CNV deletion 20811451
esv2528186 CNV deletion 19546169
esv2736758 CNV deletion 23290073
esv3543228 CNV deletion 23714750
esv3572637 CNV loss 25503493
esv3616633 CNV loss 21293372
esv4817 CNV loss 18987735
esv9692 CNV loss 19470904
nsv1017570 CNV gain 25217958
nsv1026345 CNV gain 25217958
nsv1028341 CNV gain 25217958
nsv1151006 CNV deletion 26484159
nsv396338 CNV deletion 16902084
nsv471717 CNV loss 16327809
nsv475992 CNV novel sequence insertion 20440878
nsv508499 CNV deletion 20534489
nsv819222 CNV gain 19587683
nsv831268 CNV gain 17160897

Variation tolerance for SLC25A37 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.08; 90.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A37 Gene

Disorders for SLC25A37 Gene

Relevant External Links for SLC25A37

Genetic Association Database (GAD)
SLC25A37
Human Genome Epidemiology (HuGE) Navigator
SLC25A37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A37

No disorders were found for SLC25A37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A37 Gene

Publications for SLC25A37 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Mitoferrin is essential for erythroid iron assimilation. (PMID: 16511496) Shaw G.C. … Paw B.H. (Nature 2006) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. (PMID: 11845285) Li Q.-Z. … She J.-X. (Mamm. Genome 2001) 3 4 64
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64

Products for SLC25A37 Gene

Sources for SLC25A37 Gene

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