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Aliases for SLC25A37 Gene

Aliases for SLC25A37 Gene

  • Solute Carrier Family 25 Member 37 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 37 2 3 5
  • Mitochondrial Solute Carrier Protein 3 4
  • Solute Carrier Family 25, Member 37 2 3
  • Mitochondrial Iron Transporter 1 3 4
  • Mitoferrin 2 3
  • MFRN 3 4
  • MSCP 3 4
  • Predicted Protein Of HQ2217 3
  • PRO1278 3
  • PRO1584 3
  • PRO2217 3
  • HT015 3
  • MFRN1 3
  • MSC 3

External Ids for SLC25A37 Gene

Previous GeneCards Identifiers for SLC25A37 Gene

  • GC08P023443
  • GC08P023444
  • GC08P023386
  • GC08P021931

Summaries for SLC25A37 Gene

Entrez Gene Summary for SLC25A37 Gene

  • SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC25A37 Gene

SLC25A37 (Solute Carrier Family 25 Member 37) is a Protein Coding gene. Among its related pathways are Metabolism and Id Signaling Pathway. GO annotations related to this gene include iron ion transmembrane transporter activity. An important paralog of this gene is SLC25A28.

UniProtKB/Swiss-Prot for SLC25A37 Gene

  • Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Gene Wiki entry for SLC25A37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A37 Gene

Genomics for SLC25A37 Gene

Regulatory Elements for SLC25A37 Gene

Promoters for SLC25A37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A37 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A37 Gene

Chromosome:
8
Start:
23,528,805 bp from pter
End:
23,575,463 bp from pter
Size:
46,659 bases
Orientation:
Plus strand

Genomic View for SLC25A37 Gene

Genes around SLC25A37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A37 Gene

Proteins for SLC25A37 Gene

  • Protein details for SLC25A37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ2-MFRN1_HUMAN
    Recommended name:
    Mitoferrin-1
    Protein Accession:
    Q9NYZ2
    Secondary Accessions:
    • A2RU93
    • Q53FT7
    • Q69YJ8
    • Q969S1
    • Q9P0J2

    Protein attributes for SLC25A37 Gene

    Size:
    338 amino acids
    Molecular mass:
    37323 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64141.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305}; Sequence=CAH10415.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A37 Gene

Proteomics data for SLC25A37 Gene at MOPED

Post-translational modifications for SLC25A37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A37 Gene

Antibody Products

No data available for DME Specific Peptides for SLC25A37 Gene

Domains & Families for SLC25A37 Gene

Gene Families for SLC25A37 Gene

Protein Domains for SLC25A37 Gene

Suggested Antigen Peptide Sequences for SLC25A37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYZ2

UniProtKB/Swiss-Prot:

MFRN1_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A37: view

Function for SLC25A37 Gene

Molecular function for SLC25A37 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).
genes like me logo Genes that share phenotypes with SLC25A37: view

Animal Models for SLC25A37 Gene

MGI Knock Outs for SLC25A37:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A37 Gene

Localization for SLC25A37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A37 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A37 Gene COMPARTMENTS Subcellular localization image for SLC25A37 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
peroxisome 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A37 Gene

Pathways & Interactions for SLC25A37 Gene

genes like me logo Genes that share pathways with SLC25A37: view

Pathways by source for SLC25A37 Gene

1 BioSystems pathway for SLC25A37 Gene
2 Reactome pathways for SLC25A37 Gene

Gene Ontology (GO) - Biological Process for SLC25A37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0034755 iron ion transmembrane transport IEA --
GO:0048250 mitochondrial iron ion transport IEA --
genes like me logo Genes that share ontologies with SLC25A37: view

No data available for SIGNOR curated interactions for SLC25A37 Gene

Drugs & Compounds for SLC25A37 Gene

(1) Drugs for SLC25A37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(1) Additional Compounds for SLC25A37 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SLC25A37: view

Transcripts for SLC25A37 Gene

Unigene Clusters for SLC25A37 Gene

Solute carrier family 25 (mitochondrial iron transporter), member 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: -
SP7: - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: - -
SP11: - - - - - - - -
SP12:
SP13:

Relevant External Links for SLC25A37 Gene

GeneLoc Exon Structure for
SLC25A37
ECgene alternative splicing isoforms for
SLC25A37

Expression for SLC25A37 Gene

mRNA expression in normal human tissues for SLC25A37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A37 Gene

This gene is overexpressed in Whole Blood (x32.6).

Protein differential expression in normal tissues from HIPED for SLC25A37 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A37 Gene



SOURCE GeneReport for Unigene cluster for SLC25A37 Gene Hs.596025

genes like me logo Genes that share expression patterns with SLC25A37: view

Protein tissue co-expression partners for SLC25A37 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC25A37 Gene

Orthologs for SLC25A37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A37 36
  • 99 (a)
OneToOne
SLC25A37 35
  • 99.61 (n)
  • 99.7 (a)
cow
(Bos Taurus)
Mammalia SLC25A37 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A37 35
  • 92.09 (n)
  • 92.88 (a)
SLC25A37 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a37 16
Slc25a37 35
  • 88.36 (n)
  • 91.42 (a)
Slc25a37 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A37 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A37 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a37 35
  • 87.48 (n)
  • 92.31 (a)
chicken
(Gallus gallus)
Aves SLC25A37 35
  • 74.61 (n)
  • 78.15 (a)
SLC25A37 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A37 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a37 35
  • 73.27 (n)
  • 74.83 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a37 35
  • 71.68 (n)
  • 74.58 (a)
slc25a37 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006030 35
  • 62.68 (n)
  • 57.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta mfrn 35
  • 60.45 (n)
  • 56.27 (a)
mfrn 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mfn-1 36
  • 53 (a)
OneToMany
mfn-1 35
  • 54.12 (n)
  • 55.25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR260W 35
  • 49.65 (n)
  • 42.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS4 35
  • 47.2 (n)
  • 42.31 (a)
MRS3 36
  • 39 (a)
ManyToMany
MRS4 36
  • 39 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15445g 35
  • 49.54 (n)
  • 43.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30160 35
  • 45.95 (n)
  • 42.14 (a)
rice
(Oryza sativa)
Liliopsida Os03g0296800 35
  • 50.91 (n)
  • 43.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02423 35
  • 54.47 (n)
  • 46.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8C9.12c 35
  • 48.36 (n)
  • 44.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC25A37:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A37 Gene

ENSEMBL:
Gene Tree for SLC25A37 (if available)
TreeFam:
Gene Tree for SLC25A37 (if available)

Paralogs for SLC25A37 Gene

Paralogs for SLC25A37 Gene

(2) SIMAP similar genes for SLC25A37 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A37: view

Variants for SLC25A37 Gene

Sequence variations from dbSNP and Humsavar for SLC25A37 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2942194 - 23,566,156(-) GTAGA(C/T)ACTTG reference, missense, utr-variant-5-prime
rs3736032 - 23,566,184(+) CATGC(A/G/T)GACCG reference, missense, utr-variant-5-prime
rs752778 -- 23,531,467(-) TTAAA(A/C)ATGTG intron-variant
rs1140161 -- 23,568,806(+) tagtg(C/T)ggtgt intron-variant
rs2137304 -- 23,557,727(-) CCCTC(C/T)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A37 Gene

Variant ID Type Subtype PubMed ID
nsv831268 CNV Gain 17160897
nsv508499 CNV Loss 20534489
esv2421786 CNV Deletion 20811451
esv22651 CNV Loss 19812545
esv1990641 CNV Deletion 18987734
nsv471717 CNV Loss 16327809
esv2736758 CNV Deletion 23290073
esv4817 CNV Deletion 18987735
esv2528186 CNV Deletion 19546169
nsv396338 CNV Loss 16902084
esv9692 CNV Loss 19470904
nsv819222 CNV Gain 19587683

Variation tolerance for SLC25A37 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.08; 90.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A37 Gene

HapMap Linkage Disequilibrium report
SLC25A37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A37 Gene

Disorders for SLC25A37 Gene

Relevant External Links for SLC25A37

Genetic Association Database (GAD)
SLC25A37
Human Genome Epidemiology (HuGE) Navigator
SLC25A37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A37

No disorders were found for SLC25A37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A37 Gene

Publications for SLC25A37 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Mitoferrin is essential for erythroid iron assimilation. (PMID: 16511496) Shaw G.C. … Paw B.H. (Nature 2006) 2 3
  3. Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron. (PMID: 24854990) Visconte V. … Tiu R.V. (Leukemia 2015) 3
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. (PMID: 21627978) Wang Y. … Bloomer J.R. (Exp. Hematol. 2011) 3

Products for SLC25A37 Gene

Sources for SLC25A37 Gene

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